Stefano Biondi

Digitally signed by Stefano Biondi DN: cn=Stefano Biondi, o=Innovative Solution, ou, email=stefano.biondi@innovative solution.it, c=IT Date: 2011.06.09 12:20:36 +02'00'

Innovative Solution www.innovativesolution.it Email: stefano.biondi@innovativesolution.it Tel. +39 02 36593963 Mob. +39 335 7906146

Agenda
Company Profile About us Mission Innovative Solutions Network Competences Services Pubblications Contacts

Company profile
A team of seasoned and dynamic chemistry experts from industry and academia to provide you: High-quality technical and strategic advice Ready answers to your questions

Innovative solutions
Project and managerial support Technology and IP services
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About us
Dr. Stefano Biondi, MRSC CChem Senior pharmaceutical R&D expert with more than 20 years evenly spent in big pharma and small biotech. Combine unique expertise in medicinal , pharmaceutical chemistry and pharmacology. Member of the executive team of Valevia pharmaceuticals GmbH an antibacterial startup company. Scientific and strategic advisor for innovative companies. 15 years in GlaxoSmithKline. as scientist, laboratory head research leader, in antibacterial and CNS 3 years in Neuro3D a French start-up company as chemistry director dealing with lead optimization and chemical and pharmaceutical development of CNS drugs. From 2005 till 2009 Director of Research Laboratories at Nicox, managing chemistry, pharmacology, analytical sciences and project management. Contributed to the discovery and development of numerous nitric oxide releasing compounds. Inventor of more than 40 patents, including Anti-infectives (macrolides, betalactams, squalestatin), CNS, Cardiovascular, Ophthalmic and Anti inflammatory drugs, as well as formulation and process research.
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Mission
To provide a wide range of services for pharmaceutical, chemical companies, biotechs, start up in: Medicinal Chemistry Analytical Sciences Preclinical Formulation Chemical Development Pharmaceutical development Innovative products
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Innovative Solution Network

Customer

Procurement

Experts
Innovative Solution Contract Manufacturing Organisations

In vitro/in vivo Screening

Universities Research Organisations

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Competences
R&D Discovery (Hit to Lead) Lead optimisation (Lead to Preclinical Candidate) Development (Chemical and Pharmaceutical) IP scouting, licensing Project management Change management Technologies Microwaves, flow chemistry, peptides, natural products, total synthesis, green technologies, biotechnologies
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Research and Development

Target identification & validation Lead generation Lead optimisation Preclinical development Clinical Development Regulatory approval

Biological tools Labelled compounds Library design Virtual screening Rational drug design

Hit validation Hit to Lead Lead hopping Focused Libraries Chemical tractability

Computer based drug design Parallel synthesis Structure Properties optimisation

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Research and Development

Target identification & validation Lead generation Lead optimisation Preclinical development Clinical Development Regulatory approval

Chemical route scouting & development Reference standards Impurities identification and synthesis Labelled compounds Analytical/bioanalytical standards CMO selection & supervision

Support to commercial manufacture Consistency/continuity throughout scale up process GMP manufacturing API & Drug Product Documentation development, preparation, and review of CMC sections Development strategy & problem solving Analytical development 9

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Services (1)
The following list illustrates typical requests of services provided:
Hit generation and validation Lead identification and optimisation Technology scouting and transfer Technical and strategic support for patent applications

Literature and Databank survey, analysis and evaluation

Project management

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Services (2)
The following list illustrates typical requests of services provided: Chemical route design and process optimisation R&D support for development stategy Assistance in the identification and supervision of Custom

Manufacturing Organisations
In/Out licensing support

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Training courses and conferences

On request is possible to organise masterclassess and training courses, customised to suit specific requirements.

Recent presentations at masterclasses and conferences

Giornata di Studio Farmacovigilanza 2011 Milan, 13 th April 2011 organised by GSISR Cosmetic products Cosmetic counterfaction Milan 28th Jan 2011 organised by GSISR Phase I clinical research Milan, 30th Nov 2010 organised by International Research Institute. Masterclass on Lead Optimisation Milan, 29 Sept 2010 organised by International Research Institute.
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Publications
Recently published (1)
1) Nitric oxide releasing naproxen Nicox S.A., Fr Publised on: 03 February 2011 as WO 2011012400. Inventors: Biondi Stefano, Bastia Elena, Ronsin Gael 2) NO-donor aspirin derivatives Nicox S.A., Fr Publised on: 21 October 2010 as WO 2010118968. Inventors: Gasco, Alberto; Fruttero, Roberta; Lazzarato, Loretta; Rolando, Barbara; Chegaev, Konstantin; Donnola, Monica; Ongini, Ennio; Biondi, Stefano. 3) New NO releasing steroids derivatives Nicox S.A., Fr; Publised on: 11 February 2010 as WO 2010015529. Inventors: Benedini, Francesca; Carzaniga, Laura; Ongini, Ennio; Biondi, Stefano. 4) Angiotensin II receptor antagonists Nicox S.A., Fr; Merck & Co., Inc., USA Publised on: 11 February 2010 as WO 2010015447. Inventors: Almirante, Nicoletta; Mandelli, Valentino; Nicotra, Alessia; Biondi, Stefano; Ongini Ennio; Sebhat, Iyassu K. 5) New NO-releasing steroids for the treatment of retina and macula lutea diseases. Nicox S.A., Fr. Published on: 11 February 2010 as WO 2010/015528. Inventors: Benedini, Francesca; Steele, Rebecca; Chiroli, Valerio; Ongini, Ennio; Biondi, Stefano.

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Recently published (2)

6) Nitro derivatives of furasemide and their use as diuretics Nicox S.A., Fr; Merck & Co., Inc., USA Publised on: 04 February 2010 as WO 2010014516. Inventors: Ali, Amjad; Sebhat, Iyassu K.; Franklin, Christopher, L.; Rupprecht, Kathleen, M.; Baker, Robert, K.; Nargund, Ravi, P.; Yan, Lin; Huo, Pei; Shen, Dong-Ming; Almirante, Nicoletta; Biondi, Stefano; Ferrario, Massimiliano; Nicotra, Alessia. 7) Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology Nicox S.A., Fr; Publised on: 04 February 2010 as WO 2010012567. Inventors: Benedini, Francesca; Bonfanti, Annalisa; Chiroli, Valerio; Steele, Rebecca; Ongini, Ennio; Biondi, Stefano. 8) Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma Rebecca M. Steele, Francesca Benedini, Stefano Biondi, Valentina Borghi, Laura Carzaniga, Francesco Impagnatiello, Daniela Miglietta, Wesley K. M. Chong, Ranjan Rajapakse, Alessandro Cecchi, Claudia Temperini, Claudiu T. Supuran. Bioorganic & Medicinal Chemistry Letters 19(11), 65656570, (2009). 9) New angiotensin II receptor blocker derivatives. Nicox S.A., Fr; Merck & Co., Inc., USA Publised on: 03 September 2009 as WO 2009106471. Inventors: Almirante, Nicoletta; Nicotra, Alessia; Mandelli, Valentino; Biondi, Stefano; Stefanini, Silvia; Sebhat, Iyassu K.; Lo, Michael Man-Chu. 10) Angiotensin II receptor antagonists. Nicox S.A., Fr; Merck & Co., Inc., USA Publised on: 03 September 2009 as WO 2009106470. Inventors: Almirante, Nicoletta; Nicotra, Alessia; Stefanini, Silvia; Biondi, Stefano; Ongini, Ennio; Ali, Amjad; Lo, Michael Man-Chu.

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22 March 2011

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Contacts
Innovative Solution Stefano Biondi Via Copernico 22 20016 Pero (Mi), Italy P. IVA 06984910965 Website: www.innovativesolution.it Email: stefano.biondi@innovativesolution.it Tel. +39 02 36593963 Mob. +39 335 7906146

22 March 2011

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