Beruflich Dokumente
Kultur Dokumente
- Somatostatin
o Targets GH and TSH and Insulin, it inhibits them
- Dopamine
o Targets PRL, TSH, LH and FSH, it inhibits them
Hyperpituitarism
- Pituitary Adenomas
o Benign neoplasms causing hormone secretion
o Microadenomas has no symptoms unless secrete hormones but Macroadenomas (>10cm) have
local symptoms
Impingement of optic chiasm, sever headaches
Hypothalamic invasion – loss of temp regulation
- Galactorrhea
o Lactation in those not breastfeeding, most common endocrinopathy associated with pituitary
adenoma
o Prolactinomas = 26% of all primary adenomas
o In women: estrogen deficieny, hot flashes, dyspareunia (pain on intercourse), amenorrhea,
infertility
o In men: headaches or visual disturbances, loss of libido
- Gigantism and Acromegaly
o Excessive GH almost always due to pituitary adenoma, 14% of pituitary adenomas
o If occurs in childhood it is known as pituitary giantism
Delayed puberty, hypogonadism often present
o If occurs in 30s-50s it is acromegaly
Swelling of hands and feet, protrusion of jaw, deep husky voice, skin thickens and darkens
Hyperpituitarism
- Corticotrope Adenomas (15%)
o Secondary Cushing’s disease, hypersecretion of ACTH
- Gonadotrope Adenomas (8%)
o Secrete LH and FSH, present in middle-aged men as headache, visual disturbances and acquired
hypogonadism
- Thyrotrope Adenomas (1%)
o Symptoms of hyperthyroid, goiter or pituitary mass lesion, increased TSH and thyroid hormone
- Non-functional Pituitary Adenomas (23%)
o Do not secrete excess hormones, diagnosed in older people