Collagen Peptide

(Collagen Hydrolysate)

It is usually made from type I collagen by an enzymatic hydrolysis process. Collagen is essential for the healthy growth and development of muscles, tendons and bones, giving structure to tendons, cartilage tissue, and connective tissue. Hydrolyzed collagen is mainly extracted from the bones and the skin from porcine, bovine and fish origin. FDA Safety approved Importance Our body produces and stores collagen protein during our youth; unfortunately, as we age, our collagen protein level decreases and our body cannot produce or rebuild the collagen level on its own. From the age of 25 our collagen levels reduce at about 1.5% every year as part of the aging process, as well as, the body's natural ability to repair supporting connective tissue (bone, joints, cartilage, tendons, ligaments, skin, hair and nails) begins to diminish. By the age of 45 our collagen levels will have been reduced by up to 30%. This reduction contributes to an increase in general aches and pains in our joints and muscles and longer recovery times from injuries. Amino-acid content The amino-acid content of hydrolyzed collagen is the same as collagen. Hydrolyzed Collagen contains 20 amino acids, including 8 out of 9 essential amino-acids (there is no tryptophan). It is characterized by the predominance of glycine, proline and hydroxyproline, which represents around 50% of the total amino-acid content. Glycine and proline concentration is 10 to 20 times higher than in other proteins. Amino-acids Percentage Proline/Hydroxyproline Glycine Glutamic acid Arginine Alanine Essential amino-acids Others 25% 20% 11% 8% 8% 16% 12%

Health benefits Hydrolyzed collagen is a highly digestible protein, and an oral ingestion has been reported as having beneficial effects on joint & bone health, on skin health and for weight management and sports performance. Digestibility The bioavailability of hydrolyzed collagen has been demonstrated by many studies.

In a study of 1999, scientists demonstrated on mice that more than 90% of orally administered 14C labelled hydrolyzed collagen is digested and absorbed in 6 hours after ingestion. An important part is accumulated in cartilage and skin. In another study of 2005, scientists showed that the hydrolyzed collagen is absorbed in small peptides in the blood. Joint & Bone Health The action of hydrolyzed collagen on joint health is probably the most studied. Some clinical studies report that the oral ingestion of 10g of hydrolyzed collagen by day decreases the joint pain, and that patients having the most severe symptoms benefited more. Any beneficial action is probably due to the fact that hydrolyzed collagen is accumulated in cartilage and stimulates the production of collagen by the chondrocytes, the cells of cartilage. On bone health, several studies have shown that a daily intake of 10g per day of hydrolyzed collagen for 4 to 24 weeks increases bone mass density. It seems that hydrolyzed collagen peptides stimulated the differentiation and the activity of osteoblasts, the cells that build the bone, instead of osteoclasts, those that destroy it. Collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis. Its high level of safety makes it attractive as an agent for long-term use in these chronic disorders. (PM-11071580) Uses: Collagen Hydrolysate can play a vital role for those individuals at risk of developing joint disease. Such at-risk populations include: older individuals, especially 50 years or older; being overweight; those whose occupational activities predispose to osteoarthritis (ex. jobs involving repeated knee bending); those with a history of significant joint or ligament injury; and individuals with a family history suggesting a genetic predisposition to any form of arthritis. Collagen Hydrolysate can even benefit individuals who already suffer from degenerative joint disease and arthritic conditions by reducing inflammation, decreasing pain, (thus reducing pain medications) and improving joint function, flexibility and mobility. Competitor Review 1. COLLAFLEX (Universal Medicare) Each Sachet contains 10.2 g of Hydrosylate Collagen