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Biology
Biology (Human)
Advanced SubsidiarylAdvanced
Unit Test 1
Monday 2 June 2003 - Morning
Time: l hour
Materials required for examination Items included with question papers
Ruler Nil
Instructions to Candidates
In the boxes above, write your centre number, candidate number, the paper reference, your signature,
surname and initials. The paper reference is shown above.
Check that you have the booklet for the correct unit.
Answer ALL EIGHT questions in the spaces provided in this booklet.
If you need to use additional answer sheets, attach them loosely but securely inside this booklet.
Show all the steps in any calculations and state the units. Calculators may be used.
Include diagrams in your answers where these are helpful.
Advice to Candidates
You will be assessed on your ability to organise and present information, ideas, descriptions and
arguments clearly and logically, taking account of your use of grammar, punctuation and spelling.
Total
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I 1111 IlN
N 1 6 0 3 0 A
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W850/R6101/57570 8/717/
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Edexcel
Success through qualifications
Answer ALL questions in the spaces provided. Leave
blank
1. Read through the following passage about enzymes, then write on the dotted lines the
most appropriate word or words to complete the passage.
2. (a) State two structural differences between the molecules of the polysaccharides
cellulose and glycogen.
Cellulose Glycogen
(2)
(b) State two structural differences between the molecules of the proteins collagen
and insulin.
Collagen Insulin
(Total 4 marks)
3. (a) A student was given two carbohydrate solutions, labelled A and B, and was told to Leave
perform two tests on each solution. blank
The table below shows the colour of each solution after testing.
I Solution I Colour after Test 1 Colour after Test 2
A Red
B Blue Red
(i) Complete the table to show what colour solution A would be following
Test 2.
(1)
(ii) Explain why these results indicate that solution B contained a non-reducing
sugar.
(b) Describe how you would use biuret reagent to compare the concentration of
proteins in two solutions.
(Total 6 marks)
3 Turn over
4. The table below refers to the formula and structure of some biological molecules. Leave
blank
Complete the table by writing in the name, the formula or the structure of the molecule
where appropriate in the empty boxes.
Water
H H H H H
Fatty acid H-C-C-C<-C-C
I I I I I \ o H
H H H H H
Q4
(Total 6 marks) 7
- -
5. Immobilised enzymes have a wide range of commercial applications. Leave
blank
(a) Explain what is meant by the term enzyme immobilisation.
(Total 6 marks)
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6. The diagram below shows the sequence of stages in the cell cycle. Leave
blank
(a) During the cell cycle, the DNA content of the cell changes. Identify the stage
when the DNA content increases and the stage when the DNA content decreases.
In each case give an explanation for your answer.
Explanation ..............................................................................................................
Explanation ..............................................................................................................
(b) Proteins are synthesised during interphase of the cell cycle. Protein synthesis Leave
involves transcription and translation of the genetic code. blank
(ii) The letters below show the sequence of bases in part of a gene which codes
for an enzyme.
ATGGAAAAAAGC
Use the information in the table below to work out the sequence of amino
acids which is coded for by this part of the gene. The names of the amino
acids are shortened to their first three letters. You do not need to write down
the full names of the amino acids.
Second base
A G T C
ATA} Tyr ACA}
ACG Cys
AAG ATG G
A
AGT
ser T
ACT STOP
AAT} ~ e u AGC STOP
First AAC ATC ACC TV C Third
base GGA A base
His
GTG G
GAT GCT A% T
GTT} Gln
GAC GGC GTC GCC C
(Total 8 marks) 7
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7. The photograph shows a cell in mitosis as viewed using a transmission electron Leave
microscope. blank
(a) The actual diameter of the cell between points X and Y is 50 pm. Calculate the
magnification of this photograph. Show your working.
Answer ................................
(3)
(b) In the space below make an accurate drawing of the cell. Label the chromosomes,
spindle fibres and centrioles.
(c) State the stage of mitosis that this cell is in. Leave
blank
Spindle fibres
Centrioles
(Total 11 marks)
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8. An experiment was carried out to compare the uptake of two substances, A and B, by Leave
Amoeba. Amoeba is a single-celled aquatic organism. blank
Concentration
in cytoplasm /
pg cm-3
2 3 4
Time /hours
(a) Compare the uptake' of substance A by the cells with the uptake of substance B
during the period of 6 hours.
Substance B enters the cells by diffusion. Describe and explain how the results of Leave
this experiment support this statement. blank
(c) Explain why an increase in temperature to 25 "C would increase the rate of
diffusion of substance B into the cells.
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(d) Substance A is taken into Amoeba by active transport. Describe the process of Leave
active transport. blank
(Total 13 marks)
TOTAL FOR PAPER: 60 MARKS
END