International University, Faculty of Medicine Endocrine and Metabolism Course Test

Student Name-----------------------------------------------------------------------------------------------------1. Match the hormones to the function: 1. Insulin a. stimulates the thyroid gland ( ) 2. Oxytocin b. decreases blood calcium levels ( ) 3. Estrogen c. causes lactation of the breasts ( ) 4. Glucagon d. stimulates the ovaries and the testes ( ) 5. Thyroxin e. regulates the metabolism of the body ( ) 6. Prolactin f. maintains the uterine lining after ovulation ( ) 7. Aldosterone g. increases the recovery of salt by the kidneys ( ) 8. Adrenalin h. increaser heart rate and blood pressure and sugar levels

( ) 9. Calcitonin i. causes uterus to contract for birth and breasts to lactate ( ) 10. Testosterone j. stimulates the adrenal cortex of the adrenal glands ( ) 11. Progesterone k. speeds up the removal of sugar from the blood stream ( ) 12. Growth Hormone l. causes the increased release of glucose into the blood stream ( ) 13. Luttinizing Hormone m. m. stimulates the follicle cell to release hormones ( ) 14. Follicle-Stimulating H. n. stimulates the growth of female sex organs ( ) 15. Thyroid-Stimulating H. o. stimulates the growth of male sex organs ( ) 16. Adrenocorticotropic H p. stimulates the kidneys to control the amount of water retained ( ) 17. Antidiuretic Hormone q increase fatty-acid metabolism and amino acids up-take by cells ( )
2. Match the gland to the location in the body: 1. Pituitary gland a. slightly below the larynx 2. Adrenal gland b. On top of the kidneys 3. Thyroid gland c. in the pelvic cavity ( 4. Pancreas d. outside the pelvic cavity 5. Testes e. Attached to the base of the brain 6. Ovaries f. below the stomach near the liver

( ( ) ( ( (

) ) ) ) )
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3. March the hormone to the gland that secretes it: 1. Pituitary gland 1. Insulin ( ) 2. Growth hormone ( 2. 3. 4.

3.

5. 6.

Adrenaline ( ) Adrenal gland ( ) Thyroid gland ( ) Pancreas Glucagon ( ) Testes Ovaries

4. Estrogen ( 7. Testosterone ( 10. Melatonin (

) 5. Thyroxine ( ) 8. Calcitonin ( )

) )

6. Oxytocin 9. Cortisol ) 12.

11. Progesterone (

4. True False Questions 1. The main purpose of the endocrine system is for the protection of the body ( ) 2. Honnones are the same as the enzymes that help in digestion. ( ) 3. Hormones are released only into the blood stream. ( ) 4. Adrenocorticotropic hormone is released by the adrenal gland to control the pituitary ( ) 5. Progesterone hormone is released by the ovaries. ( ) 6. The adrenal glands are both an endocrine and exocrine glands ( ) 7. The pituitary gland release hormones that control other glands and growth. ( ) 8. Lutehizing hormone is released by ovaries. 9. Oxytocin acts on both the uterus and the breast of a female before she is pregnant ( ) 10. The growth and development of the genitals is a secondary sex characteristic ( )

Select the only one best or correct response for each of the following questions 5. Which of the following hormones does not dissolve in the blood and thus require carrier proteins? a. Antidiuretic hormone b. Thyroxine c. Adrenaline . d. Prostaglandin e. Insulin
6. Which of the following is a function of insulin?

a. Stimulates gluconeogenesis b. Stimulates glycogenolysis c. Stimulates hepatic lipase

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d. Increases blood glucose level e. Phosphorylation and use of glucose 7. Which hormone would be the best indicator of pregnancy? a. Estrogen b. Progesterone c. Llutenizing hormone d. Follicle stimulating hormone e. Human chorionic gonadotropin
8. A child presents with leg-bone deformity. Blood testing shows high levels

of vitamin D in the blood. Which of the following is most likely? a. Type I rickets b. Type II rickets c. Renal stones d. Excess 1,25-OH2D3 e. Calcitonin deficiency.
9. The following statement about Parathyroid Hormone (PTH) is not true.

a. PTH increases urinary cyclic AMP excretion. b. PTH is secreted from the parathyroid glands as a pre-pro form. c. Carboxyl fragments of PTH are cleared by the kidney. d. The relationship between extracellular fluid (ECF) calcium and PTH secretion is non-linear. e. The biological activity of the PTH resides within its amino-terminal region. 10. How is Protein Kinase A (PKA) activated? a. PKA binds to a receptor tyrosine kinase and is phosphorylated by the receptor. b. cAMP binds to the regulatory subunits and the catalytic subunits are released. c. G-protein-linked receptor signalling leads to increased cytosolic Ca2+ levels, which in turn activate PKA. d. PKA binds to inositol phospholipids on the cytosolic face of the plasma membrane leading to activation of its catalytic domain. e. GTP-bound Ras binds to the N-terminus of PKA and causes a conformational change to activate PKA.
11.

Receptor tyrosine kinase proteins contain all of the following structural features, EXCEPT: a. a ligase domain b. a dimerization domain c. a cytosolic kinase domain d. a cytosolic phosphatase domain e. an extracellular ligand binding domain

12. Which of the following is NOT a common intracellular second messenger? a. Ca2+ b. 1,2-diacylglycerol (DAG) c. 3',5'-cyclic GMP (cGMP) d. adenosine triphosphate (ATP)
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e. inositol 1,4,5-trisphosphate (IP3)

13. All of the following statements about the following hormones and their receptor are true, EXCEPT: a. progesterone binds to an intracellular b. growth factors bind to cell surface c. cortisol binds to a cell surface receptor d. adrenalin binds to a cell surface receptor e. estrogen binds to a member of the steroid receptor superfamily 14. Which one of the following statements regarding parathyroid hormone (PTH) is not true? a. It acts on the gut to increase calcium absorption. b. It stimulates renal synthesis of 1,25 dihydroxyvitamin D. c. Its level may be elevated in pseudohypoparathyroidism. d. It shares biological activity with PTH-related protein (PTHRP). e. It promotes reabsorption of calcium from the glomular filtrate.

15. A 40-year-old truck driver has had difficulty using his side mirrors for traffic behind him. He has never had any major medical problems in the past. He visits an optometrist, who determines he has bitemporal hemianopsia, but his vision is 20/20. A head CT scan reveals slight enlargement of the sella turcica. Which of the following hormones is most likely being secreted in excessive amounts in this man? a. Antidiuretic hormone b. Prolactin c. ACTH d. Growth hormone e. Luteinizing hormone
16.

The following statements concerning the pancreas are true except: 1. The pancreas receives part of its arterial supply from the splenic artery 2. The main pancreatic duct opens into the third part of the duodenum 3. The uncinate process of the pancreas projects from the head of the pancreas 4. The bile duct (common bile duct) lies posterior to the head of the pancreas 5. The transverse mesocolon is attached to the anterior border of the pancreas

17.

The following statements concerning the left suprarenal gland are incorrect except: 1. It extends behind the inferior vena cava 2. It is separated from the left kidney by the pararenal fat 3. Its vein drains into the left renal vein
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4. It is usually located on the upper pole and lateral border of the left kidney 5. e) The medulla is innervated by postganglionic sympathetic nerve fibres
18.

The following statements concerning the pituitary gland (hypophysis cerebri) are correct except: 1. It is separated from the optic chiasma by the diaphragma sellae 2. The sphenoid sinus is inferior to it 3. It receives its arterial supply from the internal carotid artery 4. It is suspended from the floor of the third ventricle by the pars anterior 5. e) It is deeply placed with the sella turcica of the skull End