Beruflich Dokumente
Kultur Dokumente
Warfare Attack
Diagnosis and
Treatment
Dan Gervich, MD
Gregory C. Gray, MD, MPH
“The one that scares me to death,
perhaps even more so than tactical
nuclear weapons, and the one we have
the least capability against is
biological weapons.”
• Inexpensive
• Easy to produce
• Aerosolized (1 to 10um diameter)
• Survives sunlight, drying, and heat
• Causes lethal or disabling disease
• Results in person-to-person transmission
• Has no effective therapy or prophylaxis.
Osterholm, MT. Bioterrorism: A real modern threat. In Emerging Infections 5. Scheld WM,
Craig, WA, and Hughes JM eds. ASM Press, Washington, DC. 2001. Pps 213-222
Russian Bioweapons Program
• Smallpox • Typhus
• Anthrax • Melioidosis
• Plague • Foot and mouth virus
• Equine encephalitis • African swine fever
viruses virus
• Tularemia • Trichothecenes
• Marburg virus mycotoxins
• Q fever • Glanders
• Botulinum
• Staplococcal enterotoxin B
• Trichothecene mycotoxins
• Ricin
Comparative Lethality and Dose
for Toxins in Mouse Models
Quantity of toxin
LD50 / Molecular wt Open-air exposure to
Agent (ug/kg)/ (daltons) 100 km2
Botulinum 0.001 / 150,000 85kg
CDC - http://www.bt.cdc.gov/
JHU - http://www.hopkins-biodefense.org/