RENEE M.

CHABIN
Neptune, NJ 07753 seaview206@gmail.com SUMMARY Biochemist/Research Scientist with a broad background in biologics, immunology, infectious diseases, diabetes, obesity, and automation in the pharmaceutical industry. Extensive expertise in small molecule characterization, enzymology, enzyme and cell based assay development and optimization, assay automation and miniaturization, purification, and data management and organization. Self-motivated and a strong individual and team contributor with excellent organization, communication and problem solving skills. Masters in Chemistry. TECHNICAL SKILLS Assays HTRF, RIA, ELISA, SPA, Receptor Binding Chromatography HPLC (SEC, IEX, RPC, Affinity), FPLC, Gel Electrophoresis, Western Blotting Spectroscopy- UV/VIS, Fluorescence Liquid Handling Hamilton Star/Starlette, FRD, Mosquito, Multidrop PATENTS, PUBLICATIONS, PRESENTATIONS. 2 patents, 28 publications, 18 posters & presentations PROFESSIONAL EXPERIENCE MERCK & CO., INC., Rahway, NJ 1989 2011 Research Associate/Biologics Research-Analytical Development, GlycoFi, Inc. (A Wholly owned subsidiary of Merck & Co., Inc.), Lebanon, NH (2009 2011) Managed and developed assays for analysis of glycoengineered Pichia Pastoris yeast strains as potential therapeutic biologics. Interpreted, analyzed, deployed and managed all generated data in a timely manner. Joined the data management team to help develop and reorganize all existing data generated and organize the input of all future data for easy access. Ran key O-glycan assay to determine the humanization of the engineered yeast strains and which strains would move forward toward drug development. Determined and reported endotoxin values for purification group. Research Associate/Facility for Automation & Screening Technology, Rahway, NJ (2007 2009) Coordinated and implemented assay support for various basic research therapeutic areas. Work included assay transfer from the therapeutic area, where the assay format was optimized and miniaturized using robotics. Small molecule Medicinal Chemistry compounds were screened and titrated for potency. Generated, analyzed, managed and reported all results to the therapeutic areas and the on-site data base. Worked with cross-departmental teams to ensure the smooth transition of all information from the therapeutic areas. Developed, miniaturized, and automated an endpoint assay for a key Diabetes program which increased the screening throughput of small molecules by 4-fold and data turnaround by >50%. Contributed to the transfer of a difficult Diabetes assay to the main screening facility in less time than was allotted and was awarded the Merck Award for Excellence in 2007.

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RENEE M. CHABIN
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Research Biochemist &Research Associate/Department of Diabetes, Rahway, NJ (1999 2007) Managed, developed, optimized and provided enzymology assay support for the development of potential Type II diabetes and obesity small molecule drug candidates. Generated, analyzed, reported, and coordinated data cross-departmentally with animal research and medicinal chemistry. Developed, optimized, implemented and supported an assay for adipose derived protein Acrp30 for use as a potential phase I clinical biomarker for the identification of Type II diabetes. o Determined the therapeutic effectiveness of small molecules approximately 10 times faster than animal studies by correlating plasma/serum Acrp30 levels to glucose lowering. Awarded Merck Rahway Research Recognition Award in 2005-2006. Isolated RNA for molecular profiling for the identification of new small molecule targets in Diabetes and Obesity. Identified and characterized a 10-fold more sensitive substrate for the Insulin Receptor Activator program, increasing the assay sensitivity and window of measurement for small molecule screening. Awarded Merck Special Achievement Award in Diabetes in 2000. Developed both a radioactive TCA precipitation and HPLC assays for the Insulin Receptor Activator program to quantify bound vs. unbound substrate. Research Biochemist/Department of Endocrinology & Chemical Biology, Rahway, NJ (1992 1999) Developed, optimized and provided enzymology assay support for the development of potential inflammation and antibacterial small molecule drug candidates. Generated, analyzed and reported all results to the therapeutic areas and the on-site data base. Contributed to the set-up and development of the Murein pathway assay of the 6 Stage I enzymes involved in bacterial cell wall biosynthesis, which increased the screening throughput of small molecules 6-fold. o Featured in the American Chemical Society January 4, 1999 publication Chemical & Engineering News. o Automated and miniaturized screening for the discovery of new and novel antibiotics. o Received the Merck Award of Excellence in 1996 and a patent for this methodology. o Developed HPLC methods for each individual Mur enzyme (C-F) for fast and easy target identification. Assayed and titrated small molecule compounds towards the development of a selective inhibitor of inducible Nitric Oxide Synthase (iNOS) for the treatment of rheumatoid arthritis. o Investigated the mechanism of action of iNOS using kinetic and spectroscopic methods. Staff Biochemist/Department of Biochemistry & Enzymology, Rahway, NJ (1989 1992) Developed, optimized and provided enzymology support of assays for the development of potential inflammation small molecule drug candidates. Assayed and titrated small molecule compounds towards the development of specific Human Leukocyte Elastase (HLE) inhibitors for the treatment of chronic emphysema. o A potent selective compound advanced to Phase III Clinical trials and received Key Research & Development Program Award in 1995 for contributions. o Kinetic and spectroscopic methods were used for the analyses of inhibitor/HLE interactions. o Automated assay using Zymark Robotics.

RENEE M. CHABIN
seaview206@gmail.com PROFESSIONAL AFFILIATIONS American Chemical Society American Association for the Advancement of Science PROFESSIONAL DEVELOPMENT & TRAINING PMP certification candidate Completed Clinical Research Associate Program Completed Clinical Data Management Program EDUCATION MS, Chemistry, State University of New York at Binghamton, Binghamton, NY BS, Biology, LeMoyne College, Syracuse, NY Page 3