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LECTURE NO: II
**Type of receptors:
We have 4 types of receptors in every human body.
Receptor: kind of protein among the target and the drug.
3. Kinase-like receptors
It causes -7 protein phosphorylation -7 Genes transcription -7
protein synthesis -7 cellular effects
1
So its action becomes clear after few hours
e.g: insulin, growth factors, cytokines receptors
4. Nuclear receptors
Location: cytoplasm or in nucleus
Effect: after days
e.g: steroid receptors
drugs that don't fit the drug-receptor modal (drugs don't act
through receptors)
Pharmacokinetics:
The action of human body on the drugs (unlike
pharmacodynamics)
Co: concentration reaction outside
Ci: concentration reaction inside
T: time
As we see all these factors affecting affecting absorption
ADVICE:
Don't sit beside a smoker, because in milliseconds the smoke will
go from lungs to blood (this occur rapidly because large area
of absorption)
1. drug absorption
The passage of the drug from it's site of administration in to the
blood except LV. application (because it gives to blood directly so
there is no absorption)
Cell membrane:
It is a barrier that face the entery of drugs from outside to inside
the cell.
Zydon khrissat
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