1/14/12

Nanomedicine: Natural pol mer nanofibers for cartilage repair

Home

Databases

News

NanoBusiness

Nano Jobs

Resources

Nanowerk

Introduction to Nanotechnolog

Che ica P ec

,C a i gE

To al Sol Gel Sol

.che a .c

i . R & D Se

ion

ice, Na

Ma e ia

N P

>N :J

S 15, 2006

>

A
P ED S J F N

T
-

Natural pol mer nanofibers for cartilage repair (Nanowerk Spotlight) S , , U W .T . D ,

F

E S F T N

.T , .A , , . , .T , , . .A , , , ,

, ,

M
C
P

R
:J

T .H T , C , M ("A Z II -B S N ' &E S N ( ") :S : "W (ECM) , GAG). GAG , ,M , .P U , B , GAG ." W ("E P .B 80 % .T , N , RGD , . (F . 1B). , 20 % PEO. T "). , M Z , , . , .A .

13 , 2012

A
P :J 12 , 2012

P
P :J 11 , 2012

N
P :J 4 , 2012

P '
P

'

:D

28 , 2011

:D

23 , 2011

N P :D 22

F 75

. 1A, B

, 2011

C
P :D 20 , 2011

L
P :D 15 , 2011

F
P

A
:D

'
13 , 2011

N
P

,
:D :D 12 , 2011 9 , 2011

N
P

Fig. 1. SEM images of alginatebased nanofibers and si e distribution (inset) (A). Chondroc tes grown on alginate based nanofibers (B). (Source: Miqin Zhang, Universit of Washington)
1/3

www.nanowerk.com/spotlight/spotid=569.php

1/14/12
Self-propelled microrockets detect dangerous bacteria in food, clinical and environmental samples
Posted: Dec 8th, 2011

Nanomedicine: Natural pol mer nanofibers for cartilage repair

Spinning like the spider could cut energy cost of synthetic polymer fibers by 90%
Posted: Dec 7th, 2011

Carbon nanotube-coated sponge makes an excellent supercapacitor

Posted: Dec 6th, 2011

Figs. 2A, B and C show the exemplary images of chitosan based nanofibers fabricated by electrospinning polymer solutions of chitosan (80 wt%) and PEO (20 wt%). PEO is an FDA approved biocompatible polymer for internal consumption and injection in a variety of foods. The nanofibers have average diameters of 38 8 nm (A) when deposited randomly and 62 12 nm (B) when collected on a rotating collector. Figs. 1D and E show the SEM images of osteoblast (MG-63) and chondrocytes (HTB94) grown on the chitosan nanofibers, respectively. Osteoblasts adhered well on the nanofibrous matrix and exhibited discrete filopodia and long and numerous microvilli on their surfaces. Chondrocytes have the characteristic morphology of a round shape, indicating that the nanofibrous matrix maintained the phonotype of chondrocytes.

Novel nanoimprint technique offers a low -cost route tow ard sub-10 nm nanopatterning
Posted: Dec 5th, 2011

Nanotechnology could make battery recycling economically attractive

Posted: Dec 1st, 2011

A fast nanotechnology platform to detect/capture bacteria in clinical samples

Posted: Nov 29th, 2011

Catch and release sensing of single malaria-infected red blood cells

Posted: Nov 28th, 2011

Natural nanomaterials - they are everyw here

Posted: Nov 24th, 2011

Eavesdropping on cells w ith graphene transistors

Posted: Nov 22nd, 2011

A new tool to track the intracellular trafficking of nanomedicines

Posted: Nov 21st, 2011

Fig. 2. SEM i age f e ec chi a -ba ed a fibe c ec ed f (A) a a i a c ec a d (B) a c ec a i g a 2000 . (C): Na fibe h i (B) a highe ag ifica i . (D) a d (E): I age f e ba (MG-63) a d ch d c e (HTB-94) g he a fib a i 5 da af e ce c e. (S ce: Mi i Zha g, U i e i f Wa hi g ) Zhang explains the significance of her group's findings: "These nanostructured scaffolding materials may potentially change the way we heal joint osteoarthritis and cartilage loss clinically in the future. The ability to generate nanofibrous matrices from natural polymers may provide virtually unlimited resources for development of tissue compatible scaffolds for functional restoration of damaged or dysfunctional tissues, which currently relies mainly on the autograft and allograft the surgical procedures facing challenges of limited resources, and risk of disease transmission or viral transfection. " She points out that, in addition to the production of these clinically applicable materials, the research in this area would offer insights to the interactions between materials and biological systems at the nanoscale, and the technology developed and knowledge gained would provide a foundation that can be expanded upon to many applications in biomaterials, tissue engineering, drug delivery, materialbiological molecular interfaces, and other aspects of heath care. "We will fabricate nanofibrous natural polymer matrices with improved physical and biological properties" Zhang says. "In vitro cellular and molecular events of chondrocyte interactions with synthesized nanofiber matrix will be systematically studied to identify the proper material nano-structures (i.e., porosity, pore size, shape, nanofiber size and distribution) that provides the optimal environment for cell attachment and proliferation, and phenotype expression. To expedite the tissue regenerative process, the chondrocyte cells or stem cells and growth factors will be also incorporated in nanofiberous matrices for both in vitro and in vivo studies. Strain patterns during ingrowth into the scaffolds will be recorded to correlate with quantitative histomorphometry and radiography to define relationships between loading and tissue structure. This information will be used to develop cell culture loading systems to produce functional cartilage construct." B Michae Be ge , C igh 2006 Na e LLC

Non-toxic, solution-based inorganic solar cell chemistry w ith Earth-abundant elements

Posted: Nov 18th, 2011

Breakthrough allow s rapid, CMOS-compatible fabrication of large 3D photonic crystals

Posted: Nov 17th, 2011 Posted: Nov 16th, 2011

Nanotechnology and religion Curved microfluidic devices that self-assemble

Posted: Nov 14th, 2011

A framew ork to evaluate the uncertainties of AFM nanomechanical measurements

Posted: Nov 11th, 2011

...more nanotechnology articles

Nominate Nanotechnology News for a social media award in the Shorty Awards science category S b c ibe! Receive a convenient email notification whenever a new Nanowerk Nanotechnology Spotlight posts. Become a Spo ligh g e a ho ! Have you just published a scientific paper or have other exciting developments to share with the nanotechnology community? Let us know.

Spinal cord injur stem cell

www.puhuachina.com

A Spinal Cord Injur patient walk again after Stem Cell treatment

Knee Joint Supplement

www.NaturalJoint.org

Safe, Natural, and Effective Joint Relief Guaranteed!

www.nanowerk.com/spotlight/spotid=569.php

2/3

1/14/12

Nanomedicine: Natural pol mer nanofibers for cartilage repair

www.NaturalJoint.org

Materials Science E po
www.pittcon.org

March 11-15, 2012 in Orlando, FL. Register toda and save 50%!

Solar Energ Great Prices

www.SolarDire ct.com /SolarEle ctric

Photovoltaic Solar Electric S stems Factor Direct Kits & Pro Installs!

Privacy statement | Terms of use | Contact us | Home | Sitemap | Advertise with us The contents of this site are copyright 2012, Nanowerk. All Rights Reserved

www.nanowerk.com/spotlight/spotid=569.php

3/3