DONALD M. MCDONALD, M.D., PH.D.

DEPARTMENT OF ANATOMY, CARDIOVASCULAR RESEARCH INSTITUTE, AND COMPREHENSIVE CANCER CENTER UNIVERSITY OF CALIFORNIA, SCHOOL OF MEDICINE

513 PARNASSUS AVENUE, ROOM S-1363 SAN FRANCISCO, CALIFORNIA 94143-0130 Telephone: (415) 476-6616 or (415) 476-2118 Facsimile: (415) 476-4845 or (415) 502-0418 E-mail Address: dmcd@itsa.ucsf.edu

January 10, 2012 To whom it may concern: The laboratory of Donald M. McDonald, M.D. Ph.D., at the University of California, San Francisco has openings for full-time post-graduate researchers in the field of angiogenesis and vascular biology. We are seeking bright, highly motivated, recent college graduates with strong backgrounds in the biological sciences. The appointment is for two years. Applicants available for only one year will not be considered. This is an exciting opportunity for students whose career goals include medical school or graduate school and who want to gain research experience at a world-class institution. The position is described in more detail below. Interested students should contact us directly by e-mail at the address below. The position will be available beginning in May or early June, with the goal of having overlap with the postgraduate researcher currently in the position. The successful candidate should plan to start no later than June. Resumes should be sent to current post-graduate researcher, Casey Williamson (casey.williamson@ucsf.edu). Sincerely, Casey Williamson McDonald Lab Department of Anatomy Cardiovascular Research Institute University of California, San Francisco E-mail: casey.williamson@ucsf.edu

Postgraduate Researcher Position at UCSF

We are recruiting a full-time salaried research assistant to work in the laboratory of Dr. Donald M. McDonald, who holds appointments in the Department of Anatomy (Professor), Cardiovascular Research Institute (Investigator), and Comprehensive Cancer Institute at UCSF. The focus of the research is vascular biology, with particular interests in angiogenesis and vascular remodeling in chronic inflammation and cancer. Specifically, we are investigating (1) cellular mechanisms involved in angiogenesis, lymphangiogenesis and microvascular remodeling in animal models of chronic airway inflammation; (2) abnormal features of endothelial cells and other vascular cells of angiogenic and remodeled blood vessels, including changes in vascular permeability and expression of novel proteins; and (3) strategies of targeting abnormal endothelial cells of blood vessels in tumors and inflamed tissues, with the eventual goal of targeting the delivery of therapeutics or diagnostics to sites of disease. The major disciplines represented in this research are cell biology, pathophysiology, immunology, and molecular biology. The experiments in the laboratory involve the use of mouse models of cancer and chronic inflammation. In many experiments, tissues are analyzed by a variety of morphological and immunohistochemical techniques using light, fluorescence, confocal, and electron microscopy. After a training period, the successful applicant will perform experiments independently. The postgraduate researcher will also be responsible for ordering mice and reagents, caring for animals, preparing buffers and general laboratory upkeep, writing experimental protocols, and administering drugs to mice, as well as performing surgery, removing and processing tissues, making morphometric measurements, and analyzing results. These responsibilities often require work in excess of 8 hours per day and occasionally on weekends. However, if the applicant is self-motivated, knows how to prioritize, enjoys learning, interacts well with persons of different backgrounds, and can manage occasional inevitable technical setbacks, the job provides an excellent learning experience. The position will begin in May or June 2012. At the latest, the new research assistants should plan to begin work in early June. Although a two-year commitment is essential, the job is temporary in that it is assumed that the applicants will eventually attend medical school or graduate school. In general, we are looking for highly motivated students who have a strong science background. Oral and written language skills, effective interpersonal skills, and computer skills are also very important. No prior research experience is required, but it would be an obvious advantage. Interested students should submit a current resume to Casey Williamson at the e-mail below. Resumes should include science and math courses completed, prior research and work experience, career objectives (M.D., Ph.D., or both), MCAT or GRE exams taken and scores, earliest possible starting date, names and contact information for three references, and desired date of matriculation into medical or graduate school. Casey Williamson casey.williamson@ucsf.edu