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The Difference Between Dobutamine & Dopamine

Overview Dopamine and dobutamine are both substances that have important actions on our bodies. Both act at specific cell receptors and produce significant changes in those cells. Dobutamine is a drug that acts on the sympathetic nervous system. Physicians use it to treat heart failure and cardiogenic shock. Dopamine is a neurotransmitter that our bodies produce in order to send signals between brain cells. While the two substances are vastly different, both are important. Medical use Dobutamine is a synthetic compound with important medical uses. Physicians use it for critically ill patients with severe heart problems. While dopamine itself can increase your heart rate and blood pressure, physicians usually prescribe it in a precursor form called L-Dopa, which can penetrate the brain and treat Parkinsons disease. Natural product Dopamine is a natural product that the body produces to communicate between cells in the nervous system. Dobutamine, on the other hand, is produced synthetically for medical use. Affected cells Dobutamine acts on adrenergic receptors, mostly on cells in the heart or on blood vessels. It stimulates those cells and causes the muscle cells to contract. Dopamine attaches to receptors on cells in the central nervous system and leads to the transmission of electrical electrical signals between those cells. End result The result of dobutamine's action on the body is an increase in the action of muscle cells in the heart and blood vessels. Dobutamine makes those cells contract faster and with a greater force, creating a higher heart rate and blood pressure. Dopamine's action on the central nervous system causes changes in cognition, motivation, attention, and learning.

What is the difference between dopamine and dobutamine and what is the clinical significance ?
Posted Mar 25 2009 3:57pm
Dopamine and dobutamine are the most commonly used inotropic agents in clinical cardiology. The following table represents a simple comparison of the two drugs.

Central Venous Pressure Monitoring

Central venous pressure is considered a direct measurement of the blood pressure in the right atrium and vena cava. It is acquired by threading a central venous catheter (subclavian double lumen central line shown) into any of several large veins. It is threaded so that the tip of the catheter rests in the lower third of the superior vena cava. The pressure monitoring assembly is attached to the distal port of a multilumen central vein catheter.

Assisting with CVP placement

Adhere to institutional Policy and Procedure. Obtain history and assess the patient. Explain the procedure to the patient, include: o local anesthetic o trendelenberg positioning o draping o limit movement o need to maintain sterile field. o post procedure chest Xray Obtain a sterile, flushed and pressurized transducer assembly Obtain the catheter size, style and length ordered. Obtain supplies: o Masks o Sterile gloves o Line insertion kit o Heparin flush per policy Position patient supine on bed capable of trendelenberg position Prepare for post procedure chest X-ray

The CVP catheter is an important tool used to assess right ventricular function and systemic fluid status.

Normal CVP is 2-6 mm Hg. CVP is elevated by : o overhydration which increases venous return o heart failure or PA stenosis which limit venous outflow and lead to venous congestion o positive pressure breathing, straining, CVP decreases with: o hypovolemic shock from hemorrhage, fluid shift, dehydration o negative pressure breathing which occurs when the patient demonstrates retractions or mechanical negative pressure which is sometimes used for high spinal cord injuries.

The CVP catheter is also an important treatment tool which allows for:

Rapid infusion Infusion of hypertonic solutions and medications that could damage veins Serial venous blood assessment

Instant Feedback:

The CVP reading helps assess the function of the right ventricle and fluid status.

True False

There are two ways to read a CVP waveform:

1. Find the mean of the A wave.

read the high point of the A wave

read the low point of the A wave add the high point to the low point divide the sum by 2 the result is the mean CVP

The A wave starts just after the P wave ends and represents the atrial contraction. The high point of the A wave is the atrial pressure at maximum contraction. During the A wave the atrial pressure is greater than the ventricular diastolic pressure. At that point, the atrium is contracted, the tricuspid is open. Therefore, the high point of the A wave closely parallels the right ventricular end diastolic pressure. Remember, when the tricuspid valve is open and the right ventricle is full, the ventricle, atrium and vena cavae are all connected. Therefore, that point is the CVP.

2. Find the Z-point.

Find the Z-point which occurs mid to end QRS Read the Z-point

The Z-point coincides with the middle to end of the QRS wave. It occurs just before closure of the tricuspid valve. Therefore, it is a good indicator of right ventricular end diastolic pressure. The Z-point is useful when A waves are not visible, as in atrial fibrillation. (The c-wave occurs at closure of the tricuspid valve. The crest of the c-wave is the atrial pressure increase caused by the tricuspid valve bulging back into the atrium.)