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In a world increasingly concerned with safety legislation, we have to improve our corn@-ehension of safety issues, and make this available to our respective colleagues, customers and clients. This safety knowledge may have global, continental, national and local aspects enshrined within it, and it is our duty to become familiar with these requirements and act according to the law, or the spirit of the law. This paper attempts to cover topics around safety and aromatherapy.
P
tors 0 of 0
erceptions aromatherapy
of safety tend
issues to be
in the
using
informa-
educato fall
Material (MSDS)
company
information Information
whose
Composition/ on Ingredients
of two categories: that fail to make between the a clear hazard near
2. 3. 4.
Set 3. Hazards identification Set 4. First Aid measures Set 5. Fire Fighting measures
distinction
zero risks for the widest spectrum essential oils using convenThese are a legal requirement ered oils). written chemical MSDS goods sheets (e.g. were technical for delivessential originally language
Set 6. Accidental release measures Set 7. Handling Set 8. Exposure personal and Storage controls/ protection
tional aromatherapy
practices.
Those who adopt a more cautious approach insufficient, where scientific for example data is over
Set 9. Physical and chemical properties Set 10. Stability and reactivity information information considerations information information
in complex
for persons
responsible
Set 11. Toxicological Set 12. Ecological Set 13. Disposal Set 14.Transport Set 15. Regulatory
right-to-know
information
of Substances (COSHH)
Hazardous in for
regulations
hazardous
properties
of the
Set 16. Other information. As a customer, right to return you have a legal
materials
??
An
evaluation
the
Chemical (CMA)
needed, client/
to which is likely
Association
has
developed
supplier
acceptNational has
ask that
to be exposed.
An interpretation
in terms Similarly,
(ANSI) The
sixteen are as
information
where
sections
Help in identifying
according
to ANSI
doi:10.1054/ijar.2000.0020,
available online
at http://www.idealibrary.com
on
IOE+l@
tion is poor, and you are legally entitled to a re-submission. Aromatherapists companies bound to and aromatherapy
template. minimum
There
is an
absolute
mate-
data on essential
oils. They then make a risk assessment and recommendations used for individual The
substances Decision
in fragrances.
customers.
Additionally,
aromatherasetting are to
a chemist, of low
Tree Approach
(Cramer et al.,
is usually
priority
19 78) underlies
RIFM have used for toxicity assessment. The RIFM designed 0 Skin testing
??
In the USA a applies and with Health Hazard private and legisla-
regarding (GAS)
irritation
Service
(OSHA) requiring
Oral
and dermal
limit
tests
(at
1910.1200,
and incorrect
Phototoxicity Photosensitization Sensitization: out using the originally Kligman carried (1966)
tion additionally
requires
You
to check
human
maximization as solvent.
test, using
is usually
them and have them readily available. 2. Follow up references information construct assessment used. 3. Encourage organizations and generate aromatherapy to compile their own of every data to safety
metabolism
substances
and when necessary. The Association considers International (IFRA) Fragrance receives and
the past to allay public fears. The law now requires a personal
written process.
evaluation
and updating
ingredients fragrance
industry.
Aromatherapy unlikely
organizations
therefore,
written assessments raw material aromatherapy. 4. If possible, ified person safety queries 5. Encourage organization, aromatherapy produce
assessments
1300 substances
used in
tested by RIFM and some 50 have been subsequently not recommended (banned IFRA). for A
assessments.
professional essential
organizations
58 are subject
this respect,
guidelines
on the use The R.IFM and the IFRA The Research Institute for Fragrance in
in
the
journal. nies
Reputable adhere
Materials 1966 by
(RIFM) the
widely
to this voluntary
American Association,
is a
guidelines),
When you receive an MSDS sheet, take into tions: 0 They are constructed on a basic account the following observa-
organis wholly
to IFRA compliant
markets.
of
any
RIFM
As one of the principle tive programs toxicology, adopted and, authors on fragrant
investigasubstance
used
materials
like
MOC
Other organizations
There are a large number organizations or interact and its of additional that are directly involved oils trade e.g. the
a chemical
perhaps
surprisingly,
status
oils. This
International
Federation Trades
others,
other
of oakmoss,
could not be put on the market now in original form. are regutrade
to access. It has been stated in domain that KIFM is re-eval1300 materials that
the public
(CFTA).
Also of interest
in the bi-monthly
data are
magazine, Perficmerand Flautist, and are posted on the Internet (see Appendix).
and is evalin a
Medical Association
(AMA).
materials
worldwide survey of volume usage of all materials inventory, present become on the European although indicative at will
it is debatable
to aromatherapists
is widely
whether available
European of member
works
their
scientific legislawith See appendix. It is sometimes professional one another bodies advantageous to associate common for with aims,
associa-
a workable cooperates
other
countries.
each member
to achieve
trade associations,
share information,
formulate
findings
KIFM
perfume has
ingredient
avoided
wholesale
(BFA).
legislation policing
without under
consultation.
the
Flavours (EFFA)
IFRA voluntary s
practice
bridges in order
between to achieve Various about Almost statements essential 40 have been made toxicity. somewhat In
bodies aims.
In fact, a years
years
perfume
in recent
Essence Manufacturers
to aromatherapists and is
worrying
declaration
was made:
view of the relatively high systemic toxicity of the vapours of certain essential inhalation be disreIt is
Flavour
Netherlands,
garded, perhaps
(Kowalski
et al., 1962).
mechanisms level.
Flavour
the quantitation
of excessive
that is important.
It has to be said that IFRA voluns tary self-regulation changed system the face has of
on the toxic effects of Volatile Organic Compounds found (VOCs), information was
Manufacturers
Association
inevitably perfumery
set of 1500 is available at around $1000, or they can be purchased choosing from a published in sets of 10, list.
that related
to various e.g.
essential for
some aromatherapy
benzyl
o-terpi-
(Cooper
et al, 1995).
that from
1,8-cineole breathing
peaked
between
the levels
of exposure looked
extraorthat
It was concluded
sage oil, and over 43000 to cedar-leaf oil in their workplaces. hensive account The most compretoxicity that
in levels ofVOCs
to substan-
elimination
half-life
tially less than 25 mg/m3 were required if a non-irritating was desired (Pappas work environment et al., 2000). of exposure In a in
of thujone
I could find seems to be the Prioritybased Assessment (PAFA) of Food published Additives via the
with regard
to elimination
more extreme
example
and accumulation. Limits cineole mg/kg mg/day proposed cause had for dietary been intake of 1,8at 0.07 (private equals adult. 4.9 This to
Database FDA.
proposed
carene were found to be 80-550 mg/m3 - these are relatively high figures. Exposure products significantly respiratory tion from to terpenes coniferous and heating woods is
bodyweight/day which a 70 kg
Inhalation Whilst
communication) for
(low) limit was envisaged for from containing piper&a) confectionery intake
associated cancer
problems
chemicals A contact
continue
to pose
dietary
of
problems.
of exposure
peppermint oils.
suffering to
1986). Other studies on cl-pinene enantiomers (Falk et al., 1990) exposures indicated of lo-450
and eucalyptus
sensitization
the Council
of Europe oil
exposure
rosewood
additive
(Schaller that
after 20 minutes
to calculate
the
likely
from
a vapourizer
consider of
that 5 drops/hour
submitting
assuming
scenario.
subjects
challenge
strips (Kumar et
(only) 1975)
relatively compared
amount
vapourized
(NIOSH,
with other
severe, patients
routes of administration. In widely toxicity, Maximum Optimum conclusion scattered but there data little in on are some
asthma erbations
had exac-
inhalation way of
of airways. Millqvist followed this in 1996 in a study where nine patients tory symptoms after with respirairri-
the Limit
SO%, and we have a 5-minute tion the session, aerially Even assuming dispersed oil
Exposure Exposure
Standard (TLV)
non-specific
is actually
Limit Value
tant stimuli were subjected provocation without clamped). or placebo, filter conclusion
breathed 20.8 mg
manner.
a carbon The
inhaled, cineole.
of which
The actual dose would only be of that. studies are not on too it
hyper-reactivity could
be produced
inhalation Relevant
thujone
to our example,
Occupational
nerve,
but perhaps
operated
via a trigeminal
reflex
of the respira-
terms
would
when
tory tract or by the eyes. It was shown that for perfumes inhalation mixtures when of at least, subchronic complex fragrance a risk even and levels
massage
involves
Remarks over possible from oral gastric irritation of essential the digestive bile of acids
the aromatherapist
may absorb
inhaled
repeated
oil than the client. left assuming oil doses that, from
dosing
exaggerated (Fukayama
oils, as they pass through tract, occurs, essential ported solubilization and with
essential in
have also been made to inhalation (Pybus to dose and of Sell, the
conventional (massage,
proportion
the perfumes
procedures
to the liver. Here phase 1 P-450 take place and some converor carboxylic with glycine acids for
They
tried
estimate
reactions sion
there might be a small risk of accumulation of essential oil components, toxicity. This
to alcohols Conjugation
occurs.
Assuming be
which may lead to chronic could be of concern oils are regularly pretty more unlikely realistic
carboxylic
acid containing
where neurotoxic
or glucuronic alcohol
groupings
immediately
elimination urine.
may occur
8 m3 of air would give a concentration of 2.5 mg/m3. Since the perfume be detectable for several hours, might obvi-
LDso Issues To decide chemicals procedures. LD,, values our tolerance of oils and
workplace allergic
being
sufficient reactions
inhalation These
individuals
be classified As a
agents.
problems
such as asthma or
including
12 mg/ms (Reynolds,
of perfume
matched
where 5-25 ml of
animals (rats, guinea pigs, rabbits, mice etc.). Adaptation Koala bears thrive on a diet of eucaTheir digeshave presumand safely The dose that kills 50% of the
animals is the LD50 value, and is calculated on body weight of the animal and expressed as mg/kg. Data are often
concentration.
lyptus leaves and branches. tive metabolic ably evolved processes to tolerate
available for oral, dermal and intraperitoneal methods of administration. of LD50 values
to the body. If the oil were all at once into 8 ms of of 78.1 Clearly mg/litre this does
metabolize
of essen-
Determinations seemingly
tial oil that they consume a simple graphic concerns myrtle example illustration the oral of
to source,
not happen
as we would
be choking at this
of
this
effect of
administration
than 1 g/kg to over 5 g/kg (e.g. boldo oil from Peumus boldus at 0.3 mg/kg at one end of the scale, to say rose oil at over 5 g/kg at the other). oils with LD,, are not Some of the
say the skin absorbed oil, and if 5% of in the first minute, the
essential
25% of the essential this oil evaporated again using concentration able 2.93
was reduced
considerably induced
feeding
of myrtle 1979).
(Uehleke,
recommended by IFRA.
mg/litre, actual
perfumery
include and
time. The
concentration
would
chenopodium,
species involved
etc., toxicity
can actu-
not
recommended
for
use
in
indicated
constants
animal data to the human i.e. more toxic/ less toxic. between than
will vary from lab to lab). The cient LDso value alone for comparisons is insuffiof relative
reason
behind
Tisserand
in metabolism
statement such
that thujone
quantitative
rather
as armoise
qualitative, metabolic
to hyssop appears
may, in turn, provide information on the mechanism. Other indexes ratio are also useful.
choose
appropriate
The
modelling,
we start to draw conclusions toxicity records, dose of the material i.e. by estimareceived, or of this to
involving
cally effective
and
instances In Oral Many find dosing practicing themselves essential aromatherapists unable to will legally
substrates manner
we are
sometimes
fact eucalyptus
by the oral route than by any other i.e. oral-child TDLo= Potential TDLo=218 375 mg/kg mg/kg; oral-man (NIOSH, 1975).
prescribe
LDLo is often seen quoted in toxicological material data. It is the lowest dose of introduced by any route over a to have used is low.
countermeasures
proposed discontinuing
qualified.
should be carefully administered correct trated mouth casually. manner, and volatile should Oils as intake
in the
and discouraging
substances
dose of material
infections
resulting
in a toxic death.
had
widely oil
of pennyroyal
A suitable to find of
instead
of eucalyptus
to be more
sage oil (Millet et al., 1981) working on diet-induced dose at which sub-clinical convulsions cortical in rats. The events became
serious
of oil can be dissolved in strong sugar syrup, and then full tumbler quickly stirred into a
there
is a
0.3 g/kg for sage; i.e. 0.8 g dose for 10 kg child for child hyssop toxicity oil if
on bottles
and equipment
animal/human similar.
were at 0.13
or aromatherapy the
Convulsions
occurred
g/kg for hyssop and 0.5 g/kg for sage oil that became for hyssop and lethal above 1.25 g/kg 3.25 g/kg for sage.
of interacthe
reported
accidents
and whether
globally, with
is appropriate
(during pregmy
Interestingly, of a subclinical
repeated
is now equating
In conclusion,
dose revealed
unacceptable of those
message is that unless you are very clear on what you are doing, stay away from oral prescribing.
lative toxic effect. This paper indicated the neurotoxicity of thujone and
who
consequences
THE
INTERN.4TIONAL
.lORNAL
OF
AROMATHERAPY
2000
wol(Dnos
QD
Dermal Toxicity Dermal concerned apphcahon opposed penetrate changes from LDso (Limit test rabbit) following is
Additional
evidence
volatile quickly
with
mortality
Application shown
to dismiss
to alter
the skin and the metabolic that occur to in the skin vary For
ation kinetics a
in terms
effects.
However
coumarin,
substance.
cassia and other oils is rapidly absorbed increases increases. increase substance. the to 46% (human 64% 12% unoccluded), (rat unoccluded), (human unocto 24% p-
??
0 All
unchanged esters
(Yourick,
1997),
may
but some
absorption
of the applied
and cinnamaldehyde
(human unoccluded) Thus we have the following factors in skin absorption: degree of skin hydration important In more detail, some components will accumulate reservoir lipid-rich components pool to form (Hewitt, a cutaneous 1993) in the Others into the
skin LD,,
stratum
corneum. deeper
situation,
permeate
greater apparent
permeability
however
volatility of the materials molecular components time of contact dose and concentration between applied applied volume of individual
Eventually,
this mixture
biotransformed
and unchanged
mole-
cules will reach the systemic circulation via the dermal cutaneous applied released microvasculature. The
out in Yet
reservoir substances,
(relationship
dose and absorption and species specific) surface to occlusion/ surface degree mised area
is compound
1995),
obtained
elsewhere to
as not relevant
and region
exposure
(Schnaubelt,
1986).
has ceased.
However, we do know that the skin as a target organ is capable of is being one
comprophysical
RIFM tests was the for skin Kligman (Kligman, method The
wormseed, oils.
damage etc. age of skin number thickness of hair follicles etc. of components. of substances and their
and wintergreen of
maximization
as a solvent. is important:
this is a
test and
in an oil, many small lipophilic may quickly permeate pass into the the
a maximum even
level weak
of exposure sensitizers
eventually
identify
receptor circulation.
previously Ten
of one
procedures.
was greater
slowly, resulting
absorption Counter
of essential to this,
sate for the fact that the material applied under semi-occlusion. (Magnussan, replaced humans
was In a
restricted
materials
1969), when
tests
volunteers
became
problemwith the
of problems
between RIFM maximization s the Draize Maibach, HRIPT 1980). results test
came to light:
(Marzulli
of ultra-violet Haptens
unchanged.
tified as sensitizers.
??
electrophilic
Common
vehicles
could be sensitizers.
??
variability
when
presented with
result
tests
immune presenting
system, cells
reacts in the
expressed 0 MLD:
dermis.
well
defined
inflammatory stimulated.
response
is subsequently
(moderate) erythema
have
been
made
to
slight
sensitization
potential
from level
epicutaneous
and at an elementary
from the use of impure many may on the contained. substances have been
we can classify haptens from their functional groups: ides, and this listing include partly explain epoxwhy
classed
escher form and severe oedema. The protocols of Bueler and the in
wrongly
may
bitter an
orange
Union
associated of
compounds decreased
Economic
and but
potential. present
Oxidation
at up to 96% in bitter
In 1985 the RIFM switched to the modified Repeat Draize Injury procedure Patch Test, (Human HRIPT).
are still encountered. Lymph Node Assay and Basketter, 1992) in site has
oil, leads to the formation tram-limonene hydroperoxide, amongst carve01 tizing. others, have been oxides, carve01
of cis- and
Mouse
Local
(LLNA) depends
(Kimber
to be sensi-
Fridays
a S-week then
followed
been applied. This test gives good interlaboratory correlation, although may Banned IFRA: root oil, absolute oil, oil, and Thea fig
hour challenge
Draize
be less sensitive test and results. validation sensitizing substances. can It has and
Costus concrete,
international
elecampane verbena
sinesisabsolute,
screening potential.
abilities
leaf absolute. Restricted by IFRA: bark oil Sri Lanka, extracts, fennel oil, Peru absolute, Oakmoss under to a a
note this latter fact as there is confucommunity Low-molecular-weight haptens, essential physical are present allergens, called of by
Cinnamon cassia treemoss Opoponax balsam, Pinaceae products temporary concentration product oil,
oakmoss extracts,
in a number
derivatives,
out on humans,
dismissed RIFM data as irrelare initially Buerler s (1965) screened, guinea where pig mate-
non-sensitising. industry
However,
this practice in or
sensitization
until
extraction
can
produced
mate-
accompanied of polymorphonuprior
by
menthol
(e.g. cornmint,
rials that are not (so) sensitizing. Pinaceue derivatives including Pinus and Abies genera to the lowest practical by adding production. anti-oxidants They oils of the is kept
and aldehydes the following be strongly garlic of oils mustard, number moderate essential final
can follow without tated, but the irritant be shown age, and temperature, dermatitis exceed
Those with fair skin are more easily irrireaction to decline to increase such The with increasing with increasing that irritant must curve
and massoia.
irritant
including
thyme. limit
should
companies
self-impose
only be used when the level of peroxides is less than 10 mmol/l determined by the Essential method. Quenching where fragrant when an the other substances is a phenomenon properties of sensitization compounds aldehyde amount even simple Oils Association (EOA)
O-0.576 skin
concentration
viduals in summer. a certain a reaction, the original report rabbits minimum abraded gauze
oils in fragrances.
but the dose-response 1944 Draize test, procedure free six animals of
Sunlight cutaneous
is responsible and
of
pathologies
clipped
and intact skin tests. Materials under a square surgical or eyes) material and for the entire to (skin
are introduced
ical (the phototoxic skin exposure priate intensity not more involve simple
of the approsystem. is
trunk of the animal is wrapped up in an impervious the 24 hours keep the patch in place and to prevent easy evaporation to predict test of the volatile substance. removed The irritants. After 24 hours the patch is irritation failed potential. to distinoften
presumptuous, complex nents, oil, based problems. In Japan, embarked identify cosmetics. considered jasmine, and costus these tions, ylang the The
therefore,
regarded The
tanning
of the the
as is the case with an essential with known sensitivity Nakayama contact findings (19741984) program allergens have to in been oils
ultra-violet
absorber.
in which
more chemicals
material is dissolved strongly affects the percutanous release. and chemical carried the as such Testing agent is, therefore, effectively, (also
marginal low-grade
In the Philipis
likely to release
tested with a cumulative the application up results because besides rabbit change Union tion for to 21 days. The single strong rabbits
time of which may be test gives good testing irritants animals tried, but application Other been
called
to be ylang,
other oils, like rue, are perhaps phototoxins The time following chemand the intensity are also maximum is usually response variables. responses in optimal, at 24
the most investigated bergaptene). ical exposure light exposure produce 1 hour Animals humans fading
in perfume allergen-control
between human and have made a major to animal a European on eye irritafrom invia a algo-
with a built-in
It will be interesting
testing are likely to become study is being conducted which of converts prediction effects vitro
to phototoxins
away to zero
hours. Human testing is usually carried out on areas on the back or arm. As the phototoxic most persons, response The is common to only small testing panels body test site, the test concentration, and the time and light exposure
is an agent if applied
number rithms.
and for a long enough and basically histamine erythma the chemfrom mast
Immunological
Irritation
tered with neat undiluted containing eugenol (e.g. components clove bud,
protocol, frequency
and increased
of chemical/
affect the response. An important that following materials phototoxic from original finding was of 161 raw 21 gave a
compound
6methylcoumarin here.
is a well-
hepatic failure
to young children.
known example
a screening
It is probable Many oils have a direct central nervous action on the such as
that essential
oil metabo-
(Forbes
embryonic
For cosmetic
safety profes-
Lipophilic by passive
substances diffusion
sionals, this leaves a very large number of cosmetic ingredients to test, so that
of over-exposure
between
self-repair
is not generally of
even at this stage the overall potential and frequency of the phototoxic
substances
biotransformed
response
Observable (NOFAL)
perfumery
musk
products
recommended Tagete,
tetralin.
bergamot
others,
and angelica
against
clearance
effects exposure
We, therefore,
at concentrations mended
by IFRA. In my opinion,
Daily Intake
oil and tagete oil should not be used at all in this situation. lemon oil expressed Bitter orange oil, oil
and rectal
administration
and grapefruit
and IFRA or
treatments to bring
available
between
species,
feres with the normal either giving neonate. the embryo rise to
development
the furanocoumarin
or foetus
concentration (often
below 0.05%
to be apply
Teratogens
amot oil).
positively identified
aromatherapy neurotoxic/ Bergamot presence oil is carcinogenic of ultra-violet (UV) in the light tial oils,
situation
with regard
tial oils have included Savin oil fromJuni@rus al., 1989) and Spanish
in essen-
such
B-thujones, based
to mouse skin, but when the carcinoLittle data are domain at present. for oils
are especially
substance
which may occur up to 24% in Spanish lavender oil. Sabina oil is banned
in the public
aromatherapy
proclaim
IFRA and its sale in the UK is contrary to The Medicines of Herbal (Retail Remedies) Sale or
oils such
Supply
Order
Photoallergy
is similar
to allergy
but
Also
of concern that
lavender
with a the
mention
as an abortifacient
with no
by UV light.
of inevitable
recommend mention
pennyroyal
during
of the potential
of fulminant
of pregnancy.
Critics
of this policy have said that the amount of dietary essential outweighs practice. oil intake intake I might (in from think A mutagen is a substance defects that may
P_asarone Calamus cause inheritable arising from germ cells. result from oil is (severely) restricted by
flavourings) aromatherapy
of essential
oils was
damages
human effects
has mutagenic
on bacteria,
their action on somatic cells via cellular disruption. carcinogens, are mutagens. A mutation table vitro change testing is defined as any herimaterial. for InMany but not mutagens are
carcinogenic diploid
activity are
practice
varieties
in flavourings routes
all carcinogens
to have little
or no R-asarone
be
that
in aromatherapy.
number foetus,
take place to
exposure
mutagens of the
examining
action
of preg-
odora, lemongrass,
Ames
problem
using the Ames test to predict potential carcinogens A carcinogen is a chemical that may which is that the mutagens iden-
lemongrass
tified in the Ames test are not necessarily carcinogens, and some carcinoMethyl chavicol as a major component in
proliferain a of
Interpretation
resulting mass
oils. Methyl
growing
hepatocellular
At the simplest
level carcinogenic
mice
(Drinkwater
et al.,
testing might involve adding substances to rodent diets over a period of time, at the end of which examined approach able testing drugs, they are killed and Safrole-containing These cannot oils be legally used in many (as
investigations
of the genotoxicity
basil oils and one tarragon strated toxic, that whilst tarragon the basil oils were
countries. Safrole)
Drugs in
methyl chavicol was not the only factor in considering the genotoxic effects in
Used
Ethical
study highly
Regulations
driven the wider use of in-vitro alternatives to animal tests. Unfortunately, standard of information the
purified methyl chavicol was found free from mutagenic TlOO, whereas effects 96% in to Salmonella to test not
given by inby
900/92
as a Category together
strains 1982).
It is controlled
with
There
Structuremodelof
of other substances,
as it is a of
data
to predict
carcino-
Relationship relates
(QSAR)
genic effects of methyl chavicol in basil oil reliably, but when considering sure of the oil to children, advised. chavicol Tarragon and expois
the magnitude
property
of a series of
caution
high
methyl
movement
in question in&o
Licenses import/
contributors fragrances.
of these
and end-user
declarations
accepted
by regulatory
authorities.
causes
problems and in
ot
Reports substance
have
indicated
that
the
is hepatotoxic,
many geranium,
liver of large oral doses might involve the depletion of glutathione, needed in Anethole Trans-anethole occurs in high amounts
currently
restricted
(Nakayama
et al., 1974).
in aniseed oil, where levels may exceed 95%. There has been much debate Much of its is in of
Flung ylang oil A 5-year worldwide reactions study of cosmetics allergic reacet al.,
the
liver
necrosis
of the hepatocytes
shows frequent
about the toxicity of anethole. this is to be centered The and in is the the
(Nakayama
food
regulations
of pulegone
purity. toxic,
to 0.025 in
g/kg food
Methyl
Flavourings Statutory It is
Food
especially Anethole
This component
Instrument
no. 1971,
probably
important profession
that
flavouring
agent in Pernod
aromatherapy
but there are no current its use in beverages. such as photoanethol sible for the alleged hole. It would seem
restrictions
be out of step with regulations in other sectors. and Balacs oil should
Other
substances
component,
aromatherapy,
especially
in pregnancy.
absence
of further
to only use
et al., 1992)), DNA-binding companies on the use formulaprofesSandalwood oil study of cosmetic that sandalwood This
fresh oils, with caution, intakes for children. A 5-year worldwide reactions showed
and to restrict
restrictions in perfume
Methyl
salicylate
J3-santalol
Methyl salicylate occurs at up to 98% in wintergreen former being and sweet birch commercially oils, the
statement. that
content,
which is thought
to be a sensi-
tiser (Nakayama
et al., 1974).
obtainable
salicylate.
salicylate
legislation
limits
rubefacients pain by
of fragrance
formulations.
lung-toxic,
and
IFRA restriction
mint and in many other wild mints, and formerly Western in Japanese consumers for the taste peppermint have never of high oil. cared
(Loveless
sales that is of in
evidence intestines
R-(+)-Pulegone This component major and buchu constituent American oil and catnip, is hepatotoxic. of both pennyroyal is also It is a
much
menthooils, and
peppermint
dose at
for a 70 kg man has been estimated between 1969). human 5 and 30 ml (Gleason NIOSH (1975)
peppermint
at much
et al., a
Menthofuran pulegone
recorded
g/kg.
(LD,,
oral-rat
salicylate noted
is It can be very difficult pists to decide about for aromathera the safety o
(1978) Decision
Estimation Tree
tha!
to salicylate
physiological with
particular conflicting
Ford,
R.A.
(1990)
Metabolic
and
kinetic ductive
criteria hazard.
these oils. It is always an idea to debate personal professional use and posi
are
a large
number
of
tive and negative lists of oils with fellow therapists. Although aspects based many procedura; practices are
Falk,
A.A.,
et and
al.
(1990)
Uptake, of aby
distribution pinene in
man
1934; Levine,
inhalation.
through
that intestinal
Fukayama,
lism seems to occur mainly in the liver. Evidence suggests that blood salicylate at 20-30 minutes et al. (1984) work on after did
from an authoritative
source.
above text, and it is hoped that you may be able to find others for yourselves.
Collins
interesting
topical
Armed with this data, safe working policies and procedures can then be
Gleason,
et al. (1969):
Clinical toxi-
(an aerosol
constructed. toxicology
more
about
Cutaneous
that includes
methyl
retopical
we are able
-his-(Bcloroaniline) znedianiline
erythma
production
Brown
(1934)
Journal 01
20 minutes.
In their to The
Pharmacology
Experimental
salicylates
appeared system.
prostaglandin
Chan,
V.S.W., induction
et
al.
(1992)
:ompound luring
Norst-case scenario
Comparative
inhalation.
in cultured
L77-480. B Kauppinen, Respiratory :xposure in T.P. cancers the et and al. (1986) chemical a
manifesting
by allylbenzenes
and
wood
industry:
oil should
not be ingested
Collins,
et al. (1984)
rested case-control
study. BritishJournal
should only be used for topical applicaion and not full body massage. Do not rse wintergreen :lient is receiving uch as warfarin. rroblems in cases where the
qlndustrial Medicine 43: 8490. Journal ) Kimber,I., :he Murine Basketter, D.A. (1992)
of Ethnopharmacology l(3)
??
: 241-246.
compounds and their Journal of
anti-coagulant
drugs are
Lcommentary
We know there
tification
with chronic
salicylate inges-
products
tion in pregnancy
eading (Turner tant and lactating
properties.
1 Kligman, A.M. (1966) The identifiation of Human Iuman Contact Allergens Journal by of Exposure.
Analysis
and Environmental
Epidemiology 5 (1)
??
: 57-75.
nethyl salicylate/wintergreen.
??
Medycync
??
Reynolds,
J.E.F.
(Ed)
(1993)
The
The
Extra
Inhalation scent effects of perfume
Pharmacopoeia.
Press: London.
Pharmaceutical
??
challenge
Schnaulbelt,
K. (1986) Aromatherafi
http://library.dialog.com/products/datastar/4002-3.html
Schaller, M.M., Korting, H.C. (1993) airborne essential contact oils dermatitis used in Safety
Levine.
Toxicology 8: 239.
aromatherapy.
Uehleke,
evaluation
Lymph
M. (1979)
Assay in the final phase of an international collaborative 141-152. 235-244. 0 Millet, Y., et al (1981) Clinical trial. Toxicology 108:
for
Health
Professionals.
Edinburgh:
Churchill Livingstone.
OilResearch 1: 111-118
??
Clinical
Tisserand,
Millqvist (1996)
Placebo
4th
Edn.
challenges with
with perfume
Edinburgh:
Churchill
Baltimore:
asthma-like
symptoms.
Allergy
Perfume
Wren R.C., revised by Williamson, G., Collins, E. (1975) Fetal in E.M., Evans, F.J. (1988) Potters New Cyclopaedia of Botanical Drugs and
51(6): 434439.
??
Turner,
Nakayama,
H.
(1974)
dermatitis. Japan
Nakayama,
H.,
et
al.
Allergen
Kanehara
of
controlled
system:
H.,
l-42
et
Shuppan, Tokyo
??
Nakayama,
al.
(1984)
Toxicologyl7(3):
Pigmented
Cosmetic
Dermatitis.
G., Chamorro,
Chemists.
and
Part
VI1
Fragrance
D.L.J.
Monographs
on
Fragrance Raw Materials: Food and Cosmetics Issues I-VII. Toxicology Special
volatile
:ompounds.
International
medical
papers. to many
Flavour
Inc.
and
Fragrance
Extract
kupational
i(1): 1-8.
are available
Manufacturers
Flavour
Association of U.S.
and Illinois: Fragrance Allured
Guidelines
Mate+als.
Publishing
Applied
Therapeutics.
Inc. C. D., Sell,
Vancouver:
Co., 1987.
Food
Chemicals
Codex IV Edn.
Press,
(1999)
The
ToxLine http://toxnet.nlm.nih.gov/cgi-
National Washington.
Academy
II
I
I
Ihr n Part One of 1 outlined the importance essential understanding how the oils and I of essential oil composition; chemical could comparrd issues essential dangers degradation have safety implications, data on hurrlan and animal some of the 01 and of the melabolism toxicity. Part live explores r-elating relating
The second of a three part series based on a presentation given at Aromn 95. The full transcript is published in the Conference Proceedings. Part Three will appear in the next issue.
per se,
of apiol in
who ingested
Most essential oils are in fact consumed in the form of food flavol:rings, relatively low doses compared used in aromatherapy. much greater overdosage dermal some
I. This build-up
in many further gives
than with drrmal dosag:r, which dots not Also, apply in to the oil to
In several casts of fatal poisoning it was not until dose that death child was wormseed second oil, the second ensued. eight followed or third drops of A L-year-old by a similar
very
amounts normally given in oral dosage, IO-20 times as mrlch essential compared will enter the bloodstream dcrmal administration. Excretion
r-eproductive toxicity.
given
dose one week later [Wolf, 19351. The dose proved fdtal. A girl of 19 died Lookeren, wds taken af ter three one-drop The for lowest is 0.8 g, 14 days oil, 12 hours apart 19391. daily he fate of essential oils once they have I entered reasons. component it
110
Essential
orie
months
[&ii
the body is complex, Firstly, because has a separate makes sense oil, one must
and
(Table body
longer
the
whole
destiny of each one of the hundreds components. essential metabotiscd, will undergo oil Srcondty, component i.e. chemically than will
typical changed
while in the body, and in some cases it more one such change. great Some essential oil componenls in the skin, of metabolic but the change majority
are metabolised
takes place in the liver. Routes of administration The metabolism of essential employed. oil to the Oral components may vary according
route of administration
During 15-20
attack,
he after He
risk
to
those
with has
given he The
spoon
threshold,
i.e. a potential
shortly
epilepsy
which
a convulsion. case,
fully recovered girl, treat Toxicity can affect one, or several orgms, and this is sometimes a point of are difference normally substance destructive Essential between species. Table 2 lists labelled. effect on A neurotoxic tissue. drank a
after 3 days in hospital. an l&year-old later for she 10 of hyssop oil to hour she
cold.
exterrral use is much less of a risk, A 1967 review of olfactory stimulation in epileptics concluded that,
consciousness which
suffered
d contractions
epilepsy caused by scent in the narrowest sense of the word is very uncommon. of the [Nedbal, individual to olfactory depends on the degree of oversensitivity stimuli German) that oils (translation the external from a from the original use of essential of
In the third case a 26-year-old 2 19X1]. consecutive (Here days, and day
woman took 10 drops of hyssop oil on suffered a seizure on the second oral dosing.) between animal
is one which has a toxic or nervous oils are only likely to cause
we see another
serious physical damage to nervous tissue in fatal or near-fatal cases of poisoning [Wolf, 19351. A more common neurotoxicity and one convulsant neurotoxic, oil is convulsions, essential and oils is are in of rhe most potent result of
of cumulative
w0~ild than
oils,
hyssop. Hyssop oil is powerfully there resulting several cases of ingestion of the by humans epileptiform seiLuI-es.
oils most as
strongly being
HY=P Hyssop is convulsant of its pinoramphonr and iso-pinocamphonc content. in 1891. The Doses into
because (40%) (30%) toxicity the and human toxicity. of Secondly, the oil,
notable Some
thrsr components
is a ketone. ketones
coIlvLrlsaIlt
general to be highly stimulant to the CNS, and therefore prone Eniiel, other to epilepsy 19901. krtones However, present a risk to those and is no in there werr almost seizul-es appeared for
The risks
effects of hyssop oil were first researched of 2.5 mg/kg producing injected immediate dogs,
major
components
[Franchomme
pinocamphone ncurotoxic
epileptiform
reason to believe that essential oils rich in any danger epilepsy. While convulsants all ketones it mdy be true that all in essential in essential oils are oils are
18911. Tests in
hyssop oil, at dose levels over 0.13 g/kg; pinocamphone [Millet, was found to be convulsant and lethal to rats 1981; Millet and
found found
In the only recorded cases where seizures have been induced by essential oils, most of them apparently in non-epileptics, definitciy seizures represents to at oral the oils were taken orally. Hyssop oil most a serious risk, and
rdusr
ketones, it does not necessarily follow that convulsants (see table 3).
et al., 19791. Both pinocamphone hyssop oil arc potentially neurotoxic et al., 1980]. The amounts of hyssop oil these animal However, resulting rests were generally are three there
usrd
to laboratory
rpiieptiform levels. even This There is very good evidence that essential oil components a human in general are able to the cross the placenta and reach the fetus in pregnancy. Crossing placenta does not neccssariiy mean that there is a risk of toxicity to the fetus; this will depend plasma
roInpOuIld.
dosage that
IIIcms
dcrmal
high.
cases of low-dose
in epileptiform mother
[Arditti et al., 19781. The first case was a G-year-old whose gave him 2-3 drops of hyssop oil for his
on
the
toxicity
and
of
concentration
the the
However, there is a
Parsley preparations great mmy component responsible action used of in its to of of to illegal made from parsley have for a a majot leaf and tIeen used to procure today, notably abortion
19281.
In pregnant [Patoir
rabbits,
abortion In is gin
berries et
have al.,
PI-akash
to demonstrate
an early
times highrr
and a late abortifacient An ethanolic contain there these essential constitutes the toxic, that major some is no effects.
activity in rats extract would oil, but that the 1.5% the for oil of all
held to be and right is is also as an often paI-tly legal patients abortion, and the in has
abortitidcient. difficult because implications admitting death there apiol tend whirh
the
and since
of the nom he
abortion,
inconceivable
juniper
responsible
toxicity noted above. Nutmeg apparently contains sabinene tdblc //&cc-pincnc, and 4). components 73% of administration g/kg 01. nutmeg Postthan poor rhc in amount
humans,
been urgently
Olit of five cases Ii-om Italy, all of whom were between 2 and 7 months prrgnant, onr aborted and the of- apiol causing the and sometimes cases. A apiol 3 and 8 Juniper Juniper as pregnancy total dose days. of apiol This is Hiirhammcr, Duke, attempt of these evidence abortifacient, evidence responsible Most sources without preparation. what seems basis for juniper. the to he pigs, refer that of the 1985; has frcqucntly [Anon., 1976; Chandler, been 1934; Anon., 1986; llagged in I,ist and 1983; Czygan, being contraindicated cited had abortion and highlights bctwccn animals effect and later died, one did not abort but died, and three aborted survived case fetus [D Aprile, did 192X] not to hr which abort,
terpinen-4-01. timonene
These
son1e
Thr
In the
dead.
0.56
hlrrding,
or on maternal
is a feature
correlation
being taken daily for between day5 hefore ensued. One of the cases
19761. Myrcenr showed no reproductive toxicity when tested on pregnant 250 mg/kg, dose which is equivalent human
or abortion
traces of apiol in her urine 12 days after the last ingestion. The which for 8 lowest inducrd abortion was 0.9 g tdken equivalent to 6 ml of
[Delgado et al., 19931. Nutmeg abortifacient, juniper There juniper reputdtion, undoubtedly between oil so it seems unlikely are two likely reasons acquired which been has some
sahina).
consecutive
1987; De Smet et a1.,1993]. contraindications. that juniper but juniper above a there
A vigorous There berries is oil referenced generically, particular refers activity to of is are no is
approximately
parsley leaf oil, hrtwecn 1.5 ml and 6 ml of parsleyseed oil, or 5 ml of Indian dill oil. The ineviitable conclusion very high risk of abortion doses, and that extel-nal
SCCITI
since
is that all
(/un$~rus
also
inadvisable in pregnancy. In animal dosages In studies, of apiol pregnant considerably appear guinea
specifying to bc the
of them
tolerated.
of
abortifacient
popular
Ethanolic
and acetone
ansy,
savin
that been
and
other
and
oils
prodrtcr
Nouvelles Gpileptisantes
preuvrs
drs
[Datnow,
savin
192X].
It is ver)
oils
de I essence
juniper
D. H.
confused. readily
Any
explain
such
why
Chandler,
K. but
F.
(1986)
Journal Warnung
An
119:
Fatal
confusion
would
inconspicuous
.X3-566. 0 Czygdn,
insidious
drug.
uniper
oil might
have been
is so.
thought
If as being
dangerous
if juniper and
in pregnancy,
berries are
since satin certainly Secondly, ihortifacient, responsible ,tIspicion naturally essential fall oil.
vor \ 011
,fiir
unkritischem Wacholderhccrcn.
zYLJtothPra~ir8:
Gehrauch
Zdcchrift
if the
component then
Millet.
Y. et
(1979)
10.
propriiteb convulaivantes
csscnccs
toxiqiies
de
Reuzrr
et
commerce.
d hysope
d ~lcrtroen~r~hnlog7aphir de
Cliniqur
??
responsible
for
Amy al. la of in
is
Y. ct de
d huiles
essentielles du d hysope
beverages
0.006% It would
[Leung, seem,
there juniper oil as to regard during
19801.
therefore, that
I
0 D Aprile, F. da apiolo.
50:
MPdrcine ilbxzdqif!
0
(1981)
is no reason being
(1928) AIuuzli di An
essential
oils. Clinical and experimental
hazardous
pregnancy.
cliiiico-sprriInenralr
(2 Ginr~ologicr
I: .~~~~~inl Oil
SuJrt,y,
hy Kohert Balacs,
Livingstone,
I isserancl
puhlishcd
and
Tony 3.
is
0 der
Nedhal.
,J.
(1967) der
Der auf
hy Chul-chill
0 toxic
M.
M.
Geruchsrei7e
ISBN:
0 443 05260
experimental agents. 0
investigation produced o/
d;rzneimittd
Obslrtrics
LJ.
fragrance
(1976)
I-dW
Monographs materials.
14. 0
Agr-dwal,
0. effects
P.
et of
al.
(1980)
of
and
developmental
lCo and Co.5mdic:\ 7ixidocg ood A. et al. l apiol. A. 0. (1936) Par;.\ Lc role 3:
fruits
of beta-myI-ccnc
commimis.
W-6%3.
I atoir, de
0 De Smet, I A. G. M. et al.(eds) .
(1934)
cotlrx. Press. Hrilivh
of hrrl~~l drug\, ~JO/.
ahortif 442-446. 0
MPrlical
Anon.
j~hnrmcrtrutid Pharmaceutical 0
The
2. Hridrlberg: Duke,
Springer-Verlag. J, A. (1985)
Handbook of
Prakash,
ct al. (1985) of
Antisome
implantation indigenous
?? Van
activity 441-448. J.
Anon.
(1983)
mrdic-inn1 h&s.
~/hnrrn/~~o~oricl. Bournemouth: Herhal Medicine 0 Arditri, J. observations essences Annalrs 0 (1891) Association. et al. (1978)
Franchomme, Jollois.
(1990) Limoges: 0
cwwwr~ drugs
I, czromnfhPmpiP
PxnctPmPn/.
(1939)
chrnopodii.
Leung,
and
A. I< (1980)
irpwlirnl.~ co.smrfics.
I:ncyclopdn
oj
II nlurnl
Mdicalrs
Cadear,
with oil of chenopodium child with sickle cell anemia. Pdiattics 52: 126-l 30.
Contribution
physiologiqur
de I intoxication
Hager .r
SSEN AFET
CA RCINOGENI
TISSERAND ROBERT
TI AL Y III SIS,
0 IL
TOX IC ITY
PHOTO
The last of a three part series based on a presentation given at Aroma 95. The full transcript is published in the conference proceedings.
part
one of
outlined
the
?? Do
they
express
their of
1979)
elicited
importance essential
understanding and how of essential and I on and animal and the very reproductive final role part of
in mice also in
oils could have safety implications, data on human In part question This the third
two I
also carcinogenic
is similarly Asarone
elaborated
acceptable/unacceptable? What evidence There are is there that carcinogens oils? found in chemicals
hepatocarcinogenic 1982; Miller hcpatocarcinogenic administration injection weakly essential Do the is no question (Wiseman carcinogenic oils. carcinogens
neurotoxicity of and
13 months
controversial
oils in cancer,
oils which are known to - bela-asarone, liver tumours to elicit in but sometimes produced to infant liver or mice and methylcugenol.
well-established
data on phototoxicity.
estragole, typically
(the easiest type of tumour experimental It is important oil, or essential or contributing have rodents, have rodent extrapolates essential several assess a come and we do very to emphasise that there is causing other tumours by types. not one recorded case of any essential to cancer from in not good
express
their
carcinogenicity when in the context of an essential oil? Both calamus proved rodents. (containing asarone) carcinogenic, malignant after 1967). produced months, 59 duodenal weeks of (Taylor 90% but (Abbot 2) have most and sassafras oils have in oil 6&lweakly producing tumours dietary et al., oil safrole) of the to be carcinogenic Calamus 75.8% was
oil component,
stomach
understanding
sassafras
to from the in that (Gleason Dietary is there liver et al., 1984) safrole tumours mice and when given et al., 1963). kidney offspring and of rodents carcinogens orally to adult rats (Long produced in the
to humans
showed tumour 1
implicated
carcinogens
pregnant
(Vesselinovitch
et al.,
it is not surprising containing carcinogens carcinogenesis. containing not known. other essential the equally components (increase) Since carcinogenic is much there
that essential
Are
the
rodent in humans?
carcinogens
dose-dependent,
and a compound
may
such high concentrations demonstrate Whether essential much lower concentrations are carcinogenic could speculate in one present However, might is no evidence inhibition One
carcinogenic
be safely disposed of at low doses, while at high doses the detoxifying pathways amount formed. amount can of One become carcinogenic study can lead to a sudden metabolic This in the that the saturated. increase showed
area in which there are oils or essential a carciThe oils are but they liver humans. indeed,
very few data to go on, since there are no of any essential action found in oil components demonstrating in essential
of 1 -hydroxyestragole
frorn estragole increased from 1% to 9% as the dosage given was increased O.O5mg/kg (Zangouras have humans, urine ingested means is produced the 0.3% estragole. of to 1000 Other similar amount found the et al. 1981).
into slightly more powerful carcinogens. in most (see I -hydroxy This since is an it is metabolites important known efficient that
potentiate of either
results.
this meta-bolism
is more is of is
hydroxycstragole
excreted
in essential oils, prediction too speculative value. In the absence risk is proportionate carcinogen present.
in humans.
The saturation
probably lower than the risk to rodents. related testing is the saturation issue .
that extrapolating
levels of risk
from animal tests with high doses to the human situation is not a simple matter. that the However, WC should remember
metabolism
of many chemicals
route in is little of in
placed in a pot in the sauna room, the The woman s burns In more severe, not on skin. to were
full-thickness
burns were sustained following a 20 minule session on a sunbed, which bergamot application this instance, bergamot arms and both communication). followed oil (private In a few oil were legs
essential oils which is likely to be safe or unsafe. In some instances contain components administration external (0.1-l%) completely carcinogens aromatherapy carcinogens (lo-go%). major
before going into a steam room. Some 15 minutes later the woman showered, went for a swim, showered bcrgamot crossed again, and then (Much Severe of the burns went on to the sunbed. the epidermis.)
administration.
occur only at very low levels usage is likely to be Of best all the aspects by one of essential the of oil
oil, by that time, would have during the following to hospital and
and in these instances external safe. In the 2-10% area there toxicology, community understood of essential Since phototoxicity and is one of the scientific the least oils
steadily developed
48 hours on her arms and legs, at which time she was admitted remained there for seven days. and some blisters After leaving to
may bc some need for caution, and in this group will be found some commonly used essential oils such as fennel and nutmeg (see table 3). Oral administration recommended bear in mind or over of carcinogens. is not to oils for essential oils with 1% It is important that a few essential
understood
The skin on her arms and legs had a roasted appearance, were hospital, 1Ocm in diameter.
in aromatherapy; rcscarch
1950 we have a very good idea as to s, which ,essential which are not, for responsible oils are phototoxic and the phototoxicity components
work until her skin had healed and her limbs were fully mobile. Two years after the incident her limbs still have dark occasional streaks, and she experiences
contain more than one carcinogen. Conclusion The evidence that a few essential are carcinogenic although has oil in they been orally, into is little components rodents are all described Carcinogenicity seen following subcutaneously, the .abdominal doubt that carcinogens potential. rodent humans dosage risk is
largely well-known and well studied. We also have a very good idea how much is sale in humans, over what period An excessive can be induced particularly skin. occurs present, The In how much is not, and of time. reaction by certain the to sunlight chemicals, to the reaction agent tanning. will help is
burning sensations on the affected areas. Furanocoumarins The These absorb most common are polycyclic gives ultraviolet them phototoxic molecules the agents whose to store et al., are are the psoralens, structure or furanocoumarins. ability
is convincing,
as weak carcinogens. in rodents administration and by injection cavity. There oils possess
(UV) photons,
essential However,
containing
them for a while, and then release them in a burst on to the skin (Caporalc 1967). present Phototoxic small components amounls, even are only in a few essential 2%. to, However,
illustrate what can go wrong: Two cases A woman was treated after a 20-minute taken immediately oil with lemon for minor a sauna 1992). burns bath A few session on a sunbed, after (Anon.,
types of toxicity,
and even
say, 2%,
capable of producing
and therefore
such essential and/or relatively phototoxic can result. There family of is a the if the
guidelines. considered
Any higher
percentage
is
to
strong
(sunbeds or strong sunlight) effects whole best in The and are nonmolecules or
very severe
sunscreens,
of psoralens,
which
will risk of
known is bergapten found primarily oil. bergamot psoralens coumarins relatively volatile
the
phototoxicity. sense that the of will with time to the the the of
phototoxicity diminish following application skin. intensity phototoxic response more correctly, in oil is known or bergamot This as having an When there is no risk, or a reduced risk, of phototoxicity There applied is no risk of phototoxicity if the foils are used in a product off the skin, preparations such bergamot, distilled as citrus such which is not bath during next the hour, first remains and then hour the bergapten application, the following This is certainly (Zaynoun timescale other and citrus then will In reality
but not to
as bergaptenless bergamot
8 hours
and the same steady increase decrease time taken the it. the the the in to reach
to the oil in its natural et al., 1990). rrom the essential by from 1 for and oil The the published
if non-phototoxic
monographs Research Materials consequent Fragrance ociation depends, presence type Some several and
or distilled
the
Fragrance
cannot substance
epidermis dermis. As table oil are not impact. much used in aromatherapy, relatively poor fragrance phototoxic arter 8 hours, 10 hours. is no risk iI the parts of the the
oils have
nocoumarins, essential
of bergamot I% carried
oils contain all contribute due CO their There skin to applied should safety,
phototoxic
which probably
toxicity of the oils. We are concerned which essential Taget also with their degree oil, for instance, grapefruit not only with but to be than of phototoxicity. appears oils are phototoxic,
volunteers. that skin which oils to This and the maximum treated higher should zone with phototoxic than not be exposed 12 hours. of 2 hours,
which
been
It is recommend
are covered in such a way as to them. It sake of clothing is UV fabrics substantial Most bc that assumed, typical lightly whereas blocks for the
around 100 times more phototoxic expressed phototoxic on the the percentage skin, dilution based on
a safety essential
oil is considered
concentration or 20%
out UV
oil. A 15%
concentration still produce after 12 hours xanthotoxin 10 undiluted phototoxic produce hours, (Zaynoun Individual but
ol
bergamot
oil
can The great majority quite safe as used but the danger to of essential which oils arc do exist it is the
mutagenicity bacteria. in aromatherapy, The photobiology perfume Journal 0 Clinical products, Wilktins, attitude seems oil essential of hazards, some of and 0 tumors safrole. 604 0 metabolic carcinogenicily that occur Carcinogens 0 of this as Miller, OJ be ignored. of 0
of I -acetoxycstragole
in
Jourrlal Duberlret, of
of the National Caww L. et bergamot an al. (1990) and oil as a a,nd overview.
et al., 1977).
concenlration
areas
are very real and cannot very agree the much in the
As I have said on many occasions, interests to, aromatherapy on safety trade and to industry guidelines the implement
phototoxic ceased
Photochemistry
Photobiolo~~ 7: 362365 Gleason, toxicology 5th edn. M. N. et al. (1984) of commercial Williams & Liver
profession
In a study on 63 volunteers, did not significantly responses colour (Zaynoun statistical brown. bergamot phototoxic individuals average colour black of was a affect
in eye colour, age, sex and ability to tan to bergamot ct al., 1977). difference The average oil, There
aromatherapists ignoring pretending This attitude. thorough hazards retailers, teachers to essential subjecl something increase oil should for It
to be one
in rats by feeding
Archives of Pathology 75: 595Miller, J. A. et al. (1982) activation of and E. naturally in many Mutagens C. et al. The and spices. in the
significant
and unrealistic
between those with concentration to produce in compared those with brown of a these to an skin or
skin described
alkenylbenzenes
we will be able to distinguish Ihe illusory writers, or practitioners, our safety. not I be Whether
we are manuracturers, researchers, we all need believe regarded advanced be basic to training. knowledge
Environ.ment 1: 83-96 (1983) of mouse the and and Structure-activity carcinogenicities rat of some synthetic relaled 0 Toxicity variety). 0 (1979) to studies in the naturally safrole J. of M.
described (Zaynoun
A suntan
occurring and et
gave light skin some extra protection. When There Firstly, used there are
LWO
alkenylbcnzene
so-called
is an increased scenarios
risk
of the
training
Cancer Research 43: 1124-l 134 Taylor, of oil calamus and S. safrolc.
phototoxicity in which oils risk of phototoxicity if several together, may be increased. phototoxic the For risk are if the increases
any serious
instance,
and cumin oils are both used in equal proportions, safe percentage if will be 0.2% concentrated 01 essential Citrus a oil oils large or 0 Chronic 0 warning. 0 Abbot, D. D. et al. (1961)
carcinogenesis 0 Wiseman.
Research 39: 4378-4380 R. W. et al. (1987) studies of safrole of the to on male (1981) of to the l alkenylStructure-activity hepatocarcinogenicities benzene estragole administration mice. 0 G et al. (1967) of some activily estragole q/ derivatives and oral toxicity Anon (1992) of oil of sassafras
for each, not 0.4% for each. Secondly, (deterpenated) maximum degree generally amount of (rdeterpenised, tcrpcncfree) possess (including much larger concentrated all the citrus their of citrus oils are used, the in proporlion to the
related
percentage
and safrol.
: 62
burn
should be reduced
,Journal
:4
Deterpenated oils therefore components in (1976) of oil will of So, a 10 times lemon
terpenelcss, other
furanocoumarins)
amounts. expressed
Zaynoun, phototoxic
study of bcrgamot a
have a maximum
safe ConcenlraLion
methoxybenzenc) xyestragole
Dermatitis 3: 225-239