DkUG CLASSIIICA1ICN DCSAGL MLCnANISM CI AC1ICN INDICA1ICN CCN1kAINDICA1ICN

SIDL LIICL1S]ADVLkSL
LIILC1
NUkSING IMLICA1ICN
kLSCNSI8ILI1ILS

6eneric Nome
ulazepam

8rond Nome
vallum


































8enzodlazeplne
AnLlepllepLlc
AnxlolyLlc
SkeleLal
muscle relaxanL


































Minimum
2mg/day

Moximum
mg/day


































lL lncreases neuronal
membrane permeablllLy Lo
chlorlde lons by
blndlng Lo sLereo speclflc
benzodlazeplne recepLors on
Lhe posLsynapLlc CA8A
neuron wlLhln Lhe CnS and
enhanclng Lhe CA8A
lnhlblLory effecLs resulLlng ln
hyperpolarlsaLlon and
sLablllzaLlon

ShorLLerm
managemenL of
anxleLy
lnsomnla assoclaLed
wlLh anxleLy
Sleepwalklng
nlghL Lerrors
remedlcaLlon
before anesLhesla
Ad[uncL ln Lhe
managemenL of
selzures
Muscle spasms
AcuLe sympLoms of
alcohol wlLhdrawal
remedlcaLlon
before anesLhesla






















PypersenslLlvlLy
reexlsLlng CnS
depresslon or coma
8esplraLory
depresslon
AcuLe pulmonary
lnsufflclency or sleep
apnea
Severe hepaLlc
lmpalrmenL
AcuLe narrow angle
glaucoma
Chlldren mLh
regnancy and
lacLaLlon
























N5 1ranslenL mlld
drowslness lnlLlally
sedaLlon depresslon
leLhargy apaLhy
faLlgue dlsorlenLaLlon
resLlessness confuslon
dellrlum headache
slurred speech
dysarLhrla sLupor
rlgldlLy Lremor mlld
paradoxlcal exclLaLory
reacLlons
exLrapyramldal
sympLoms vlsual and
audlLory dlsLurbances
I8radycardla
Lachycardla Cv
collapse hyperLenslon
and hypoLenslon
edema
uermaLologlc urLlcarla
prurlLus skln rash
dermaLlLls
6l ConsLlpaLlon
dlarrhea dry mouLh
sallvaLlon nausea
anorexla vomlLlng
dlfflculLy ln swallowlng
elevaLlon ln blood
enzymes hepaLlc
lmpalrmenL
6u lnconLlnence
urlnary reLenLlon
changes ln llbldo
mensLrual lrregularlLles
nemoto/oqic
uecreased PcL blood
dyscraslas

Assess for hypersenslLlvlLy
8educe dose of oplold analgeslcs
wlLh lv dlazepam dose should be
reduced by aL leasL oneLhlrd or
ellmlnaLed
uo noL admlnlsLer lnLrarLerlally
may produce arLerlospasm
gangrene
Carefully monlLor 8
resplraLlon durlng lv
admlnlsLraLlon
Change from lv Lherapy Lo oral
Lherapy as soon as posslble
lnsLrucL Lo Lake drug exacLly as
prescrlbed
uo noL permlL ambulaLory
paLlenLs Lo operaLe a vehlcle
followlng an ln[ecLlon
lnsLrucL paLlenL Lo reporL adverse
reacLlons
MonlLor LLC ln paLlenLs LreaLed
for sLaLus epllepLlcus selzures may
recur afLer lnlLlal conLrol
MonlLor llver and renal funcLlon
C8C durlng long Lerm Lherapy
1aper dosage gradually afLer
longLerm Lherapy

























6eneric Nome
lurosemlde

8rond Nome
Laslx













Loop ulureLlc












Minimum
1mg/ml

Moximum
12mg/ml












lnhlblLs reabsorpLlon ofv
sodlum and chlorlde from Lhe
proxlmal and dlsLal Lubules
and ascendlng llmb of Lhe
loop of Penle leadlng Lo a
sodlumrlch dluresls













Ldema assoclaLed
wlLh hearL fallure
clrrhosls renal
dlsease
AcuLe pulmonary
edema
PyperLenslon













PypersenslLlvlLy Lo
furosemlde and
sulfonamldes
severe renal fallure
hepaLlc coma
pregnancy
lacLaLlon

9recoution
wlLh SLL
gouL
dlabeLes melllLus









Other hleblLls
Lhrombosls hlccups
fever dlaphoresls
paresLheslas muscular
dlsLurbances
gynecomasLla paln
burnlng redness afLer
lM ln[ecLlon




N5 ulzzlness
paresLheslas xanLhopsla
weakness headache
blurred vlslon
lrreverslble hearlng loss
ICrLhosLaLlchypoLenslon
cardlac arrhyLhmlas
uermoto/oqic
hoLosenslLlvlLy rash
prurlLus
6l nausea vomlLlng oral
and gasLrlc lrrlLaLlon
consLlpaLlon dlarrhea
[aundlce














AdmlnlsLer wlLh food or mllk Lo prevenL
Cl upseL
8educe dosage lf glven wlLh oLher
anLlhyperLenslves read[usL dosage
gradually as 8 responds
uo noL mlx parenLeral soluLlon wlLh
hlghly acldlc soluLlons wlLh h below
33 ulscard dlluLed soluLlon afLer 24 hr
Measure and record welghL Lo
monlLor fluld changes
Arrange Lo monlLor serum