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COREL PHARMA CHEM

“COREL HOUSE”, Nr. Shayona Marble, S. G. Highway, Gota, Ahmedabad 382481, India.
Phone: 91-79-27665556/58/59. Fax: 91-79-27661754
Email: marketing@corelpharmachem.com
Edition:01058
Paracetamol Syrup by Acrysol K-150
Function and Benefit
Acrysol K-150
• It is solublizer to improve water solubility of water insoluble products like API,
perfumes or oil.
• It is odorless, tasteless and colorless liquid which is used in topical and oral
applications.

Advantages:

Acrysol K-150 Propylene glycol (PG)


Less quantity consumption High quantity consumption
Almost tasteless Irritative taste in more quantity
More transparent Transparent
More glossiness Glossiness

Formulation:
Batch size: 100.0 ml Paracetamol syrup

Ingredient Weight Function


Part- I
Paracetamol 2.5 gm Active ingredient
Acrysol K-150 10.0 gm Solubilizer
Glycerin 2.5 gm Diluent
D.M water 30.0 ml Diluent

Part II
Sucrose* 30.0 gm Sweetening agent
D.M.Water 20.0 gm Diluent
Sweetener 0.220 gm Sweetener
Sodium Methyl Paraben 0.150 gm Preservative
Sodium Propyl Paraben 0.030 gm Preservative
Sodium Benzoate 0.150 gm Preservative
Citric acid mono-hydrate** 0.070 gm pH modifier
Colour 2.50 mg Coloring agent
Flavour 0.25 ml Flavoring agent

* It is recommended to take quantity of sucrose less than 35% of total Paracetamol syrup batch
size for better formulation.
**Such that the final pH of syrup remains between 3.80-6.10

ACRYCOAT – ACRYPOL – ACRYSOL – COLORCOAT - KYRON


THE NEXT GENERATION POLYMER TECHNOLOGIST
COREL PHARMA CHEM
“COREL HOUSE”, Nr. Shayona Marble, S. G. Highway, Gota, Ahmedabad 382481, India.
Phone: 91-79-27665556/58/59. Fax: 91-79-27661754
Email: marketing@corelpharmachem.com

Physical Property
Appearance Clear and Transparent
pH 5.90

Procedure:
Part-I
1. Heat Acrysol K-150 at 50°C and add Paracetamol in it. Stir the solution for 30 minutes.
2. Heat Glycerin at 50°C and then add in step -1 solution (Acrysol K-150 + Paracetamol)
under continues stirring. Stir the solution for 20 minutes. Transparent solution will be
obtained.
3. Heat water at 50°C and put it under continuous stirring.
4. Add step-1 solution (Acrysol K-150 + Paracetamol + Glycerin) slowly in to D.M.
Water under continuous stirring. Transparent solution will be obtained.

Part-II
5. Weigh accurately sucrose. Add sucrose in hot (65°C.) D.M. water under continuous
stirring till it is dissolved.
6. Filter above solution through filter press. Keep filtrate under stirring.
7. Add Citric acid monohydrate, Sodium methyl paraben, Sodium propyl paraben
Sweetener and Sodium benzoate in it with continuous stirring for 10 minutes.

Mixing of Part-I & Part-II


8. Slowly add part-I in part-II under continuous stirring. Stir it till clear solution is
obtained.
9. Check pH of above solution. If pH is not between 3.80-6.10 than add accordingly Citric
acid solution to adjust pH.
10. Add colour solution in above solution under stirring. Now, add flavor under continuous
stirring.
11. Make volume 100 ml by D.M water if required.
12. Clear transparent Paracetamol syrup is obtained.

Note:
1. The congealing temperature of Acrysol K-150 is lower so heating up to 50°C is
mandatory before using for proper mixing with Paracetamol.
2. This is the tentative formulation and the information is based on laboratory work with
small scale equipment and does not indicate the product performance.
3. Full scale testing and end product performance are the responsibility of the user.

ACRYCOAT – ACRYPOL – ACRYSOL – COLORCOAT - KYRON


THE NEXT GENERATION POLYMER TECHNOLOGIST

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