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PAPER NAME : MINOR 3

1) Which of the folloing system would be transparent

A) W/O emulsion

B) O/W emulsion

C) Microemulsion

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D) Suspension

o
Correct Answer is C

f.c
2) An ideal controlled drug delivery system is

A) Delivers a drug at a predetermined rate

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B) Deliver a drug at a predetermined rate for specified period of time

C) Deliver a drug at a predetermined rate for unspecified period of time

D) Deliver a drug at a undetermined rate for specified period of time

Correct Answer is B
m
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3) Liposomes are targeted drug delivery systems. They act via

A) Uptake by neurons
ph

B) Uptake by Reticuloendothelial system (RES)

C) Uptake by GIT goblet cells

.b

D) Uptake by Peripheral neurons

Correct Answer is B
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EXP : Liposomes are targeted drug delivery systems and are uptaken by RES (comprised of Liver,
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kidney and Bone marrow) when given systemically. The drug entrapped in it would localize in the liver

primarily and subsequently the lipid structure of liposomes would be metabolized and drug would
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release there (like anticancerdrug used in liver carcinoma). When orally given liposome lipids would be

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digested in GIT and would release drug there itself and targeting purpose of the drug to liver would be

lost

4) In transdermal drug delivery system the potential gradient is used to increase the drug permeation

across skin. The technique is known as

A) iontophoresis

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B) Phonosoresis

C) Electrophoresis

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D) None of the above

f.c
Correct Answer is A

EXP : Iontophoresis is used to encrease potential difference acriss skin to increase the drug permeation

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of ionic drugs.

5) Enteric coated tablet is example of m

A) Controlled release

B) Sustained release
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C) Delayed release
ph

D) Repeat action tablet

Correct Answer is C

6) Transdermal patch of Diclofenac is example of the following type of system

.b

A) Delayed release
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B) Controlled release

C) Fast release
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D) None of the above

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Correct Answer is B

7) Enteric coated tablet release drug

A) in controlled manner
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B) for longer duration of time

C) at intestine only

D) All of these

Correct Answer is C

8) A drug is to sent specifically to the targeted site in case of liver carcinoma. Which of the following

m
system would be suitable to formulateA) Enteric coated tablet

o
B) Controlled release formulation

f.c
C) Liposomes

D) Transdermal patches

stu
Correct Answer is C

EXP : Liposomes are targeted drug delivery systems and are uptaken by RES (comprised of Liver,

kidney and Bone marrow) when given systemically. The drug entrapped in it would localize in the liver
m
primarily and subsequently the lipid structure of liposomes would be metabolized and drug would
ar
release there (like anticancerdrug used in liver carcinoma). When orally given liposome lipids would be

digested in GIT and would release drug there itself and targeting purpose of the drug to liver would be
ph

lost

9) Which of the following is not targeted drug delivery system

.b

A) Liposome

B) Nanoparticle
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C) Dendrimers
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D) Buccal tablets

Correct Answer is D
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10) Reticuloendothelial system comprises of the following. Which is irrational

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A) Liver

B) Spleen

C) Blood

D) Bonemarrow

Correct Answer is C

m
EXP : RES (comprised of Liver, kidney and Bone marrow. Liposomes nanaparticles, resealed

erythrocytes are uptaken by these and degraded in the target organ to release drug specifically to these

o
organs.

f.c
11) Which of the following drug would be most suited for dermojet delivery systems:

A) Aspirin

stu
B) Propranolol

C) Insulin m
D) All may be given

Correct Answer is C
ar
EXP : Dermojet systems are used to alleviate the need of needle. Insulin is given by SC route and it is
ph

very painful. Aspirin, propranolol may be given effectively by oral route but not the insulin.

12) Spectroscopically what is true for the result of attachment of Nitro Group to Ethene?

A) Gives a UV spectra at higher energy

.b

B) Absorption maxima is increased

w

C) Electron requires UV radiation of lesser wavelength to transit

D) All of these
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Correct Answer is C
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EXP : Nitro group will act as an auxochrome & hence hyperchromic shift.

13) Theoretically which of the solvent gives UV spectra at minimum energy?

A) Water
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B) Acetone

C) Carbon tetra chloride

D) Chloroform

Correct Answer is C

EXP : Carbon tetra chloride is a non polar sovent.

m
14) Which electronic transition requires maximum energy?

o
A) pie-pie*

f.c
B) n-pie*

C) sigma-sigma*

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D) n-n*

Correct Answer is C

EXP : sigma bonding to sigma antibonding requires max energy & hence not general in UV

spectrophotometer.
m
ar
15) Calculate the theoretical molar absorptivity constant for 1000 ml. Aq. solution containing 122gm of

Benzoic acid if it shows UV extinction coefficient of 0.50 at 246nm.

ph

A) 0.5 unit

B) 0.005 unit
.b

C) 5 unit

D) 50 unit
w

Correct Answer is A
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EXP : Apply beer lamberts law A=abc

16) Calculate the mole present in a solution of 5 gm of an unknown substance which has molar
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absorptivity constant & specific absorptivity constant 0.4 & 0.1 respectively.

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A) 1/8 mole

B) 1/3 mole

C) 1/8 mole

D) 1/5 mole

Correct Answer is C

m
EXP : Apply the mole concept: M.wt= Avegedro No = 1 mole

17) What will be the maximum UV wavelength on attachment of a phenyl group at 6 positions for

o
3-Octene-2-one?

f.c
A) 253 nm

B) 245 nm

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C) 285 nm

D) 258 nm m
Correct Answer is C

EXP : Apply the concepts of woodword fishure rules for unsaturated dienes.
ar
18) For experimental point of view what is the correct increasing sequence of stes in operating UV
ph

spectrophotometer?

A) zeroing-scanning-integrating absorption

B) scanning-zeroing-integrating absorption
.b

C) integrating absorption-scanning-zeroing
w

D) Only Zeeroing

Correct Answer is A
w

19) Select the most suitable Sterilization technique for tetanus vaccine.
w

A) Dry heat

B) Autoclaving

C) Gaseous
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D) Filtration

Correct Answer is D

EXP : Clostridium titani releases tetanus exotoxin which are thermolabile & hence the best technique is

filtration (membrane filters)

20) Which of the following is match with Endotoxin

m
A) Clostridium

o
B) Water soluble

f.c
C) Metabolites

D) All of these

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Correct Answer is D

EXP : These all are the properties of exotoxins.

21) What will be the best option for urgent Immunity?

A) Antigen containing prepration

m
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B) Antibody containing prepration

C) Sera
ph

D) Both b & c

Correct Answer is D
.b

EXP : Sera or Antibody containing prepration provides urgent immunity for therepeutic purpose.

22) In genetic recombination, RecA is responsible for?

w

A) The repair of DNA double strand breaks (DSBs)

w

B) Breaking of DNA strands

C) Breaking of RNA strands

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D) None of these

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Correct Answer is A

EXP : Genetic recombination is catalyzed by many different enzymes, called recombinases. RecA, the

chief recombinase found in Escherichia coli, is responsible for the repair of DNA double strand breaks

(DSBs).

23) Recombination hotspots are?

m
A) Genomic regions of sexually reproducing organisms, exhibits highly elevated rates of meiotic

recombination.

o
B) Regions with high DNA density

f.c
C) Any genomic region have good recombination potential

D) Genomic regions , exhibits highly elevated rates of meiotic recombination.

stu
Correct Answer is A

EXP : Recombination hotspots are small regions in the genome of sexually reproducing organisms that
m
exhibit highly elevated rates of meiotic recombination. The peak recombination rate within hotspots can

be hundreds or thousands of times that of the surrounding region.

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24) Food poisonings is caused due to
ph

A) Exotoxin

B) Endotoxin

C) Bacterial cells
.b

D) Becterial cells
w

Correct Answer is B

25) Select the first auxin was isolated

w

A) Indole 3-acetic acid

w

B) Purine

C) Indole acetoacetic acid

D) Indole acetaldehyde
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Correct Answer is A

EXP : Compounds are generally considered auxins if they can be characterized by their ability to

induce cell elongation in stems and otherwise resemble indoleacetic acid (the first auxin isolated) in

physiological activity.

26) Select the chemical nature of the plant hormon ABA

m
A) Monoterpenoidal (10 Carbon)

o
B) Sesquiterenoid (15 Carbon)

f.c
C) Glycosidal

D) Terpenoidal

stu
Correct Answer is B

EXP : ABA is a naturally occurring compound in plants. It is a sesquiterpenoid (15-carbon) which is

partially produced via the mevalonic pathway in chloroplasts and other plastids

27) Select the biosynthetic precursor of gibbrellin

m
ar
A) Acetyl CoA

B) Tryptophen
ph

C) Violaxanthin

D) Xanthonin
.b

Correct Answer is A

EXP : Gibberellins are diterpenes synthesized from acetyl CoA via the mevalonic acid pathway. They
w

all have either 19 or 20 carbon units grouped into either four or five ring systems.
w

28) The chemical nature of Zetain (One type of cytokinin plant hormon) is

A) Adenine derivative
w

B) Purine derivative

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C) Tryptophen derivative

D) Terpenoidal derivatives

Correct Answer is A

EXP : It is 6-substituted adenine derivative. Two cytokinins are: Kinetin & Zetain

29) Select the best pair of synthetic plant growth inhibitor

m
A) ABA & Meleic hydrazide

B) ABA only

o
C) Meleic hydrazide only

f.c
D) Phosphon & Meleic hydrazide

Correct Answer is B

stu
EXP : ABA is a naturally occurring compound in plants & acts as a plant growth inhibitor. Except

ABA all here are synthetic plant growth inhibitor. m

30) Select the correct biosynthetic intermediate for ethylene as a plant growth regulater

A) ABA
ar
B) ACC
ph

C) S-Adenosylmetionine

D) Violaxanthin

Correct Answer is B
.b

EXP : ACC: 1-Aminocyclopropane-1-carboxylic acid. S-Adenosylmetionine is the precursor.

w

31) In measuring the Vein-islet no of a herbal crude drug, which chemical is used to remove Ca-oxalate

crystals
w

A) Cloral hydrate
w

B) Na-hypochlorite

C) HCl

D) NaCl
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Correct Answer is C

EXP : Cloral hydrate is used for cleaning the leaves & Na-hypochlorite is for bleaching.

32) Select the unofficial leaf constant

A) Stomatal No

B) Palisade ratio

m
C) Guard cell no

o
D) Vein-termination no

f.c
Correct Answer is C

33) Select the best pair of crude drug which can be distinguished through their vein-termination no

stu
A) Indian & Egyptian senna

B) Clove & aloe

C) Aloe & senna

D) All of these
m
ar
Correct Answer is A

EXP : vein-termination no is good to distinguish for two closely related species.

ph

34) Select the constant leaf constant throught the age of a plant

A) Stamatal index
.b

B) Stomatal No

C) Vein-termination No
w

D) Vein-islet No
w

Correct Answer is A

35) Which of the following would give fast onset of action:

w

A) Tablet

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B) Capsule

C) Solution

D) Ointment

Correct Answer is C

EXP : In solution the drug is ready to be absorbed across biological membranes while dissolution is to

m
take place first in rest of three and then absorption would take place.

36) Which is not related with controlled release

o
A) Incresed safety margin

f.c
B) Improved patient compliance

C) Incresed fluctuation in steady state

stu
D) Reduced total amount of dose administerd

Correct Answer is C m
EXP : Controlled Release Decreased the Fluctuation at Study State

37) Lipososomes Related With

ar
A) Hydration of phospholipids
ph

B) Self organinization of amphiphilic lipids to form supermolecular structure

C) In auueous mixture lipid molecules are able to form various phase some of them are stable and some
are
.b

meta stable

D) All the above

w

Correct Answer is D
w

38) Following is true about Resealed erythrocytes

A) Osmotically ruptured erythrocytes and resealed in isoosmotic medium

w

B) Targeted drug delivery system

C) Defected erythrocytes recognized by RES

D) All are true

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Correct Answer is D

39) Osmotic Pump is Based on

A) vapour pressure

B) osmotic pressure

C) vapour & osmotic pressure

m
D) partial pressure

o
Correct Answer is B

f.c
40) A person is suffering with acute and intolerable pain. Analgesic drug should be given by which of

the following form:

stu
A) Oral solution

B) Liposome

C) Dendrimer

D) Parenteral route
m
ar
Correct Answer is D

41) Nanoparticulate drug delivery systems are most suitable for treatment of
ph

A) Cancer

B) Headache
.b

C) Blood pressure

D) Peptic ulcer
w

Correct Answer is A
w

EXP : In cancer cytotoxic drugs are used which have lot of adverse effects. To reduce side effects it is

desired to give them in targeted delivery systems.

w

Page 9/9

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