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Carandang
Notes from Lecture
USTMED ’07 Sec C – AsM
TREMATODES OR FLUKES
PHYLUM
- Platyhelminthes
CLASS
- Trematoda
NOTES
- Species parasitic in humans belong to the Digenea, in
which sexual reproduction in adult is followed by
asexual multiplication in the larval stages in snails.
MORPHOLOGY
- Adult digenetic trematodes are usually flat, elongated,
leaf-shaped worm but they may be ovoid, conical or
cylindrical
- Vary in size from less than 1 mm to several centimeters
- Worm is enveloped by a noncellular integument which
may be partially or completely covered with spines,
tubercles or ridges
INTEGUMENT
- plays an important role in the absorption of
carbohydrates
- serve for secretion of excess metabolites and mucus
- by electron microscopic studies, it is syncitial without
LIFE CYCLE
nuclei, contain many vacuoles and mitochrondria, and
connected by protoplasmic tubes with an inner layer of - definitive host (usually a vertebrate, multiplication
cells. takes place sexually with the production of eggs)
- no microtrichia or pore canals are found in the - primary or first intermediate host (usually a snail
producing asexual generations)
integument of cestodes.
- secondary or 2nd intermediate host (fish, crustacean,
SCHEMATIC REPRESENTATION OF MORPHOLOGY OF A TYPICAL TREMATODE snails or aquatic plants)
- causes urinary schistosomiasis, schistosomal hematuria, - Tropical and subtropical. Africa, Iran, Iraq, Saudi Arabia,
vesical schistosomiasis, or urinary bilharziasis Yemen, Syria, India, Mauritus, Malagasy Republic,
Zanzibar
Shell of a Bulinus
snail
Other genera:
Physopsis
Biophalaria
male female
PATHOGENESIS
LIFE CYCLE - skin rash at site of cercarial penetration (swimmer’s
itch)
- within a few days after penetration, the young flukes
become coated with host red cell antigens and
histocompatibility antigens, so they are not recognized
as foreign and live free from host attack to develop and
produce eggs for long periods
- it is the eggs not the adult flukes which are responsible
for the clinical features and damage to the bladder or
ureters
- Eggs trapped in the bladder wall and surrounding tissues
cause inflammatory reactions with the formation of
granulomata (contains egg, toxic products, eosinophils,
epitheloid cells, and lymphocytes).
- Many of the eggs die and become calcified producing
what are known as “sandy patches” in the bladder.
- In heavy infection, eggs can be carried to other parts of
the body
SYMPTOMATOLOGY
- in light infections, symptoms may not develop for years
- in heavy infections, symptoms may be just noticed as
early as 1 month after infection
- following prolonged untreated infection and marked
cellular response, the ureters may become obstructed
and the bladder wall thickened, leading to abnormal
bladder function with painful and frequent urination,
urinary infection, and eventually kidney damage.
- terminal hematuria is the most characteristic symptom.
- in some areas, S. haematobium infection has been
linked to an increase in Salmonella typhi and S.
paratyphi carriers following acute infection
- patients are more likely to become urinary rather than
fecal carriers
- patients may also exhibit a syndrome of chronic,
intermittent, enteric bacteremia that clinically
resembles Kala-azar
- Both of these chronic bacterial infections have been
attributed to a mechanism of adhesion of the bacteria
to the integument of the intravascular schistosomes.
LABORATORY DIAGNOSIS:
- Specific
o Finding the eggs or occasionally the hatched
miracidia in the urine
o occasionally, eggs can be found in faeces
o detecting eggs in rectal biopsy or bladder
mucosal biopsy
Eggs of S. haematobium. White Ciliated, and rapidly motile
arrows show the position of the miracidium hatched from an
flame cells S. haematobium egg in urine that has
been left to stand.
NON-SPECIFIC FINDINGS
- hematuria
- proteinuria
- cells, especially eosinophils can often be found in the
urine
- bacteriuria may accompany urinary schistosomiasis
SCHISTOSOMA MANSONI GEOGRAPHICAL DISTRIBUTION
- Parts of Africa, Middle East, South America (Brazil), West
India
male female
LIFE CYCLE
PATHOGENESIS/SYMPTOMATOLOGY
- skin rash after cercarial penetration
- flukes acquire host antigen protecting them from host
immune response
- eggs penetrate through the intestinal wall and are
excreted in the faeces often with blood and mucus
- host reaction to eggs leads to the formation of
granulomata, ulceration, and thickening of the bowel
wall
- a proportion of the eggs reach the liver through the
portal vein
- reaction to the eggs causes thickening of the portal
vessels known as claypipe-stem fibrosis
- hepatomegaly with fibrosis
- splenomegaly
- portal hypertension
- ascites
- ova can be deposited in the spinal cord, lungs, and other
organs of the body
- Salmonella infections can become chronic and prolonged
LABORATORY DIAGNOSIS
- finding S. mansoni ova in faeces
- occasionally may also be found in the urine following
fecal contamination
- Rectal biopsy especially after a patient has been
partially treated
OTHER FINDINGS
- mucus and blood are often present in fecal specimens
- blood eosinophilia
- for patients with hepatic involvement, increased liver
enzymes, low serum albumin, increased serum protein
due to increased globulin
SCHISTOSOMA JAPONICUM GEOGRAPHICAL DISTRIBUTION
- China, Philippines,
Western Indonesia
- Eastern Visayas and
Mindanao
male female
PATHOGENESIS/SYMPTOMATOLOGY
- skin rash at the site of cercarial penetration
- 20-60 days after infection, patient develop fever,
muscular and abdominal pain, spleen enlargement,
urticaria, and eosinophilia (Katayama reaction or
Katayama fever)
- Reactions to eggs in the tissue can cause intestinal or
hepatosplenic disease with dysentery, liver fibrosis,
marked hepatosplenomegaly egg deposition in the lungs,
CNS, and other parts of the body
o acceleration of flow of water by proper
grading and clearing of the stream bed
Portal hypertension with prominent and removal of debris
ascites
o construction of ponds if the area cannot
be drained
o covering snail habitats with land fills
• Chemical method
• Environmental sanitation
-fin-
OTHER FINDINGS
- Mucus and blood in fecal specimen
- blood eosinophilia
- in patients with hepatic involvement raised hepatic
enzymes, low serum albumin, increased total protein
due to increased globulin
OTHER SCHISTOSOMA
SCHISTOSOMA INTERCALATUM
SCHISTOSOMA MEKONGI
TREATMENT
- Praziquantrel
- Health Education
- Control snail vector
• Environmental method
o Removing the environmental requirement
of the snails
o drainage of breeding sites and proper
management of irrigation system
o removal of shade or shelter from the sun
by clearing vegetation armed bodies of
water
o prevention of breeding on the banks of
streams or irrigation canals by living
these concretes or making these more
perpendicular