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Wound Healing Pathophysiology
1. Inflammatory Phase
2. Proliferative Phase
3. Remodelling Phase
Inflammatory Phase
thrombus formation
vasodilation
phagocyte emigration
digest debris
neutrophils arrive first, ingest bacteria, gone by day 3-4
wounds may heal in absence of neutrophils, they cannot heal without macrophages
Proliferation Phase
lasts up to 3wks
tissue is fragile and bleeds easily during to the # of newly formed capillary buds
in primary intention healing, epidermal cells seal the wound within 24-48h
epithelial cells require a moist surface for proliferation, therefore will wait to migrate
under newly formed scab.
Remodelling Phase
tensile strength increases to 70-80% over the next 4 wks before plateau
1. Malnutrition