Product Information

S1026 Imatinib Mesylate

c-Kit

Novel Life Science Reagents

for Cell Signaling Research

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Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 589.71 C29H31N7O.CH4SO3 DMSO 99% at -20 2 years 220127-57-1
N CH4O3S O N N H N H N N N

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Tech Support
tech@selleckchem.com
(chemistry support)

Synonyms: Gleevec,

Glivec, CGP-57148B

techbio@selleckchem.com
(bio support)

Biological Activity
A reversible tyrosine kinase inhibitor effective in treatment of chronic myelogenous leukemial (CML), [1] gastrointestinal stromal tumors, eosinophilic disorders, and systemic mast cell disease.The drug binds preferentially to ATPbinding sites of the c-kit protooncogene product, platelet-derived growth factor receptor (PDGF-R), and Abelson kinase (c-ABL) [2,3] impeding the ensuing signal transduction. The IC50 values for imatinib mesylateinhibited T-cell proliferation stimulated by DCs and PHA were 3.9 M and 2.9 M,respectively. At 4.4 M imatinib mesylate, the amount of activated NK-kB was reduced to 58.7% and decreased to 38.4% at 17.6 M.

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References
[1] Heinrich MC et al.Blood. 2000 Aug 1;96(3):925-932 [2] Allan B. Dietz et al. Blood.2004 August 15;104(4):1094-1099 [3] Dietz AB et al. J Hematother Stem Cell Res. 2000 Feb;9(1): 95-101

Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA

Please visit www.selleckchem.com to download MSDS and CoA.

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

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