The use of net analyte signal (NAS) in near infrared spectroscopy pha...

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The use of net analyte signal (NAS) in near infrared spectroscopy pharmaceutical applications: interpretability and figures of merit.
by Mafalda Cruz Sarragua, Joo Almeida Lopes Save reference to library Chemistry Chromatography Papers Share

Overview Analytica Chimica Acta (2009) References Related research 21 Volume: 642, Issue: 1-2, Pages: 179-185 PubMed: 19427474 Available from www.ncbi.nlm.nih.gov or Find this paper at:

Abstract
Near infrared spectroscopy (NIRS) has been extensively used as an analytical method for quality control of solid dosage forms for the pharmaceutical industry. Pharmaceutical formulations can be extremely complex, containing typically one or more active product ingredients (API) and various excipients, yielding very complex near infrared (NIR) spectra. The NIR spectra interpretability can be improved using the concept of net analyte signal (NAS). NAS is defined as the part of the spectrum unique to the analyte of interest. The objective of this work was to compare two different methods to estimate the API's NAS vector of different pharmaceutical formulations. The main difference between the methods is the knowledge of API free formulations NIR spectra. The comparison between the two methods was assessed in a qualitative and quantitative way. Results showed that both methods produced good results in terms of the similarity between the NAS vector and the pure API spectrum, as well as in the ability to predict the API concentration of unknown samples. Moreover, figures of merit such as sensitivity, selectivity, and limit of detection were estimated in a straightforward manner.

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4 Readers on Mendeley by Discipline 50% Chemistry 25% Engineering 25% Medicine by Academic Status 50% Researcher (at an Academic Institution) 25% Doctoral Student 25% Post Doc

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