20092010NEUROSCIENCESHANDBOOK

TableofContentsPage DepartmentalDirectory 24 NeurosciencesatCWRU 58 ProgramRequirements 810 Courses 1113 Examinations 1415 ChangeofStateNotification 15 ResearchIntegrity 15 GuidelinesforThesisResearch 1518 MasterofNeuroscienceDegree 1819 PostdoctoralFellows 19 NeurosciencesFacilities 1922 OtherFacilities/Services 22 UsefulWebsites 23 Currentstudents 24 AlumnioftheNeurosciencesProgram 2526 *pleasesendanycorrectionsforthehandbooktoKatieWervey(kar18@case.edu)*

PRIMARYFACULTY
HeatherBroihier(htb) SchoolofMedicineE714 OfficePhone#3684326 LabPhone#3680657 RebeccaJames(rej10) NanLiu(nxl23) Crystal(Kozora)Miller(cxk81) InnaNechipurenko(ivn2) YiLanWeng(yxw71) GemmaCasadesus(gxc40) SchoolofMedicineE729&728 OfficePhone#3688503 LabPhone#3682018 JaewonChang(jxc176)
DeniseHatala(dah13) HyunjinKim(hxk199) JenniferReeves(jer112)

DavidKatz(dmk4) SchoolofMedicineE712 OfficePhone#3686116 LabPhone#3686179 IanAdams(ita) MichaelOgier(moo3) DanielleSchmid(das197) TaliaSukol

(talia.sukol@gmail.com) QifangWang(qxw12)(E717)

EvanDeneris(esd) SchoolofMedicineE648 OfficePhone#3688725 LabPhone#3688724 StephanieFox(srf12) ChenLiu(cxl115) KatherineLobur(kjl16) HiroshiMaeno(hxm57) StevenWyler(scw58) DavidFriel(ddf2) SchoolofMedicineE647 OfficePhone#3684930 LabPhone#3681915 RobertoGalan(rfg8) SchoolofMedicineE725 OfficePhone#3680811 GermanCardenasLeroy(gxc128) PavelPuzerey(pxp190) KarlSteinke(gks5) YenanZhu(yxz107) AlisonHall(axh8) SchoolofMedicineE709 OfficePhone#3686711 LabPhone#3686710 SarahO'Keeffe(seo5)x5655 JamieRhodes(jlr124) StefanHerlitze(sxh106) SchoolofMedicineE643 OfficePhone#3681804 DavinaGutierrez(dvg1) TakashiMaejima(txm130) EugeneOh(exo16)

DianaKunze (dkunze@metrohealth.org) MetroHealthMedicalCenter 2500MetroHealth ClevelandOhio44109 OfficePhone#2167788967 LynnT.Landmesser(ltl)CHAIR (E643A)E627Lab SchoolofMedicineE653 OfficePhone#3683996 LabPhone#3684896 KseniaKastanenka(kvk3) KatherineLobur(kjl16) YukaMaenoHikichi(yxm29) ShengWang(sxw203) GaryLandreth(gel2) SchoolofMedicineE649 OfficePhone#3686101 LabPhone#3683435 BrentCameron(bdc22) PaigeCramer(pec9) ColleenKarlo(jck2)E640 DonnaKirsch(djk15) ChungYing(Daniel)Lee(cxl142) ShwetaMandrekar(sdm19) LaurenOgrich(lmo11) DanielaPopescu(dcp58) JoannaPucilowska(jxp190) ErinReed(egr3) JulieSavage(jcs30) WendyMacklin UofColoradoDenverHealth SciencesCenter Aurora,CO80045 OfficePhone#3037243426 YiDong(yxd26)

RobertMiller(rhm3) SchoolofMedicineE721 OfficePhone#3686269 LabPhone#3686170 LianhuaBai(lxb65) AndrewCaprariello(avc9)DPB AnneDeChant(akd6)x5473 SharylFyffeMaricich(slf53) SaraVandommelen(slv15)x6269 YanYang(yxy33) AnitaZaremba(axz2)

(Wendy.Macklin@ucdenver.edu)

JerrySilver(jsx10) SchoolofMedicineE661 OfficePhone#3682150 LabPhone#3685574(E658) WarrenAlilain(wja4) SarahBusch(sab37) MarcDePaul(mxd359) TeresaEvans(teresa.evans) HongmeiHu(hxh67) BradleyLang(btl21) Angela(Nord)Filous(arn29) BenStrowbridge(bxs48) SchoolofMedicineE659 OfficePhone#3686974 LabPhone#3681041 YuanGao(yxg30) RobertHyde(rah38) LorenSchmidt(ljs102) RossAnderson(rwa4)DPB IsaacYoungstrom(iay4) BruceTrapp(trappb@ccf.org) ClevelandClinicFoundation BuildingNC30 9500EuclidAvenue ClevelandOhio44195 OfficePhone#2164447177 LabPhone#2164448712 MariaSmith(mcs59) ElizabethYoung(eay9) RichardZigmond(rez) SchoolofMedicineE701 OfficePhone#3684614 LabPhone#3684615 AliciaLisowitz(aal39)

SECONDARYFACULTY
KumarAlagramam(kna3) Otolaryngology Lakeside7123 OfficePhone#2168447261. Chunyang(Brian)Bai(cbb9) Genetics BRB621 OfficePhone#3680305 SusannBradyKalnay(smb4) Molecular&Microbiology SchoolofMedicineW214b OfficePhone#3680330 MatthiasBuck(mxb150) Physiology&Biophysics SchoolofMedicineE646 OfficePhone#3688651 HillelChiel(hjc) Biology301 OfficePhone#3683846 LabPhone#3683574 ThomasDick(ted3) Pulmonary/CriticalCare BRB319 OfficePhone#3688637 RishiDhingra(rxd50) DominiqueDurand(dxd6) BiomedicalEngineering Wickenden112 OfficePhone#3683974 PaulErnsberger(pre) Nutrition DentalSchool201 OfficePhone#3684738 JosephLaManna(jcl4) Neurology BRB525 OfficePhone#3681112 BruceLamb(btl)(Adjunct) Genetics BRB7thFloor OfficePhone#3682979 SunghoLee(sxl265)

ShastaSabo(sls79) Pharmacology SchoolofMedicineW305C OfficePhone#3685683 RuthSiegel(res7) Pharmacology SchoolofMedicineW319 OfficeTelephone#3685554 LabPhone#3686024 CoreySmith(cbs16) Physiology&Biophysics SchoolofMedicineE645 OfficePhone#3683487

RichardJohnLeigh(rjl4) Neurology Lakeside3080 OfficePhonel#2168443190 StephenMaricich(smm18) Pediatrics SchoolofMedicineE765 OfficePhone#3682194 LabPhone#3680066 SaedAbokor(sxa359) BrianMcDermott,Jr.(bmm30) Otolaryngology WearnBldg.,Room452 OfficePhone#2168446036 MaureenMcEnery(mwm4) GeneralMedicalSciences SchoolofMedicineWG11 OfficePhone#3683377 IrvineMcQuarrie(igm) NeurologicalSurgery VAMedicalCenter OfficePhone#7913800 ElizabethPehek(eap6) Psychiatry VAMedicalCenterBrecksville OfficePhone#4405263030 RobertPetersen(rbp) Pathology InstituteofPathology204 OfficePhone#3686709

SophiaSundararajan(srt2) Neurology Lakeside3080 OfficePhone#2168448421 ManSunSy(mxs92) Pathology BRB9thFloor OfficePhone#3681268 ErikvanLunteren(exv4) Pulmonary/CriticalCare VAMedicalCenter OfficePhone#7913800 NicoleWard(nlw4) Dermatology BRB526 OfficePhone#3681111 ChristopherWilson(cgw5) Pediatrics RB&C OfficePhone#2168447356

RoyRitzmann(rer3) Biology BiologyBuilding207 OfficePhone#3683554 ShenandoahRobinson(sxr47) NeurologicalSurgery OfficePhone#2168444922 Lab:SOME720 QingLi(qxl5)x4865 StephanieEaton(see14) RobertRuff(rlr) Neurology LakesideHospital3080 OfficePhone#2164213040

 ADMINISTRATIVEOFFICE
SchoolofMedicineE653 NarleneBrown(nrb) AdministrativeManager OfficePhone#3686253 PamMcGregor(pam7) GrantsManagementSpecialist OfficePhone#3686251 KatieWervey(kar18) GraduateStudentCoordinator/AssistanttoChair OfficePhone#3686252

CENTERFORTRANSLATIONALNEUROSCIENCES
http://www.case.edu/med/CTN/index.html SchoolofMedicineE722 RobertMiller,Director,3685473,(rhm3) AnneDeChant,AdministratorfortheCenter,3685473,(akd6)

CWRURODENTBEHAVIORCORE
http://neurosciences.case.edu/crbc/home SchoolofMedicineE729 GemmaCasadesus,CoreDirector,3688503,(gxc40) JenniferReeves,CoreTechnician(jennifer.reeves@case.edu)

NEUROSCIENCESIMAGINGCENTER
http://neurosciences.case.edu/imaging/index SchoolofMedicineE632 BenStrowbridge,Director,3686974,(bxs48) MaryannePendergast,TrainingandFacilityManager,3682575orcell:2162248649,(mxp19) LynnLandmesser,GarvinProfessorandChair,Neurosciences,3683996,(ltl)

ITSpecialist
HarryMenegay(hxm8)

NeurosciencesatCWRU TheDepartmentofNeurosciences,locatedintheEastWingoftheCWRUMedicalSchool,offers graduateeducationandpostdoctoraltraininginawiderangeofdisciplinesinmodern neuroscience.Trainingisprovidedthroughacombinationofresearch,courseworkand seminars.Thedepartmenthostsweeklyseminars,journalclubs,asocialhour,andinvites talentedundergraduatestoparticipateinresearchoverthesummer.Thesisresearch opportunitiesareavailablewithmorethan20facultymembersworkinginareassuchas developmentofmotorandsensorysystems,regeneration,pathfindingbyaxons, neurogenetics,regulationofneurotransmitterexpression,neuronglialinteractions,synaptic physiologyandplasticity,ionchannelbiophysicsandinformationprocessing.Inthelastdecade, ourdepartmenthasconsistentlyrankedinthetopfifteenpercentofNeuroscienceprograms nationwideinNIHfunding(2005Caseranked14thinNIHfunding).Onefeatureofthe Departmentthatmakesitparticularlyattractiveisthehighlyinteractiveatmosphere, characterizedbyextensivecollaborationsamonglaboratoriesandwithotherinvestigators. NeurosciencesDepartmentOfficeSOME653 Phone2163686253FAX2163684650 Website:http://neurosciences.case.edu/ TrainingPhilosophy GraduateeducationinNeurosciencesatCWRUaddressesmanyaspectsofthescience profession,andinvolvesbothformalcourseworkandinformalinteractions.Bothfacultyand studentsprosperwhenstudentsareconsideredaspromisingjuniorcolleagues,deserving dedicatedguidancefromthescientificcommunity. "TheDoctorofPhilosophydegreeisthehighestacademicdegreegrantedbyNorthAmerican universities.Itisaresearchdegreeandistobedistinguishedfromotherdoctoratessuchasthe M.D.,J.D.orEd.D.degrees,whicharedesignedforprofessionaltrainingorwhichfocuson appliedratherthanbasicresearch....TheDoctorofPhilosophydegreeisdesignedtopreparea studenttobecomeascholar,thatis,todiscover,integrateandapplyknowledge,aswellas communicateanddisseminateit...Theprogramemphasizesthedevelopmentofthestudent's capacitytomakesignificantoriginalcontributiontoknowledgeinacontextoffreedomof inquiryandexpression." CouncilofGraduateStudies Neuroscientiststodayrequiremanyskillstosucceedinacompetitiveenvironment.Our Neurosciencestudentscanexpecttrainingin1)scientificexcellence,withcloseinteractions withfacultyadvisorsleadingtoanunderstandingofproblemsolving,criticalanalysisofdata andmoderntechnicalapproaches,2)communicationskills,includingpracticeandadviceinthe analysisofcontemporaryliterature,grantsmanship,andoralpresentationsand3)Ethics,to makecomplexdecisionsonauthorship,datahandling,andintellectualproperty.

 StudentActivities.Graduatestudentsareexpectedtoinitiateandparticipateinavarietyof activitieshavingtodowithprofessionalgrowth: DepartmentalRepresentativestoCaseprograms.AlldepartmentscontributetotheCWRU GraduateStudentSenate(http://gss.case.edu/)thatdiscussesissuesthataffectgraduate students.TeresaEvansandAngela(Nord)FilousarecurrentNeurosciencerepresentativesto GSS. JournalClubsandSeminars.Journalclubsandseminarsofferanopportunitytolearnabout broadareasofNeuroscience,andformanimportantpartofgraduatetraining.Allstudents, postdoctoralfellowsandfacultyareexpectedtoattendboththeJournalClubMondaysatnoon (SOME646)andtheNeurosciencesSeminarThursdaysatnoon(BRB105unlessotherwise specified).Studentsarestronglyencouragedtoactivelyparticipatebyaskingquestionsat seminarsandjournalclubs.Dr.RichardZigmond(rez)organizestheseminarscheduleandDr. GaryLandreth(gel2)organizesthejournalclubcalendar. Togainoralpresentationskills,studentsandpostdoctoralfellowsshouldmakeformal presentationstotheNeurosciencecommunityatleastonceayear,afterpracticewiththeir facultyadvisors.Studentsinthefirst3yearsmayelecttopresentacurrentresearcharticle fromaprominentjournal.Facultyofferconstructivecriticismtothestudentdirectlyfollowing thepresentation.Postdoctoralfellowsandexperiencedstudentsusuallypresenttheirresearch workwithrelevantbackgroundandsignificance,butmayopttodoajournalclub. Meetingoutsidespeakersforlunch.Studentsandpostdoctoralfellowsareencouragedto meetwithvisitingspeakersatlunchfollowingthenoonseminar.Thisisagoodopportunityto practicetalkingaboutscienceinaconcise,interestingway.Further,itoffersameanstogetto knowthespeaker,his/herinstitutionandtodiscussscientificstrategiesorcollaborations.To meetwithaspeaker,contactthestudentlunchcoordinators,RossAnderson(rwa4)orLoren Schmidt(ljs102)(for200910academicyear)toreserveafreelunch.Astudentorpostdoc shouldexpecttomeetwithatleast4speakersayear. Neurosciencetextbookandcomputer.StudentscommittedtotheNeuroscienceProgramfor theirthesisworkareprovidedacopyofKandel,SchwartzandJessell,PrinciplesofNeural Science.Similarly,oncestudentscommittoalaboratory,alaptopcomputerwillbeprovidedfor useincompletingstudies.Ifastudentsubsequentlychangesprograms,thetextbookand laptopmustbereturnedforfutureuse. Studentsponsoreddepartmentalspeaker.Onespeakerayearisselectedandsponsoredby thegraduatestudentsintheDepartment.Visitingfacultyarehonoredbythisdistinctionand areveryaccessibletostudentsduringthevisit.Facultyinputaboutcandidatesisencouragedto ensurethat"studentfriendly"speakersareselected.Studentscreatethescheduleforthe speaker,arrangelunchwithstudentsandpostdocs,introducethespeakerattheseminar, createadepartmentwidedinnerwiththespeaker,areresponsiblefortransittoandfrom theairportandhotelreservations. GraduateStudentSymposium.Thegraduatestudentsinthebiomedicalsciencesorganizea symposiumonceayearthatincludesstudentpostersandakeynotespeakerinvitedby
6

students.ThefacultyadvisorforthisprogramisDavidMacDonald.Manystudentissuesare representedbytheNationalAssociationofGraduateandProfessionalStudents (http://www.nagps.org/). Attendingnationalmeetings.Studentsareencouragedtopresenttheirworkatnational meetingsonceayear.ThemostappropriatemeetingsmaybetheSocietyforNeurosciences AnnualMeetingoraGordonConference.Studentsshouldcompeteforindividualtravelgrants aswellasfundsfromtraininggrants.MSTPstudentsoftencangetpartialreimbursementfor meetingcostsiftheypresentaposterortalkatascientificmeeting. Recruitmentofprospectivegraduatestudents.Oftenthemostcandidviewofourprogram comesfromcurrentstudents,andthatviewpointisveryvaluabletoprospectivestudents. StudentshostprospectivestudentsfromotherinstitutionsduringtheSpringrecruitment weekend,andserveasambassadorsoftheinstitutionandprogram. IndividualPredoctoralSupport.Onceaccepted,graduatestudentswhotrainwith NeurosciencesDepartmentP.I.sareguaranteedstipendsupportbytheDepartmentforfive yearsiftheyremainingoodstanding.Supportforadditionalyearsmaybeprovidedbut requiresanindividualpetition.StudentswhochoosetotrainwithP.I.soutsidetheDepartment ofNeurosciencesshouldnotethattuitionandstipendsupportwillbetheresponsibilityofthe trainingP.I.andhis/herdepartment.AletterofsupportisrequiredfromthetrainingP.I.and chairofdepartmentstatingthattuitionandstipendwillbeguaranteedforatleastfiveyears. ThislettermustbereceivedbytheDepartmentofNeurosciencesbeforeastudentbegins trainingwiththechosenP.I.StipendsupportmayderivefromNIHtraininggrants,NIH individualresearchgrants,federalandprivateresearchgrantsanduniversityresources.Tuition isgenerallypaidbythetrainingfacultymembersprimarydepartment.Itishighly advantageousforstudentstosuccessfullycompeteforindividualgrantsupportfrom extramuralsources,andthedepartmentstronglyencouragessuchapplications.Neuroscience studentshavebeensuccessfulinobtainingNationalResearchScholarFellowshipsfromtheNIH (pleaseseehttp://grants.nih.gov/grants/guide/noticefiles/NOTOD07052.html)andthe AmericanHeartAssociation(pleasesee http://www.americanheart.org/presenter.jhtml?identifier=2457#Predoc).Notethatseveral agenciesrequireapplicationsearlyingraduatetraining.TheOfficeofGraduateEducation maintainsalistofgraduatefundingopportunities http://casemed.case.edu/gradprog/grantsources.html. GraduateStipendandBenefits FulltimeregisteredNeurosciencestudentsareeligiblefortuitionandstipendsupport(see above).Thestipendleveliscurrently$25,000fortwelvemonthsforthe20092010academic schoolyear.StipendsarefundedbyNIHtraininggrants,NIHindividualresearchgrants,federal andprivateresearchgrantsanduniversityresources.InAugust,2000,theDeanofGraduate Studiesinformedstudentsthat"incometaxwillbewithheldonlyonthestipendportionof compensation(stipendplustuition)chargedtofederalresearchgrants."Notethatstudents mayalsoberequiredtopaylocaltaxesiftheyliveoutsidethecityofCleveland.Informationcan beobtainedfromeachmunicipality.TheDepartmentpaysforstudenthealthservices.Acopy oftheCWRUMedicalPlanforStudentscanbeobtainedattheUniversityHealthServices,2145 AdelbertRoad. UniversityHealthService2163682450
7

Appointments: GeneralClinic2163684539 WomensClinic2163682453 MentalHealth2163682510 UniversityCounselingService2163682510 NeurosciencesProgramRequirements Itistheresponsibilityofthestudenttobecomefamiliarwiththegeneralrulesandregulations oftheUniversity(availableintheGeneralBulletin,http://www.case.edu/bulletin/)aswellas thespecificruleswhichapplyforthecourseofstudyinNeuroscience(thisdocument). TheNeurosciencesGraduateProgramAdvisor(GPA)is Dr.GaryLandreth E649(SOM) 3686101;gel2@case.edu TheGraduateProgramAdvisoroverseesgraduatetrainingintheNeurosciencesProgram.The GPAisavailabletodiscussprogressandprovideadviceoncourseselection.TheGPAalso coordinatesstudentactivitiesandservesasastudentadvocateshoulddifficultiesarise. AllstudentsmustsubmitaPlannedProgramofStudy(PPOS)bytheendoftheir2ndsemester throughtheStudentInformationSystem(SIS)byusingthe"CoursePlanner"and"MyProgram" tabs(thebasiccurriculumwillbegiventonewstudentsattheirinitialmeetingwiththeGPA whentheyfirstarrivetothedepartment.Credithoursshouldneverexceed9hoursinany semestersinceaidisnotavailableforanythingabove9credithours).Ifastudentfailsto submitaPPOSduringtherequiredtimeframe,aregistrationholdwillbeplacedonthe student'saccount.ArevisedprogramofstudymustalsobesubmittedviatheSISwhenany changeintheoriginalplanoccurs.QuestionsaboutthePPOScanbedirectedtotheGraduate StudiesOfficeatgradadmit@case.edu,(216)3684390. RegistrationforclassesisalsodoneonlineinSIS. MoststudentsarriveJuly1andimmediatelybeginalabrotation.Becausethesummersession isnotencumberedbycoursework,oftenthisrotationisanexcellentlaboratoryexperience.In theFall,studentsgenerallyenrollinthecorrelatedcurriculumincellbiology(CBIO453)and molecularbiology(CBIO455)andpursuelabrotations. StudentsarerequiredbytheUniversitytotake36semesterhoursofgraduatecoursesbefore advancingtocandidacy;thisincludesrequiredcourses,advancedelectivesand601research. Atleast24hoursmustbegraded. NeurosciencesPh.D.ProgramRequirements: CBIO453CellBiologyI CBIO455MolecularBiologyI IBMS500BeingaProfessionalScientist(Ethicalissuesinscienceresearchseminar) NEUR402PrinciplesofNeuralSciences
8

NEUR415NeurosciencesSeminarSeries NEUR540AdvancedTopicsinNeuroscienceEthics(Studentswhomatriculatedbefore2004 areexemptfromtakingthiscourse) Electivegraduatecourses NeurosciencesJournalClub Aminimumof18hoursofNEUR701thesisresearch SuggestedCourseofPh.D.Study Year1Fall CBIO453CellBiology1(4credits) CBIO455MolecularBiology1(4credits) NEUR601ResearchinNeuroscience(1credit) Year1Spring NEUR402PrinciplesofNeuroscience(3credits) Electivegraduatecourse(23credits) NEUR415NeuroscienceSeminars(1credit) NEUR601ResearchinNeuroscience(23credits) IBMS500Onbeingaprofessionalscientist(0credits,tobetakeninMay) SummerCompletepreliminaryexambyJuly31 Beginthesisresearch Year2Fall Electivecourses(6credits) NEUR601ResearchinNeuroscience(3credits) Year2Spring ElectiveCourses(6credits) NEUR601ResearchinNeuroscience(3credits) CompleteQualifierExambyJuly31 Formthesiscommittee Research Prepareindividualfellowshipapplication Year3Fall NEUR701ResearchinNeuroscience(9credits) ThesisCommitteeMeetingsevery6months Year3Spring NEUR540AdvancedTopicsinNeuroscienceEthics(0credits) (Allstudentsmatriculatingin2004andlatermusttakethiscourse) NEUR701ResearchinNeuroscience(9credits) ThesisCommitteeMeetingsevery6months Year4+ NEUR701ResearchinNeuroscience(1crediteachFallandSpringSemesteruntilgraduation)
9

Thesiscommitteemeetingsevery6months SummerSessions:Studentsmustregisterfor(0)credithoursofRSCH750(SummerResearch) everysummerusingDeniseDouglasastheinstructor,unlessyouaregoingtodefendinthe summer;inthiscase,pleaseseeKatie. MedicalScienceTrainingProgram(MSTP) MSTPstudentsintheneuroscienceprogramareexpectedtocompletetherequirementsfor MSTPstudentsasoutlinedintheMSTPguidelines.Thegeneralguidelinesandperformance expectationsforMSTPstudentsintheneuroscienceprogramareidenticaltothoseforgraduate students.MSTPstudentsarerequiredtotakeNEUR402PrinciplesofNeuroscience,and3 otherelectivecourses,atleastoneofwhichisinNeurosciences.Studentsareencouragedto takeNeurosciencegraduatecoursesduringthefirsttwoyearsofmedicalschool.Inparticular, inlightofmedicalschoolcurriculumchanges,itisadvisedthatMSTPstudentscompleteNEUR 402duringyear1ofmedicalschool.Ingeneral,studentsareencouragedtotakeagraduate schoolelectivecourseinyear2ofmedicalschool,whilealsopreparingfortheUSMLEstep1. Preliminaryexamshavethesameformatasthatforothergraduatestudents,andshouldbe completedinthefirstsummerfollowingidentificationofalaboratoryandmentor.The qualifyingexamshouldbecompletedattheconclusionofrequiredcoursework,andmustbe completedinthesecondsummerfollowingadmissionintothegraduateprogram.Inkeeping withMSTPprogram,eachstudentmusthaveamemberoftheMSTPsteeringcommitteeand oneMDorMD/PhD.onthethesiscommittee.TheMSTPsteeringcommitteememberfor NeurosciencesisDr.JerrySilver(jxs10). LaboratoryRotationsandSelection Oneofthemostimportantdecisionsastudentmakesisthechoiceofafacultyadvisor.To obtainexperienceindifferentlaboratories,studentscompleteaminimumofthreerotationsof approximately46weeksdurationduringthefirstsemester.Studentsareencouragedtostart rotationsJuly1toallowforthreeextendedrotationsbyDecember.Theserotationsgive studentsadiverseintroductiontoapproachesforstudyingneuralfunctionandserveasthe basisforchoosingalaboratoryforthePh.D.thesis.Astudentshouldrealizethat2025hours perweekoflaboratoryworkareexpectedduringthesemester.A3pagerotationreport describingtheprojectandarotationevaluationformmustbepreparedattheconclusionof eachrotation.Aftertheformiscompleted,thestudentandfacultyadvisormeettodiscuss comments.Copiesoftherotationreportandsignedevaluationformaresubmittedtothe graduateprogramadvisor,theNeurosciencesOffice(givetoKatie),andtheBSTPOffice(for BSTPstudents).Thisisthestudent'sresponsibility. Bytheendofthefirstsemester,studentscommittoaspecificlaboratoryandfacultyadvisorfor doctoralstudies.ThedateofthiscommitmentisgenerallyaroundDecember15.Anyfaculty advisorwhoagreestotakearotationstudentmustdosoonlywithconfirmedfinancialsupport shouldthestudentdecidetoworkinthatlaboratory.

10

 Courses PotentialelectivecoursesmaybelistedinNeuroscience,CellBiology,Genetics,Pharmacology orotherdepartments.Thisisapartiallistofavailablecourses:

NEUR402:PRINCIPLESOFNEURALSCIENCECreditHours:3.0 Offeredeveryspringsemester. ZIGMOND,R. Description:Lecture/discussioncoursecoveringconceptsincellandmolecularneuroscience,principlesofsystems neuroscienceasdemonstratedinthesomatosensorysystem,andfundamentalsofthedevelopmentofthe nervoussystem.ThiscoursewillpreparestudentsforupperlevelNeurosciencecoursesandisalsosuitablefor studentsinotherprogramswhodesireanunderstandingofneurosciences.Prereq:CBIO453.CrosslistedasBIOL 402. NEUR405:CELL&MOLECULARNEUROBIOLOGYCreditHours:3.0 Offeredeveryfallsemester. DENERIS,E.andFRIEL,D. Description:Cellbiologyofnervecells,includingaspectsofsynapticstructurephysiologyandchemistry.The applicationofmolecularbiologicaltoolstoquestionsofsynapticfunctionwillbeaddressed.Prereq:BIOL473. NEUR411:NEUROBIOLOGYOFDISEASECreditHours:3.0 Offeredalternatingyears,fallsemester(beginningfall2008). MILLER.R. Description:Designedtoshowhowbasicresearchinneurosciencehascontributedtothemanagementofclinical problemsinhumanneurologyandtodiscusssomeofthefurtherchallengesposedbyhumandiseaseforresearch inneurobiology.Thegeneralformatwillincludeclinicaldescriptionsofpatientpresentation,discussionofthe diseasemechanismsandananalysisofcontributionsofcellularandsystemsneurosciencetounderstandingofthe humandisorder.Specifictopicstobediscussedincludemyastheniagravis,dementia(includingAlzheimer's disease),multiplesclerosis,Duchenne'smusculardystrophy,poliomyelitis,seizuresandstrokes.Prereq:NEUR402 orNEUR405. NEUR415:NEUROSCIENCESEMINARSCreditHours:1.0 Everyfallandspringsemesters.Onlyregisterforthisonetime. Description:Currenttopicsofinterestinneurosciences.Studentsattendweeklyseminars.Fromthisseries, studentspreparecritiques.Nocreditisgivenforlessthan75%attendance. NEUR425:STEMCELLBIOLOGY&THERAPEUTICSCreditHours:3.0 Offeredeveryspringsemester. BUNTING,K. Description:Thiscourseisintendedtoteachcurrentunderstandingofstemcellsasitrelatestotheir characterization,function,andphysiologicandpathologicalstates.Thecoursewillexposestudentstothecurrent understandingofvarioustypesofstemcells,includingembryonicandadultstemcellsofvarioustissues, techniquesfortheirisolationandstudy.Experimentalmodelsandpotentialbiomedicaltherapeuticapplications willbediscussed.Thecoursewillbetaughtbythefacultyofthe"CenterforStemCellandRegenerativeMedicine" whoareaffiliatedwithmultipledepartmentsofCaseWesternReserveUniversity,ClevelandClinicFoundationand thepartneringbiomedicalcompanies.CrosslistedasPATH425. NEUR427:NEURALDEVELOPMENTCreditHours:3.0 Offeredalternatingyears,fallsemester(lastofferedinfall2006). BROIHIER,H. Description:Topicsincludecellcommitment,regulationofproliferationanddifferentiation,celldeathandtrophic factors,pathfindingbytheoutgrowingnervefiber,synapseformation,relationshipsbetweencenterandperiphery indevelopmentandtheroleofactivity.CrosslistedasBIOL427.

11

 NEUR432:CURRENTTOPICSINVISIONRESEARCHCreditHours:3.0 Offeredalternatingyears,springsemester(lastofferedinspring2010). Park,P. Description:Visionresearchisanexcitingandmultidisciplinaryareathatdrawsonthedisciplinesofbiochemistry, genetics,molecularbiology,structuralbiology,neuroscience,andpathology.Thisgraduatelevelcoursewill providethestudentwithbroadexposuretothemostrecentandrelevantresearchcurrentlybeingconductedin thefield.Topicswillcoveravarietyofdiseasesandfundamentalbiologicalprocessesoccurringintheeye. Regionsoftheeyethatwillbediscussedincludethecornea,lens,andretina.Visiondisordersdiscussedinclude agerelatedmaculardegeneration,retinalciliopathies,anddiabeticretinopathy.Instructorsinthecourseare expertsintheirfieldandaremembersofthemultidisciplinaryvisualsciencesresearchcommunityhereatCase WesternReserveUniversity.Studentswillbeexposedtotheexperimentalapproachesandinstrumentation currentlybeingusedinthelaboratoryandinclinicalsettings.Topicswillbecoveredbytraditionallectures, demonstrationsinthelaboratoryandtheclinic,andjournalclubpresentations.Studentswillbegradedontheir performanceinjournalclubpresentations(40%),researchproposal(40%),andclassparticipation(20%).Cross listedasPATH432andPHRM432. NEUR435:VISION:MOLECULESTOPERCEPTIONCreditHours:3.0 Offeredalternatingyears,springsemester. STAFF Description:Theorganization,physiology,andfunctionofthevertebratevisualsystemareconsideredindetail. ThevisualpathwayfromretinatoLGNandvisualcortexisdescribedwithanemphasisoncircuitsthatproduce successivelymorecomplexreceptivefieldproperties.Classicpapersandcurrentliteratureformthebasiccourse material.Assessmentisbasedonstudentpresentations,classparticipation,andatermpaper.Prereq:NEUR402 orconsentofdepartment. NEUR440:SYNAPTICTRANSMISSIONCreditHours:3.0 Offeredspringsemester,basedonstudentinterest. STROWBRIDGE,B. Description:Thiscoursewillexplorethebasicmechanismsofsynaptictransmissionthatoperateatcentraland peripheralsynapses.Studentswillreadandpresentamixtureofhistoricalandmodernpapersthatestablishedthe fundamentalprinciplesofsynaptictransmissionandplasticity.Thecoursewillbeginwithabriefreviewofcellular neurophysiologyandthetechniquesusedtostudysynapticpotentials.WewillthenreadclassicpapersbyKatzand colleaguesthatdefinedthemechanismscontrollingtransmitterreleaseattheneuromuscularjunction.Nextwe willconsidertheroleofcalciuminregulatingthereleaseofneurotransmittersandinshorttermmodulationof synapticpotentials.Wewillthenexplorepreandpostsynapticprocessessuchasreceptorsaturationandvesicle dynamicsthatgoverntheamplitudeandtimecourseofpostsynapticpotentials.Quantalanalysisandsilent synapseswillbediscussedinthecontextofthepresentdaycontroversiesregardinglongtermpotentiationat centralsynapses.Wewillalsoconsidertherelationshipbetweenshortandlongtermsynapticplasticityand behavioralfunctionssuchaslearningandmemory.Occasionalfacultylectureswillcomplementstudent presentationsonprimaryresearcharticles.Studentgradeswillbebasedontwoshort(5page)essaysandclass participation.Prereq:Permissionofthecoursedirector. NEUR473:INTRODUCTIONTONEUROBIOLOGYCreditHours:3.0 Offeredeveryfallsemester. CHIEL,H. Description:Hownervoussystemscontrolbehavior.Biophysical,biochemical,andmolecularbiologicalproperties ofnervecells,theirorganizationintocircuitry,andtheirfunctionwithinnetworks.Emphasisonquantitative methodsformodelingneuronsandnetworks,andoncriticalanalysisofthecontemporarytechnicalliteraturein theneurosciences.Termpaperrequired.Twolecturesperweek.Prereq:Consentofdepartment.Crosslistedas BIOL473 NEUR474:NEUROBIOLOGYOFBEHAVIORCreditHours:3.0 Offeredeveryfallsemester. RITZMANN,R. (SeeBIOL374).CrosslistedasBIOL474.

12

NEUR476:NEUROBIOLOGYLABORATORYCreditHours:3.0 Offeredeveryfallsemester. WOOD,D. (SeeBIOL476).CrosslistedasBIOL476. NEUR478:COMPUTATIONALNEUROSCIENCECreditHours:3.0 Offeredalternatingyears,springsemester(lastofferedinspring2006) THOMAS,Peter(MATHEMATICS) Description:Computersimulationofneuronsandneuralcircuits,andthecomputationalpropertiesofnervous systems.Studentsaretaughtarangeofmodelsforneuronsandneuralcircuits,andareaskedtoimplementand explorethecomputationalanddynamicpropertiesofthesemodels.Thecourseintroducesstudentstodynamical systemstheoryfortheanalysisofneuronsandneuralcircuits,aswellastocabletheory,passiveandactive compartmentalmodeling,numericalintegrationmethods,modelsofplasticityandlearning,modelsofbrain systems,andtheirrelationshiptoartificialneuralnetworks.Termprojectrequired.Twolecturesperweek.Cross listedwithEECS478&BIOL478. NEUR479:SEM:COMPUTATIONALNEUROSCIENCECreditHours:3.0 Offeredalternatingyears,springsemester(lastofferedinspring2005) BEER,R.andCHIEL,H. Description:Readingsanddiscussionintherecentliteratureoncomputationalneuroscience,adaptivebehavior, andothercurrenttopics.CrosslistedasBIOL479. NEUR482:DRUGS,BRAIN,ANDBEHAVIORCreditHours:3.0 Offeredeveryspringsemester. WOOD,D. (SeeBIOL482).CrosslistedasBIOL482. NEUR518:SIGNALINGVIACELLADHESIONCreditHours:3.0 Offeredalternatingyears,springsemester(lastofferedinspring2006). BRADYKALNAY,S. (SeeMBIO518).CrosslistedasMBIO518. NEUR540:ADVANCEDTOPICSINNEUROSCIENCEETHICSCredithours:0. Offeredeveryotherspringsemester(beginning2008)Studentswhomatriculatedbefore2004areexemptfrom takingthiscourse). Strowbridge,B.W.andZigmond,R.E. Description:Thiscourseofferscontinuingeducationinresponsibleconductofresearchforadvancedgraduate students.Thecoursewillcovertheninedefinedareasofresearchethicsthroughacombinationoflectures,online coursematerialandsmallgroupdiscussions.Six2hrmeetingspersemester.Maximumof15studentswith preferencegiventograduatestudentsintheNeurosciencesprogram.AllNeurosciencesgraduatestudents matriculatingin2004andlatermustcompletethiscourse(typicallyduringtheir3rdor4thyearintheprogram.) NEUR601:RESEARCHINNEUROSCIENCECreditHours:1.018.0 NEUR651:THESISM.S.CreditHours:1.06.0 (Creditasarranged).Prereq:M.S.candidatesonly. NEUR701:DISSERTATIONPH.D.CreditHours:1.018.0 ResponsibleConductinResearch.Allstudentsarerequiredtocompletethecourse,

IBMS500:ONBEINGAPROFESSIONALSCIENTISTattheendofthefirstyearofstudy.This coursethatoutlinesfundamentalinformationandsomecasestudiesisgenerallypresentedin oneweekinMay.Asecondresponsibleconductcourse,NEUR540:ADVANCEDTOPICSIN NEUROSCIENCEETHICSwillbecompletedinthethirdorfourthyearofgraduatestudy(spring semesters)andengagesmoredetaileddiscussion.Students,postdocsandfacultyare

13

encouragedtoparticipateinmonthlyworkshopspresentedbytheOfficeofResearch Compliance(http://ora.ra.cwru.edu/research/orc/rcr/index.cfm;workshopcalendarat http://ora.ra.cwru.edu/research/orc/education/onlinecalendar.cfm). Examinations ProgresstowardthePhDismarkedbygradesincoursework,laboratoryresearchandsuccessful completionofexams.Universityregulationsregardingqualitypointaverageandacademic probationformtheminimumexpectationsofourstudents.Anystudentwithaqualitypoint averagebelow3.0attheendof2ndor4thsemestersofgraduatestudymaybeseparatedfrom theUniversitybyamajorityvoteoftheprimaryfacultyintheDepartmentofNeurosciences. PreliminaryExamendoffirstyear.Thegoalofthisexamistoidentifystudentswhoexhibit significantgapsinbasicknowledge.Thestudentisgivenaprimaryresearcharticleselectedby thefacultyadvisor.TheadvisorandtwoadditionalNeurosciencetrainingfacultywhoare selectedbyrotationfromalistofalltrainingfaculty(seeNarleneBrowntodeterminethe compositionofyourcommittee)formanexaminationcommittee.Thechairofthecommittee mustbeaprimaryfacultymemberintheNeurosciencesDepartment.Oneweeklaterthe studentmakesa30minpresentationincludingrelevantbackground,descriptionofthe experiments,andacritiqueoftheresultsanddiscussion,andthestudentwillbebroadly questionedinanexamthattypicallytakes1.5hours.Studentsshouldpracticetheir presentationstoensurethatthepresentationtimelimitisfollowed.Thestudentisnotrequired todiscussallfacetsofthepaperbutshouldemphasizeitsimportantaspects.Successful completionoftheexamisrequiredforprogressiontothesecondyearofgraduateschool.A personalizedcourseofstudymayberecommendedifnecessary.Theexamcommitteechairwill submitawrittenreportwithinoneweektotheGraduateProgramAdvisor.Theexammustbe completedbyJuly31ofthefirstyearofstudy. QualifyingExamendofsecondyear.Thisexamconstitutesacriticalmilestoneingraduate training.Itteststheabilityofastudenttoidentifyanimportantproblemandproposecreative andfeasiblesolutions.Afourmembercommitteewillbedeterminedbythefacultyadvisorand studentandmustincludeatleasttwoNeurosciencestrainingfaculty.Iftheadvisorisnota primaryNeurosciencefacultymember,thecommitteemustbeconstitutedofatleast3primary facultymembers,outofwhich,onemustbeamemberoftheGraduateEducationCommittee, andtheadvisor.Thechairoftheexamcommitteemustbeaprimaryfacultymemberinthe NeurosciencesDepartment.Atopicforaminigrantproposal,clearlydistinctfromthestudent's andsponsoringlab'sresearchprojectwillbeselectedbythefacultycommitteeandgiventothe student.Thequalifyingexamcommitteeisresponsibleforinsuringthattheexamtopicis appropriatelydistinctfromthestudentsthesiswork. Oneweekafterreceivingthetopic,thestudentwillsubmitspecificaimsfortheproposalthat mustbeapprovedbythecommittee.Threeweekslater(4weekstotal),thestudentwillsubmit tothecommitteea10pageresearchproposal(Approx.3pagesintroduction,background& significanceand7pagesspecificaimsandexperimentaldesign).Theproposalshoulddescribe 13experimentsthatarefeasiblewithina3yeartimeinterval.Questionsaboutthetopic shouldbedirectedtomembersofthestudent'sexaminationcommitteeandnottoother facultyorstudents.Oneweekaftersubmittingtheproposalthestudentwillgiveanoral presentationtothecommitteeanddefendtheproposal.Copiesofthedocumentsthat supportedsuccessfulexamsareavailableforstudentstoview(seeKatie).Ifthestudentfails,
14

thecommitteemaygivethestudentasecondattempttopasstheexam.Thechairwillsubmita reporttotheGraduateProgramAdvisorwithinoneweek.Thisexamshouldbecompletedby July31ofthesecondyearofstudy.Satisfactoryperformanceonthisexamwilladmitthe studenttoCandidacyforthePh.D.inaccordancewithUniversityguidelines. ChangeofStateNotification.Thegraduateschoolrequireswrittennotificationofevery advancementinagraduatestudent'sprogresstomarkeachofthefollowingevents1)selection ofresearchadvisor2)selectionofthesiscommitteemembers3)successfulcompletionof qualifyingexam4)successfulcompletionofPh.D.program.StudentsshouldemailKatieWervey (kar18)toletherknowtheseadvancementshavebeenachieved. ResearchIntegrity.Studentsshouldcarefullyattributematerialgeneratedbyothers.Asa generalworkingdefinition,theOfficeofResearchIntegrityconsidersplagiarismtoincludeboth thetheftormisappropriationofintellectualpropertyandthesubstantialunattributedtextual copyingofanotherswork.Itdoesnotincludeauthorshiporcreditdisputes.Substantial unattributedtextualcopyingofanothersworkmeanstheunattributedverbatimornearly verbatimcopyingofsentencesandparagraphswhichmateriallymisleadtheordinaryreader regardingthecontributionsoftheauthor.ORIgenerallydoesnotpursuethelimiteduseof identicalornearlyidenticalphraseswhichdescribeacommonlyusedmethodologyorprevious researchbecauseORIdoesnotconsidersuchuseassubstantiallymisleadingtothereaderorof greatsignificance.Formoreinformationonthisissue,see http://ori.dhhs.gov/policies/plagiarism.shtml GUIDELINESFORTHESISRESEARCH A. GoalsforGraduateStudents: Studentsmuststrivetodevelopwiththeadvisoraresearchprojectthatyieldsacoherentand originalbodyofwork. Thethesismustbewritteninascholarlymannerwithadetailedhistoricalintroductionanda criticaldiscussion. Thefirstdraftofthethesismustbetheoriginalandindividualeffortofthestudent.Thedraft submittedtotheThesisCommitteeshouldbeapolisheddocumentdevelopedin consultationwiththementor. Ingeneral,thethesisresearchshouldutilizemorethanonetechnicalapproach.Inthethesis document,thesisseminar,andthesisdefense,thestudentshoulddemonstratethat he/shehasbecomeanexpertinthefieldofresearch. Bythetimeofthethesisexamination,thestudentshouldhavesubmittedforpublicationat leastonepeerreviewedexperimentallybasedmanuscriptonwhichhe/sheisthefirst authorandhavecompletedabodyofworkthatthestudent'scommitteejudgeswill leadtoasecondmanuscript,andadraftofthesecondmanuscriptshouldbecompleted. Thefirstdraftofallmanuscriptsshouldbewrittenbythestudent. Duringthecourseofstudy,studentsshouldpresenttheirdataat,atleastonenationalmeeting. B. GoalsfortheTrainingFaculty: TrainingfacultyofPh.D.studentsmustbeactiveparticipantsintheNeurosciencesProgram andcontributetocourses,collaborativeresearchprojectsand/orjournalclubs.The
15

programperiodicallyreviewsfacultyfortrainingstatus,andfacultywhohavebeen inactivewillbedeclined. Thethesisadvisormustprovidethestudentwithintensivetraininginthescientificmethod, includingtheabilityformulateclearresearchquestions,developfeasibleresearch approachestoansweringsuchquestions,evaluatedatafromthestudentsown researchandthatofothers,anddiscussthebroadcontextandsignificanceofthe studentswork. Thethesisadvisor,inconjunctionwiththeThesisCommittee,isresponsiblefordevelopingand implementingatrainingplanwiththestudent,includingtheelaborationofan independentresearchproject. Thethesisadvisorisresponsibleforprovidingphysical,financial,andintellectualresources necessaryforaccomplishingtheresearchplan. Thethesisadvisorshouldworkregularlywiththestudenttodevelopgoodcommunication skills,inbothspeakingandwriting. Thethesisadvisorshouldencouragethestudenttothinkbroadlyabouttheresearchproject andnotnecessarilybelimitedtoapproaches/techniquescurrentlyusedintheadvisors laboratory. TheThesisCommittee Graduatetraininghasasitsgoaltheextensionofknowledgeandthedevelopmentof scholarship.Thisrequiresinputfromfacultyadvisorswhoworktogetherwiththestudentand facultyadvisortoguidethescopeoftheresearch,andhelpthestudentdevelopintoan authorityinhis/herfield.Thesiscommitteemembersshouldhaveexpertisethatcorresponds withtheproposedworkandanacknowledgedinterestincontributingconstructivelytothe student'sprogress. Uponsuccessfulcompletionofthequalifyingexam,eachstudentwillnotifytheGraduate StudentCoordinator(KatieWervey)sotheAdvancementtoCandidacyformcanbefilledout andsenttoGraduateStudies.Studentshave6monthsfromtheirqualifiertoformtheirthesis committeesandmustnotifyKatiewiththenamesofthecommitteemembers,whowillbethe chairofthecommittee,andwhenthefirstmeetingwilltakeplace. Thethesiscommitteeshallhaveaminimumofthreemembers(thethesisadvisorservesasa fourth,exofficio,member),andtheUniversityrequiresthatonememberhasaprimary appointmentoutsidethisdepartment.AprimaryappointeeintheDepartmentof Neuroscienceschairsthemeetings.Thecommitteeistoserveasthestudent'sadvocatein advancingtowardthedoctorate.Thestudentshouldfeelfreetoconsultindividualmembersat anytime.Thepresenceofonehalfplusoneofthemembersofthecommitteeconstitutesa quorum.Themembershipofthethesiscommitteecanchangeduringthecourseofwork,andis recommendedifthedirectionofworkshiftssubstantially.Whenthecommitteeagreesthatthe bodyofworkaccomplishedisadequatetoearnadoctoraldegree,thepurposeofthe committeetakesontheadditionalroleofensuringthecompletionofascholarlythesis. Atthefirstcommitteemeeting,thetrainermustbringthestudentfileandrotationreports, andpreliminaryexamandqualifyingexamreportsshouldbereviewedatthistime.Thefirst meetingneedaccomplishnomorethanadiscussionofthegeneraltopicsforthesisresearch.A frankdiscussionofthestrengthsandweaknessesoftheworkshouldbeencouraged.The
16

meetingshouldendwiththedevelopmentofaconsensusplanforthenext6months. Subsequentmeetingsshouldputnewworkinthecontextoftheentireproject,andoutline advancesandproposedareasforwork.Thecommitteechairmustsendashortsynopsisofthe meetingtotheGraduateProgramAdvisorandNeuroscienceDepartmentalAssistantwithinone week. TheThesisCommitteemustmeetatleastonceasemestertomonitorstudentprogress.Itisthe responsibilityofboththeChairoftheCommitteeandthestudentthatthesemeetingstake place.StudentswillnotbeallowedtoregisterforasemesteriftherehasnotbeenaCommittee meetingduringtheprevioushalfyearperiod. Atleasttwoweekdayspriortoeachmeeting,abriefwrittensummaryofthestudent'sprogress sincethelastmeetingshouldbegiventoeachcommitteemember.Itistheresponsibilityof committeememberstoreadthereportpriortothecommitteemeeting. Aftereverymeeting,adateforthenextmeetingwillbesetfor6monthslater(unlessdirected bythecommitteetomeetsooner),sothatthestudentandcommitteememberscanenterit intotheircalendars.Itisveryimportantthatstudentsandtheircommitteesmeetevery6 months,evenifthestudentdoesnotfeelheorshehasenoughdatatoreport,sothatthe committeecanbekeptuptodateonhisorherprogressandcanadvisethestudent. TheThesisCommitteeevaluatesthestrengthsanddeficienciesinthetrainingplanorinits implementationanddiscussesthesewiththementorandstudent.TheCommitteeshouldserve asasoundingboardifthestudentencountersproblemsinthegraduateprogramandshould createarelationshipwiththestudentwhereitisclearthatsuchinterchangesareencouraged. TheCommitteeisresponsibleforseeingthatthestandardsandtherequirementsofthe programarefulfilled.ItisultimatelytheresponsibilityoftheChairoftheCommitteetobring anyunresolvedproblemstotheattentionoftheDirectorofGraduateStudiesand/orthe DepartmentalGraduateEducationCommittee. ProgressReportsmustbecompletedwithinoneweekofthecommitteemeetingandsentto themembersofthecommitteeandtotheDepartmentalAssistantforplacementinthe studentsconfidentialfolder.Thereportmustcontainaclearassessmentofwhetherornot satisfactoryprogressisbeingmadetowardsaPh.D.degree.Thisassessmentisoneofthekey responsibilitiesoftheAdvisoryCommittee.Ifthestudentreceivestwounsatisfactorygradesin NEUR701,thestudentisseparatedfromtheUniversity. Ifthestudent,mentorandcommitteecannotcometoanagreementaboutthetrainingplan, theyshouldbringtheirdifferencestotheDepartmentalGraduateEducationCommittee(*see underStudentAdvocatesnextsection),theGraduateProgramAdvisor,ortheChairofthe Department. TheThesisCommitteeisresponsibleforapprovingtheshiftinthestudentsprioritiesfrom doingexperimentstowritingthethesis.Beforedoingthis,thestudentmustpresenttothe Committeeabriefoutlineoftheproposedwrittenthesis.
17

TheDissertation AllcandidatesforthePhDdegreemustsubmitawrittendissertationasevidenceoftheirability toconductindependentresearchatanadvancedlevel.Thedissertationmustrepresenta significantandoriginalcontributiontoexistingknowledgeinthestudent'sfield.Atleastsix monthsbeforethestudentanticipatesPhDcompletion,athesiscommitteemeetingshouldbe heldtodiscusswhetherthestudent'sprogresstowardthedegreeissufficient.Thecommittee shouldagreeatthattimetotheformatofthethesis.Itisinastudent'sinteresttosubmitany manuscriptsbeforeleavingtheUniversity,becauseonceapostdoctoralpositionisbegun,other concernsarise.Becausemanystudentshavepublishedmanuscriptsontheirstudies,thethesis oftenreflectsthatworkaschapters,placedincontextwithageneralIntroduction,anda Discussionthatconsiderstherelevanceofthestudies.Theformofthethesisisnotproscribed bythedepartment,butisarrivedatbythestudentandthesiscommittee.Examplesof NeurosciencegraduatethesesareintheNeurosciencelibrary.Detailedregulationsconcerning format,quality,timeofsubmissionandoraldefenseareestablishedbytheDeanofGraduate StudiesandResearch,andinstructionsareavailablefromtheOfficeofGraduateStudies. StudentAdvocates.Intheeventthatdifficultiesariseduringgraduatetraining,astudentis advisedtoseekadvicefromoneormoresourcesincludingthestudent'sfacultyadvisor,the graduateprogramadvisor,theGraduateEducationCommittee,thedepartmentalchairperson orifrelevant,theMSTPdirector.TheGraduateEducationCommitteewithintheDeptof NeuroscienceswillmeetonanadhocbasistodiscusspolicyissuesinGraduateEducation.A graduatestudent,thesisadvisor,Committeemember,orGraduateProgramAdvisorcanbring totheCommitteeatanytimecaseswhereseriousbreakdownsincommunicationhave occurredwithrespecttothestudentsgraduatestudiesandasktheCommitteetointervene. MembersoftheGraduateEducationCommitteeincludeDrs.RichardZigmond,AlisonHall, StefanHerlitze,DavidKatz,andBenStrowbridge(CommitteeChair).Studentsarealso encouragedtoseekadvicefromtheDirectorofGraduateEducation,Dr.AlisonHall,inTG1, whowillworktoeffectresolution.Ifnecessary,studentsmayexpressagrievanceagainst actionsofstudentsorfacultyandstaffthroughprocedureshandledbyGraduateStudies(for academicproblems)ortheUniversityOfficeofStudentAffairs(fornonacademicproblems). MembersoftheUniversitycommunitywhobelievetheyhavebeensexuallyharassedare entitledtoaninvestigation;officialsintheProvost'sOffice,OfficeofStudentAffairsand/orthe OfficeofAffirmativeAction/EqualEmploymentOpportunitywillprovideoptionsforresolution. MasterofNeuroscienceDegree.TheNeuroscienceprogramisaDoctoraldegreegranting programanddoesnotofferaMastersofSciencecurriculum.Nostudentwillbeadmittedto theProgramforthesolepurposeofearningaM.S.degree,andundernocircumstanceswilla MastersdegreebeawardedaspartofaDoctoralcurriculum.Onrareoccasions,however,an individualmayleavetheDoctoralprogramaftercompletingasignificantbodyofcoursework andindependentresearch.Undertheseconditions,aMasterofNeurosciencedegree(TypeB) maybeawardedundertherecommendationofthestudent'sthesisorqualifyingcommittee.To completetherequirementsforaMasterofNeuroscience,astudentmustmaintaincontinuity ofregistrationandaminimumcumulativegradepointaverageof2.75(seeGraduateStudent Handbook,pg.17).Thestudentmustsuccessfullypassthepreliminaryexamaswellasaspecial Mastersqualifyingexam,andhavecompletedatotalof27semesterhoursofcoursework.At least18hoursofcourseworkmustbeatthe400levelorhigher.Anyrequirementsnot specificallyaddressedbelowsuchasthosepertainingtogradepointaverage,residencyand feesconformtotheregulationsfortheMastersdegreespecifiedinthegeneralUniversity
18

Bulletin.Thisprogramisaimedatstudentswhohavetakenmostorallofthecoursesrequired forthePh.D.andwhohavepursuedaresearchprogram.ToearnthisMastersdegreeoneof twoexaminationsmustbepassed:PassageoftheNeurosciencequalifierexamorsuccessful oraldefenseofaresearchreport.TheNeurosciencequalifierexaminationconsistsofanNIH styleresearchproposalthathasbothwrittenandoralcomponents.Theresearchreportis basedonthestudentsoriginalresearchandwillbetestedinanoralexaminationbythe studentsadvisorycommittee.Uponsuccessfullypassingoneofthetwoexaminationsand fulfillingtheaboverequirements,thesestudentswillearnaMasterofSciencein Neurosciences. PostdoctoralFellowsareadvisedtobegintoestablishindependentscientificidentities.This maybeachievedbythepursuitofaclearlydefinedanduniqueprojectwithinthelab increasinglydirectedbythepostdoctoralfellow.Postdoctoralfellowsareencouragedto presenttheirworkatnationalmeetings,toprovidetopicallecturesinrelevantgraduate courses,andtobegintosupervisepersonnelinthelaboratoryasappropriate.Formore informationaboutpostdoctoralpolicy,contactGraduateStudies. Postdoctoralfellowsmaywishtocontactthe CWRUPostdoctoralResearchersAssociationat http://www.case.edu/provost/gradstudies/pra.html Postdoctoralfellowsarestronglyencouragedtoobtaintheirownoutsidefinancialsupport,in ordertodevelopgrantskillsandachievethedistinctionofindependentsupport.Ingeneral, theseproposalsaredevelopedbythefellow,readandconstructivelyeditedbythePI,and oftenreadbyotherinvestigatorswiththeintentionofdemonstratinggoodgrantskillsduring thisenterprise.Currently,amajorsourceforpostdoctoralfundingistheNationalInstitutesof HealthNationalResearchScholarAward(NRSA).Additionalagenciesthatsupportparticular researchareasincludeAmericanHeartAssociation,MultipleSclerosisFoundation,Paralyzed Veterans,JaneCoffinChilds,etc.FormsareavailablefromtheOfficeofResearchGrants. Foreignstudents.TheUniversityAttorneysoffice,OfficeofForeignFacultyandScholars (x4289,FAXx1881)isaresourceforforeignstudents. NEUROSCIENCEFACILITIES Laboratoriesarefullyequippedforadvancesincellular,molecularandphysiologicalanalysesof neuralfunction.Additionalspecializedfacilitiesareavailable: NEUROSCIENCESIMAGINGCENTER(E632) MaryannePendergast,Manager(mxp19,office:3682575orcell:2162248649) BenStrowbridge,Director(bxs48) http://neurosciences.case.edu/imaging/index TheNeurosciencesImagingCenter(NIC)hasbeeninexistencesince1994andistheoldest opticalimagingfacilityoncampus.AlthoughthecenterislocatedwithintheDepartmentof Neurosciences,ithasalwaysoperatedasacompletelyopencorefacility(anyoneinthe communitycanusetheseinstrumentsatthesamehourlyrate).TheNIChousessomeofthe mostsophisticatedmicroscopesavailabletoday,includingtheZeissLSM510METAconfocal,the
19

LeicaTCSSP2MPconfocal/multiphotonandtheBioRadRadiance2100multiphotonlaser scanningsystem.TheNeurosciencesdepartmenthasoneofthelargestconcentrationsof2 photonmicroscopesinthecountry(theBioRad2100MPandLeicaTSCSP2MPintheNICand twocustomsystemsintheStrowbridgelaboratory). TheZeissLSM510METAistheprimaryconfocalmicroscopetheNIC.Itcanbemountedon eitheramotorizedinvertedstand(Axiovert200M)oramanualuprightstand(AxioImagerZ1). Thesystemofferseightexcitationwavelengths(405nm,458nm,477nm,488nm,514nm, 543nm,594nmand633nm)andfordetection,threeseparatereflectedlightPMTs,eachwith itsownadjustablepinholeandemissionfilterwheel.TheLSM510METAscanheadcanacquire lambdastacksin10nmincrementsoverabroadspectralrange(411753nm).Alambdastack collectedfromindividualreferencedyescanbeusedtogenerateanemissionfingerprintthat cansubsequentlybeusedforspectralunmixingofcloselyrelateddyesandisoftenusedto separatedifferentGFPvariants.Fourcommonlyusedsoftwaremodules(Multitime, Physiology,FRETandFRAP)areavailableforonlineimaging.Tofacilitatelivecellimaging,a BiopticsDeltaT4heatingstageandobjectiveheatercanbeusedwithboththewidefieldand confocalsystemswithinthefacility. AZeissLSM410confocalmicroscope,thepredecessortotheLSM510,isalsoavailableforuse atareducedhourlyrate.ThesystemconsistsofanLSM410scanheadmountedonaninverted Axiovert100microscopestandandoffersfiveexcitationwavelengthsandfordetection,three separatePMTs,eachwithitsownadjustablepinholeandemissionfilterwheel.Despiteitsage, thissystemremainsinexcellentcondition,iseasytouse,andisoftenavailablewhenthe LSM510isfullybooked.TheLSM410islocatedinitsownroom(E638). TheBioRadRadiance2100MPisadedicated2photonlaserscanningsystemattachedtoan uprightmicroscope.2photonmicroscopyidealforimagingthroughliveorfixedbraintissue, therebyavoidingtheneedtoresectiontissueforconfocalmicroscopy.2photonimagingalsois wellsuitedtoimagelivingspecimenssinceitgeneratesmuchlessphototoxicity.BoththeLeica TCSSP2MPandtheBioRad2100MPcanperform2photonimaging.SincetheLeicasystemis basedonaninvertedmicroscope,itiseasiertouseforliveculturecellswhiletheBioRad systemismoreconvenientforintactorsemiintacttissue.TheBioRadsystemalsoisequipped forpatchclampelectricalrecordingsandcanbeusedforbrainsliceexperiments. TheLeicaTCSSP2MPconfocal/multiphotonmicroscopecombinesspectrophotometric detectionwithconfocaland2photonmicroscopy.Insteadoftraditionaldichroicfiltersets,a prismisusedtoseparatetheemittedfluorescence,resultinginaveryflexibleandefficient detectionsystem.Forexcitation,thesystemofferssixvisiblelightwavelengths(458nm,476nm, 488nm,514nm,543nm,and633nm)plusatunable(720nm950nm)IRlightsource(Choherent ChameleonXRMPlaser)for2photonexcitation.Whilethissystemhasmanyadvanced features,itstillcanbeusedasageneralpurposeinvertedconfocalmicroscope.Itislocatedin itsownroom(E639). AnotherZeissinvertedmicroscopestandisequippedforTIRF(TotalInternalReflection Fluorescence)imaging.ThissystemismountedonaZeissAxiovert200Mmicroscopeand includesa100mWmultiline(458nm,488nm,and514nm)Lassos77laserandahighNA(1.45) 100xplanFLUARobjective.Theevanescentfieldformedbythissystemcanvarybetween60 330nmandisabletoexcitedyesinanaqueousenvironmentatornearthecoverglass/cell
20

interface.Thissystemisdesignedtoimagefluorescencelabelsinorverynear(withinafew hundrednm)theplasmamembraneinculturedcells. WealsooperateageneralpurposeInvertedWideFieldMicroscopethatintegratesaZeiss Axiovert405microscopewithsoftware,computersandcameras.Thesoftware(Metamorph andMetafluor)isdesignedtosupportimageacquisition,morphometricanalysis,calciumratio imaging,3Dreconstruction,andtimelapseexperiments.Tofacilitatelivecellimaging,a BiopticsMtypestageheaterandadjustableobjectiveheaterareavailableforusewiththis system. TheNeurolucida3DreconstructionandstereologysystemisbasedonaZeissAxioplanupright microscopewithahighresolutionmotorizedstageandisdesignedtofacilitatethree dimensionaltracingsandreconstructionsofneuronsfilledwithfluorescentoropaquedyes.In additionthesystemoffersaseparatestereologypackagethatallowstheusertoestimatecell numberandmorphologicalpropertiesof3Dstructuresfrom2Ddata. TheBioRadmodel3000VersadocGelImagingSystemisdesignedtocaptureandanalyze digitalimagesfromawiderangeofsamples,includinggels,blots,autoradiograms,TLCplates andmicroplates.Thesystemisabletodetectandquantifystandardnucleicacidandprotein specificstainsaswellaschemiluminescent,chemifluorescent,colorimetric,andfluorescent samples. ThedepartmentsComputerLabisalsolocatedintheNeuroscienceImagingCenter,room E632b.ItincludesMacintoshandPCworkstationsloadedwithsoftwarefordataanalysis, manuscriptpreparation,andimageprocessing.AnofflineversionoftheLSM510software, Release3.5isavailableonthePCcomputer.PeripheralequipmentincludesPolaroid5000and 6000slidemakers,anEpsonStylusPhoto2200printer,andaMicrotekscannercapableof scanningbothreflectiveandtransparentimages.Foradditionalinformation,pleasecontact MaryannePendergast(mxp19,office:3682575orcell:2162248649). PHOTOGRAPHYSUITE.Apointlightsourceenlarger,adiffuselightsourceenlarger,rapid processorsandahighqualitycopystandareprovidedintheE630darkroomsuite.For informationortrainingcontactMaryannePendergast(mxp19x2575). ICYCLER. LocatedintheZigmondLab,roomE734a TheBioRadiCycleriQPCRdetectionsystemallowstheusertobothmonitorandquantifya PolymeraseChainReaction(PCR)inrealtime.Abroadspectrumtungstenlightsourceand multiplefilterspermitawiderangeofexcitationandemissionbetween400700nm,andalso themultiplexingofuptofour(4)differentreporterfluorophors.Onlinedisplayallowsvisual confirmationofthePCRamplificationinprogress,anda350,000pixelCCDdetectormakes possiblethesimultaneousdetectionofupto96samples.Forinformationortrainingcontact RichardZigmond(rezx4614).
21

CASERODENTBEHAVIORCORE. CoreDirector:GemmaCasadesus(gxc40x8503). http://neurosciences.case.edu/crbc/index ThegoaloftheRodentBehaviorCoreintheSchoolofMedicineistoconductstateoftheart rodentbehavioraltestingforinvestigatorsatCaseandothernearbyinstitutions.Thecore facilityisequippedtoperformacomprehensivebatteryofbehavioralteststothoroughly phenotypeoverallmotorandsensoryfunctionofratsandmiceaswellasphenotypespecific behaviorsthatareofinteresttotheinvestigators(learningandmemory,motorfunctionand gaiting,place/fearconditioning,pain/analgesia,andanxietyrelatedbehaviors).TheCorecan assistinallaspectsofrodentbehavioraltestingincludingdesignandexecutionofbehavioral tasksaswellasdataanalysisandinterpretation.TheCorelaboratoryistemporallylocatedin theWolsteinBuildingbutwillexpandtoitsmainlocationinthenewlyrenovatedAnimal ResourceCenter(ARC)inNovember2007. OTHERFACILITIES/SERVICES ELECTRONMICROSCOPYFACILITY. Director:Dr.HisashiFujioka(hxf3x2490) TrainingandFacilityManager:MidoriHitomi(mxh67x3454) InstituteofPathology(IPRoom116) TheelectronmicroscopyfacilityincludesJEOL1200EXtransmissionelectronmicroscope,afully equippedsampleprocessinglaboratory,asectioningroom,andadarkroom.Forinformation, contactMidoriHitomi. ANIMALFACILITY.Allindividualsinvolvedinresearchusingvertebrateanimalsarerequiredto betrainedandtobelistedonanapprovedanimalprotocol.Theseindividualsmustreadand signtheprotocol.InformationaboutanimalresearchatCWRUisavailableat http://casemed.case.edu/ora/iacuc/. BASICSCIENCEINSTRUMENTATIONREPAIRFACILITY. WilliamM.Frank,Manager(wmf3x3225). (SOM,B05atthebasementintersectionofWood,Tower,East,andBRB). http://casemed.case.edu/sirc/default.htm. Mechanicalandelectricaldiagnosisandrepairofgeneralandspecializedlaboratoryequipment, equipmentdesignandmodification,fabrications,retrofitting,reconditioningofolder equipment. VENDORS.Selectedvendorshavecommonlyuseditemsandspecialordersatfacilitieson campus,administeredbydepartments: Gibco/BRL/Invitrogen,PharmacologyW361 BoehringerBiochemistryW450 NewEnglandBiolabs,BiochemistryW450 Fisher,BRB547
22

UsefulWebsites: TheNationalAssociationofGraduateProfessionalStudents http://www.nagps.org/ JohnsHopkinsPostdoctoralAssociation http://www.med.jhu.edu/jhpda Sciencenextwave http://nextwave.sciencemag.org/uk SocietyforNeurosciences http://www.sfn.org AmericanSocietyforCellBiology http://www.ascb.org/ FASEB http://www.faseb.org AssociationforNeuroscienceDepartmentsandPrograms www.andp.org NationalScienceFoundation(NSF) http://www.nsf.gov/ DepartmentofHealthandHumanServices http://www.os.dhhs.gov/

23

CurrentStudentsintheNeurosciencesGraduateProgram(2010)
Name BrentCameron GermanCardenasLeroy PaigeCramer MarcDePaul RishiDhingra YiDong TeresaEvans Angela(Nord)Filous StephanieFox DavinaGutierrez RobertHyde RebeccaJames KseniaKastanenka HyunjinKim BradleyLang ChungYingLee SunghoLee ChenLiu ShwetaMandrekar Crystal(Kozora)Miller InnaNechipurenko EugeneOh JoannaPucilowska PavelPuzerey JulieSavage LorenSchmidt MariaSmith YiLanWeng StevenWyler ElizabethYoung IsaacYoungstrom Yearenteredintoprogram 2008 2009 2007 2009 2008 2006 2009 2008 2004 2003 2008 2008 2006 2008 2009 2006 2009 2003 2005 2005 2005 2005 2007 2009 2008 2008 2005 2006 2009 2005 2009

24

 AlumnioftheNeurosciencesProgram
NamePresentPosition XingbinAi,Ph.D.1999AssistantProfessor,Medicine,BostonUniversityMedicalCampus MeredithAlbrecht,MSTP,PhD1999StaffAnesthesiologist,MassachusettsGeneralHospital KatherineAlex,PhD2006VisitingAsst.Prof.,OberlinCollege AgnieszkaBalkoweic,Ph.D.Asst.Prof.,Univ.ofOregonHealthSciencesCtr. RamaniBalu,MSTP,PhD2006Resident,Neurology,UniversityofPennsylvania KarenBaracskay,PhD2002ResearchFellow,Molecular&BehavioralNeurosciencesInst.,MentalHlth.Res.Inst.,Meador WoodruffLa.,UofMichigan BrianBlock,MDPh.D.1996Instructor,Partner,PainMed.Specialists(PrivatePractice);Dept.Anesthesiology&CriticalCare, JohnsHopkinsUniv. KristenBoeshore,Ph.D.1999AssistantProfessor,Biology,LebanonValleyCollege,PA TheresaAnnBrosenitsch,PhD2001Faculty,Dept.ofMedicine,Univ.ofPittsburgh SueBurdenGully,Ph.D.ResearchAssoc.,CWRU,MolecularBiology&Microbiology SarahBusch,Ph.D.2009PostdoctoralFellow,CWRUNeurosciences,SilverLab Christy(Gray)Butler,MSTP,PhD2007Resident,Anesthesiology,JohnsHopkinsUniversity DavidCanning,Ph.D.Asst.Prof.MurrayStateUniversity,KY LingCheng,PhD2004UCSanFrancisco,PI:G.Davis ElizabethChiang,MSTP,PhD2007CWRUMedicalSchool StephenColgrove,M.S.2001Unknown ColinCombs,Ph.D.Assoc.Prof.U.NorthDakota AndrewCordle,MSTP,PhD2005Resident,OrthopedicSurgery,ClevelandClinic BethanyCruise,PhD2004Analyst,DecisionResources,Boston,MA StephenDavies,Ph.D.Assoc.Prof.,Univ.ofColoradoHealthSciencesCtr. DavidDewitt,Ph.D.1996Dir.,Ctr.forCreationStudies,AssociateProfessor,LibertyUniversity,KY ChristopherB.Eckman,PhD2000Professor,MolecularNeuroscience,MayoClinic,Jacksonville SonyaEnsslen,PhD2004PostdoctoralFellow,DanielJayLab,Physiology,TuftsUniversitySchoolofMedicine GuopingFan,Ph.D.AssociateProfessor,HumanGenetics,DavidGeffenSchoolofMedicineatUCLA MichaelFitch,MSTP,PhD1999Asst.Prof.,EmergencyMed.,WakeForestUniv.BaptistMed.Ctr.;Director,EDSimulationProg.; Member,WFUCoreTeachingFaculty;NeuroscienceProgramFaculty NicoleFrancis,Ph.D.2000Asst.Prof.ofMolecular&CellularBiology,HarvardUniversity MollyFuller,MSTP,PhD2007MDIntern,Ophthalmology,UniversityHospitalsHealthSystems DmitryFyodorov,Ph.D.1999Asst.Prof.ofCellBiology,AlbertEinsteinCollegeofMedicine LiminGao,PhD2006Homemaker YuanGao,PhD2009ResearchAssociate,CWRUNeurosciences,StrowbridgeLab AndrewGarnerMDPh.D.1996InstructorinPediatrics,CWRU,UniversityHospitalsHealthSystems LauraGault,MSTP,PhD1997Assoc.Res.Scientist,ChildStudyCtr.,YaleSchoolofMedicine EdwardGilmore,MSTP,PhD1999InstructorinPediatrics,PediatricsChildrensHospital,Harvard NadineGoodman,Ph.D.ScienceTeacher,GilmourAcademy GuyGuidry,Ph.D.1999Deceased BrianHalabisky,PhD2003PostdoctoralFellow,GladstoneInstituteofNeurologicalDisease,LiGanLab,UCSF AlisonHall,PhD,Professor,Neurosciences,CWRU;Director,OfficeofGraduateEducation,SchoolofMedicine,CWRU JingHan,PhD2007PostdoctoralAssociate,MolecularandHumanGenetics,ZhogbiLab,BaylorCollegeofMedicine MartinGartzHanson,PhD2004PostdoctoralFellow,Univ.ofColoradoHealthScienceCtr.,Denver AliciaHawthorne,PhD2009PostdoctoralFellow,TheOhioStateUniversity,PhillipPopovichlab JeannetteHayes(Davies)Ph.D.Asst.Prof.,Neurosurgery,Univ.ofColoradoHealthScienceCenter,Denver CarolHaney,Ph.D.1999Unknown TimHendricks,PhD2003PostdoctoralFellow,SalkInstitute,MartinGouldingLab LibinHo,PhD1997InternalMedicinePediatricsandAdolescentMedicine,DeanHealthSystem,Madison,WI KevinHorn,Ph.D.2009MedicalSchoolTheOhioStateUniversity QingguangJiang,PhD2008Postdoc,JohnsHopkinsU.,Dr.DavidGintyLab KristinLongKaelber,MSTP,PhD.PrimaryCarePhysician,CambridgeHealthAlliance;InstructorinMedicine,HMS PaulKammermeier,Ph.D.1997Asst.Prof.Pharmacology&Physiology,U.RochesterSchoolofMedicineandDentistry ShiChuKao,Ph.D.,2001StaffScientist,Clonetech AmberKerstetter,PhD2009PostdoctoralFellow,CaseWesternReserveUniversity,ErinLavikLab JessicaKoenigsknechtTalboo,PhD2005AssistantDirectorforDevelopment,WashingtonUniversityMedicalSchool KatherineKrueger,PhD2008PostdoctoralFellow,NorthernCaliforniaInst.forRes.andEduc.(NCIRE)Dr.LillyBourguignonlab attheSanFranciscoVAMedicalCenter rd PhillipLarimer,MSTP,PhD2009CWRU3 yearMedicalSchool TimothyLehman,M.S.PfizerPharmaceuticals JessicaLerchHaner,PhD2008PostdoctoralFellow,UniversityofMiami,FL,VanceLemmonLab XiangLi,PhD2007PostdoctoralResearchFellow,E.KandelLab,ColumbiaUniversity AllisonLimpert,PhD2005PostdoctoralFellow,VanderbiltUniversity,CarterLab

25

AlumnioftheNeurosciencesProgram(continued)
NamePresentPosition StephenMaricich,MSTP,PhD1999AssistantProfessorPediatrics,UniversityHospitalsHealthSystems/CWRU DougMcDonaldMSTP,Ph.D.1997AssistantProfessor,Allergy&Immunology,HarvardMedicalSchoolAssistantin Medicine:ChildrensHospital,Boston JenniferMcDonough,Ph.D.AssistantProfessor,Neurosciences,SchoolofBiomedicalSciences,KentStateUniv.,OakClinic RobertMcKeon,Ph.D.AssistantProfessor,EmoryUniversity KatyaMelnikMartinez,PhD2008PostdoctoralFellow,BiologicalSciences,UCSD,Dr.AmyPasquenelliLab StaceyMembergMDPh.D.1995Pediatrician,PrivatePractice,Aetna,Medina,OH HarryMenegay,II,Ph.D.2000Analy/ProgrammerIII,Ctr.forMemory&Aging,CWRU,UH CatherineMeyer,M.S.2001Unknown LouiseMilner,MD,Ph.D.Radiologist,ClevelandClinicFoundation FredMoeslein,MSTP,PhD1999Resident,Radiology,CCF RobertMohney,Ph.D.1998PostdoctoralFellow,LabofSignalTransduction,NationalInstituteofEnvironmentalHealth Sciences ShibaniMukerji,PhD2008CWRUMedicalSchool MikeMyers,Ph.D.1996GroupLeader,ProteinNetworks,InternationalCtr.forGeneticEngineeringandBiotechnology(ICGEB), Trieste,Italy NenadIlic,M.S.2005Unknown DianaOrentas,Ph.D.1997RegionalScientificAssociateDirector,CNS(Pharmaceuticals) StephenOstrowski,MSTP,PhD2007CWRUMedicalSchool DollyPadovaniClaudio,MSTP,PhD2006Residency,Ophthalmology,UniversityofMichigan CarlosPena,Ph.D.DesignatedFederalOfficial,PAC,OfficeofScienceandHealthCoordination,OfficeoftheCommissioner,FDA LuisPoloParada,Ph.D.1999AssistantProfessor,MedicalPharmacology&Physiology,Univ.ofMissouri,Columbia,MO ToddPressler,PhD2006Postdoc,WadeRegehrLab,HarvardUniversity LoriRaetzmann,MSTP,PhDAsst.Prof.,Molecular&IntegrativePhysiology&NeuroscienceUniv.ofIllinois,UrbanaChampaign VicRafuse,Ph.D.AssociateProfessor,DalhousieUniversity ErinReedGeaghan,PhD2010PostdoctoralFellowCaseWesternReserveUniversity,StephenMaricichlab AnnaRivkin,PhD2002ClinicalTrialsCoordinator,MerckPharmaceuticals KarenRollins,M.S.StaffResearcher,MI CatherineRottkamp,MSTP,PhD2007Resident,ChildrensHospital,Boston,MA IvySamuels,PhD2008PostdocDr.NealPeacheyLabClevelandVAMed.Ctr.andDeptofOphthalmicResearchColeEyeInst. ClevelandClinicFoundation AndrewSchaefer,Ph.D.Assoc.Res.Scientist,Mol.Cell&Dev.Biol.,Paul.ForscherLab,YaleUniversity MichaelScott,PhD2005PostdoctoralFellow,J.ElmquistLab,UTSouthwestern AnnetteShadiack,Ph.D.ExecutiveDirector,PreclinicalR&D,PalatinTechnologies,Inc. MelissaShirley,M.S.1997Highschoolteacher,Olengtangy,OH SarahShoemaker,PhD2006PostdoctoralRes.Assoc.,NeuroscienceCenter,SniderLab,Univ.NorthCarolina,ChapelHill,NC DianeSnow,Ph.D.AssistantProfessor,DepartmentofSpinalCordandBrainInjuryResearch,UniversityofKentucky,Lexington StaceyStephans,Ph.D.1997Sr.AssociateDirector,Programs,Neurology,EmoryUniversity EstherStoeckli,Ph.D.AssociateProfessor,UniversityofZurich YiSun,Ph.D.1997Asst.Prof.UCLA,Assoc.AcademicDir.UCLAInst.forStemCellBiol.&Medicine KenSwanson,Ph.D.1998ResearchFellowinMedicineHarvardUniv.:BethIsraelDeaconessMed.Ctr.Hematology/Oncology LoriTaylor,Ph.D.VicePresident,ElanPharmaceuticals XiaoyingTang,M.S.2007ResearchAsst.,ClevelandClinicFoundation VeronicaTom,PhD2004PostdoctoralResearcher,anatomyControl,DepartmentofNeurobiologyandAnatomy,JohnHoule Lab,DrexelUniversityCollegeofMedicine,PA HuiHsinTsai,PhD2002PostdoctoralFellow,DavidRowitchLab,Univ.California,SanFrancisco MaryanneUsiak,Ph.D.2000Homemaker NicholasVarvel,PhD2008GuestScientistattheHertieInstituteforClinicalBrainResearch,U.ofTubingen,Germany,Advisor: MathiasJucker DanielVogt,PhD2007PostdoctoralFellow,Neurosciences,PimplikarLab,ClevelandClinicFoundation EricWong,Ph.D.AssistantProfessor,Biology,UniversityofLouisville ChristiWylie,PhD2010PostdoctoralFellow,SanFrancisco ZongqiXia,PhD,2003Fellow,Neurology,HarvardMedicalSchool MianXie,PhD2007PostdoctoralFellow,AlanFadenLab,Neurosciences,GeorgetownUniversity PinXu,PhD2007PostdoctoralFellow,GabrielCorfasLab,ChildrensHospital,Boston,MA XiaohongXu,PhD2006Postdoc,N.ShahLab,UCSF XiangDongYang,Ph.D.1997Cardiologist XiuYang,PhD2008Resident,WashingtonUniversity YuefangZhou,Ph.D.AssistantProfessor,DepartmentofNeurologyandPsychiatry,St.LouisUniversity,St.Louis,MO LixinZhou,Ph.D.1997Sr.ResearchAssociate,Pediatrics,UniversityHospitalsHealthSystems,Cleveland,OH TheresaZwingman.Ph.D.2000StaffScientist,AllenInstitute,Seattle,WA

26