SYMCHEM

Research Labs Pvt Limited

MISSION
“To build a world class custom synthesis and contract
manufacturing company that uses its own R&D and can
deliver products conforming to highest standards of
process validation using optimal resources and with
equal emphasis on technology, quality, safety with a NO
COMPROMISE attitude on ethical, ecological, moral
and social values”

SYMCHEM serves Pharma and Chemical industries in the

following areas :

Custom Synthesis
Synthesized compounds involving variety of chemistries and
exported to Europe and USA.

Impurity Synthesis
Impurity synthesis and exporting to European countries.

Process Research & Development

Multi-steps Chemical process develop for large Indian pharma
company.

Chemistry performed
Amino acid. Carbohydrate Chemistry and synthesis of Pyridine
& Imidazole derivatives. Compounds were sold to Indian clients
and exported.

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Research Labs Pvt Limited

Heterocyclic Compound
6-Bromopicolinic acid 2-Bromo-6-methylpyridine 2-Amino-6-methylpyridine
21190-87-4 5315-25-3 1824-81-3

HOOC N Br H3C N Br H3C N NH2

4-Amino-3-nitropyridine 4-Hydroxy-3-nitropyridine 3,4-Diaminopyridine

1681-37-4 5435-54-1 54-96-6
NH2 OH NH2
NO 2 NO 2 NH2

N N N

3-Methyl-4-nitropyridine 3-Aminopyridin-4-ol 4-Amino-3-methylpyridine

1678-53-1 6320-39-4 1990-90-5
NO 2 OH NH2

CH3 NH2 CH3

N N N

4-Ethylpyridin-2-amine 2-Bromo-6-methylpyridine 2-Pyridinamine, 6-chloro-5-

33252-32-3 5315-25-3 methyl
CH3
442129-37-5
CH3

H3C N Br
N NH2 H2N N Cl

4-Amino-5-methyl-3- 3,6-Dichloropyridazine 3,6-Diiodopyridazine

nitropyridine 141-30-0 20698-04-8
Cl I
18227-67-3
NH2
N
H3C NO 2 N I N
Cl N

N
3,6-Dibromopyridazine 4,5-Pyridazinediamine 2-Chloro-3-
17973-86-3 28682-70-4 methylquinoxaline
Br NH2
32601-86-8
H2N N Cl
N
Br N N
N N CH3

Furo[3,4-B]Pyridin-5(7h)-One N-(Diphenylmethylene)glycine 2-Hydroxytetrahydrofuran

5657-51-2 ethyl ester 5371-52-8
69555-14-2 O
OH
O
N
O

CH3

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Research Labs Pvt Limited

API IMPURITIES
Name CAS No. API Structure
N-Desmethyl 139755-82-1 Sildenafil
Sildenafil

Thio Sildenafil 479073-79-5 Sildenafil

HO O
Simvastatin 139893-43-9 Simvastatin CH3

Hydroxy Acid H3C CH3

HO
-
O NH4
+

Ammonium Salt
O O
H
CH3

H3C

Tauroursodeoxycho 14605-22- 2 Tauroursodeoxyc

lic Acid holic Acid

CH3
Rosuvastatin 503610-43-3 Rosuvastatin O
CH3

N N
Lactone S CH3
H3C O N

OH

O
F

N-acetyl 51-59-2 Mesalamine COOH

mesalamine OH
O

NH
Rabeprazole 117976-47-3 Rabeprazole O
Sulfone
O
NH

N S N
O
O

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Research Labs Pvt Limited

Name CAS No. API Structure

2-Pyridyl acetic 13115-43-0 N O
Betahistine
Acid OH

25-Des Acetyl 16783-99-6 Rifampicin

Rifampicin

Dihydralazine Dihydralazine NH2

HN
Sulphate Impurity A Sulphate
N
N

NH2
Dihydralazine Dihydralazine NH2
HN
Sulphate Impurity C Sulphate
N
N

Ramiprilate; 87269-97-4 Ramiprile HOOC H

O
Ramipril Diacid ; HO H3C
N
(EP Impurity E)
NH H
O

CH3
Ramiprile 108731-95-9
diketopiperazine
O H3C O
(EP Impurity D) O H
N N

O
H

O-Desmethyl 16412-54-7 Tramadol HO

Tramadol
OH
N

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Research Labs Pvt Limited

Name CAS No. API Structure

HO O
Lovastatin Hydroxy 75225-51-3 Lovastatin +
-
Acid Sodium Salt O
O Na
HO

H3C O
H
CH3 CH3

H3C

HO O
Lovastatin Hydroxy 237073-64-2 Lovastatin
+
Acid Ammonium
-
O NH4
O
HO
Salt Salt
H3C O
H
CH3 CH3

H3C

Montelukast DCHA 577953-88-9 Montelukast

Montelukast Acid 158966-92-8 Montelukast

N-Desmethyl Olanzapine
Olanzapine

H3C O
Atorvastatin 125995-03-1 Atorvastatin O
CH3

O
Lactone Lactone N
NH
OH

H
3-OH Desloratidine 119410-08-1 Desloratidine N

Cl OH

25-Des Acetyl 100324-63-8 Rifabutene

Rifabutene

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Research Labs Pvt Limited

Name CAS No. API Structure

Lansoprazole 615-16-7 Lansoprazole H
N
Impurity D;
OH
1H-Benzimidazol-
N
2-ol ;
2-
Hydroxybenzimidaz
ole
Lansoprazole 83-39-1 Lansoprazole H
N
Impurity E ;
SH
1H-Benzimidazol-2-
N
thiol ;
2-
Mercaptobenzimida
zole

API IMPURITIES
(Proposed to Synthesis Pharma Impurity of following API as per requirement
of Client)

Sr No Name Sr No Name
1 Enalapril Maleate 19 Pitavastatin
2 Fosinopril 20 Pravastatin
3 Lisinopril 21 Rosuvastatin
4 Quinalpril 22 Candesartan
5 Ramipril 23 Eletriptan
6 Trandolapril 24 Eprosartan
7 Benazepril 25 Irbesartan
8 Dapoxetine 26 Losartan
9 Aripiprazole 27 Olmesartan
10 Fluconazole 28 Telmesartan
11 Lansoprazole 29 Valsartan
12 Omeprazole 30 Duloxetine
13 Pentaprazole 31 Imatinib
14 Rabeprazole 32 Montelucast
15 Atorvastatin 33 Oxybutynin chloride
16 Fluvastatin 34 Rizatriptan
17 Lovastatin 35 Pioglitazone
18 Mevastatin 36 Rosiglitazone

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Research Labs Pvt Limited

List of Pesticide Impurity

Name Pesticide Structure
O CH3
2-Amino-N-(1-methylethyl)benzamide Bentazone
NH CH3

NH2
O CH3
[2-[[(1-methylethyl)-amino]carbonyl] Bentazone
phenyl] sulfamic acid NH CH3

NH
SO 3H
H3C
4-({4-[(Dimethoxyphosphorothioyl)- Temephos
H3C O O
oxy]phenyl}thio)phenyl dimethyl P
O O
P CH3
phosphate (Temephos oxon) S
O S
O
CH3 S

H3C
O-{4-[(4-{[Methoxy(methylthio)- Temephos H3C O O
phosphoryl]oxy}phenyl)thio]phenyl}- P
O O
P CH3
O O
O,O-dimethyl thiophosphate (Iso- CH3
O
S
S

temephos)

H3C H C2H5
N–(1 –methyl propyl) – 3,4 Xylidine Pendimethalin C
NH

CH3
CH3

N–(1 –Ethyl propyl) – 2,3 Xylidine Pendimethalin C2H5 H C2H5

C
NH
CH3

CH3

Pendimethalin NH2

3,4-Dimethyl 2,6-dinitro aniline O2N NO2

CH3
CH3
NO
N-Nitroso Pendimethalin Pendimethalin N-CH-(CH2CH3)2
O2N NO2

CH3
CH3

N–(1 –Ethyl propyl) – 6-nitro 3,4 Pendimethalin C2H5 H C2H5

C

Xylidine NH
O2N

CH3
CH3
O
D,L,N-(2,6-dimethyl-phenyl)-N-(2'- Metalaxyl Cl O
CH3

chloroacetyl)-alanine methyl ester O N CH3

[DMPCAME] H3C CH3

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Research Labs Pvt Limited

Symchem Research Labs Pvt Limited aims to be the best and foremost contract
research organization committed to serve the pharmaceutical industry worldwide
with high quality standards, at par with the international regulatory and professional
expectations. Symchem is established in Hyderabad, India by professionally
qualified and experienced personnel. Symchem is committed to maintain total
confidentiality, intellectual property protection and supports clients in cost
containment. Symchem is actively involved in developing alternate, patent non-
infringing processes for APIs, for the inventors to manage late life cycle and leading
generic drug manufacturers. With years of experience, experimentation and
application, the scientists at Symchem are the right people to be tapped for contract
research projects. The Research team is specialized in process design for new
drug candidates, its development up to gram/kilo scale, structural elucidation,
impurity profile studies, process validation, and process optimization. At Symchem
we believe that results are important; but we also believe in “The way we achieve
results” is equally important. Our commitment to this principle is the key to sustain
client’s trust and confidence in our company.

Symchem Research Labs Pvt Ltd, is located in Hyderabad, India, wholly owned by
its founder, Surendra Pandey, Ph D. Symchem is a R&D organization that focuses
on process development and manufacturing of fine organic chemicals and drug
substances. Symchem helps their clients by supporting them in Drug Development,
Custom Synthesis ,Process Research, Pilot-Scale Manufacturing, cGMP
Manufacturing. Symchem has standard as well as specialty organic laboratory
capabilities.

Contact Us
Symchem Research Labs Private Limited

Surendra Pandey, Ph.D.

Managing Director
Cell : +91-9963220006
E-link : spandey@symchem.com

Adj to F-6, Road No 18, IDA Nacharam, Hyderabad 500 076 India
Tel : +91-40-27176491
Fax : +91-40-27176491
E-link : info@symchem.com

Adj to F 6, Road No 18, IDA Nacharam,Hyderabad- 500076 INDIA

Tel Fax : 91-40-27176491 email : info@symchem.com website : symchem.com