Technical Information

January 2008 Supersedes issue dated September 2006 EMM 050402e-02/Page 1 of 6

Cremophor A Grades
Nonionic emulsifiers for the manufacture of cosmetic O/W emulsions.

= Registered trademark of BASF SE

Care Chemicals & Formulators

EMM 050402e-02 January 2008

Page 2 of 6

Cremophor A Grades

Chemical description

Nonionic emulsifiers produced by reacting higher saturated fatty alcohols with ethylene oxide. Cremophor A 6 also contains free stearyl alcohol. Cremophor A 6: Cremophor A 25: Cremophor A 6: Cremophor A 25: Cremophor A 6: Cremophor A 25: Ceteareth-6 (and) Stearyl Alcohol Ceteareth-25 68439-49-6, 112-92-5 68439-49-6 30035137 30274706

INCI name

CAS-No.

PRD-No.

Description

Cremophor A 6 is a whitish waxy substance. Cremophor A 25 is supplied in the form of free-flowing, non-dusting microbeads. Identity Appearance Degree of ethoxylation HLB value Surface tension* Cremophor A 6 white wax 6 10-12 33.4 mN/m Cremophor A 25 white microbeads 25 15-17 42.0 mN/m

* according to EN 14370, 23C, 5 g/l Specification See separate documents: Standard Specification (not for regulatory purposes) available via BASFs WorldAccount: https://worldaccount.basf.com (registered access). The Cremophor A grades dissolve in water and alcohol to form either a colloid or a clear solution. They are soluble in vegetable and mineral fats and oils. The warm emulsifiers can be mixed with mineral, vegetable, and synthetic fats and oils, as well as with fatty alcohols, fatty acids, mono- and di-stearates, and with polyethylene glycols. In aqueous solution, the Cremophor A grades are largely resistant to acids, bases and salts. The presence of these electrolytes does not impair the products efficiency as emulsifying agent. The Cremophor A grades are oil-in-water emulsifiers and are used for the production of ointments, creams, liquid emulsions, gels and other cosmetic preparations. They can be used for oils with a wide range of polarities, preferably in combinations of Cremophor A 6 and Cremophor A 25. Creams and lotions can be produced without problems. If Cremophor A 25 is used together with cetyl or stearyl alcohol or both, homogeneous ointment and cream bases are obtained that can absorb as much as 90% water. Cremophor A 25 is a very efficient protective colloid and can increase the stability of dispersed systems. In concentrations of 21-30%, Cremophor A 25 forms gel-like, brushable hydrates with water. The consistency of these gels can be varied from solid to liquid by adding small amounts of Luviskol K 17.

Solubility

Miscibility

Resistance to electrolytes

Application

EMM 050402e-02 January 2008

Page 3 of 6

Cremophor A Grades

Processing notes

Conventional methods are suitable for preparing emulsions with Cremophor A grades. The emulsifying agents are melted at 70-80 C, together with the oils and fats and the oil-soluble additives. The water phase is also heated to 7080C, together with all the water-soluble additives. The oil phase is slowly and thoroughly stirred into the water phase. The time and temperature required for emulsification and homogenization depend on the type of emulsion, the consistency, and the nature of the additives.

Preservation

Emulsion preparations must be preserved. Preservation must take further additives and production conditions into account.

Stability/Storage

The Cremophor A grades are stable for 2 years if stored in unopened containers at room temperature and protected from light. An investigation of raw materials gave no indication of harmful effects to health if the substance is used for the stated applications and concentrations. Due to the large variety of applications and possible combinations with other products, users are responsible for their own safety assessment of their products. The respective safety data sheets are available.
Sun protection lotion, O/W No. 53/00135

Toxicity

Safety data sheet Typical formulations

% A

Ingredients

Supplier INCI name (1) (1) (11) (44) (1) (1) (25) (1) (1) (1) Ceteareth-6, Stearyl Alcohol Ceteareth-25 Glyceryl Stearate SE Dimethicone Benzophenone-3 Ethylhexyl Methoxycinnamate Potassium Cetyl Phosphate Panthenol, Propylene Glycol PEG-25 PABA Propylene Glycol

2.00 Cremophor A 6 2.00 Cremophor A 25 3.00 Imwitor 960 K 0.20 Abil 350 2.00 Uvinul M 40 3.00 Uvinul MC 80 0.50 Amphisol K

2.00 D-Panthenol 50 P 2.00 Uvinul P 25 3.00 1,2 Propylene Glycol Care q.s. Preservative 66.40 Water, dem.

Aqua (6) (11) (1) (1) (1) Carbomer Caprylic/Capric Triglyceride Triethanolamine Tocopheryl Acetate Tocopherol

C D E

0.30 Carbopol 934 12.00 Miglyol 812 0.40 Triethanolamine Care 1.00 Vitamin E Acetate 0.20 DL-alpha-Tocopherol q.s. Perfume

Production:

Heat phases A and B separately to approx. 80C. Stir phase B into phase A whilst homogenizing and continue homogenizing for a while. Stir in phase C, neutralize with phase D and homogenize again. Cool to about 40C, add phase E and homogenize again. Viscosity: approx. 2000 mPas pH value: approx. 7.0

Properties:

EMM 050402e-02 January 2008

Page 4 of 6

Cremophor A Grades

Sun protection cream, O/W

No. 53/00046

% A

Ingredients

Supplier INCI name (44) (1) (1) (1) (11) (47) (1) (1) (20) Glyceryl Stearate SE Ceteareth-6, Stearyl Alcohol Ceteareth-25 PEG-7 Hydrogenated Castor Oil Caprylic/Capric Triglyceride PPG-3 Myristyl Ether Benzophenone-3 PEG-25 PABA Glycerin Aqua

12.00 Tegin 1.00 Cremophor A 6 1.00 Cremophor A 25 0.30 Cremophor WO 7 10.00 Miglyol 812 10.00 Witconol APM 3.00 Uvinul M 40

5.00 Uvinul P 25 3.00 Glycerin 87% q.s. Preservative 54.70 Water, dem.

q.s. Perfume Heat phases A and B separately to approx. 80C. Stir phase B into phase A and homogenize. Cool to about 40C, add phase C and homogenize again. Viscosity: approx. 50000 mPas pH value: approx. 7.5

Production:

Properties:

Body lotion

No. 62/00068

% A

Ingredients

Supplier INCI name (1) (1) Ceteareth-6, Stearyl Alcohol Ceteareth-25 Phytantriol Mineral Oil (11) (27) (44) (1) (1) Glyceryl Stearate SE Cetearyl Alcohol Dimethicone Panthenol, Propylene Glycol Propylene Glycol

2.00 Cremophor A 6 2.00 Cremophor A 25 1.00 Phytantriol 8.00 Paraffin Oil 3.00 Imwitor 960 K 1.00 Lanette O 0.50 Abil 350

4.00 D-Panthenol 50 P 3.00 1,2 Propylene Glycol Care q.s. Preservative 65.90 Water, dem.

Aqua (6) (1) (1) (1) Carbomer Cetearyl Ethylhexanoate Triethanolamine Tocopheryl Acetate

C D E

0.30 Carbopol 934 7.00 Luvitol EHO 0.30 Triethanolamine Care 2.00 Vitamin E Acetate q.s. Perfume

Production:

Heat phases A and B separately to about. 80C. Stir phase B into phase A whilst homogenizing and continue homogenizing for a while. Stir in phase C, neutralize with phase D and homogenize again. Cool to about 40C, add phase E and homogenize again. Viscosity: approx. 6000 mPas pH value: approx. 6.5

Properties:

EMM 050402e-02 January 2008

Page 5 of 6

Cremophor A Grades

Vitamin lotion, Type O/W

No. 62/00073

% A

Ingredients

Supplier INCI name (1) (1) (27) (27) (1) (44) (1) Ceteareth-6, Stearyl Alcohol Ceteareth-25 Glyceryl Stearate Cetyl Alcohol Cetearyl Ethylhexanoate Mineral Oil Dimethicone Phytantriol Propylene Glycol

2.00 Cremophor A 6 2.00 Cremophor A 25 3.00 Cutina GMS 3.00 Lanette 16 10.00 Luvitol EHO

10.00 Paraffin Oil 0.50 Abil 350 0.20 Phytantriol B 4.00 1,2-Propylene Glycol Care q.s. Preservative 62.20 Water dem. C 3.00 Vitamin E Acetate 0.10 DL-alpha-Tocopherol q.s. Perfume Production: (1) (1)

Aqua Tocopheryl Acetate Tocopherol

Heat phases A and B separately to about 80C. Stir phase B into phase A and homogenize. Cool to about 40C, add phase C and homogenize again. Viscosity: 4500 mPas Brookfield RVD VII+ pH value: 6.0

Properties:

Suppliers

1.

BASF SE 67056 Ludwigshafen, Germany Tel.: +49(621) 60-0 Fax: +49(621) 60-42525 www.basf.de Noveon Inc. 9911 Brecksville Road, OH 44141 Cleveland, USA Tel.: +1(216) 447-5000 Fax: +1(216) 447-5250 www.noveon.com Sasol Germany GmbH Witten Arthur-Imhausen-Str. 92, 58453 Witten/Ruhr, Germany Tel.: +49(2302) 925-537 Fax: +49(2302) 925-358 www.sasol.com Merck KGaA Frankfurter Strae 250, 64293 Darmstadt, Germany Tel.: +49(6151) 72-7869 Fax: +49(6151) 72-8333 www.merck.com Givaudan S.A. 5 chemin de la Parfumerie, CH-1214 Vernier-Geneve, Switzerland Tel.: +41(22) 780-9111 Fax: +41(22) 780-9595

6.

11.

20.

25.

EMM 050402e-02 January 2008

Page 6 of 6

Cremophor A Grades

27.

Cognis Deutschland GmbH Care Chemicals Henkelstrae 67, 40191 Dsseldorf-Holthausen, Germany Tel.: +49(211) 7940-2289 Fax: +49(211) 798-2016 www.cognis.com Goldschmidt GmbH Goldschmidtstrae 100, 45127 Essen, Germany Tel.: +49(201) 173-01 Fax: +49(201) 173-3000 www.goldschmidt.com Witco Corporation 1 American Way, CT 06831 Greenwich, USA Tel.: +1(203) 552-3373 Fax: +1(203) 552-2893 www.witco.com

44.

47.

Note

This document, or any answers or information provided herein by BASF, does not constitute a legally binding obligation of BASF. While the descriptions, designs, data and information contained herein are presented in good faith and believed to be accurate, it is provided for your guidance only. Because many factors may affect processing or application/use, we recommend that you make tests to determine the suitability of a product for your particular purpose prior to use. It does not relieve our customers from the obligation to perform a full inspection of the products upon delivery or any other obligation. NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR INFORMATION SET FORTH, OR THAT THE PRODUCTS, DESIGNS, DATA OR INFORMATION MAY BE USED WITHOUT INFRINGING THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION, DATA OR DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERMS AND CONDITIONS OF SALE. January 2008

BASF SE
Care Chemicals Division - Care Chemicals & Formulators - 67117 Limburgerhof - www.cosmetics.basf.com