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Approaching the ideal sedation without respiratory depression1,2,3

XamdexTM is an alpha2-adrenoreceptor agonist sedative with analgesic properties indicated for sedation of initially intubated and mechanically ventilated post-surgical patients who have undergone routine surgery during treatment in an intensive care setting.

Agitation is frequent and challenging problem in peri-operative and ICU patient care
Multiple pharmacologic agents typically administered during peri-operative and ICU care may 6 result in significant and often unpredictable outcomes Concomitant administration of these agents may lead to or worsen agitation and confusion
6

Agents that may contribute to agitation and delirium in peri-operative and ICU care patients
Benzodiazepines Opiates Volatile anaesthetics Muscle relaxants Anticholinergics Antibiotics Xamdex TM
TM

Yes Yes Yes Yes Yes Yes 6 Minimal

Xamdex may be of great benefit in treating and preventing agitation and delirium in 6 peri-operative and ICU care patients
Described as being effective in treating agitation and hyper-adrenergic states refractory to haloperidol6 Successfully lowers the incidence of emergence delirium after general anaesthetic
6

dexmedetomidine HCL

Xamdex

TM

Sedation Redefined

See the difference

XamdexTM has several advantages over traditional narcotics, 6 benzodiazepines and propofol for use as a sedative in the ICU
Sedation, anxiolysis and analgesic effect in a single agent
6

Sympatholysis leads to modest decrease in heart rate and blood pressure No respiratory depression:
1,2,3

4,6

Facilitates sedation in non-intubated patients6 Allows for extubation without the need to discontinue Xamdex infusion
TM

Minimal interference in the extubation process with Xamdex Ease of arousability in the treated patients
6

TM

Patients can be easily and calmly awakened Facilitates ease of patient evaluation and care

dexmedetomidine HCI HCL

Xamdex

TM

Sedation Redefined

See the difference

Approaching the ideal in sedation
1,5

SEDATION, ANALGESIA and ANXIOLYSIS in a SINGLE AGENT resulting in AROUSABLE, CALM, COMFORTABLE and CO-OPERATIVE PATIENTS with NO RESPIRATORY DEPRESSION and DECREASED AGITATION and DELIRIUM1,2,3,6

dexmedetomidine HCL

Xamdex

TM

Sedation Redefined

References:
1. 2. 3. 4. 5. 6. Maze M, Morrison P. Redefining sedation. International Congress and Symposium Series 221. Royal Society of Medcine Press Limited; 1998. Bhana N, Goa KL, McClellan KJ. Dexmedetomidine. Drugs 2000; 59(2):263-268. XamdexTM package insert. Tobias JD. Dexmedetomidine in Trauma Anaesthesiology and Critical Care. Traumacare 2007; 17(1): 6-18. Cain JG. Dexmedetomidine and Hextend: Their Role in Trauma Care. Traumacare 2007; 17(1): 4-5. Shukry M, Cain JG. Dexmedetomidine Prevents and treats Agitation, Delirium and Withdrawal. Traumacare 2007; 17(1): 24-26.