Beruflich Dokumente
Kultur Dokumente
1. The fig on the right presents the ADME time course of a drug in the body. Which curve
describes the drug concentration change at the drug absorption site? Check graph.
3. The following states are true except: Two pharmaceutical equivalents have the same…
a. Two pharmaceutical equivalents have the same active ingredient(s)
b. Same dosage form
c. Same route of administration
d. Same release mechanism
e. Same strength or concentration
4. The following factors can cause low bioavailability of an oral drug product except:
a. Insufficient time in GI tract
b. Fast degradation in the GI tract
c. Fast drug absorption in the GI tract
d. Intestinal secretion of drug by transporters
e. First-pass metabolism by liver
5. Which of the following examples is a drug delivery system intended for local delivery?
a. Transdermal delivery of nicotine from a patch
b. Transdermal delivery of nitroglycerin froma patch for chest pain
c. sublingual delivery of nitroglycerin for chest pain
d. Oral delivery of antacid suspension to neutralize excess gastric acid
e. oral delivery of acetaminophen for muscle pain
6. Which of the following routes of administration has hepatic first pass effects
a. peroral drug delivery
b. transdermal drug delivery
c. intravenous injection
d. topical delivery
e. vaginal delivery
7. Which of the following routes is used for local effect only?
a. sublingual route
b. pulmonary route
c. rectal route
d. otic route
e. nasal route
16. The following types of metabolism are conducted by CYP450 enzymes except:
a. oxidation
b. hydrolysis
c. introduce NH2 group
d. Introduce OH group
e. Introduce CH3 group
22. Which of the following routs rae usually considered the minor route for transdermal delivery
a. intercellular penetration route
b. diffusion between the cells
c. transcellular penetration route
d. diffusion across the cells
e. transappendageal penetration
23. All the following will affect the percutaneous absorption except:
a. hydration of the skin
b. the drug molecular weight
c. the application method
d. The blood flow rate variations
e. The pH of skin surface and drug preparation
24. The following compounds have been used as skin penetration enhancer except:
a. Azone
b. propranolol
c. Polyethylene glycol
d. Dimethyl acetamide
e. dimethyl sulfoxide
26. The following subjects can be used as experimental models for percutaneous drug
absorptions except:
a. Human
b. Snakeskin
c. Animal model
d. Excised animal skin
e. hypodermic cell culture
27. Which of the following is true?
a. Electrophoresis applies electro current o deliver ionic drug molecules across the skin
b. Iontophoresis applies ultrasound to enhance the percutaneous drug absorption
c. Sonophoresis applies electro current to delvier negatively charged drug molecules
across the skin
d. Phonophoresis applies electro current to deliver positively charged drug molecules
across the skin
e. None of the above
28. Transdermal drug delivery systems are usually controlled release device because:
29. The system shown on the right is: a membrane controlled TDDS
31. Which transdermal delivery system uses the stratum corneum to control the drug absorption
rate?
a. Drug in adhesive transdermal delivery system
b. Membrane controlled TDDS
c. Monolithic TDDS
d. Membrane controlled Multi Layer TDD
e. None of the above
32. Which of the following products is the first FDA approved transdermal drug delivery system:
a. clonidine
b. nitroglycerine
c. nicotine
d. SCOPOLAMINE!!!
22. Which of the following ointment bases are oil in water emulsions?
a. Oleaginous bases
b. Hydrocarbon bases
c. Absorption bases
d. Water removable bases
e. Water soluble bases
34. Which of the following is not an oligeanous base?
a. Petrolatum USP
b. White Petrolatum USP
a. Hydrophilic petrolatum USP
c. Yellow Ointment USP
b. White Ointment USP
36. Which of the following preparation technique requires heating the materials?
a. incorporation
b. fusion.
c. levigating
d. pulverization by intervention
e. roller mill
37. According to the two-layer membrane skin model on the right, the transdermal permeability
coefficient P of a drug through the skin is expressed as some gay equation. When a drug diffuses
across the skin, the path lenths are ls = 350 um, ly = 150 um. The diffusion coefficients are Ds =
10^-7 cm2/sec and Dy = 10^-10 cm2/sec. The partition coefficient of this drug is 10. Calculate
the transdermal permability coefficient of this drug. 6.67 x 10^-10 cm/sec
Use the equation: P = (DyDs) / [(KlvDs) + (lsDv)]
38. In a transdermal DDS, a drug passes through a 1 mm thick rate controlling membrane with a
diffusion coefficient of 4.23x 10^-7 cm2/sec. The oil water partition coefficient (K=So\Sw) of
the drug is 2.03. The area exposed to the drug reservoir is 2 cm2, and the concentration of the
drug is 0.5 mg/mL. Calculate the diffusion rate of the drug through the membrane of the system
8.58*10^-6 mg/sec
39 and 40 are apparently too complicated and won’t be repeated on the final exam.