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PHARMA VISION FOR GPAT 2012 & NIPER JEE 2012

Vision : We are gland to present compressive study Material for All india level Pharma entrance examination as per new patten.

Pharma Vision Provides 2 facilities which help you throughout your study for All india level Pharma entrance examination .

 We are launching a GPAT Study material according to new syllabus and it is our gurantee that if you will read our material of only 800 pages which is divided in four modules surely it will give success in GPAT-2012.  The study material was prepared by NIPER , Mohali & M.S. University students.  For Your satisfaction some portion of a Module will be provided as free sample.  Then as per your choice you can buy the material.  The cost of this GPAT study material package is Rs.1500/ NIPER Study Materials is 800/- .  MCQ Bank is 800/-. 1. GPAT Study Material
The content of study material is follows:

1.Module -I-Pharmaceutics 2.Module-II-Pharmaceutical Chemistry 3. Module-III-Pharmacognosy 4. Module-IV-Pharmacology Pharma vision GPAT & NIPER Study Material,& MCQ Bank, Model Paper Conatct: 09427360746 E-mail : pharmavisiongpat@gmail.com

5. NIPER's Previous Year paper & study material 6.List of important books related to GPAT 8. CD containing Soft copy of Books ( 3 books of Each Module)

2. MCQs BANK :
Pharma-vision is very proud to announce a multiple choice questionnaire,a book unlike others ,provides modules specific chapter wise questions. MCQ Guides contains single line, Assertion & Reasoning and Statements type MCQ as per new patten. GPAT & NIPER JEE Model Papers y 20 section wise GPAT Model Papers y 10 pre GPAT Model Papers y 10 pre NIPER JEE Model Papers

Get free updates for GPAT & NIPER JEE. Type ON PHARMAVISIONGPAT send to 9870807070. Contact : 09427360746 E-Mail : pharmavisiongpat@gmail.com

Pharma vision GPAT & NIPER Study Material,& MCQ Bank, Model Paper Conatct: 09427360746 E-mail : pharmavisiongpat@gmail.com

Size separation Particle Size sepration by different method Size sepration method Sieving Sedimentation (a) Gravitational (b) Centrifugal Elutrition (a) Water and Air gravitational (b) Centrifugal Cyclone separation 10-500 0.5-50 2-50 5-1000 0.1-5 Particle diameter (micron) 5-10000

Standards of powder: Grade of powder Sieve through which all particle Sieve through <40% must pass particle pass 10 22 44 85 120 350 (90% pass) 90%pass through 10 micron 44 60 85 120 -

Coarse Moderately coarse Moderately fine Fine Very fine Microfine Superfine

Pharma vision GPAT & NIPER Study Material,& MCQ Bank, Model Paper Conatct: 09427360746 E-mail : pharmavisiongpat@gmail.com

Types of Binders TABLE. CLASSIFICATION OF BINDERS SUGARS Sucrose Liquid glucose NATURAL BINDERS Acacia Tragacanth Gelatin Starch Paste Pregelatinized Starch Alginic Acid Cellulose SYNTHETIC/SEMISYNTHETIC POLYMER Methyl Cellulose Ethyl Cellulose Hydroxy Propyl Methyl Cellulose ( HPMC) Hydroxy Propyl Cellulose Sodium Carboxy Methyl Cellulose Polyvinyl Pyrrolidone (PVP) Polyethylene Glycol (PEG) Polyvinyl Alcohols Polymethacrylates

TABLE. COMMONLY USED BINDERS BINDER Starch 1500 Methocel CATEGORY MANUFACTURER

Partially Pregelatinized Maize Starc Colorcon h Hydroxy Propyl Methyl Cellulose Dow Chemicals Wolff-Cellulosics

Walocel

Hydroxy Propyl Methyl Cellulose

Natural Starch and Chemical Compan y BASF Company BASF Company BASF Company

Luvitec Luvicross Luvicaprolacta m

Polyvinylpyrrolidone Polyvinylpyrrolidone Polyvinylcaprolactam

Pharma vision GPAT & NIPER Study Material,& MCQ Bank, Model Paper Conatct: 09427360746 E-mail : pharmavisiongpat@gmail.com

3.Lipids Saponification value  Saponification is the base-catalyzed hydrolysis of an ester. mgs of KOH required to saponify 1 g of fat.  Products of the reaction are- An alcohol and An ionized salt which is a soap  Acid Value  Number of mgs of KOH required to neutralize the Free Fatty Acids in 1 g of fat, that number indicate degree of rancidity

Iodine Value  Number of iodine (g) absorbed by 100 g of oil.  Molecular weight and iodine number can calculate the number of double bonds. 1 g of fat adsorbed 1.5 g of iodine value = 150. Rancidity  Due to long exposure to air, a foul odour or smell comes known as rancidity.

Oxidation (Air, Moisture,Light)


 Triglyceride Fatty acids

Lipase
Specially C4 butyric acid and other short chain fatty acids in butter are the real problem. Fatty Acids Palmitic acid Stearic Acid Oleic acid Myristic acid Linoleic acid Linolenic acid Arachidonic acid Lauric Acid Capric Acid No. of Carbons (Double bonds) 16(0) 18(0) 18(1) 14(0) 18(2) 18(3) 20(4) 12(0) 10(0)

Pharma vision GPAT & NIPER Study Material,& MCQ Bank, Model Paper Conatct: 09427360746 E-mail : pharmavisiongpat@gmail.com

Types of Density True Density Helium pycnometer (Porous solid) Liquid displacement (Non Porous solid) Mercury displacement method M/Vt

Granule Density

M/Vg

Bulk Density

Graduated cylinder method based on Tapping the powder from i1 inch height Thricely in 2 min interval

M/Vb

CARR s INDEX % Compressibility 5-15 12-16 18-21 23-28 28-35 35-38 > 40 Flow Excellent Good Fair Poor Poor Very poor Extremely poor

HAUSNER Ratio HAUSNER Ratio Less then 1.25 1.25- 1.5 More then 1.5 Type of Flow Good flow Moderate Poor Flow

Pharma vision GPAT & NIPER Study Material,& MCQ Bank, Model Paper Conatct: 09427360746 E-mail : pharmavisiongpat@gmail.com

ANGLE OF REPOSE ANGLE OF REPOSE <25 25- 30 30-40 > 40 Type of Flow Excellent Good Passable Poor Flow

Pharma vision GPAT & NIPER Study Material,& MCQ Bank, Model Paper Conatct: 09427360746 E-mail : pharmavisiongpat@gmail.com

PHARMACEUTICAL CALCULATIONS
Calculations of Doses for Children: The following are used for calculation of doses for children: 1. Young Formula: Age (Years) X Adult Dose = Dose of the Child ________ Age+ 12 2. Dilling s Formula: Age (years) _________ 20 X Adult dose = Dose of the child

3. Cowling s Formula: Age (years) x Adult dose =Dose of the child _________ 24 4. Fried s formula: Age ( Months) x Adult dose Dose of the child __________ 150 5. Clarke s formula

6. Bastedo s formula: Age (years) + 3 X Adult dose = Dose of child __________ 30 7. Calculation based on body surface area:

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Usually the body surface area of an adult is taken as 1.73 sq. m.

ALKALOID True alkaloids: contain heterocyclic Nitrogen which is derived from amino acid and always basic in nature due to presence of lone pair of electrons on nitrogen. Proto alkaloids: are simple amines in which Nitrogen is not heterocyclic. E.g. ephedrine, Colchicine, mescaline Pseudo alkaloids: they are not derived from amino acids but they show positive test for alkaloids. E.g. purines (caffeine), steroidal and terpenoidal alkaloids Conessine, solanidine, protoveratrine, aconine. Volatile alkaloids: coniine, nicotine, sparteine Colored alkaloids: Berberine (yellow), Betanidin (Red) Some of proto and pseudo alkaloids show higher solubility in water e.g. Colchicine, caffeine, quinine HCl are freely soluble in water. So solubility of alkaloid is also employed for extraction procedures. Alkaloids with Primary amine Nitrogen: Mescaline Alkaloids with Secondary amine Nitrogen: Ephedrine Alkaloids with Tertiary amine Nitrogen: Atropine Alkaloids with Quaternary Nitrogen:

Pharma vision GPAT & NIPER Study Material,& MCQ Bank, Model Paper Conatct: 09427360746 E-mail : pharmavisiongpat@gmail.com

Tubocurarine Chemical test: i. Mayer s reagent test (K+ mercuric iodide solution) ppt ii. Dragendroff s reagent (K+ bismuth iodide solution) Cream colored Red brown Wagner s Red brown Yellow

ppt iii. reagent (iodine K+ iodide solution ) ppt iv. Hager s reagent (Picric acid)

colored ppt v. colored ppt Classification:

Picrolonic acid Yellow

a. Pyrrole and Pyrrolidine ring: Hygrine, Cocoa b. Pyridine and piperidine : Coniine, Arecoline, Lobeline c. Quinoline : Camptothecin (Anticancer), Quinine, Cinchonine d. Isoquinoline: D-Tubocuarine (Skeletal muscle relaxant), Morphine, Berberine, Emetine e. Physostigmine f. Imidazole: Pilocarpine g. Quinazoline: Vasaka (antitussive & expectorant) Indole: Ergot, Reserpine, Vinca, Strychnine,

Pharma vision GPAT & NIPER Study Material,& MCQ Bank, Model Paper Conatct: 09427360746 E-mail : pharmavisiongpat@gmail.com