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Drug Name bromphenirami ne maleate (parabromdyla mine maleate) (brome fen ir' a meen) BroveX, BroveX CT, Bidhist, Lodrane XR, LoHist 12 Hour, VaZol Pregnancy Category C Drug class Antihistamine (alkylamine type) Oral

Dosages

Allergic conditions (urticaria, rhinitis, conjunctivitis) Adult: 4-8 mg 3-4 times daily. Individualise dosage according to patient's response and tolerance. Child: 3 yr: 0.4-1 mg/kg/ day, given as 4 divided doses. 3-6 yr: 1-2 mg and 6-12 yr: 2-4 mg, doses to be given 3-4 times daily. Parenteral Allergic conditions (urticaria, rhinitis, conjunctivitis) Adult: 10 mg every 8-12 hr. Dose can be given via SC, IM or slow IV inj. Max: 40 mg/24 hr.

Therapeutic Actions Brompheniram ine is an antihistamine with antimuscarinic and moderate sedative actions.

Indications Symptomatic relief of symptoms associated with perennial and seasonal allergic rhinitis runny nose, sneezing, itching nose and throat, watery eyes

Adverse effects CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely, rashes and hypersensitivity reactions; blood disorders, convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, confusion, sleep and GI disturbances, tinnitus, hypotension, hair loss.

Contraindications Premature infants or neonates.

Nursing considerations Assessment History: Allergy to any antihistamines, tartrazine, narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, asthmatic attack, bladder neck obstruction, pyloroduodenal obstruction, third trimester of pregnancy, lactation Physical: Skin color, lesions, texture; orientation, reflexes, affect; vision examination; P, BP; R, adventitious sounds; bowel sounds; prostate palpation; CBC with differential Interventions Give orally with food if GI upset occurs. Teaching points Take as prescribed; avoid excessive dosage; take with food if GI upset occurs. Avoid alcohol while on this drug; serious sedation could occur. Oral liquid and oral suspensions differ in strength; do not use interchangeably. You may experience these side effects: Dizziness, sedation, drowsiness (use

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caution if driving or performing tasks that require alertness); epigastric distress, diarrhea or constipation (take with meals); dry mouth (frequent mouth care, sucking sugarless lozenges may help); thickening of bronchial secretions, dryness of nasal mucosa (try a humidifier). Report difficulty breathing, hallucinations, tremors, loss of coordination, unusual bleeding or bruising, visual disturbances, irregular heartbeat.

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