Product Information

S2198 SGI-1776
PIM

Novel Life Science Reagents

for Cell Signaling Research

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Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 405.42 C20H22F3N5O Unknown 99% at -20 2 years 1025065-69-3
N N H N N N

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Biological Activity
SGI-1776, a member of the imidazo[1,2-b]pyridazine chemical class, was selected for its ability to exploit an extended ATP-binding and solvent pocket, thereby making it a selective Pim family kinase inhibitor.Extensive biochemical characterization of SGI-1776 confirmed its specificity for the three isoforms of the Pim family. The IC50 of SGI-1776 for the three isoforms of the Pim kinase family, Pim-1, Pim-2, and Pim-3, were in the low nanomolar range (7 1.8 nmol/L, 363 27.6 nmol/L, and 69 9.2 nmol/L).SGI-1776 is a fairly selective inhibitor of the Pim kinases and can cause a reduction in prostate cancer cell viability and alter overall cytotoxic responses to taxanes. SGI-1776 can disrupt cell cycle progression, induce apoptosis, promote taxane sensitivity, and overcome acquired chemoresistance by inhibiting multidrug resistance (MDR)1 activity in specific prostate cancer models.SGI-1776 induces apoptosis in CLL and that the mechanism involves Mcl-1 reduction. SGI-1776 exhibited inhibitory activity against two other kinases: Flt-3 (IC50, 44 nmol/L) and Haspin (IC50, 34 nmol/L).[1][2]

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Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

References
[1] Mumenthaler, S. M., P. Y. Ng, et al. (2009).Mol Cancer Ther 8(10): 2882-2893. [2] Chen, L. S., S. Redkar, et al. (2009).Blood 114(19): 4150-4157.

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Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

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