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Your 72-year-old patient presented to your office with severe back pain,
upper leg pain, hearing loss, and high some signs of cardiac failure. You took
an X ray of the pelvis and noticed that bone architecture in the femur and spine
was abnormal. You described the architecture as mosaic. Which lab abnormalities w
ould you expect to see in this patient?
A Increased alkaline phosphatase levels
B Decreased calcium levels
C Decreased phosphorus levels
D Decreased alkaline phosphatase levels
E Normal alkaline phosphatase levels
Your team has just admitted a 36-year-old female who complains of feelin
g really down for the last two weeks and has no interest in her usual activities
. She has been waking at 3 a.m. every day. Her appetite is poor and she feels li
ke she is moving in slow motion. She admits that she has thought about killing h
erself because life isn't worth living anymore. Which of the following medicatio
ns would you prescribe?
A Alprazolam (Xanax)
B Amitriptyline (Elavil)
C Chlorpromazine (Thorazine)
D Fluoxetine (Prozac)
E Temazepam (Restoril)
You have just told your 55-year-old patient that she has inoperable panc
reatic cancer that has metastasized to the liver and that she has at most six mo
nths to live. She laughs at you and says, Don t be silly. I feel fine. I'm going to
live to be 100.' Which stage of grieving is she currently in?
A Acceptance
B Anger
C Bargaining
D Denial
E Grieving
An eight-week-old infant is brought to clinic by his Old World Mennonite
parents. They have noticed sweet-smelling urine in this child, and they also ha
ve a three-year-old daughter who has failed to meet developmental milestones. Up
on evaluation of the infant's urine, which metabolite would you expect to be ele
vated?
A Histidine
B Homocystine
C Homogentisate
D Phenylalanine
E Valine
A 16-year-old female comes into your office for a routine physical exam.
She tells you that she is shorter than the rest of her classmates. On physical
exam, you notice that she has an increase in skin folds around the neck (webbed
neck). When taking her blood pressure, you find it to be 145/92 when taken from
her left arm and 90/55 in her left leg. Upon further questioning, you find that
she has never had a menstrual period. What is the chromosomal abnormality you wo
uld expect to find in this patient?
A 45, XO
B 45, XY with trisomy 18
C 45, XY with trisomy 21
D 47, XXY
E 47, XYY
An infant is diagnosed and admitted to the hospital with bacterial meningitis
based on CSF studies, an elevated WBC, and her clinical presentation. On rounds
, you are asked to describe why chloramphenicol should not be used in this patie
nt's therapy. Which of the following is the deficient phase II process resulting
in the gray baby syndrome ?
A Epoxidation
B Glucuronidation
C Glutathione reaction
D Hydroxylation
E Methylation
Your 64-year-old patient with congestive heart failure (CHF), hypertensi
on (HTN), and diabetes mellitus type II (DM2) complains of seeing yellow-green h
aloes around lights. She is currently taking digoxin, hydrochlorothiazide, metfo
rmin, hydralazine, and glyburide. Which of these drugs causes the previously men
tioned side effect?
A Digoxin
B Glyburide
C Hydralazine
D Hydrochlorothiazide
E Metformin
An 84-year-old white male presents to the outpatient clinic with a chief
complaint of back and leg pain. History reveals that his hat size has increased
. Physical exam shows decreased auditory acuity, 2 + lower-extremity pitting ede
ma, and skin warmth over the bilateral thigh. Plain films of his femurs demonstr
ate large bones, increased bone density, and thick cortical bone with mottled ap
pearance. Which is the following is most consistent with this disease process?
A Normal serum alkaline phosphatase
B Normal risk of cardiac failure
C Normal risk of fracture
D Normal risk of neoplasia
E Normal serum calcium
On internal medicine rounds, the attending physician is discussing amino
acids. You remember that some amino acids are essential that is, found only in th
e diet. Which of the following is an essential amino acid?
A Arginine
B Asparagine
C Glutamate
D Glycine
E Proline
F Serine
G Tyrosine
A 29-year-old male returns from a two-day trip to Mexico with frequent loose
stools that do not contain blood. You diagnose the patient with traveler's diarr
hea. Of the following organisms, which is most likely to cause nonbloody, watery
diarrhea?
A Campylobacter jejuni
B Entamoeba histolytica
C Enterotoxigenic E. coli
D Salmonella
E Shigella
A patient comes into your office for her prenatal visit. She is currentl
y four weeks pregnant and has no complaints. She casually mentions that she is t
hinking about adopting a kitten for her five-year-old son so that he won't be je
alous when the baby comes. This will be the first time that she has owned a kitt
en. You are most concerned about which infection?
A Cat scratch fever
B CMV
C Francisella tularensis
D Rubella
E Toxoplasmosis
A 58-year-old white male presents to the emergency room with complaints
of frequent morning headaches and vomiting. The patient has a cigarette habit of
two packs per day for 40 years. Physical exam reveals papilledema, positive Ker
nig and Brudzinski signs, but no photophobia. CT reveals three well-demarcated,
spherical, dense foci with significant edema and displacement. Two masses are fr
ontal, while one appears to be dural. Which is the most likely primary site?
A Acoustic canal
B Frontal lobe
C Lung
D Meninges
E Posterior fossa
You are in the pediatric clinic doing a well child check on an eight-year-old b
oy. He has a past medical history of asthma that is currently being treated as n
eeded (PRN) with albuterol, given via a multidose inhaler. When asked, his mothe
r tells you that he has been using the inhaler daily for the last month due to i
ncreased shortness of breath. What is the most appropriate thing to do?
A Add inhaled corticosteroids such as fluticasone on a dai
ly basis, reserving the albuterol for exacerbations only
B Add systemic steroids
C Congratulate them on using the albuterol as prescribed
D Stop the albuterol; the child has outgrown his asthma
E Stop the albuterol; prescribe only inhaled corticosteroi
ds
A 28-year-old patient with no significant medical history is undergoing
general anesthesia for the first time for a surgical procedure. The patient is p
ut under anesthesia but soon into the operation experiences a sudden rapid rise
in temperature, muscle rigidity, sweating, and tachycardia. Which of the followi
ng statements best explains what is happening to the patient?
A The patient is experiencing malignant hypertension secon
dary to defects in a potassium-channel receptor
B The patient is experiencing malignant hypertension secon
dary to defects in a sodium-channel receptor
C The patient is experiencing malignant hyperthermia secon
dary to defects in a calcium-channel ryanodine receptor
D The patient is experiencing malignant hyperthermia secon
dary to defects in a chlorine-channel receptor
E The patient is experiencing malignant hyperthermia secon
dary to defects in a selenium-channel receptor
A cruise ship returns to port early, due to an outbreak of diarrhea. Eig
ht hundred of 2000 passengers have been affected. Physicians aboard the ship bel
ieve that Norwalk virus is probably responsible. Which of the following statemen
ts is correct?
A Antiviral therapy will attenuate the symptoms.
B Norwalk virus infection has equal incidence in children
and adults.
C Immunity after infection is life-long.
D The primary mode of transmission is via inhaled particle
s.
E Symptoms usually subside within 24 h.
After attempting to replicate Columbus's original voyage, a 40-year-old
sailor comes to your office describing a several-month trip across the Atlantic
Ocean with few provisions. In your office, he presents with swollen gums, anemia
, and diffuse bruises over his body. Which of the following vitamin deficiencies
best explains your patient's current presentation?
A Vitamin A
B Vitamin B1
C Vitamin C
D Vitamin D
E Vitamin E
A 15-week pregnant female comes to the clinic complaining of nausea and
vomiting. The patient has had one cesarean section in the past for breech presen
tation. Her gynecologic history includes menarche at age 14 and regular menses.
All prenatal lab samples are drawn, including a full hormone panel. Which of the
following statements is true of hormones during pregnancy?
A Human placental lactogen has anti-insulin properties.
B The high level of human placental lactogen in pregnancy
prevents milk letdown.
C Progesterone and estrogen are made by corpus luteum unti
l the fetoplacental until can take over production.
D Prolactin starts to increases after birth.
E There is a steady increase in hCG during pregnancy.
A test for disease X is known to have a sensitivity of 0.95, specificity
of 0.65, positive predictive value of 0.73, and negative predictive value of 0.
93. What is the false-negative rate?
A 0.05
B 0.08
C 0.27
D 0.35
E Undeterminable from the information given
As a third-year medical student on your surgery clerkship, you are obser
ving a direct inguinal hernia repair on a 24-year-old man. The attending physici
an is now ascertaining your knowledge regarding direct inguinal hernias. He asks
you what makes up the medial border of Hesselbach's triangle, also known as the
inguinal triangle. What is your response?
A Conjoint tendon
B Inferior epigastric vessels
C Inguinal ligament
D Lacunar ligament
E Lateral edge of the rectus abdominis muscle
An 18-year-old female presents to the gynecology clinic, concerned because sh
e has never had a menstrual period. A physical exam reveals an absence of axilla
ry and pubic hair. The patient has breast tissue present bilaterally. A pelvic e
xam reveals the vagina ending in a blind pouch. A bimanual exam reveals an absen
ce of cervix, uterus, and ovaries. What is the most likely karyotype of this pat
ient?
A 45, XO
B 46, XX
C 46, XY
E 47, XYY
On the Internal Medicine service, you are working as an intern. A patien
t of yours has a history of TB in the distant past, along with gastroesophageal
reflux, myocardial infarction, stroke, and osteoporosis. The patient is currentl
y admitted for pneumonia. He also complains of back pain, for which you have rel
uctantly given him narcotics to assuage his continued complaining. On a past CT
of his spine, you observe some spherical hypodensity in the psoas muscle. You or
der an MRI for a better look and bring up the likely diagnosis of which of the f
ollowing?
A Fracture of vertebral bodies secondary to osteoporosis
B Prosthetic placement
C Recurrent TB infection
D Torn muscle
E Tumor metastatic to the psoas muscle
A college rugby player comes to the student health clinic for a hot, inflamed
knee. It has been this way for almost five days, since a big game during the pr
evious weekend. The patient does not remember injuring it, nor can you find any
evidence of a scrape. The left knee has the following qualities: calor, dolor, r
ubor. The patient is limited in his range of motion and cannot walk due to the p
ain. You aspirate the knee and Gram-stain it yourself. Your findings are as foll
ows: bean-shaped, gram-negative diplococci. You infer that your history should h
ave included which of the following?
A Eye exam
B History of IV drug use
C History of passing out
D History of trauma within the past year
E Sexual history