Introduction

Menopause is a time of physical, mental and emotional change for women. Most women going through menopause experience varying degrees of moodiness and emotional upset. A significant percentage of women experience elevated instances of depression and anger. Coping with these emotions can be challenging. It is important to seek the assistance of your physician and establish a good support system. Menopause is the phase of a woman's life when she stops ovulating and stops her monthly menstrual bleeding. Menopause is associated with significant hormonal changes in particular, the rapid cessation of estrogen production by the ovaries and rapid decline in estrogen available to the woman's body. These hormonal changes cause a range of symptoms in the period leading up to menopause, known as peri-menopause or the menopausal transition. At this time, menstrual cycles become irregular and hormone levels fluctuate. Symptoms of menopause often persist post-menopause (i.e. for more than one year after a woman's final menstrual cycle). Symptoms that occur peri- and post-menopause include vasomotor symptoms (e.g. hot flushes), sexual symptoms and mood changes.

Psychological changes during menopause

The causes of mood changes associated with menopause are not well understood and there are a few different theories. Some health professionals argue that the mood changes occur as a result of the hormonal changes of menopause. This theory is plausible because oestrogen plays a role in many brain functions that affect mood and memory. Other health professionals argue that mood changes associated with menopause are due to sleeplessness resulting from hot flushes and other life changes (e.g. kids leaving home) that occur at this time of life. Women experience many stresses at the same time as menopause, and it is also possible that these stresses could be responsible for the mood changes that commonly occur in the menopausal period. Stressors which occur at the same time as menopause may be external (e.g. having to care for an ageing parent) or internal (e.g. regret about past life choices). Problems with current relationships or a lack of social support may worsen mood symptoms during menopause. Other symptoms of menopause, including hot flushes and sexual dysfunction, can also have an effect on mood and relationships. Changes to the body and associated issues with body image, as well as attitudes towards ageing, can all affect a woman's mood as she transitions to menopause.

Types of mood swings during menopause

Regardless of whether mood changes are directly associated with menopause or occur as a result of other factors, many women experience mood changes in the menopausal period. They can take mild forms such as feeling irritated and upset, or more severe forms such as rapid temper changes and aggression. Feelings commonly experienced include:

Anxiety, which may be accompanied by: Rapid heartbeat; Rapid breathing; Sweating; Dizziness; Depressed or unstable mood Phobias Low self-esteem Irritability Tearfulness Lack of motivation or energy Poor concentration Poor sleep Reduced confidence Forgetfulness; and Panic attacks.

CAUSES OF MOOD CHANGES

Some women are more likely than others to experience mood symptoms during menopause. They include: Women whose peri-menopausal period exceeds 27 months; Women who experience moderate to severe hot flushes. Experiencing hot flushes is associated with a 4.6 times increased risk of developing depression; Women with a history of depression are 49 times more likely to experience depressed mood in the menopausal transition; Women with other factors that increase the risk of depression, including: Poor relationship satisfaction; Significant life stress; Low self-esteem; Negative body image; Lack of exercise; and/or Excessive alcohol intake.

Cultural influences and mood changes in menopause

The psychological changes that occur at menopause vary between women from different cultural backgrounds. These differences are thought to arise because of the different social meanings of menopause and the relative value different cultures place on younger and older female bodies. Western cultures tend to emphasize youthful women and give them the most visible and valuable female roles in society. This can make women approaching or passing menopause feel undervalued. Similarly, cultures that emphasize fertility and women's child-bearing roles tend to undervalue post-menopausal women.

Effects of mood changes during menopause

The mood changes that occur in the menopause transition can cause women considerable distress and affect their quality of life. They may also have an effect on other people, particularly people the woman spends considerable periods of time with, such as her partner, family and colleagues

Investigating mood swings during menopause

Many women go to the doctor to discuss menopausal mood changes and possible treatments for them. It is highly likely that the doctor will ask detailed questions about the woman's life in order to assess whether the symptoms are caused by menopause or another health condition. For many women, menopause may be a catalyst to discuss existing issues with their doctor, and it is important to tell the doctor whether or not the symptoms began before other menopausal symptoms. One of the key areas of questioning is the woman's history of psychological illness (e.g. depression), as those who have experienced psychological conditions in the past are more likely to also experience such symptoms during menopause. Women with a history of psychological illness who display symptoms of depression in the menopausal transition will generally be referred to a psychological health specialist for further assessment. The specialist will be able to determine whether the woman's symptoms are a result of menopause, or if they are cause by a psychological illness that requires treatment. Women should be aware that not all mood disorders which occur at the time as menopause are due to menopausal changes. It is useful to consider whether or not there are other factors which may be affecting mood. Such factors include: Life circumstances: Including: Roles and responsibilities at work and in the home; Whether or not there have been recent role changes; and Levels of satisfaction with life roles; Relationship dynamics: Including: The presence or absence of a partner; Quality of the intimate relationship, including whether or not sexual symptoms of menopause have impacted on the relationship; Changes in relationships with family members, including parents (e.g. becoming the carer for one of your parents) and children (e.g. who may be leaving home); Support networks, including the availability of supportive friends. A lack of social support is associated with a higher likelihood of experiencing menopausal symptoms; Medical disorders which may be affecting mood; Attitude towards menopause: Having a negative attitude towards menopause for example, seeing it as a crisis rather than the start of a new phase of life has been shown to increase the likelihood of menopausal symptoms. Cultural issues may also be contributing to menopausal mood changes (e.g. the extent to which post-menopausal women are viewed as socially valuable or desirable within the cultural group); and Body image: The physical changes that occur at menopause may cause some women to become dissatisfied with their bodies, which can contribute to depression.

Treatment
Hormone replacement therapy

Oestrogen
Oestrogen is the primary hormone produced by a woman's ovaries. It is implicated in numerous reproductive functions, including regulating menstruation, female sexual response (e.g. lubrication) and female sexual development. Oestrogen shows promise in relieving minor mood disorders and appears to exert an effect over and above the indirect effect of reducing hot flushes. However, further research is needed and oestrogen has not been demonstrated to be effective in treating menopausal women with major depression. There is some evidence that oestrogen can enhance the effects of antidepressants (selective serotonin reuptake inhibitors) in the treatment of depression. Oestrogen appears to be more effective in the perimenopausal period than post-menopause.

Progesterone
Progesterone is a hormone produced by the ovaries which plays an important role in regulating menstruation, pregnancy and breastfeeding. Progesterone alone appears to have a negative effect on mood in menopausal women. When progesterone is added to oestrogen for hormone replacement therapy (which is standard for all women who have not undergone hysterectomy), it reduces the moodenhancing effects of oestrogen.

Androgens
Androgens, including testosterone, are hormones produced by both males and females. Two different hormones from the androgen group, testosterone (produced by the ovaries and the adrenal gland) and dehydroepiandrosterone (produced naturally by the adrenal gland) have both been demonstrated effective in small trials for improving depressed mood in menopausal women. Testosterone has also been shown to improve menopausal anxiety.

Tibolone
Tibolone is a synthetic hormone with oestrogenic, progesterogenic and androgenic properties, meaning that it fulfils similar functions in the human body to hormones from the oestrogen, progesterone and androgen groups. Initial evidence suggests that tibolone improves mood in post-menopausal women. Further research is needed to confirm the results of early trials.

Isoflavones
Isoflavones are a type of natural oestrogen found in plants. A recent review of evidence found that red clover isoflavones significantly improved depression and mood compared to women who did not receive the treatment (placebo). These results have been confirmed in a further randomised controlled trial which showed a 76% reduction in depression and anxiety symptoms in a group of post-menopausal women receiving 80mg red clover twice daily, compared to a 21% improvement in placebo. However, researchers were unsure whether the improvement in mood was a direct result of the supplement or an indirect result due an 80% improvement in hot flushes.

Another isoflavone, soy protein, has not demonstrated any significant improvement of irritability, depression or anxiousness.

Tips for reducing mood changes of menopause

Women experiencing menopause-related mood changes may try the following tips to reduce the impact of mood changes: Exercise regularly to promote better sleep, which can in turn improve mood; Ensure regular mental stimulation (e.g. by doing crosswords or puzzles) to maintain cognition and reduce symptoms of poor concentration and forgetfulness; Engage in social activities to improve mental function; Reduce alcohol consumption, as excessive alcohol can have a negative effect on memory; Learn some relaxation or stress reduction strategies to help cope when symptoms arise; For severe symptoms or to cope with stressful events, seeing a counsellor may be useful; Talking to trusted family members and friends can also be useful; Examine your attitude to ageing and other changes which are occurring (e.g. body changes). Focus on the positive things that await you post-menopause, and try to look forward to the next stage of your life; Find a role that will satisfy you and make you feel important. You may wish to get a job, work as a volunteer, enrol in a course or join an interest group; Work on your relationships. Satisfying relationships with an intimate partner, family and friends are all important aspects of coping with and reducing the impact of mood changes associated with menopause; Treat other symptoms of menopause, including sexual dysfunctions and hot flushes, as these can significantly impact on a woman's quality of life and her mood; Keep a diary of your thoughts and feelings. This may help you identify things that trigger bad moods and develop strategies for coping with them; Treat yourself by taking time out and doing something special that you have always wanted to do; Think about your achievements and focus on these when you are feeling down; Identify the things that cause stress and try to reduce them.

CONCLUSION
In puberty, hormones stimulate other organs to produce hormones and therefore, cause other organs in the body to start functioning. In the female the hypothalamus sends a message to the pituitary gland which causes the FSH, and LH to cause the ovaries to start producing estrogen and progesterone. It is these hormones that cause the menstrual cycle to commence. It is also the regression of these hormones that will cause the menstrual cycle to terminate at a period in life called menopause. Menopause can be a frightening and traumatizing when the female is not made aware of some of the

signs along the way. Much of this fear is credited to the lack of knowledge of hormonal change in the body. This insufficient knowledge may stem back as far as puberty or menstruation and the function of the hormones. This lack of knowledge can lead to mixed feelings and relate to more complex problems. There are many physician specialists that can help during various periods in life to arrest many of the anxieties associated with menopause.

BIBLIOGRAPHY
1) www.webmd.com/menopause/guide/emotional-roller-coaster 2) www.virtualmedicalcentre.com 3) ww.netplaces.com/menopause/perimenopause. 4) womenshealth.gov/menopause/menopause-mental-health 5) menopause.about.com 6) www.healthcommunities.com