Books Received

Handbook of Chemistry and Physics, 57th ed., 1976-1977, R. C. Weast, Ed., CRC Press, Inc., 18901 Cranwood Parkway, Cleveland, Ohio 44128 (cat. No. 457). $34.95. Received Aug. 1976. We are delighted to direct your attention to the latest edition of this bulky classic, well known to all chemists and physicists as authori-

tative and definitive. Its price makes

it one

of the few bargains

extant,

certainly among reference books of

this caliber.

The Sorvall#{174}RC-3 spinsmore RIA tubes faster than any other refrigerated centrifuge.

Physicians Desk Reference for Radiology and Nuclear Medicine. 6th ed. M. D. Blaufox and L. M. Freeman, Editorial Consultants. Medical Economics Co., Oradell, N. J. 07649. x + 187 pp. $10.00. Pub. 1976.

The Soil Factor in Nutrition:Animal

and Human (Nutrition and Clinical Nutrition Series, Vol. 2). K. C. Beeson
and G. Matrone, Marcel Dekker, Inc., New York, N. V. 10016. xiv + 152 pp.
Pub. 1976. Self-Assessment of Current Knowledge in Clinical Biochemistry, 2nd ed. $19.75.

M. A. Brewster.

Med. Examination

Pub. Co., Inc., Flushing, N. Y. 11365.

174 pp. $8.00. Pub. 1976. Consists of 500 multi-choice questions and referenced explanatory answers. Most of the questions come from examinations in biochemistry from School of Medical Technology, University of Arkansas (where AACC member Brewster is an assistant professor). Useful for teaching purposes or to find out, without embar-

rassment, how much or how little you

know about the subject.

Nursing Assessment and Health Promotion Through the Life Span. R. Murray, J. Zentner, et al. Prentice-I-tall, Inc., Englewood Cliffs, N. J. xiii + 354 pp. Paperback. Pub. 1975. Death: The Final Stage of Growth. E. Kubler-Ross. Prentice-Hall, Inc., Englewood Cliffs, N. J. xxii + 181 pp. Paperback. Pub. 1975. Drug-Inactivating Enzymes and Antibiotic Resistance. 2nd International
Symposium on Antibiotic Resistance (Castle of Smolenice, Czechoslovakia, 1974). S. Mitsuhashi, L. Rosival, V. Krcmery, Eds. Springer-Verlag

The Soivall#{174} refrigerated centrifuge has a capacity RC-3 of 280 tubes from 10 x 75 mm to 12 x 75 mm. And it can spin them at speeds to 5,250 rpm and forces to 7,120 x g. Equipped with the Sorvall#{174} Tube Rack Rotor, the HL-2 RC-3 accepts all standard multi-tube racks from major manufacturers. And since you can load the racks directly on the rotor without removing the tubes, its possible to prepare one rotor load while another is being centrifuged. Another rotor, the Soivalltm HL-8, takes multiplace inserts to make loading rapid and efficient And Du Pont offers a full range of Sorvall#{174} accessories designed to let you handle almost any combination of tubes. To find out in more detail how the Sorvall#{174} can make RC-3 your RIA work more efficient, write Du Pont Instruments, Room 24021C,Wilmington, DE 19898.

New York Inc., New York, N. Y. 10010. xiii + 493 pp. $42.20. Pub.
1975.

Glutathione: Metabolism and Function. Kroc Foundation Series, 6. I. M. Arias and W. B. Kakoby, Eds. Raven Press, New York, N. V. 10036. xii + 382 pp. $24.00. Pub. June, 1976.

Du PontInstruments
CIrcle No.69 on Reader.

Service

Card

CLINICAL CHEMISTRY,Vol. 23,No.2,1977 311

Fcte

Proc
I

cTh

@llfiafi@1ll
Compiled by J. S. King, Executive Editor

Student Travel Grants

The Committee on Education, AACC, has budgeted $1500 for 1977 to assist pre- and postdoctoral students to travel
to the national meeting of the Association. This amount has been designated by the Education Committee to provide 15 one-hundred dollar student travel

Changes in Qualifications

following
perience
in

additional
Qualifications

Professional

Ex-

for Certification by ABCC

In keeping with its charter to establish and periodically standards for Certification, obligations

for Certification

Toxicological Chemistry of current

to enhance
the Ameri-

grants.

Directors

toral programs

of pre- and postdocare requested to submit

the names of students in their program

desiring to receive these grants on a priority basis (i.e., first, second, third, etc., recommendation). The students are then required to request such grants by writing to the Chairman of the Sub-

can Board of Clinical Chemistry (ABCC) has established new Professional Experience Qualifications for Certification in Clinical Chemistry, effective July 1, 1977. The following compares existing and new Professional Experience Qualifications for new applicants for Certification in Clinical Chemistry. (Corresponding requirements exist for Certification in Toxicological Chemistry): Until June 30, 1977 1. All applicants must possess

ABCC diplomates in Clinical Chemistry, which became effective April 15, 1975: Persons who hold a current Certificate of Qualification in Clinical Chemistry issued by ABCC must have, sub. sequent to issuance of that certificate, satisfactorily completed at least one

year of postdoctoral training in toxicological chemistry in an ABCC-accredited program or acquired at least one year of acceptable full-time experience
in toxicological chemistry (or part-time equivalent thereof). Corresponding requirements exist for

committee on Continuing Education. The names of 15 of those students receiving a first priority recommendation
will then be drawn by lot from a pool

Certification in Clinical Chemistry of ABCC diplomates in Toxicological

at least Chemistry.

containing all their names. The first 15 chosen will be awarded the travel grants. Those chosen may meet each morning, Monday through Friday, during the
national meeting with a member of the Education Committee at breakfast

three years of acceptable full-time experience in clinical chemistry (or parttime equivalent thereof), acquired subsequent to receipt of the doctoral degree.
2. Applicants must have completed the professional experience requirements prior to 6/30/77, and applications

roundtables

from 7:30-8:30 a.m. to dis-

cuss the various employment avenues open to clinical chemists. Students eligible for the travel grants must either be members or student
members of the American Association for Clinical Chemistry. Directors of the academic program must also be members of AACC. Only one travel grant will
he given to a program fewer than 15 programs unless there are requesting this

Other qualifications and requirements for Certification remain unchanged. Full details are available from Dr. John Savory, Secretary-Treasurer, American Board of Clinical Chemistry, Clinical Chemistry Laboratory, North Carolina Memorial Hospital, Chapel Hill, N. C. 27514, Tel: (919) 966-2361.

must

be received

by ABCC

by that

date.
Effective July 1, 1977

Two New Proposed Standards from NCCLS

The National Committee for Clinical Laboratory Standards [described in Clin. Chem. 21, 1531 (1975)] has issued two new Proposed Standards: Guidelines for standards to assess the quality of radioimmune assay systems (PSLA-1) and Standard for determining spectrophotometer performance criteria (PSI-3). Price of each is $4, from NCCLS, 771 E. Lancaster Ave., Villanova, Pa. 19085.

1. General applicants must possess at least five years of acceptable full-time experience in clinical chemistry (or part-time equivalent thereof), acquired
subsequent to receipt of the doctoral degree. 2. Persons who have satisfactorily

assistance. The deadline of May 1, 1977, has been set for receiving applications

for these grants to assist in travel to the meeting i#{174} Chicago, illinois, July 17-22, 1977.Students residing within 50 miles of Chicago will not be eligible for the travel grants.
Program directors
graduate

completed

an ABCC-accredited

pre-

doctoral training program, or who have satisfactorily completed at least two years of postdoctoral training in an

are requested

to

ABCC-accredited program, must possess at least four years of acceptable

full-time experience in clinical chemistry (or part-time equivalent thereof),

submit their recommendations

dents

Role of the Clinical

Chemist in the U.K.
The registrars in clinical biochemistry
at Addenbrookes Hospital, Cambridge, organized a symposium in October on clinical biochemistry and the medical

for their

students, and graduate stuare requested to submit their written request for a travel grant to:
Herndon G. Shepherd, Ph.D.,
Chairman

of Subcommittee on Continuing Education, AACC Education Committee,

Mason-Barron Laboratories,

acquired subsequent to receipt of the doctoral degree. Postdoctoral education/training can be part of such experience.
The Board, in order qualified clinical chemists to encourage to document

graduate.

Thirty-seven

medical gradu-

West Montrose Ave., Tel: (312) 282-9500.

Inc., 4720 Chicago, 111.60641,

their additional qualifications in toxicological chemistry, has established the

ates in training and 14 seniors, including seven professors met. Says Lancet (Oct. 30, 1976, p 945):

CLINICAL CHEMISTRY,Vol.23, No.2,1977 317

to the surprise of some, individual trainees disagreed about the importance of clinical contact. Some had the laboratory as their main base, but were caring for patients with diseases of which they had special knowledge. Others had no direct patient responsibility, but were often at the bedside helping in the interpretation of biochemical results. Yet others were mainly engaged in pure scientific research. The symposiasts regarded this variety of interest as valuable and to be encouraged. One speaker described the clinical biochemist as a jack of all trades, but master of one. The special interest, whether predominantly scientific or clinical, should begin during a period of training in research. An improved recognised-training scheme would do much to attract new recruits. It could be in two parts, the first providing a comprehensive basic training and the

to obtain Continuing Education Units under the ACCENT Program, a Workshop-Seminar-Symposium Program has been designed to encourage the local
section officers to organize activities for their members. The national Education Committee of AACC has budgeted funds to encourage programs of this type. These funds are available to the local sections upon application and may

be used as seed money to develop the program. For further information on the
Workshop-Seminar-Symposium Pro-

gram, and to obtain application forms, please contact: Herndon G. Shepherd,

second allowing for development of the special interest. The first would include both laboratory training-analytical techniques,
personnel management, clinical measurement (e.g., use of radioactive tracer techniques in the study of metabolism)-and a period of clinical responsibility to gain experience in the clinical management of biochemical disorders. Part of this time would be spent in the laboratory and wards of a district general hospital. The second part of training, perhaps leadingto an M.D. or Ph.D. in the trainees special interest, should probably be in a teaching hospital. Increased

Edwin C. Whitehead
Technicons

Ph.D., AACC Education Committee, Mason-Barron Laboratories, Inc., 4720 West Montrose Ave., Chicago, 111.60641, Tel: (312) 282-9500.

Medical Information

Sys-

tem.
the The proceedings were enlivened by chance to see and listen to some speakers that are well known: Robert Good (Sloan-Kettering), Paul Astrup (Rigshospitalet, Copenhagen; winner of the first Leonard Skeggs Award for

Status of Selected Methods, vol. 8

We are informed that libraries and individuals have asked when this volume is to appear. The desire of the authors of two chapters to acquire and incorporate

outstanding

contributions to medical knowledge through laboratory practice),

more data has prolonged the transition from journal article to bound volume [see Clin. Chem. 19, 1207 (1973)] more
than was anticipated on Selected Methods. by the Committee

contact with the Royal College of Pathologists would also be welcome during the training period. Two speakers suggested joint clinical! laboratory training appointments, possibly on a rotational basis. (Such posts could be valuable to physicians in training, as well as to clinical biochemists.) The laboratory would benefit from increased clinical contact and the medical clinical biochemist in training could achieve in this way the clinical part of his basic training. In research, too, there was room for increased cooperation between laboratory staff and clinicians. Yet the medical clinical biochemists should be sure not to lose their important links with other pathology disciplines. There was no evidence, the meeting felt, of a decline in the importance of medical graduates in clinical biochemistry, even though many posts remained unfilled. Growth of the specialty depended on more attention to the laboratory!clinical

(CDC Director, whom the public became acquainted with on their

David Sencer

TV screens during the Legionnaires disease episode), John Knowles (President of the Rockefeller Foundation), and others.

This is to re-assure

our readers that

The other

major

attraction

was

this volume will be issued; we now plan on its release in early Fall. It will be announced in this section of the journal and elsewhere in due course.

Technicons unveiling of innovative first-generation instrumentation, most notably their desk-top STAC (Single

Test

Analyzer

with

Computer)

sys-

Microfiche Version of Clinical Chemistry: A Reminder

New and old (1973)] readers

connection.

tem-stick in the sample and read the print-out-their SMA Il-ditto, 90 1.2-gil samples per hour, it is claimedand their Automated RIA System, which processes results in 15 minutes. The principle of the last is especially ingenious. Its key feature is a separation technique in which antibodies are bound to tiny iron particles. At the appropriate step in the process, the serum being

[The Clinical
19, 1236

Chemist,
that

are reminded Clin. Chem.

this

journal is

available in microfiche form. Foreign (except Canada) readers can subscribe to the journal in this form for the same price as for the regular version: $30 per 12-issue volume. The microfiche version
of each issue, released only a few days after the regular version, is air-mailed to the subscriber. Canadian and American subscribers can arrange to receive the

Technicon International
Congress

analyzed passes an activated magnet and the iron particles with antibodies
attached-and at this stage antigens as well-are separated instantly from the remaining materials. They are then read by a built-in radioisotope counter and processed with a built-in calculator. These and other developments will be

microfiche version, but must also subscribe to the regular hard-copy edition (combined price: $42). Orders should be
directed Business to our Office. Washington, D. C.,

Most of our readers are familiar with the Congresses that Technicon Corp. has sponsored over the years, beginning with one in Frankfurt/Main in 1964. Understandably devoted almost exclusively to continuous-flow analysis (still synonymous with AutoAnalyzer), these meetings have progressively increased in elaborateness and elegance,
and the proceedings of each have been published in book form by Technicon. The 1976 Congress was the most ambitious yet. About 4000 persons gathered at the New York Hilton on December 13-15, to hear some 180 papers on all
aspects of continuous-flow analysis medicine and industry, plus reports
318 CLINICAL CHEMISTRY,

further described, no doubt, in the advertising pages of this journal. We of course await with pleasure the published version of the whole Congress.

Progress in Standardization on the Continent

The Commission M#{233}thodes r#{233}f#{233}rde ence, Comit#{233} Standardisation, de Soci#{233}t#{233} de Biologie Clinique, has Fran#{231}aise published two announcements [Ann.
Biol. Clin. 34,235-239 (1976)] that will interest clinical chemists throughout the

Local Section Activities in Continuing Education

The members of the national Education Committee wish to remind the members of the local section executive committees that we are anxious to complement your continuing education programs for local members. In order for the membership

world. The first, on reference

and se-

in on

lected methods in clinical biochemistry, lists documents released [Ann. Biol. Clin. 33, 51(1975) on terminology; and Inform. Sci. Biol. 1, 12 (1975), on stan-

Vol. 23, No. 2, 1977

dardization and standards] and those about to be released or in preparation.

The second is a description of (a) the precise categorization of types of methods [cf. Clin. Chem. 22,532(1976)],
the criteria that a method proposed as a selected or definitive method must meet, and (c) an outline of the recommended description of a selected
(b)

condensation of peptide fragments instead of amino acids. Following repeated practice guided by the spirit of independence and self-reliance, we succeeded in synthesizing first of all a new supporting medium which provisionally met our reqwrements. We shall describe in the present paper the successful total synthesis of the nonacosapeptide glucagon using this supporting medium.

Drake

expects

to

expand

it into

book.
Suffice it to say here that the search by epidemiologists, bacteriologists, virologists, toxicologists, chemists, et al.

method

in clinical

biology.

The protocol of classification and the choice of a selecte4 method are to appear in the publications of the French and German societies. Other countries can participate in the choice. The selected methods will then be published in the journals of the various societies. The projected program was described to other European societies of clinical chemistry at Biochemische Analytik 76 in Munich, and their cooperation was sought in this difficult and important work. A selected method for measurement of serum iron will be published in Inform. Sci. Biol. as soon as the counsel of the participating biologists has been

The other journal we receive is the

Medical Journal, an 80-p bimonthly, entirely in English. Its contents bears out observers comments
that medicine in China places great

was variegated, highly competitive among (and sometimes within) disciplines, but was finally unsuccessful, when this account was written, and that it taught everyone a number of lessons
in hindsight about how future all-out

Chinese

emphasis on day-to-day and down-toearth problems, and on investigation and use of traditional and indigenous drugs. Typical titles in recent issues are Shoulder-Pole Clinics, Chiangchen Communes Barefoot Doctors (a photo piece), How Women and Child Health Work is Promoted in Our Country, and Pharmacologic Study and Clinical
Observations on Muscle Relaxant

searches of this kind, the impediments to which are clearly described, could better be prosecuted. The mystery is now partly solved, it is believed, but a moral to the story is that, even with all the most sophisticated tools and minds brought to bear on the problem such as this, nature is still so subtle that mans imperfect mastery can still be unnervingly demonstrated. It should keep us humble.
-J.S.K.

compiled.

Chi Sung. These in addition research pieces of a more conventional (to Western eyes) nature. A very considerable proportion of each issue is oc-

Han to clinical

OMalley New Oxford Labs. President

Dr. John A. OMalley, chairman of the Northern California section of AACC,
has been promoted to president of Ox-

Insights into Biochemistry and Clinical Chemistry in the Peoples Republic of China
The non-Sinologist catches only glimpses of what things are like with respect to science and scientists in the PRC, usually from accounts by visitors, such as that provided for us a year ago by Lilla Sun [Clin. Chem. 22, 281 (1976)] or the privately prepared
diary-transcript count appears account (a briefer acin the Duke Alumni

cupied by politically oriented inspirational and directive articles, such as Upholding Dictatorship of the Proletariat and Deepening the Revolution in Health Work, A Great Victory (the appointment of Hua Kuo-feng as First Vice-Chairman of the Central Committee of the Party and Premier of the

ford Laboratories Inc., manufacturer of laboratory instruments and diagnostic tests. He has been vice president (chemistry) since joining Oxford in
1973.

State
Correct

Council,

PRC),

and Reversing

Before joining Oxford, Dr. OMalley

was vice president of research and development with Harleco, a division of

Verdicts Goes against the Will of the People (the title is a quotation from Chairman Mao; the piece discusses

the American

Hospital

Supply Corpo.

Magazine) by Technicons Board Chairman Edwin Whitehead, of which he kindly sent us a copy. Other conceptions are provided by
journals, of which this office receives

such attempts tionists).

by

Right

devia-

However different the approach to

biochemistry and medicine in the PRC, from all accounts it seems to be working for them, certainly better than in some other parts of the world (as described in

two, by exchange. One of them is Acta

Biochimica et Biophysica Sinica, in Chinese, with abstracts (and most references) in English. The December 1975 issue (7/2) was received on December 24, 1976, and includes a typical abstract of apparently sophisticated work by the

the continuing series in Hospital Practice). For example, it seems fair to say
that essentially everyone in the PRC has easy access to medical care-and runs

no risk of being impoverished

by it.
-J.S.K.

Protein Synthesis Group at the Shanghai Institute of Biochemistry, quoted here in part: which is

Chairman Mao taught us, One should seriously sum up ones experience. Looking back at the experiences of our own and of others in the past decade or so on the total synthesis of proteins and p0lypeptides, we have analyzed the inherent contradictions of the two alternative routes of synthesis on the basis of the dialectical viewpoint of one divides into two. Either the solid phase or the solution synthesis is fraught with difficulties when the target exceeds 100 amino acids. A new synthetic strategy was developed which we believe could resolve the contradictions inherent in the synthesis of large peptides-the solid phase stepwise

Legionnaires Diseasea Postscript

In the Sunday, Nov. 14, Review and Opinion section of The Philadelphia Inquirer, medical writer D. C. Drake

John A. OMaIIey ration in Philadelphia. He was formerly assistant professor of chemistry at

expertly summarized, in a five-page piece, the scramblings by city, state, and

federal (CDC) investigators to unravel the mysterious etiology of the malady that so fiercely struck a state convention of American Legionnaires at the Bellevue Stratford Hotel in Philadelphia in late July and early August 1976. A CDC official assures me that the
account is accurate, and thinks that Mr.

Drexel University.
Dr. OMalley received the Ph.D. degree in physical chemistry from the University of Pennsylvania and the B.S. degree in chemistry from Rutgers. He is treasurer of the National Committee for Clinical Laboratory Standards and a member of several scientific associations. He has published numerous articles and a book on chemistry.
319

CLtNICALCHEMISTRY, Vol.23,No. 2, 1977

Early Professional Recognition The Awards Committee of the Chicago Section, AACC, is providing information and receiving submissions for the Young Investigator Award in Clinical Chemistry, which is being sponsored by Hycel Corporation, and is to be given during the 29th national meeting. The Committee
will

Expenditures for Health and Medical Care under Public Programs of Social Welfare
Year 1950 1960 Federal Millions $ 1362 2918
16600 39863 Note

tion contains
descriptive chemicals,

First published in 1889, the new edinearly 2000 pages listing

monographs drugs, and alphabetically of some 10000

biologicals
by generic

ar-

State and Local

Millions

ranged
volume index,

or

nonproprietary
comprises Chemical

name. In addition, the

500 organic name reof names, formula Abstracts registry

1704
3478 8791 18 957

actions, a cross-index
numbers, formation
chemists, physicists,

is convinced

that

each

entrant

receive educational,

professional,

1970 1976
-excerpted
tistics
DHEW,

and spiritual benefits by participating. This should encourage every clinical chemist younger than 35 to submit an application for the Award. Details appear on page 1947, November 1976 issue of Clinical Chemistry. Call or write for further details Alfred H. Free, Ames Co., Division Miles Labs., Elkhart, Ind. 46514, Tel: (219) 262-7339.

and a variety of tabular inof value to chemists, bio-

from Research and Sta(no. 22, Dec. 2, 1976), USOffice of Research and Statis-

pharmacists,
chemical

botanists,
and

engineers,

others interested

in the life sciences.

tics. Advertising and Reality

We received a flyer from our friends at Instrumentation Laboratory, Analytical Instrument Division, Jonspin Road, Wilmington, Mass. 01887. It describes
the IL 751 dual-channel atomic absorption spectrophotometer to be introduced at the Pittsburgh Conference in March. It says, among other things, We do not wish to est. We believe that one of the five most the history of atomic appear unduly modthis introduction is significant events in absorption spectros-

Meetings
An International Forum on Assay of Biological Samples for Drugs and Other
Drug-assay Bioanalytical forum.

The cross-index of names of over 50000 synonyms represents chemical, trivial, generic, and trademark names of the compounds listed in the monograph section. More than half of the monographs are illustrated with modern, stereochemical structural formulas, and 7500 offer information on general, medical, or veterinary uses as well as
toxicity. Monographs also embrace data such as molecular weight, percentage composition, literature references, physical data, derivation, and trademark owner. In the 9th edition almost
1000 monographs are new and more

Trace Compounds will be held at the

University

London),

of Surreys new campus (near on Sept. 12-15, 1977. Topics MS as an assay tool,

include HPLC, method development,

GC technology,

than 5500 have been revised and updated with titles conforming to latest
USAN and WHO
book

comparative
analytical

effectiveness
approaches.

of various

copy.
Although other two-channel atomic absorption instruments have been introduced in the past, one as long ago as 1967,

nomenclature.

Practical work opportunities. Registration: #{163}33. Write University of Surrey, Wolfson Bioanalytical Centre, Guildford GU2 5X1L U.
K.

all have suffered from drawbacks which

prevented their realizing anywhere near their full potential. Please forgive us for any note of boastfulness that you may detect in this letter. We are so proud of the IL 751 that we could bust (and perhaps we will).

International Society for Clinical Enzymology. The Inaugural Meeting of

this society will be held in London, U.

K., on September 19-21, 1977. Further particulars may be obtained from Professor J. H. Wilkinson, Department of Chemical Pathology, Charing Cross Hospital Medical School, Fuiham Palace Road, London, W6 8RF, England.

is available from Merck at $18 (U. S.) or through any scientific book dealer worldwide. Merck & Co., Inc. also publishes The Merck Manual, a physicians handbook of diagnosis and therapy, and The Merck Veterinary Manual, a veterinarians handbook of animal disease and treatment.

The

International Symposium Hormones, 18 and 19 June

on Gut 1977, Lauof the first

sanne, Switzerland.
anniversary

To mark the 75th

of the discovery

hormone by Bayliss and Starling, an international symposium sponsored by the Widmar Foundation will review the

whole field of gastrointestinal

mones. Each hormone will be depth and the wider clinical tific implications discussed tensive sessions. Topics:
Evolution/Developmental,

hor-

Claimed improvements include doubled analytical speed (two elements are analyzed for at a time), greatly improved accuracy, and simplified sample preparation. The instrument includes a microcomputer and printer-sequencer. Such claims seem to us to warrant mention in this space, but wed be interested to know (preferably in the form of a paper) if users of this instrument agree, or if the boys at IL just got carried away.

Handbook of Mass
Spectra Contracted
The U. S. Environmental Protection Agency (EPA) has contracted with the American Chemical Societys Chemical Abstracts Service to produce a Mass Spectra Handbook corresponding to the content of the EPA/National Institutes of Health machine-readable mass spectral data base. The handbook will contain mass spectra for approximately 30000 substances along with the substances structure diagrams, names, molecular formulas, molecular weights, and CAS Registry Numbers. It will include previously unpublished mass spectral data. The handbook will be compiled and organized entirely by computer and composed through CASs computerdirected photocomposition system. Mass spectra in the handbook will be generated and photocomposed from computer-readable data provided by

covered in and scienin eight inChemistry, Techniques,

CK-LDH isoenzymes Workshop

Helena Laboratories, 1530 Lindbergh Drive, P. 0. Box 752, Beaumont, Tex.
77704, is holding a series of 20 workshops in major U. S. cities, January 24 to February 25. For information, call tollfree (800) 231-1430 (or in Texas call collect (713) 842-3714).

Secretin,

Motilin,

CCK,

Pancreatic

Polypeptide, GIP, Gastrin, Glucagon, Paracrine/Neurotransmitter system, VIP, Somatostatin, Neurotensin/Bom-

besin/Sub P/Endorphins, Duodenal Ulcer, Endocrine Tumours. Organising Committee: S. R. Bloom, P. Menat, J. M. Polak, and J.-P. Felber. Write for further information to Dr. S. R. Bloom,
Department of Medicine, Hammer-

The Merck Index, 9th EdItion, 1976

The 9th edition of The Merck Index, the familiar and valuable encyclopedia of chemicals and drugs, was published in October 1976 by Merck & Co., Inc., Rahway, N. J. 07065.

EPA. Names and molecular formulas

will be extracted automatically from the

smith

Hospital,

Du Cane Road, London

W12 OHS, U.K.

CAS Chemical Registry System, and most structure diagrams in the handbook will be generated algorithmically

320 CLINICALCHEMISTRY,Vol. 23, No. 2, 1977

.2

5 Thyro Specialist arrange an appoint- I istrate the Ames SERATEKe Thyroid Anti-

nai information about Ames SERA-TEK sts.

(ptease print)

Slale one

Zip

from connection table records stored in the CAS Registry files. The handbook is being produced by CAS under an extension of a contract with EPAs Management Information and Data Systems Division under which CAS has been registering chemical substances in various data files, including the mass spectral data base, and providing Registry Numbers, names, and connection tables for use in the

courses in a 33-p catalog. Courses include audio, film, teaching aids. Subjects include spectroscopy, chromatography. Write American Chemical Society, Educational Activities Dept., 1155 16th St., N. W., Washington, D. C. 20036.

Lipoxygemc Micromethod for Specific

Determination of Lipase Activity in Serum and Duodenal Fluid Henning F. Proelss and Bffly W. Wright Use of Equilibrated Blood for Internal Blood-Gas Quality Control Elizabeth Teng Leary, Collene J. Delaney, and Margaret A. Kenny Evaluation of a Semi-Automated Blood Urea Nitrogen Analyzer Daniel J. Hanson and Nancy S. Bretz Alkaline Phosphatase Activity in the Plasma of Children and Adolescents Gerard A. Fleisher and Lila R. Elveback Extraction and Measurement of Circulating Angiotensins I and II Jack D. Barrett, Peter Eggena, and
Mohinder P. Sambhi

Information Needed by Ochsner Biographer

For a biography
Ochsner Clinic,

NIH/EPA
contract

Chemical Information
since 1974.

Sys-

of Dr. Alton Ochsner of New Orleans, opinions,

tem. CAS has registered approximately 100 000 substances for EPA under this

Useful Information
New 6-page Beckman Guide to UV/Vis Cells provides spectrophotometric analysis with valuable, practical information. A section on choice of proper cells considers window material, pathlength, volume, and flow cells. Details are tabulated for easy, concise reference.
A section prevention

evaluations, anecdotes, reminiscences, photos are needed. Photos will be carefully handled and returned. All material will be gratefully received by: Ira Harkey, Ph.D., 401 Metairie Road, 706, Metairie, La. 70005.

Forthcoming Papers
Evaluation of Serum Triiodothyronine

on how to clean and maintain of cell deterioration. Pho-

and Adjusted Triiodothyronine (Free Triiodothyronine Index) in Pregnancy Margaret E. Parslow, Thomas H. Oddie, and Delbert A. Fisher
$-Lipoprotein Cholesterol with Polycations
C. C.

Hydrolysis of Steroid Glucuromdes

C-Glucuronidase Preparations Bovine Liver, Helix pomatia,
coli Volkmar Graef, Etsuko Osamu Nishikaze

with from and E. and

UV/Vis cells covers causes, effects, and tographs illustrate commonly used cells. For a free copy of the Guide, write
Beckman Instruments, Inc., Technical

Quantitation

Furuya,

Heuck and G. Schlierf Separation of Serum Creatine Kinase Isoenzymes by Ion-Exchange Column
Chromatography

Information Section, Scientific Instruments Division, 2500 Harbor Blvd.,

Fullerton, Calif. 92634.

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Urinary Free Norepinephrine and Dopamine Determined by ReversePhase High Pressure Liquid Chromatography Leroy D. Mell and Anthony B. Gustafson

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