INDEX NURS 2236 Clinical Form 3: Clinical Medications Worksheet

(You will need to made additional copies of these forms)

Generic Trade Classification Dose Route Time/Frequency
Name Name
ezetimibe Zetia Cholesterol 10 mg PO qday hs
Lowering agent
Peak Onset Duration Normal Dosage range 10mg qday PO
4-12 hr UNK UNK

Why is your patient taking this medication? For IV meds, compatability with IV drips and/or solutions

Mechanism of action and indications Nursing Implications (what to focus on)

Treatment of primary hypercholesterolemia alone or with
an HMG-CoA reductace inhibitor (statin); treatment of
homozygous sitosterolemia as an adjunct to diet
Works at the lining of the small intestine inhibiting the
absorption of cholesterol, but does not inhibit cholesterol
synthesis in the liver or increases biles acid excretion.
Thus it decreases the amount of intestinal cholesterol
available to the liver. Lowers both total cholesterol and
low-density lipd (LDL) cholesterol.
Interactions with other patient drugs, OTC, or herbal
medicines (ask patient specifically)
cholestryramine; bile acid sequestrants; fibrates;
cyclosporine; HMG CoA-reductase inhibitors
Contraindications/warnings/interactions Hypersensitivity; concurrent us with
HMG-CoA reductase inhibitor in patients with active liver disease or elevated serum
transaminases; moderate to severe hepatic disease; concurrent administration with
fibrates; lactation; pregnancy; mild hepatic insufficiency.
Common side effects Fatigue; arthralgia; back pain; myalgia; angiedema;
myopathy; dizziness; headache; abdominal pain; diarrhea; pharyngitis; sinusitis;
cough; thrombocytopenia; rash; hepatitis; pancreatitis; rhabdomyolysis.
nausea;
Lab value alterations caused by medicine
Evaluate serum cholesterol and triglyceride levels before initiating, after 2-4 week
of therapy, and periodically thereafter. May cause increased liver transaminases;
Monitor liver enzymes.
Be sure to teach the patient the following about this medication
Medication should be used in conjunction with diet restrictions. Exercise and
cessation of smoking. Does not assist in weight loss; Notify doctor of unexplained
muscle pain, tenderness, or weakness occur. Follow-up appointments
are important to determine effectiveness and to monitor for side effects

Nursing Process - Assessment Assessment Evaluation

(Pre-administration assessment Why would you hold or not give Check after giving
Obtain diet history; this med?
Assess for unexplained muscle pain, tenderness Decrease in serum LDL and total cholesterol
and weakness. Rhabdomyolysis levels.
Angioedema Increase in HDL cholesterol levels
Liver disease