TANZILYA KHAYRULLINA, PHD

14 Falcon Road, Flanders, NJ 07836

(973) 252-1485
tkd2663c@westpost.net
CAREER OBJECTIVES
I am a scientist with 10 years of experience in the field of
inflammation/autoimmunity, along with medical degree with experience
in the healthcare, seeking for a position in a biotech/pharmaceutical
industry where my experience, talent, education and accomplishments
will contribute towards achieving the set goals of the organization.
SCIENTIFIC SKILLSETS:
The primary area of my research is immunology: The links between
innate and adaptive immune responses; Pathogenesis of immune-mediated
diseases: MS, Crohn's disease, RA, pulmonary fibrosis and pain at the
cellular and molecular levels; Prostaglandins and cell-mediated
immunity; Microglia as mediator of inflammation, pain and
degeneration.

TECHNICAL SKILLSETS:
_Molecular Biolo__gy_: Isolation of RNA/DNA from cells and animal
tissues, RT-PCR, TaqMen, microarray, immunoassays including
ELISA/LUMINEX, Western blotting, in-cell Western, FLIPR.
_Cell Biology_: Isolation of murine dendritic and T cells, neonatal
astrocytes, microglia and dorsal root ganglion cells, growth and
transfection of immortalized cells, cell based assays,
immunofluorescence, flow cytometry, proliferation/apoptosis assay.
_Animal w__ork_: breeding and phenotyping of transgenic mice,
microdissection (murine spinal cord, brains), drug administration,
transcardial perfusion. Experience in development of in vivo animal
models: collagen-induced arthritis (CIA), inflammatory bowel disease
(IBD), and experimental autoimmune encephalomyelitis (EAE), chronic
mouse models of human multiple sclerosis.
_Automation and Computer_: Microsoft Word, Microsoft Excel, Power
Point, Sigmaplot and BLAST; Spectromax, Envision, and Prism. Skilled
user of scientific search engines such as PubMed and Medline.

Additional qualifications:
_Communication skills_: possess negotiating and organizing skills,
excellent verbal and written communication ability. Enjoy interacting
and building interpersonal relations with people from diverse
background.
 _Teamwork_: a confident team player with exceptional experience in
teamwork through strong communication skills.
_Critical Thinking_: developing critical and logical thinking in the
research study, dealing with problematic issues with continuous
development of analytical and problem solving expertise.
Other: self motivated, ambitious, energetic with an exceptional work
ethic and willing to go the extra mile to achieve targets; confident,
hardworking, innovative and resourceful.
PROFESSIONAL TRAINING AND WORK EXPERIENCE
2008- PRESENT POSTDOCTORAL FELLOW AT SANOFI-AVENTIS PHARMACEUTICALS
*
The aim of the research was target identification and validation,
biomarkers selection, assay method validation and application to
understand the mechanisms of the pulmonary fibrotic disease
progression. Implemented molecular techniques to identify key
signaling molecules that are central in pulmonary fibrosis including
extracellular matrix production, epithelial-mesenchymal transition
and cellular proliferation.
*
Research focus was on cellular and molecular mechanisms of
prostaglandins in inflammatory pain. Designed experiments to clarify
molecular mechanisms of glial-neuronal interactions, developed and
validated tertiary functional cell based assays for in vitro
pharmacology: identified and validated targets, evaluated dose
responses, kinetics, mechanisms of action, established IC50 values.
Results are summarized in research article being prepared for
publication
2006-2008 VISITING RESEARCH SCHOLAR AT DEPARTMENT OF MICROBIOLOGY
AND IMMUNOLOGY, TEMPLE UNIVERSITY, PHILADELPHIA, PA
Research goals were to establish variety of laboratory methods and
in vivo models of autoimmune diseases to investigate roles of PGE2 in
autoimmunity, gain expertise in the field of cellular and molecular
neuro-immunology.
*
Accomplished the study on interaction of neuro-immune systems.
Verified PGE2 effects on IL-23 release by microglia. Evaluated
impacts of PGE2 on murine model of experimental autoimmune
encephalomyelitis (EAE), acute mouse models of human multiple
sclerosis (MS).
2004-2008 GRADUATE STUDENT (PH.D. PROGRAM), DEPARTMENT OF
BIOLOGICAL SCIENCES, RUTGERS STATE UNIVERSITY, NEWARK, NJ
Goals of the program were to perform independent research for PhD
thesis, gain expertise in the field of autoimmunity.
Defended PhD thesis: "Exposure to PGE2 during differentiation
primes bone marrow-derived dendritic cells for a proinflammatory
response". Results of the thesis work were summarized in research
papers published in peer review journals.
*
Established the roles of the prostaglandin E2 (PGE2) in the
pathogenesis of T cell-mediated autoimmune responses in mouse models
of human autoimmune disease, such as CIA and IBD. Results summarized
in research papers published in peer review journals.
2001-2004 GRADUATE STUDENT (MS PROGRAM), DEPARTMENT OF BIOLOGICAL
SCIENCES, RUTGERS UNIVERSITY, NEWARK, NJ
Aim of the program was to accumulate knowledge in biological
disciplines, develop expertise in a wide range of molecular and cell
biology techniques.
*
Investigated mechanisms by which the neuropeptides VIP and PACAP
affect cytokine production in dendritic and Th1/Th2 effector and T
regulatory cells differentiation, as well as transduction pathways
and transcriptional factors.

*
Investigated mechanisms of p75-mediated death of hippocampal
neurons. Interaction of survival and death signaling in basal
forebrain neurons: Roles of NGF and pro-NGF signaling in
neurodegenerative diseases.
2001-2005 TEACHING ASSISTANT, DEPARTMENT OF BIOLOGICAL SCIENCES,
RUTGERS UNIVERSITY, NEWARK, NJ
*
Teaching and mentoring of undergraduate students. Teaching subjects:
General Biology, Anatomy and Physiology, Comparative Anatomy of the
Vertebrates, Mammalian Physiology.
EDUCATION
2004 - 2008 Ph.D., Molecular and Cellular Biology, Department of
Biological Sciences, Rutgers University, Newark, NJ
2001 - 2004 MS., Molecular Biology, Department of Biological
Sciences, Rutgers University, Newark, NJ
1994 MS., Central Asian Institute of Pediatric Medicine, Tashkent,
USSR
AWARDS AND ACHIEVEMENTS
2008 Recipient of an American Association of Immunologists Trainee
Abstract Award
2008 Research paper was recognized by the "Faculty of 1000 Biology"
2007 Recipient of Dissertation Fellowship from the Rutgers Graduate
School-Newark
2004, 2005 Recipient of Johnson & Johnson Neuroimmunology
Fellowship grant
2001-2005 Recipient of Teaching Assistantship grant
PUBLICATIONS
Khayrullina T., Yen J-H., and Ganea D. (2008). _"Differentiation of
dendritic cells in the presence of PGE2 alters the IL-12/IL-23
balance and promotes differentiation of Th17 cells"_. J. Immunology,
181, pp.721-35 (_This work has been __recognized__ __by__ the
__Faculty__ __of__ __1000__ __Biology_).
Yen J-H., Khayrullina T. and Ganea D. (2008), _"PGE2-induced
metalloproteinase-9 is essential for dendritic cells migration"_.
Blood, 111, pp. 260-70
Sheibanie A.F., Khayrullina T., Safadi F. F., Ganea D. (2007).
_"PGE2 exacerbates collagen-induced arthritis through the
inflammatory IL-23 ____ IL-17 axis"_. Arthritis and Rheumatism
Vol.56, No.8, pp. 2608-2619
Sheibanie A.F., Yen J-H., Khayrullina T., Emig F., Zhang M., Tuma
R., Ganea D. (2007), _"The proinflammatory effect of PGE2 in
experimental inflammatory bowel disease is mediated through the IL-23
____IL-17 axis"._ J. Immunology, 178, pp.8138-8147
CONFERENCE PRESENTATIONS
Khayrullina T., Yen G-H. and Ganea D., "_Dendritic cells
differentiation in the presence of PGE2 primes dendritic cells for
proinflammatory response, induces IL-23, and promotes Th17
differentiation_", 95th Annual Meeting of the American Association of
Immunologists, San Diego, CA, April 2008
Khayrullina T., Yen G-H. Ganea D., "_Effects of PGE2 on antigen
presenting cells_",7th Annual Dawn B. Marks Research Conference,
Philadelphia, PA, December 2007
Khayrullina T. and Ganea D., "_Dendritic cells generated in the
presence f PGE2 promote IL-17 production in activated CD4+ T cells_",
94th Annual Meeting of the American Association of Immunologists,
Miami Beach, Florida, May 2007
Khayrullina T. and Ganea D., "_The role of PGE2 in the CNS_", 6th
Annual Dawn B. Marks Research Conference, Philadelphia, PA, December
2006
Khayrullina T. and Ganea D., "_Pro-inflammatory role of PGE2 in
microglia"_, 7th International Symposium in NeuroVirology,
Philadelphia, PA, June 2006
Khayrullina T., Ganea D.,_ "Microglia generated in the presence of
PGE2 exhibit strong pro-inflammatory characteristics"_, Annual
Meeting of the American Association of Immunologists, Boston, MA, May
2006
Khayrullina T. and Friedman W., _"Role of proNGF in basal forebrain
neuronal survival"_, Neuroscience Minisymposium, Newark, NJ, November
2003