LSEB407, 24 Cummington St., Phone: 3-3443, 3-3444 e-mail: jenwelin@bu.

edu Teaching Fellow: Shirley-Eva Sanchez LSEB 412 : 24 Cummington St., Phone: 3-6963 e-mail: sanchs@bu.edu

Class Time

Lecture: MTW: 9 - 11:30. (PHO201) Discussion: MW: 11:30-12:30 Neuroscience, 4th ed; Purves, et al. Lin: T: 11:30-12:30 TF: By Appointment Midterm 1: 30% Midterm 2: 25% Final: 30% Discussion attendance & participation (Mandatory): 15% BI108, BI203 (or equivalents with permission of instructors)

Textbook: Required Office Hours

Grading

Pre-requisites

Date 1 7/5

Topic Introduction Electrical Signals of Nerve Cells Voltage-Dependent Membrane Permeability Channels and Transporters Channels and Transporters Synaptic Transmission Synaptic Transmission Neurotransmitters, Receptors and Their Effects Molecular Signaling within Neurons Synaptic Plasticity Synaptic Plasticity; Review midterm1 The Somatic Sensory System Pain Vision: The Eye Vision: The Eye Central Visual Pathways The Auditory System The Vestibular System The Chemical Senses Lower Motor Neuron Circuits and Motor Control Upper Motor Neuron Control of the Brainstem and Spinal 12 7/27 Cord Review 13 8/1 Midterm2 Modulation of Movement by the Basal Ganglia Modulation of Movement by the Cerebellum Eye Movements and Sensory Motor Integration The Visceral Motor System Sleep and Wakefulness Early Brain Development Construction of Neural Circuits Modification of Brain Circuits as a Result of Experience Repair and Regeneration in the Nervous System Final

Chapter 1 2 3 4 4 5 5 6 7 8 8

Discussion ND

Wk1

7/6

7/8

7/1

Wk2

5 6 7

7/12 7/13 7/18 7/19

9 10 11 11 12 13 14 15 16 5

Wk3

7/20

10

7/25

Wk4

11

7/26

17

18 19 20 21 28 22 23 24 25

ND

Wk5

14

8/2

15

8/3

16

8/8

Wk6

17

8/9

18

8/10

Crick

Francis Crick, The Astonishing Hypothesis (1994)

Sydney Brenner

~1m

Golgi, Camillo
At this point, while I shall come back to this question later, I must declare that when the neuron theory made, by almost unanimous approval, its triumphant entrance on the scientific scene, I found myself unable to follow the current of opinion, because I was confronted by one concrete anatomical fact; this was the existence of the formation which I have called the diffuse nerve network.

Neuron doctrine

Ramn y Cajal, Santiago

True, it would be very convenient and very economical from the point of view of analytical effort if all the nerve centres were made up of a continuous intermediary network between the motor nerves and the sensitive and sensory nerves. Unfortunately, nature seems unaware of our intellectual need for convenience and unity, and very often takes delight in complication and diversity.
Britannica

Reticular theory

Localized protein distribution in neurons: (A) culture neuron: red:tau, Green: tubulin; (B) Developing neuron: red: actin, Green: tubulin. (C) Epithelial cell, red: actin; (D) astroglia cell, red: actin.

CNS: astrocytes and oligodendrocytes PNS: Schwann cells

CNS: astrocytes and oligodendrocytes PNS: Schwann cells

Astrocytes red: astrocyte specific protein

Oligodendrocytes green: oligo. Specific protein

micrglia Myelin: red Green: channels at node of Ranvier

 Cellular level 1. definitions and mental pictures of various parts of a neuron 2. Distribution of molecules can be very localized.

Important definitions: Divergence and convergence Local circuit neurons (interneurons) Projection neurons

(Afferent)

(Efferent)

Extracellular recordings

record

record

record

record

intracellular recordings

Circuitry level: 1. afferent, efferent, interneurons 2. excitatory and inhibitory synapses. 3. excitatory and inhibitory synaptic potentials. 4. time scale of AP and PSP, ms. 5. def. intracellular and extracellular recordings.

* * * * *

* *

* * *

*Gray matter * *
X

Blockage of Medullary branch of vertebral artery, not labeled.

Blockage of Medullary branch of vertebral artery, not labeled.