Q. No 5. Solve any four of the following sub-questions (5 marks each; max. limit: 15 lines) 20 marks 5.1.

State various methods for enhancement of bioavailability of orally administered drugs? 15 5.2. Explain in brief accelerated stability study protocol involving Arrhenius theory? 5.3. Explain in brief with one example 3 2 factorial design for optimization? 5.4. The drug candidate is suffering severe first pass effect and degrading in acidic pH, suiggest drug delivery system for this drug and justify 5.5. Enumerate and explain in brief NDDS approaches for ophthalmic purpose. 5.6. Suggest & justify drug delivery system for a drug acting locally in stomach and having short half life. -----16

ANNEXURE-III
Model Question Paper for Ph. D Admission Entrance Test (Paper-II) in Pharmaceutical Sciences -----------------------------------------------------------------------------------------------------------------University of Pune Paper code Faculty: Pharmaceutical Sciences Subject & Subject code: Pharmaceutical & Medicinal Chemistry (PY02) Date: Time: (Max. time for section-I: 30 min.) ---------------------------------------------------------------------------------------------------------------Instructions to the Candidates a. All questions are compulsory b. Answer book of section-I shall be collected at end of 30 minutes from the beginning of the examination. c. Draw figures, sketches and diagrams where ever necessary. d. Limit of lines for answers doesn t apply when figures, tables and schematic diagrams are drawn as a part of answer. ---------------------------------------------------------------------------------------------------------------SECTION-I Q. 1.0: Solve all following sub-questions (One mark each) 20 marks 1.1. Molarity of simple syrup USP is A) 5.8 B) 8.5 C) 4.7 D) 85 1.2. Complete mixing of magnesium stearate with tablet granules will A) Decrease the crushing strength of tablets B) Increase tablet hardness C) Increase tablet dissolution D) Increase tablet disintegration 1.3. Rate of elimination of drug from body is, if follows zero order kinetics, then it A) is constant B) Depends on plasma concentration C) Depends on type of metabolic pathway D) None of the above 1.4. 2, 2 , 2 , 2 - {[4, 8 dipiperidino (5, 4 -D) pyrimidino - 2, 6 - diyl}dinitrilo} tetraethanol is A) Disopyramide B) Dipyridamole C) Dicyclomine D) Disulfiram 1.5. The parent nucleus present in the structure aconitine is A) Benzazulene B) Imidazole C) Indole D) Piperidine 17 1.6. The malonic ester synthesis of barbital yields which of the following main form? A) -form B) -form C) -form D) -form 1.7. Following receptors are membrane proteins, except a) Receptors for fast neurotransmitters coupled directly to an ion channel b) Receptors for many hormones and slow transmitters, coupled to effectors System

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c) Receptors for insulin and various growth factors, which are directly linked to Tyrosine kinase. d) Receptors for steroid hormone 1.8. Opoid receptors act via a) Opening of potassium channels b) Inhibition of calcium channels c) Both (a) and (b) d) Opening of sodium channels 1.9. _1- receptors are coupled with_______ G protein. a) Gs b) Gi c) Gq d) Go 1.10. The apparatus recommended in BP for the hydrodistillation of volatile oil is known as ____________ A) Soxhlet apparatus B) Clavengers apparatus C) Supercritical fluid extractor D) Enfleurage 1.11. The amount of volatile oil in volatile oil containing plant is determined by using A) Soxhlet apparatus B) Karl-Fischer apparatus C) Clevenger apparatus D) Wildman trap flask 1.12. The chemicals which are coloured red when diluted tincture of alkane stains the cell walls are A) Peptidoglycan, mucilage B) Cutin, suberin C) Lignin, protein D) Starch, calcium oxalate 1.13. The C=O (aldehydic) bond shows characteristic stretching band at about A) 1730 - 1700 cm-1 B) 2830 - 2695 cm-1 C) 1060 - 1275 cm-1 D) 1000 - 1200 cm-1 18 1.14. A Ramachandran plot shows __________ (A) The amino acid residues that have the greatest degrees of rotational freedom. (B) The sterically allowed rotational angles between the side chain groups in a peptide and the peptide backbone. (C) The sterically limited rotational angles (domains) where phi and psi are allowed in the protein backbone. (D) The angles that are allowed about the bonds connecting the amide nitrogen in a peptide bond. 1.16. The neurotransmitter derived from tryptophan is a. GABA b. Epinephrine c. Serotonin d. nor-epinephrine 1.16. Sterilization indicator used for ethylene oxide sterilization is A) Bacillus osteoarthropathies B) Bacillus pumilus C) Bacillus subtilis var. niger D) Pseudomonas dimunata 1.17. If a drug is not labeled in a prescribed manner, it is deemed to be .. A) Spurious B) Adulterated C) Substandard D) Misbranded 1.18. The patient suffering from complex partial seizures was treated for six months with carbamazepine, but recently, has been experiencing breakthrough seizures on a more frequent basis. You are considering adding a second drug to this patient s anti-seizure regimen. Which one of the following is least likely to have a pharmacokinetic interaction with carbamazepine A) Topiramate B) Tiagabine C) Levetiracetam D) Lamotrigine 1.19. The chi-square distribution always has . A) Positive values B) Negative values C) Positive and Negative Values D) None of the above 1.20. The paired T- test is used to compare . A) Median B) Standard deviation C) Mean D) None of the above 19

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SECTION-II Q. No 2. Solve all following sub-questions (One mark each; max limit: 2 lines) 15 marks 2.1. Write chemical name for Benzyl Penicillin (Penicillin G) as per IUPAC nomenclature. 2.2. Give a structural formula of a diuretic, which contains a pyrazine ring? 2.3. Name the specific type of antagonism for the combination of Dimercaprol and mercury. 2.4. Name the liver metabolism products of isoniazide. 2.5. Acyclovir is converted to its triphosphate metabolite by which enzyme? 2.6. Name any antimony compound used as anthelmintics. 2.7. How many NMR signals are possible for following compound? 2.8. What is Reads formula? 2.9. Name the microorganism used in the microbiological assay of Rifampicin IP 2.10. Why pioglitazone is not preferred over sitagliptin in the treatment of type II diabetic patient who is diagnosed with heart failure? 2.11. Absence of which structural feature makes enalapril to prefer over captopril? Why? 2.12. Explain why HMG CoA reductase (Statins) inhibitors are taken at bedtime? 2.13. Calculate the pH of 10-8 molar HCL solution 2.14. Enumerate metabolic pathways of lidocaine. 2.15. Explain why acidic drugs are better absorbed from stomach? Q. No 3. Solve all following sub-questions (Two marks each; max limit: 3 lines) 30 marks 3.1. Draw the four stereo isomers of ephedrine. 3.2. Write the structure of active metabolite of testosterone. 3.3. Outline the synthesis of isoniazid 3.4. Enlist any two long- and fast-acting insulin analogues.
H3C Br COOH

20 3.5. One of the isomers of ibuprofen is biologically active whereas other possesses very very low activity. It is quite possible to manufacture and market only active isomer. In spite of this fact, explain why ibuprofen is marketed as racemic mixture? 3.6. Enlist minimum four diseases or ailments from Schedule J for which no drug can claim to prevent or cure. 3.7. Explain the term chemical shift in NMR. 3.8. Write the significance of chi-square test,. 3.9. What is cheese reaction? 3.10. What are intellectual property rights (IPR)? 3.11. What is Biuret test? Which types of compounds are usually tested? 3.12. (-) Epinephrine exhibits 12-15 time more vasoconstrictor activity than (+) epinephrine, why? 3.13. Why valcyclovir is preferred over acyclovir? 3.14. Give structure & mechanism of action of baclofen. 3.15. Enumerate the phases in cancer cell cycle. Q. No 4. Solve any five of the following sub-questions (Three marks each; max limit: 7 lines) 15 marks 4.1. Give a scheme of synthesis for Ibuprofen. 4.2. Give chemical classification of H1- antagonists with suitable examples. 4.3. What are disappointments of QSAR? 4.4. Enlist various ways by which anti malarial drugs exert their action 4.5. Define the various terminologies used in synthon approach 4.6. Explain why penicillin G is orally inactive & ampicillin is orally active? 4.7. Explain the mechanism of action of alkylating agents.

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Q. No 5. Solve any four of the following sub-questions (5 marks each; max limit: 15 lines) 20 marks 5.1. Explain the importance of enantioselectivity in drug metabolism with suitable examples. 21 5.2. Derive a general equation for kinetics of decay of radiopharmaceuticals. 5.3. Explain important points in Structure Activity Relationship of anabolic steroids. 5.4. Write short note on Receptor binding assay 5.5. Tetracycline undergoes ionization and exhibits three p Ka values at 3.3, 7.7 and 9.5. Write the structure and groups undergoing ionisation 5.6. Give planar & conformational structures of any two biologically active steroids representing one each to 5- & 5- cholestane type steroids. -----22

ANNEXURE-III
Model Question Paper for Ph. D Admission Entrance Test (Paper-II) in Pharmaceutical Sciences -----------------------------------------------------------------------------------------------------------------University of Pune Paper code Faculty: Pharmaceutical Sciences Subject & Subject code: Pharmacology (PY03) Date: Time: (Max. time for section-I:30 min.) ---------------------------------------------------------------------------------------------------------------Instructions to the Candidates a. All questions are compulsory b. Answer book of section-I shall be collected at end of 20 minutes from the beginning of the examination. c. Draw figures, sketches and diagrams where ever necessary. d. Limit of lines for answers doesn t apply when figures, tables and schematic diagrams are drawn as a part of answer. ---------------------------------------------------------------------------------------------------------------SECTION-I Q. 1.0: Solve all following sub-questions (One mark each) 20 marks 1.1. Molarity of simple syrup USP is A) 5.8 B) 8.5 C) 4.7 D) 85 1.2. Complete mixing of magnesium stearate with tablet granules will A) Decrease the crushing strength of tablets B) Increase tablet hardness C) Increase tablet dissolution D) Increase tablet disintegration 1.3. Rate of elimination of drug from body is, if follows zero order kinetics, then it A) is constant B) Depends on plasma concentration C) Depends on type of metabolic pathway D) None of the above 1.4. 2, 2 , 2 , 2 - {[4, 8 dipiperidino (5, 4 -D) pyrimidino - 2, 6 - diyl}dinitrilo} tetraethanol is A) Disopyramide B) Dipyridamole C) Dicyclomine D) Disulfiram 1.5. The parent nucleus present in the structure aconitine is A) Benzazulene B) Imidazole C) Indole D) Piperidine 23 1.6. The malonic ester synthesis of barbital yields which of the following main form? A) -form B) -form C) -form D) -form 1.7. Following receptors are membrane proteins, except a) Receptors for fast neurotransmitters coupled directly to an ion channel b) Receptors for many hormones and slow transmitters, coupled to effectors System c) Receptors for insulin and various growth factors, which are directly linked to Tyrosine kinase. d) Receptors for steroid hormone

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