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of randomly occurring mutations, developing from the simplest forms to complex forms which are more prolific and stronger, due to their better adaptation to their environment. provided this insight that establishes a great chain connecting the distant
past to the present.
The well known showed that simple components can react abiotically (or in the absence of life) to give rise to biologically important compounds such as components of proteins and nucleic acids.
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apparatus type used in the Miller and Urey experiment demonstrating the formation of organic compounds in abiotic, primitive atmospheric conditions. Water is heated in a closed system containing NH3, CH4, and H,. An electric discharoe is passed throuqh the
At the molecular level, evolution is the history of the emergence of more complex biomolecules from simpler organic monomeric units or even from inorganic counterparts.
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After the spontaneous synthesis of organic molecules, the next step in evolution was the formation of macromolecules. Under prebiotic conditions, macromolecules are formed spontaneously from monomeric building blocks as shown below.
Monomeric subunits Letlers of DaoxlriLFRucl$tids Enslish (26dimrredr kinds) i+diffetent kjn(ls)
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From macromolecules come supramolecular complexes which now become integral parts and components of living cells.
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One of the important molecules of life is what we know as genes - but are actually chemically, deoxyribonucleic acids (DNA) - that define biological structure and maintain cellular integrity. These genes encode proteins that make up cellular structures and carry out many activities in the cell, particularly catalytic activity, that increases rates of cellular reactions producing large numbers of complex molecules. The "decoding" or expression of coded genetic info in DNA into proteins is made possible by another molecule - the ribonucleic acids
This trio of macromolecules - DNA, RNA and proteins - is present in all cells. The rest are polysaccharides, water, inorganic ions and a large array of small organic molecules.
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The central dogma of molecular biology illustrated in the figure below shows the organizing principle in the flow of genetic information: DNA to RNA to protein.
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Of the macromolecules in present-day cells, only the nucleic acids are capable of directing their own self-replication. Nucleic acids can serve as templates for their own synthesis as a result of specific base pairing between complementary nucleotides, "A critical step in understanding molecular evolution was thus reached in the early 1980s, when it was discovered in the and laboratories of that RNA is capable of catalyzing a number of chemical reactions, including the polymerization of nucleotides. RNA is thus uniquely able both to serve as a template for and to catalyze its own replication.
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Consequently, RNA is generally believed to have been the initial genetic system, and an early stage of chemical evolution is thought to have been based on self-replicating RNA molecules a period of evolution known as the RNA world.
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5) ANIMALIA
prokaryotic organisms unicellular eukaryotes such as Euglena, Volvox, Amoeba, Paramecium 3) FUNGI - yeasts, molds, mushrooms 1) MONERA
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Another approach to classification has also been established - the three classification scheme (nicknamed the "tree of life").
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This system has shown that some of the organisms that were traditionally classed together as "bacteria" are as widely divergent in their evolutionary origin as is any prokaryote from any eukaryote. The prokaryotes in this scheme comprise two distinct groups that diverged early in history of life: the BACTERIA (or eubacteria = true bacteria) and the ARCHAEA (or archaebacteria = early bacteria). The third division or domain is EUCARYA which include all eukaryotes.
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Archaebacteria are sometimes called extremophles because they are common inhabitants of extreme environments. It includes three groups: 1) strict anaerobes that produce methane from CO2 and H2 2) - require very high salt concentrations 3) - require high temperatures and acid conditions for growth, typically B0-90oC and pH2
Complete genomes are being obtained for organisms from all the th?ee domains; some genomes have been completely sequenced as shown in the figure below.
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organisms - a small compartment bounded by a semipermeable membrane filled with concentrated aqueous solution of chemicals and non-living products of its activities that is able to carry on independently all the basic life functions
All the information - to build an organism along with all its structures, run all its activities and make more of themselves are stored and encoded in the collection of its genes packaged into a set of chromosomes. The information is hereditary and are stored in the cell's DNA.
anized structur
The cell is complex because of the great
reproduce by division on which the contents of "mother" cell, after faithfully dupticating its genetic material (DNA) is distributed into two "daughter" cells, usually equally.
these parts are put in order and in their proper places consistently. As a
consequence, /ess error is
tolerated in the nature and interactions of the parfs placed in a system that is regulated and controlled.
Photo lrom Lodish, HaNey el. al.2004. Moleculat CeI Biology. 51r ed.W.L. Freeman and company, New York.
4. Cellacquires and utilizes energy. Virtually, all of the energy required by life on the earth's surface arrives in the form of electromagnetic radiation from the sun-which photosynthetic cells trap by their light-absorbing pigments present in cell membranes. The light energy is converted by photosynthesis into chemical energy that is stored as sucrose or starch.
5. Cellengages in metabolism.
Metabolism is the sum total of all the chemical reactions in the cell. The chem ica I tra nsformations that proceeds require enzymes that greatly increase the rate at which a chemicaI reaction occurs.
6. Cellengages in mechanical activities.
sugar glucose (usually from the degradation of starch or glycogen). Glucose in cells are metabolized in such a way that it's energy content is stored in a readily available form (such as ATP).
Dynamic, mechanical changes are carried out by the cell: transport of materials from place to place, assembly and disassembly of structures or the cell itself moves from one site to another.
7.
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For multi-cellular organisms like plants and animals. their cells have special -'interact" structures called receptors that with substances in the environment. The interaction is communicated to the interior of the cell. The cell may respond by altering some metabolic activities, prepare for cell division, initiate movement or commit suicide (apoptosis).
The complex system of cells require that they put proper order and organization to all the materials that make up their structure and, to all their mechanical and metabolic activities especially in the acquisition of energy to sustain themselves and to reproduce. The requirement is satisfied by constant regulation. The importance of regulation is greatly magnified by its breakdown. The cell may lose many of its important functions or becomes aberrant that it is transformed into an uncontrolled cell as in the case of cancer cells.
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Prokaryotes from an evolutionary point of view, are considered to be "ancestors" of eukaryotic cells. In the current three domain classification scheme, prokaryotes are divided into two major divisions: the ARCHAEA (or achaebacteria) and the BACTERIA (or eubacteria).
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meihanogens ( prokaryotes converting CO2 and H2 gases into methane gas); halcphiies (prokaryotes that live in extremely salty environments); thermcacidcphi les (prokaryotes that live at very high temperatures and very low pH).
The types of prokaryotes belonging to the domain Bacteria includes the myeaplasma, the smallest living cells. it also includes the most complex prokaryotes - the cyanabaeteria, which has elaborate arrays of cytoplasmic membranes serving as sites of photosynthesis. Aside from photosynthesis, many cyanobacteria are also capable of nitrogen fixation - the conversion of N2 gas into reduced forms of nitrogen such as ammonia that is used by cells in the synthesis of nitrogen- containing compounds like nucleotides and amino acids.
- Frsteobacteria:
a diverse group including photosynthetic sulphur bacteria (using H2S as an electron donor in photosynthetic pathways), mitochondria relatives, and some human pathogens (Salmonella, Vibrio cholerae)
- Cyanobacteria:
probably the first oxygenic photosynthetic organisms, they are similar structurally and physiologically to chloroplasts in eukaryotes.
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motile and often parasitic pathogens (syphilis, Lyme disease)
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Outside the plasma membrane are thin but strong layers of p*pticir:glycar:s (sugar polymers cross-linked by amino acids) which gives the cell shape and rigidity protecting the cell. Bacterial cells have varying cell walls with different affinilies for the dye Gentian violet, which is the basis for Gram's stain - (gram+ bacteria retain the dye and gram- bacteria do not).
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similar mechanism for photosy,nthesis (cyanobacteria and g'reen plants); similarity in the conservation of ,chemical energy as ATP {in Plasma membrane of 'pr.o'karyotes and the mitochond r'ial membrane of eukaryotes). '
.Sorr.cs Kary, GercH. 2002. cd and Mdectlat Biolagy corcepls ahd E\@nhenb 7 ed John Wy
Lehnihger,
and
Abed et.
The most outstanding difference is the presence or absence of the nucleus which became the basis for the terms: prokaryotic - (pro=before, karyon = nucleus) eukaryotic - (eu=true, karyon = nucleus),
The genetic material of a prokaryotic cell is found in a nucleoid: a poorly demarcated region of the cell that lacks a boundary membrane to separate it from the surrounding cytoplasm. On the other hand, eukaryotes possess a nucleus: a region bounded by a complex membranous structure called the nuclear envelope.
Prokaryotes
mainly unicellular
5-100pmin
diameter
DNA
proteins in chromosome;
chromosomes in nucleus with
membranous
envelope
RNA and
Above:The nucleoid region in prokaryotic cells; Right: an electron micrograph of eukaryotic nucleus, the dense region in the middle is the nucleolus.
LdhnkqeL Abert et. d.1993 Pnndples of Abchenislry
RNA and
RNA
protein
proteins synthesized in
synthesized in
nucleus;
proteins in cytoplasm
ed.
Woft tublishe6
Characteristic
Cell Division
Prokaryotes
fission or
Characteristic Nutrition
budding; no mitosis
mitotic
spindle; centrioles in many species almost always diploid or polyploid mitochondria, chloroplasts (in plants, some algae), endoplasmic reticulum,
Golgi
oxidative
enzymes packaged in
Ploidy
usually haploid
mitochondria; oxidative
enzymes bound to plasma
Compartmentalization (Membranebounded
absent
organelles)
cytoplasmic streaming,
endocytosis, phagocytosis, mitosis, vesicle
transport