Bicol College COLLEGE OF NURSING Daraga, Albay

Course Code: NCM 106 Course Description: Care of Clients with in Inflammatory and Immunologic Disorders Units: Time: 1:00-5:00 General Course Objectives: Successful completion of this course will promote the general student learning outcomes listed below. The student will be able to:
1. Describe the general concepts of disease processes and factors associated with

disease causation.
2. Identify the function of basic cellular structures, determining the sequelae of

selected cellular malfunctions.

3. Describe the responses of the body to injury and immunologic challenge. 4. Discuss the etiology, pathogenesis, and treatment modalities of frequently

occurring diseases. Specific Course Objectives: Upon successful completion of the course the student will be able to:
1. Describe and understand the common diseases and disorders of the human

body systems.
2. Discuss the pathophysiologic changes that occurs as a result of cellular injury. 3. Analyze the role of the immune system in disease processes. 4. Describe the pathophysiologic changes that occur in selected disease processes 5. 6. 7. 8.

for each body system. Correlate the cellular and system changes that occur in selected disease processes with common presenting clinical manifestations. Define the common treatment modalities and procedures associated with various disease processes. List the categories of pathogenic organisms and the effects these organisms have on the human body. Describe events related to common disorders, major disease processes, and outline the inflammatory response events.

Course Content:

A. Anatomy and Physiology of the Immune System 1. Functions 2. Characteristics/ Properties a. Self versus non self recognition b. Antibody production c. Self regulation d. memory 3. Components of Immune System Bone marrow a. Thymus gland b. Spleen c. Lymph nodes d. Tonsils and adenoids

B. Immunity a. Types 1. Natural/ innate 2. Acquired/ artificial b. Immune Response/ Three Means of Defense 1. Phagocytic immune response 2. Humoral/ antibody response 1.a antigen recognition 1.b role of antibodies 1.c types of antibodies c. stages of immune response 1. Recognition stage 2. Proliferation stage 3. Response stage 4. Effector stage

4. Pathophysiology of the Development of the Cells of Immune System

C. Assessment of Immune Function a. Health history i. Gender ii. Nutrition iii. Infection and immunization iv. Allergy v. Disorders/ diseases vi. Medications and blood transfusions vii. Lifestyle factors viii. Psychoneuroimmunologic factors b. Physical examination c. Diagnostic examination i. Leukocyte and lymphocyte count ii. Humoral immunity test iii. Cellular immunity test iv. Phagocytic cell function test v. Complement component test vi. Hypersensitivity test vii. Specific antigen-antibody tests viii. HIV infection tests ix. ANA titer determination x. Skin testing xi. Anti-DsDNA antibody test D. Immune System Disorders a. Immunodeficiencies i. Primary Defect on Phagocytic Cells Hyperimmunoglobulinemia E (HIE) syndrome / Job Syndrome Chronic Granulomatous Disease (CGD Defect on B-Lymphocytes Bruton agammaglobulinemia/ Brutons disease/Sex linked Agammaglobinemia Hypogammaglobulinemia or Common Variable immunodeficiency (CVID) Defect on T-Lymphocytes Di Georges syndrome or Thymic hypoplasia Chronic Mucocutaneous Candidiasis

 Defect on B and T-Lymphocytes Severe Combined Immunodeficiency disease(SCID) Ataxia telangiectasia Nezelofs Syndrome Wiscott-Aldrich Syndrome Defect on Complement System Angioneurotic edema Paroxysmal nocturnal hemoglobinuria (PNH) ii. Secondary AIDS b. Gammopathies Multiple Myeloma c. Autoimmune Diseases Systemic Lupus Erythematosus Rheumatoid Arthritis Myasthenia Gravis Multiple Sclerosis Hashimoto Thyroiditis d. Hypersensitivity Types of Allergens General Etiologic Factors Hereditary Congenital Contact Factors Related to the Degree of Allergic Response Chemical Mediators of Hypersensitivity Primary mediators o Histamine o Eosinophil chemotactic factor of anaphylaxis o Platelet activating factor o Prostaglandin o Basophil kallikrein Secondary mediators o Bradykinin o Serotonin o Heparin o Leukotrienes Four Types of Hypersensitivity Reactions Type I (Anaphylactic)/Immediate Reaction Allergic rhinitis/Hay fever Atopic dermatitis Dermatitis Medicamentosa/ Drug Reactions Urticaria Angioneurotic Edema Hereditary Angioedema Food Allergy Latex Allergy Type II (Cytotoxic) Reactions Blood transfusion reaction RH incompatibility Type III (Immune Complex) Reaction Serum Sickness Systemic Lupus Erythematosus

 Acute Glomerulonephritis Arthus Reaction Type IV (Cell-Mediated)/ Delayed Reactions Tuberculosis Contact dermatitis Transplant rejection