Fibrodysplasia Ossificans Progressiva (FOP) 1

The Rare Disorder of Fibrodysplasia Ossificans Progressiva Noelle Nakagaki National University Human Anatomy and Physiology 1

Fibrodysplasia Ossificans Progressiva (FOP) 2 I. Introduction a) Background of Fibrodysplasia ossificans progressiva b) Symptoms and Characteristics of Fibrodysplasia Ossificans Progressiva c) Treatment for Fibrodysplasia Ossificans Progressiva Though Fibrodysplasia ossificans progressiva is a rare disorder, it has opened the possibilities to researchers in discovering cures for other bones related disorders. II. Body a) Background of Fibrodysplasia ossificans progressiva 1) Affected areas a) Skeletal Muscles b) Connective Tissue 2) Genetic Disorder a) Can be inherited from mother or father b) Maternal mosaicism 3) Demographics a) Affects one in two million individuals b) No ethnic patterns c) Only 185 cases in the United Stated And only 700 confirmed cases. b) Symptoms and Characteristics of Fibrodysplasia Ossificans Progressiva 1) Symptoms a) Malformed of big toe at birth 2) Early Childhood a) Swelling in the shoulders b) Inflammation in the upper back area

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c) Treatment for Fibrodysplasia Ossificans Progressiva 1) Surgery a) Makes the condition worse 2) Pharmaceutical Drugs a) To reduce the inflammation b) Slow bone growth 3) Things to avoid a) Deep tissue trauma b) Intramuscular injections III. Conclusion a) Summary 1) Background of Fibrodysplasia ossificans progressiva 2) Symptoms and Characteristics of Fibrodysplasia ossificans progressiva 3) Treatment for Fibrodysplasia ossificans progressiva

References:

Fibrodysplasia Ossificans Progressiva (FOP) 4 International Fibrodysplasia Ossificans Progressiva Association. (2009). Fop skeleton. [0]. Retrieved from http://www.ifopa.org/en/what-is-fop/fop-skeleton.html

Pignolo, R. J., Shore, E. M., & Kaplan, F. S. (2011). Fibrodysplasia ossificans progressiva: Clinical and genetic aspects. Orphanet Journal of Rare Diseases, 6(1), 80-80. doi:10.1186/17501172-6-80

Kaplan, F., Zasloff, M., Kitterman, J., Shore, E., Hong, C., & Rocke, D. (2010). Early mortality and cardiorespiratory failure in patients with fibrodysplasia ossificans progressiva. Retrieved from http://dmrocke.ucdavis.edu/early mortality.pdf

[Kaplan FS, Shore EM, Pignolo RJ (eds), name of individual consortium member, and The International Clinical Consortium on FOP. The medical management of fibrodysplasia ossificans progressiva: current treatment considerations. Clin Proc Intl Clin Consort FOP 4:1-100, 2011]

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Kreeger, K. (2006, April 23). Penn researchers discover gene that creates second skeleton. Retrieved from http://www.usbjd.org/research/research_op.cfm?dirID=233 (Kreeger, 2006)

Kaplan, F. S. M. (28 O). Pubmed central. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424023/ (Kaplan, 28 O)

McRot, W. (2012, may 14). Nih genetics home refrence. Retrieved from http://ghr.nlm.nih.gov/condition/fibrodysplasia-ossificans-progressiva (McRot, 2012)

Ucsf benioff children. (2011, Sept 27). Retrieved from http://www.ucsfbenioffchildrens.org/conditions/fibrodysplasia_ossificans_progressiva/ ("Ucsf benioff children," 2011) Paul, C. (Jan ). Biology @ suite 101. Retrieved from http://paulcampobasso.suite101.com/fibrodysplasia-ossificans-progressiva-stone-man-syndrome-a400243 (Paul, Jan ) ashland.ed. (2010, september 27). Retrieved from http://apps.ashland.edu/index.php/Fibrodysplasia_Ossificans_Progressiva ("ashland.ed," 2010) Shawn, A. M. (June). Medscape . Retrieved from http://emedicine.medscape.com/article/390416overview (Shawn, June)

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