:Glycolysis occurs in (1 .a) Mitochondria .b) Cytoplasm of liver only .c) Nucleus .d) Cytoplasm of all cells .

e) None of the above :Hemolytic anemia occurs due to deficiency of the following glycolytic enzyme (2 .a) PFK1 .b) Phosphoglycerate kinase .c) Enolase .d) Pyruvate kinase .e) Glucokinase :G-6-P dehydrogenase is (3 .a) NAD dependent .b) FAD dependent .c) NADP dependent .d) None of the above :HMP pathway occurs in the cytosol of (4 .a) Liver .b) Adipose tissue .c) Testis .d) All of the above .e) None of the above :Favism is due to deficiency of (5 .a) Glucose-6-phosphatase .b) Pyruvate kinase .c) G-6-P-dehydrogenase .d) Aldolase B .e) None of the above :Essential pentosuria is due to deficiency of (6 .a) Pentokinase .b) G6PD .c) L-xylulose reductase .d) PRPP synthase .e) None of the above :As regards von Gierks disease, all are correct, except (7 .a) It is due to deficiency of G-6-phosphatase in the liver & kidneys .b) There is fasting hypoglycemia .c) There is hyperlipidemia and ketosis .d) There is hypouricemia :Hereditary fructose intolerance is due to deficiency of (8 .a) Fructokinase .b) F1,6 bisphosphatase .c) Aldolase B .d) Hexokinase .e) None of the above :Galactosemia is mainly due to deficiency of (9 .a) UDP-glucose-4 epimerase .b) Galactokinase .c) Galctose-1-P-uridyl transferase .d) None of the above .e) b and c :In galactosemia there is (10 .a) Cataract due to increased dulcitol in eye lens .b) Normal growth and development .c) Liver failure and mental retardation .d) All of the above .e) a and c :All of the following conditions lead to fasting hypoglycemia, except (11 .a) Liver damage .b) Insulinoma .c) Addisons syndrome .d) Pheochromocytoma .e) Von Gierks disease :All of the following conditions lead to glucosuria, except (12 .a) Diabetes mellitus .b) Diabetes insipidus .c) After gastrectomy .d) Pheochromocytoma .e) Renal disease :Most dietary lipids are packaged and exported from the intestinal mucosal cells is in the form of (1 .a) Free fatty acids .b) Mixed micelles .c) Free triacylglycerol .d) 2-monoacylglycerol .e) Chylomicrons :The end products of digestion of TAG by pancreatic lipase include all the following, except (2

.a) 1-MAG .b) DAG .c) Free fatty acids .d) 2-MAG .e) Glycerol :As regards depot fat, all are correct, except (3 .a) It is composed only of TAG .b) It is rich in saturated fatty acids .c) It is termed variable element .d) It acts as heat insulator :The immediate precursor of mevalonic acid is (4 .a) Mevalonyl CoA .b) Mevalonyl pyrophosphate .c) Acetoacetyl-CoA .d) 3-Hydroxy-3-methylglutaryl CoA :The key enzyme of fatty acid synthesis is (5 .a) Acyl CoA synthase =.b) Propionyl CoA carboxylase .c) Acetyl CoA carboxylase .d) FA synthase .e) None of the above :Arachidonic acid (6 .a) Is an essential fatty acid .b) Can be formed from -linolenic acid .c) Can be formed from linoleic acid .d) Non-essential FA which contain 3 double bonds .e) None of the above :NSAIDs inhibit prostanoid synthesis through inhibition of (7 .a) Lipooxygenase .b) Phospholipase A2 .c) Cyclooxygenase .d) Peroxidase .e) None of the above :Aspirin is used as antithrombotic drug due to (8 .a) Inhibition of synthesis of PGI .b) Decrease TX formation by inhibiting phospholipase A2 .c) Inhibition of cyclooxygenase .d) Stimulation of TX synthase .e) None of the above :Gauchers disease is due to deficiency of (9 a) -glucosidase .b) Ceramidase .c) Sphingomyelinase .d) -galactosidase .e) None of the above :The key enzyme of cholesterol synthesis is (10 .a) HMG CoA lyase .b) HMG CoA synthase .c) HMG CoA reductase .d) Ketothiolase .e) None of the above :The key enzyme of bile acid synthesis is (11 .a) Cholate synthase .b) Cholate reductase .c) 7-hydroxylase .d) 1-hydroxylase .e) None of the above :The lipoprotein which is responsible for reverse cholesterol transport is (12 .a) VLDL .b) LDL .c) HDL .d) Chylomicrons :Ketone bodies formation occurs in (13 .a) Mitochondria of extrahepatic tissues .b) Cytosol of liver .c) Hepatic mitochondria .d) Muscle mitochondria .e) None of the above :All of the following increase ketogenesis, except (14 .a) Starvation .b) Diabetes mellitus .c) Insulin in case of diabetes .d) Hypersecretion of anti-insulin hormone .e) Carbohydrate deficiency :Oxidation of acetoacetate occurs in (15 .a) Hepatic mitochondria .b) Cytosol of liver

.c) Mitochondria of extrahepatic tissues .d) Endoplasmic reticulum of brain .e) None of the above :All of the following are causes of ketosis, except (16 .a) Starvation .b) Prolonged and severe muscular exercise .c) Severe uncontrolled diabetes mellitus .d) Nephrotic syndrome .e) High fat, low carbohydrate diet :One of the following is not a complication of ketosis (17 .a) Hypokalemia .b) Acidosis .c) Hypernatremia .d) Dehydration .e) Coma :Diabetic ketoacidosis is treated by (18 .a) Glucose by intravenous infusion .b) Insulin by intravenous infusion .c) Potassium .d) Bicarbonate .e) All of the above :As regards VLDL (19 .a) It is synthesized in the liver .b) The main lipid is cholesterol .c) It contains apo B48 as main protein .d) Acts as reservoir for apo C and A e) Important for removal of cholesterol from tissues to liver