11th World Congress in Fetal Medicine

Sunday 24 June 2012

08:00-09:00 09:00-09:10 Registration Welcome to the World Congress

Serono Symposia International Foundation Born after ART: from the laboratory to the delivery room
09:10-09:25 09:25-12:30 Discussants: 09.25-09:50 09:50-10:15 10:15-10:40 10:40-11:05 11:05-11:40 11:40-12:05 12:05-12:30 12:30-13.00 13:00-14:00 14:30 16:30 14:30-15:30 15:30-16:30 14:20-16:30 Introduction Infertility and obstetric complications Giuseppe Grimaldi (Italy), Kypros Nicolaides (UK) Biological versus chronological ovarian age Selection of embryos to avoid multiple pregnancies PCOS: infertility and obstetrical problems Preimplantation screening and diagnosis Coffee break Implantation and obstetric complications Obstetrical problems in ageing patients Cell free plasma RNA in pregnancy complications Lunch break Serono Symposia International Foundation Workshops Preimplantation screening and diagnosis Dagan Wells (UK) Ultrasound in ART Renato Fanchin (France) Eurofoetus scientific meeting on fetal therapy Carlos Simon (Spain) Avi Tsafrir (Israel) Carl Weiner (USA) Robert Fischer (Germany)

Carlos Alviggi (Italy) Markus Montag (Germany) Angelique Goverde (Netherlands) Dagan Wells (UK)

Intrauterine blood transfusion Discussants: Dick Oepkes (Netherlands), Greg Ryan (Canada) 14:20-14:10 Long term follow up after intrauterine transfusions 14:10-14:20 MCA-PSV in previously transfused fetuses 14:20-14:30 MCA-PSV in previously transfused fetuses Diaphragmatic hernia and other lung diseases (90 min) Discussants: Jan Deprest (Belgium), Greg Ryan (Canada) 14:30-14:40 Tracheal occlusion in the fetal rabbit 14:40-14:55 Quantification of lung development in CDH 14:55-15:10 Lung assessment in other lung diseases 15:10-15:20 Liver to thoracic cavity volume ratio in CDH 15:20-15:30 Stomach position & liver to thoracic cavity volume ratio 15:30-15:40 Experience with FETO 15:40-15:50 Late FETO followed by postnatal ECHMO 15:50-16:00 Lung mass: Radiofrequency ablation 16:00-16:10 Pediatric outcome after pleuroamniotic shunting 18:00-19:15 Discussants: 18:00-18:25 18:25-18:50 18:50-19:15 19:15-20:00 21:00-24:00 Fertility: past, present and future Erik Ernst (Denmark), Antonio Pellicer (Spain) Egg donation Germ line stem cells ageing Fertility preservation: oncology and social reasons Future of non-invasive prenatal diagnosis Welcome party

Irene Lindenburg (Netherlands) Wessam Kurdi (Saudi Arabia) Monika Hermann (France)

Aline Vuckovic (Belgium) Jan Deprest (Belgium) Greg Ryan (Canada) Jacques Jani (Belgium) Anne-Gael Cordier (France) Alexandra Benachi (France) Roland Axt-Fliedner (Germany) David Baud (Canada) Rohan DSouza (Canada)

Antonio Pellicer (Spain) Leanne Jones (USA) Erik Ernst (Denmark) Rossa Chiu (China)

Monday 25th June 2012

Eurofoetus Meeting: Fetal and postnatal surgery

09:00-10:20 Discussants: 09:00-09:20 09:20-09:40 09:40-09:50 09:50-10:10 10:20-11:00 Discussants: 10:20-10:40 10:40-11:00 11:00-11:30 11:30-13:00 Discussants: 11:30-11:45 11:45:12:00 12:00-12:15 12:15-12:35 12:35:12:50 13:00-14:00 14:00-16:25 Discussants: 14:00-14:15 14:15-14:30 14:30-14:45 14:45-15:00 15:00-15:15 15:15-15:25 15:25-15:40 15:40-15:50 15:50-16:00 16:00-16.10 16:10-16:25 18:00-18:40 Discussants: 18:00-18:20 18:20-18:40 18:40-19:10 Discussants: 18:40-18:50 18:50-19:00 19:00-19:10 19:10-20:00 19:10-19:40 19:40-20:00 Abdominal wall and gastrointestinal defects Alan Flake (USA), Jan Deprest (Belgium) AWDs: Postnatal management and long term outcome AWDs: Prenatal management Gastroschisis: advantage of delivery at 37 wks Necrotizing enterocolitis: Postnatal management Obstructive uropathy Mark Kilby (UK), Greg Ryan (Canada) Results of the PLUTO trial Long term outcome of fetuses with PLUTO Coffee break Spina bifida Alan Flake (USA), Jan Deprest (Belgium) Natural history of spina bifida Open fetal surgery: results of MOMS trial Open fetal surgery: results from a European centre Fetoscopic repair: clinical results Long term follow up after prenatal repair Lunch break Eurofoetus scientific meeting on monochorionic twins Kurt Hecher (Germany), Yves Ville (France) MC twins: Timing of delivery MC twins: Outcome according to method of conception Laser for TTTS: Stage related long term outcome Laser for TTTS: Effect of experience on outcome Laser surgery: Persistent anastomoses Equatorial dichorionization TAPS: Vascular pattern in the placenta TAPS: Management options TAPS: Cerebral injury after expectant management Selective termination: Long-term neurodevelopment Selective FGR: Surgical management Head and neck defects Agostinho Pierro (UK), Alan Flake (USA) Surgery for skull deformities Management of oropharyngeal and neck masses New applications of fetoscopy Yves Ville (France), Kypros Nicolaides (UK) Upper airway obstruction Inter-hemispheric arachnoid cyst Abdominal wall defects Special lectures The small fetus: SGA vs. FGR Hippocrates on Obstetrics and Gynecology

Agostinho Pierro (UK) Dominique Luton (France) David Baud (Canada) Agostinho Pierro (UK)

Katei Morris (UK) Divyesh Desai (UK)

Deborah Sival (Netherlands) Alan Flake (USA) Marta Paliga (Poland) Roland Axt-Fliedner (Germany) Deborah Sival (Netherlands)

Greg Ryan (Canada) Liesbeth Lewi (Belgium) Yves Ville (France) Kurt Hecher (Germany) Liesbeth Lewi (Belgium) Ahmet Baschat (USA) Romain Favre (France) Ariadna Grigoriu (Canada) Enrico Lopriore (Netherelands) Jeanine van Klink (Netherlands) Eduard Gratacos (Spain)

Stefan Berg (Netherlands) Stefan Berg (Netherlands)

Eduard Gratacos (Spain) Gihad Chalouhi (France) Kurt Hecher (Germany)

Eduard Gratacos (Spain) Stefanos Geroulanos (Switzerland)

Tuesday 26th June 2012

International Society for Prenatal Diagnosis: Molecular Techniques for Prenatal Diagnosis
09:00-13:00 Discussants: 09:00-09:20 09:20-10:45 Non-invasive prenatal diagnosis (NIPD) Peter Benn (USA), Howard Cuckle (UK) Fetal aneuploidy testing from DNA in maternal plasma Results from clinical implementation Ariosa Diagnostics Beijing Genome Institute LifeCodexx Natera NIPD Genetics Sequenom Verinata University of Paris Established aneuploidy markers in the post-NIPD era Coffee break Perspective of patients and healthcare professionals Lynn Chitty (UK)

Peter Benn (USA) Ken Song (USA) Wei Wang (China) Michael Lutz (Germany) George Gemelos (USA) Philippos Patsalis (Cyprus) Alan Bombard (USA) Amy Sehnert (USA) Laurent Salomon (France) Howard Cuckle (UK)

10:45-11:00 11:00-11:30 11:30-11:45 11:45-13:00 Discussants: 11:45-12:05 12:05-12:25 12:25-12:50 12:50-13.00 13:00-14:00 14:30-16:20 Discussants:

Molecular diagnosis in CVS and amniotic fluid samples Eugene Pergement (USA), Mark Evans (USA) Overview of techniques Is karyotyping still necessary? Results of the NIH prenatal micro-array trial Genomic SNP array in routine prenatal diagnosis Lunch break Eurofetus scientific meeting on monochorionic twins Dick Oepkes (Netherlands), Liesbeth Lewi (Belgium)

Peter Benn (USA) Francesca Grati (Italy) Ron Wapner USA) Malgorzata Srebniak (Netherlands)

TTTS: Classification of severity 14:30-14:40 Reference range of amniotic fluid with gestational age 14:40-14:50 Modification of Quintero staging 14:50-15:00 Laser surgery <17 and >26 wks 15:00-15:10 Fetal cardiovascular profile and relation to survival Laser surgery for TTTS: technique and outcome 15:10-15:20 Mapping vascular equator prior to laser surgery 15:20-15:30 CUSUM to assess performance of laser surgery 15:00-15:40 Prevention of iatrogenic membrane rupture 15:10-15:50 Antenatal cerebral lesions after laser surgery 15:50-16:00 Neurodevelopment at 30-36 months of life 16:00-16:10 Eurofoetus II trial Selective termination in monochorionic twins 16:10-16:20 Selective termination >24 wks 14:30-16:30 Course on fetal echocardiography

Philip DeKoninck (Belgium) Krzysztof Preis (Poland) David Baud (Canada) Ozhan Turan (USA)

Nicolas Fontanarosa (France) Laurent Salomon (France) Nicolas Fontanarosa (France) Yves Ville (France) Krzysztof Preis (Poland) Yves Ville (France)

Slomo Lipitz (Israel) Rabih Chaoui (Germany) Simcha Yagel (Israel)

18:00-19:05 Discussant: 18:00-18:20 18:20-18:35 18:35-18:50 18:50-19:05 19:05-19:15 19:15-20:00 Discussant: 19:15-19:30 19:30-19:40 19:40-20:00

Targeted micro-arrays in fetal medicine Eugene Pergament (USA) General review and the future Cardiac abnormalities Skeletal abnormalities Brain abnormalities Increased nuchal translucency Carrier screening Ron Wapner (USA) The need for conceptual change High throughput carrier screening Fragile X syndrome PerkinElmer Asuragen Dinner party

Ron Wapner (USA) Rabih Chaoui (Germany) Lyn Chitty (UK) Eugene Pergament (USA) Richard Choy (China)

Howard Cuckle (UK) Matthew Rabinowitz (USA) Sylvie Langlois (Canada) Sara Seneca (Belgium)

21:00-24:00

HIPPOCRATIC OATH
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I swear by Apollo Physician and Asclepius and Hygiea and all the gods and goddesses, making them my witnesses, that I will fulfill according to my ability and judgment this oath and this covenant: To hold my teacher as equal to my parents, to share my substance with him, and relieve his necessities if required; to regard his offspring as equal to my brothers and to teach them this Art - if they desire to learn it - without fee or stipulation. I will impart my knowledge of the Art to my own sons, and those of my teachers, and to disciples bound by an oath according the law of medicine, but to none others. I will follow the method of treatment which, according to my ability and judgment, I consider for the benefit of my patients, and abstain from whatever is deleterious. I will give no deadly medicine to any one if asked and in like manner I will not give a woman a pessary to produce abortion. In purity and holiness I will guard my life and my Art. I will not use the knife, not even on sufferers from stone, but will leave this to be done by men who are practitioners of this work. Whatever house I may visit, I will enter for the benefit of the sick, remaining free of all intentional injustice, of all mischief and in particular of sexual relations with either females or males, be they freemen or slaves. Whatever I may see or hear in the course of the treatment, or even outside of the treatment in regard to the life of men, I will not divulge, as reckoning that all such should be kept secret. If I fulfill this oath and do not violate it, may it be granted to me to enjoy life and art, being honoured with fame among all men for all time to come. But should I trespass and violate this Oath, may the reverse be my lot.

Wednesday 27th June 2012

09:00-11:00 Discussants: 09:00-09:10 09:10-09:20 09:20-09:30 09:30-09:40 09:40-09:50 09:50-10:00 10:00-10:10 10:10-10:20 10:20-10:30 10:30-10:40 10:40-11:00 11:00-11:30 11:30-13:00 Discussants: 11:30-11:50 11:50-12:00 12:00-12:10 12:10-12:20 12:20-12:30 12:30-12:40 12:40-12:50 12:50-13:00 13:00-14:00 14:30-16:40 Discussants: 14:30-14:50 14:50-15:00 15:00-15:10 15:10-15:30 15:30-15:50 15:50-16:00 16:00-16:10 16:10-16:25 16:25-16:40 18:00-19:00 Discussants: 18:00-18:10 18:10-18:20 18:20-18:30 18:30-18:40 18:40-18:50 18:50-19:00 19:00-19:10 19:10-20:00 Screening for aneuploidies Katia Billardo (Netherlands), Kypros Nicolaides (UK) The Big Bang theory of the origin of increased NT Effect of operator experience on NT distributions st Catalan 1 trimester combined screening st Serum PLGF in 1 trimester screening st Serum PLGF & AFP in 1 trimester screening Ductus venosus PIV mixture model nd 2 trimester BPD to NB ratio in aneuploidies nd 2 trimester frontonasal fold to NB ratio in trisomy 21 nd 2 trimester prefrontal space ratio in trisomy 21 Amniocentesis 20G vs. 22G and perinatal outcome Metabolomics in aneuploidies and preeclampsia Coffee break Impaired placentation Ahmet Baschat (USA), Kypros Nicolaides (UK) Prevention of complications by low-dose aspirin RCT: uterine artery Doppler at 20 wks and pregnancy outcome rd 3 trimester uterine artery Doppler rd 3 trimester combined screening Estimation of fetal weight by MRI Antenatal prediction of stillbirth FGR: Cortical development to predict neurological outcome FGR: Prenatal prediction of cardiovascular programming Lunch break Course on the 11-13 weeks assessment Katia Bilardo (Netherlands), Kypros Nicolaides (UK) Screening for aneuploidies: New FMF algorithm Effect of CRL on 1st trimester combined screening Manual and semi-automated measurement of NT Implications of increased NT The early anomaly scan Uterine artery Doppler in predicting PE, FGR, abruption Prospective combined early screening for PE Early screening for PE: Competing risk model Screening for PE and FGR: New FMF algorithm Preterm birth Roberto Romero (USA), Kypros Nicolaides (UK) Preterm birth: RCT of Arabin pessary in singletons Preterm birth: RCT of Arabin pessary in twins The Arabin pessary: an MRI observational follow-up study Preterm birth: Prediction from fetal adrenal gland Preterm birth: Proteomic identification of novel markers PPROM and infection: Proteomics to identify markers PPROM and infection: Pulsation of the fetal splenic vein Great obstetric syndromes Emmanuel Bujold (Canada) Elisa Llurba (Spain) Elisa Llurba (Spain) Jonathan Lai (UK) Yasmine Kacem (Belgium) Leona Poon (UK) Gabriela Egaa (Spain) Monica Cruz-Lemini (Spain)

Eugene Pergament (USA) Jiri Sonek (USA) Elena Casals Font (Spain) Oliver Kagan (Germany) Jo-Ann Johnson (Canada) Nerea Maiz (Spain) Alvaro Seplveda-Martnez (Chile) Waldo Sepulveda (Chile) Oliver Kagan (Germany) Apostolos Athanasiadis (Greece) Ray Bahado-Singh (USA)

Kypros Nicolaides (UK) Oliver Kagan (Germany) Merel Bakker (Netherlands) Katia Bilardo (Netherlands) Rabih Chaoui (Germany) Luxmimalar Velauthar (UK) Adolfo Etchegaray (Argentina) Ranjit Akolekar (UK) Kypros Nicolaides (UK)

Elena Carreras (Spain) Jesus Calvo (UK) Jacques Jani (Belgium) Ozhan Turan (USA) Mark Evans (USA) Marian Kacerovsky (Czech R) Ivana Musilova (Czech R) Roberto Romero (USA)

Thursday 28th June 2012

08:30-10:45 Discussants: 08:30-08:40 08:40-08:50 CNS defects 08:50-09:00 09:00-09:10 09:10-09:20 09:20-09:30 09:30-09:45 Cardiac defects 09:45-09:55 09:55-10:05 10:05-10:15 10:15-10:25 10:25-10:35 10:35-10:45 10:45-11:05 11:40-11:50 11:50-12:00 11:05-11:30 11:30-11:45 11:45-13:00 Discussants: 11:45-11:55 11:55-12:05 12:05-13:00 Fetal defects Rabih Chaoui (Germany), Gerry Visser (Netherlands) The fetal eye: a simple window for a more complex diagnosis MRI and Ultrasound fusion imaging for prenatal examination Georges Haddad (France) Laurent Salomon (France)

Spina bifida: Screening by BPD & AFP at 11-13 wks Spina bifida: Posterior brain at 11-13 wks Absent corpus callosum: Prediction at 11-13 wks Distinction of Blakes pouch and Dandy Walker complex Fetal brain examination by 2D-US, 3D-US and MRI

Jean-Pierre Bernard (France) Athena Souka (Greece) Robert Lachmann (Germany) Efstathios Varvarigos (Italy) Eldad Katorza (Israel)

Ectopia cordis at 11-13 wks The STIC in the first trimester of pregnancy Stenting the atrial septum in left atrial hypertension Diagnosis and assessment of HLHS Diagnosis of premature obstruction of foramen ovale Effect of cardiac defects on fetal brain growth Fetal CMV infection st Value of 1 trimester IgG avidity index Assessment by US and MRI Coffee break Pregnancy after solid organ transplantation Gestational Diabetes Mellitus Gerry Visser (Netherlands), Ahmet Baschat (USA) Fetal and maternal serum salucin levels Fetal liver length in the prediction of macrosomia Screening and managing risks in diabetes mellitus

Waldo Sepulveda (Chile) Carmela Votino (Belgium) Greg Ryan (Canada) Christian Enzensberger (Germany) Christoph Berg (Germany) Sifa Turan (USA)

Yves Ville (France) Shlomo Lipitz (Israel)

Miroslaw Wielgos (Poland)

Ebru Celik (Turkey) Julia Murlewska (Poland) Gerry Visser (Netherlands) Ahmet Baschat (USA)

13:00-14:00

Lunch

16:00-24:00

Boat trip to Bodrum, Turkey