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Casediscussions

DrSubhashKumarMD,DM AssociateConsultantNeuroradiology

31yearsoldmale k/c/oGilbertsyndrome45years Suddenonsetgiddinesson06/12/2011 Progressiveneurologicaldeterioration AdmittedatSBAMItracheostomised,stable vitals

Gliomatosiscerebri Multifocalglioma

AnaplasticOligoastrocytoma

NeuroepithelialTumorofUncertainOrigin Atleasttwolobes(esp.cortex)maybediffusely infiltratedwitharelativelackofmasseffectand distortion(i.e.,preservationofneuronal architecture) Peakageis40to50years,butoccurinalladult agegroups. WHOclassificationisgradeIII. Itisnotuncommontohavethefrontaland temporallobesinvolvedwiththebasalganglia andthalami.

The neurobiology of gliomas: from cell biology to the development of therapeutic approaches Manfred Westphal & Katrin Lamszus. Nature Reviews Neuroscience 12, 495-508 (September 2011) doi:10.1038/nrn3060

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