Cardiovascular Drugs

Wednesday, July 28, 2010 11:45 AM

SNS Drugs Alpha -1 antagonists: ends in -zosin Alpha-2 agonist: clonidine Beta blockers: ends in -lol Non-selective: propranolol Selective: rest ending in -lol Calcium-channel blocker Can act on heart (contractility, conduction, HR) and as well on peripheral vasculature by preventing vasoconstriction of blood vessels, thus lowering SVR Action on VSM Nifedipine, amlodipine Action on VSM and heart Verapamil, dilitaizem RAAS Drugs ACE inhibitors: ends in -pril SE: dry cough due to bradykinin ARB: same action ACE inhibitors but doesn't cause dry cough since it doesn't produce bradykinin Angiotensin II receptor blockade Aldosterone blockade: these are all diuretics so you're targeting the preload SE: fluid/electrolyte imbalance, thus dehydration Potassium-sparing diuretics is another name for aldosterone blockage

Mean arterial Blood Pressor MAP = CO * SVR CO = Stroke Volume * Heart Rate SV = Preload, contractility, afterload Preload: filling pressure in the right atrium; it's the venous return to the heart Look at central venous pressure (CVP) to measure Value: 4 - 12 mmHg Preload will indicate for fluid status, thus high CVP means fluid overload Contractility: force of contraction of the ventricles Measure by looking at ejection fraction (EF) using echocardiogram Normal EF: 50 - 70 % of blood will be ejected EF < 40% indicates for heart failure Values MAP: (SBP + 2DBP)/3 90-110 CO: 4 - 8 L/min SVR: 800-1200 Cardiac Index (CI): CO/BSA 2.5 - 4 SV: 60 - 70 mL / beat HR: 60 - 100 Normal Chem6 (basic metabolic panel) Na ClBUN
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Normal Chem6 (basic metabolic panel) Na ClBUN 135-145 10-20 3.5-5 K+ Hematology WBC 5-10 20-26 CO2 1 Creatinine Glucose 70-110

Hb 15-18

PLTS (platelets)

150,000 - 450,000 45-55 (1:3 ratio between Hb and HCT) HCT

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