Ma. Adeliza F.

Mortalla

BSChE-4

March 20, 2012

Engr. Felix A. Ojario

cGMP refers to the Current Good Manufacturing Practice regulations enforced by the US Food and Drug Administration (FDA). cGMPs provide for systems that assure proper design, monitoring, and control of manufacturing processes and facilities. Adherence to the cGMP regulations assures the identity, strength, quality, and purity of drug products by requiring that manufacturers of medications adequately control manufacturing operations. This includes establishing strong quality management systems, obtaining appropriate quality raw materials, establishing robust operating procedures, detecting and investigating product quality deviations, and maintaining reliable testing laboratories. This formal system of controls at a pharmaceutical company, if adequately put into practice, helps to prevent instances of contamination, mix-ups, deviations, failures, and errors. This assures that drug products meet their quality standards. Why are cGMPs so important? A consumer usually cannot detect (through smell, touch, or sight) that a drug product is safe or if it will work. While cGMPs require testing, testing alone is not adequate to ensure quality. In most instances testing is done on a small sample of a batch (for example, a drug manufacturer may test 100 tablets from a batch that contains 2 million tablets), so that most of the batch can be used for patients rather than destroyed by testing. Therefore, it is important that drugs are manufactured under conditions and practices required by the cGMP regulations to assure that quality is built into the design and manufacturing process at every step. Facilities that are in good condition, equipment that is properly maintained and calibrated, employees who are qualified and fully trained, and processes that are reliable and reproducible, are a few examples of how cGMP requirements help to assure the safety and efficacy of drug products. How does FDA determine if a company is complying with cGMP regulations? FDA inspects pharmaceutical manufacturing facilities worldwide using scientifically and cGMP- trained individuals whose job it is to evaluate whether the company is following the cGMP regulations. FDA also relies upon reports of potentially defective drug products from the public and the industry. FDA will often use these reports to identify sites for which an inspection or investigation is needed. Most companies that are inspected are found to be fully compliant with the cGMP regulations. If a manufacturer is not following cGMPs, are drug products safe for use? If a company is not complying with cGMP regulations, any drug it makes is considered adulterated under the law. This kind of adulteration means that the drug was not manufactured under conditions that comply with cGMP. It does not mean that there is necessarily something wrong with the drug. For consumers currently taking medicines from a company that was not following cGMPs, FDA usually advises these consumers not to interrupt their drug therapy, which could have serious implications for their health. Consumers should seek advice from their health care professionals before stopping or changing medications. Regulatory actions against companies with poor cGMPs are taken as a preventive measure because the manufacturing processes do not meet FDAs regulatory standards. By focusing on the procedures and processes used to make these drugs, FDA is working to ensure that drugs meet their quality standards and are safe and effective. The impact of cGMP violations depends on the nature of those violations and on the specific drugs involved. A drug manufactured in violation of cGMP may still meet its labeled specifications, and the risk that the drug is unsafe or ineffective could be minimal. Thus, FDAs advice will be specific to the circumstances, and health care professionals are best able to balance risks and benefits and make the right decision for their patients. What can FDA do to protect the public when there are cGMP violations? If the failure to meet cGMPs results in the distribution of a defective drug, the company may subsequently recall that product. This protects the public by removing these drugs from the market. While FDA cannot force a company to recall a drug, companies will usually recall voluntarily or at FDAs request. If a company refuses to recall a drug, FDA can warn the public and could seize the drugs that are on the market.

Even if the drugs are not defective, FDA can bring a seizure or injunction case in court to address cGMP violations. When FDA brings a seizure case, the agency asks the court for an order that allows federal officials to take possession of adulterated drugs and destroy them. This enables FDA to immediately prevent a company from distributing those drugs to consumers. When FDA brings an injunction case, FDA asks the court to order a company to stop violating cGMPs. Both seizure and injunction cases often lead to court orders that require companies to take many steps to correct cGMP violations, such as hiring outside experts, writing new procedures, and conducting extensive training of their employees. FDA can also bring criminal cases because of cGMP violations, seeking fines and jail time. HAZARD ANALYSIS AND CRITICAL CONTROL POINT (HACCP) SYSTEM AND GUIDELINES FOR ITS APPLICATION PREAMBLE The HACCP system, which is science based and systematic, identifies specific hazards and measures for their control to ensure the safety of food. HACCP is a tool to assess hazards and establish control systems that focus on prevention rather than relying mainly on end-product testing. Any HACCP system is capable of accommodating change, such as advances in equipment design, processing procedures or technological developments. HACCP can be applied throughout the food chain from primary production to final consumption and its implementation should be guided by scientific evidence of risks to human health. As well as enhancing food safety, implementation of HACCP can provide other significant benefits. In addition, the application of HACCP systems can aid inspection by regulatory authorities and promote international trade by increasing confidence in food safety. The successful application of HACCP requires the full commitment and involvement of management and the work force. It also requires a multidisciplinary approach; this multidisciplinary approach should include, when appropriate, expertise in agronomy, veterinary health, production, microbiology, medicine, public health, food technology, environmental health, chemistry and engineering, according to the particular study. The application of HACCP is compatible with the implementation of quality management systems, such as the ISO 9000 series, and is the system of choice in the management of food safety within such systems. DEFINITIONS Control (verb): To take all necessary actions to ensure and maintain compliance with criteria established in the HACCP plan. Control (noun): The state wherein correct procedures are being followed and criteria are being met. Control measure: Any action and activity that can be used to prevent or eliminate a food safety hazard or reduce it to an acceptable level. Corrective action: Any action to be taken when the results of monitoring at the CCP indicate a loss of control. Critical Control Point (CCP): A step at which control can be applied and is essential to prevent or eliminate a food safety hazard or reduce it to an acceptable level. Critical limit: A criterion which separates acceptability from unacceptability. Deviation: Failure to meet a critical limit.

Flow diagram: A systematic representation of the sequence of steps or operations used in the production or manufacture of a particular food item. HACCP: A system which identifies, evaluates, and controls hazards which are significant for food safety. HACCP plan: A document prepared in accordance with the principles of HACCP to ensure control of hazards which are significant for food safety in the segment of the food chain under consideration. Hazard: A biological, chemical or physical agent in, or condition of, food with the potential to cause an adverse health effect. Hazard analysis: The process of collecting and evaluating information on hazards and conditions leading to their presence to decide which are significant for food safety and therefore should be addressed in the HACCP plan. Monitor: The act of conducting a planned sequence of observations or measurements of control parameters to assess whether a CCP is under control. Step: A point, procedure, operation or stage in the food chain including raw materials, from primary production to final consumption. Validation: Obtaining evidence that the elements of the HACCP plan are effective. Verification: The application of methods, procedures, tests and other evaluations, in addition to monitoring to determine compliance with the HACCP plan. PRINCIPLES OF THE HACCP SYSTEM The HACCP system consists of the following seven principles: PRINCIPLE 1 Conduct a hazard analysis. PRINCIPLE 2 Determine the Critical Control Points (CCPs). PRINCIPLE 3 Establish critical limit(s). PRINCIPLE 4 Establish a system to monitor control of the CCP. PRINCIPLE 5 Establish the corrective action to be taken when monitoring indicates that a particular CCP is not under control. PRINCIPLE 6 Establish procedures for verification to confirm that the HACCP system is working effectively. PRINCIPLE 7 Establish documentation concerning all procedures and records appropriate to these principles and their application.

GUIDELINES FOR THE APPLICATION OF THE HACCP SYSTEM Prior to application of HACCP to any sector of the food chain, that sector should be operating according to the Codex General Principles of Food Hygiene, the appropriate Codex Codes of Practice, and appropriate food safety legislation. Management commitment is necessary for implementation of an effective HACCP system. During hazard identification, evaluation, and subsequent operations in designing and applying HACCP systems, consideration must be given to the impact of raw materials, ingredients, food manufacturing practices, role of manufacturing processes to control hazards, likely end-use of the product, categories of consumers of concern, and epidemiological evidence relative to food safety. The intent of the HACCP system is to focus control at CCPs. Redesign of the operation should be considered if a hazard which must be controlled is identified but no CCPs are found. HACCP should be applied to each specific operation separately. CCPs identified in any given example in any Codex Code of Hygienic Practice might not be the only ones identified for a specific application or might be of a different nature. The HACCP application should be reviewed and necessary changes made when any modification is made in the product, process, or any step. It is important when applying HACCP to be flexible where appropriate, given the context of the application taking into account the nature and the size of the operation. APPLICATION The application of HACCP principles consists of the following tasks as identified in the Logic Sequence for Application of HACCP (Diagram 1). 1. Assemble HACCP team The food operation should assure that the appropriate product specific knowledge and expertise is available for the development of an effective HACCP plan. Optimally, this may be accomplished by assembling a multidisciplinary team. Where such expertise is not available on site, expert advice should be obtained from other sources. The scope of the HACCP plan should be identified. The scope should describe which segment of the food chain is involved and the general classes of hazards to be addressed (e.g. does it cover all classes of hazards or only selected classes). 2. Describe product A full description of the product should be drawn up, including relevant safety information such as: composition, physical/chemical structure (including Aw, pH, etc.), microcidal/static treatments (heat-treatment, freezing, brining, smoking, etc.), packaging, durability and storage conditions and method of distribution. 3. Identify intended use The intended use should be based on the expected uses of the product by the end user or consumer. In specific cases, vulnerable groups of the population, e.g. institutional feeding, may have to be considered. 4. Construct flow diagram

The flow diagram should be constructed by the HACCP team. The flow diagram should cover all steps in the operation. When applying HACCP to a given operation, consideration should be given to steps preceding and following the specified operation. 5. On-site confirmation of flow diagram The HACCP team should confirm the processing operation against the flow diagram during all stages and hours of operation and amend the flow diagram where appropriate. 6. List all potential hazards associated with each step, conduct a hazard analysis, and consider any measures to control identified hazards The HACCP team should list all of the hazards that may be reasonably expected to occur at each step from primary production, processing, manufacture, and distribution until the point of consumption. The HACCP team should next conduct a hazard analysis to identify for the HACCP plan which hazards are of such a nature that their elimination or reduction to acceptable levels is essential to the production of a safe food. In conducting the hazard analysis, wherever possible the following should be included:

the likely occurrence of hazards and severity of their adverse health effects; the qualitative and/or quantitative evaluation of the presence of hazards; survival or multiplication of microorganisms of concern; production or persistence in foods of toxins, chemicals or physical agents; and, conditions leading to the above.

The HACCP team must then consider what control measures, if any, exist which can be applied for each hazard. More than one control measure may be required to control a specific hazard(s) and more than one hazard may be controlled by a specified control measure. 7. Determine Critical Control Points There may be more than one CCP at which control is applied to address the same hazard. The determination of a CCP in the HACCP system can be facilitated by the application of a decision tree (e.g. Diagram 2), which indicates a logic reasoning approach. Application of a decision tree should be flexible, given whether the operation is for production, slaughter, processing, storage, distribution or other. It should be used for guidance when determining CCPs. This example of a decision tree may not be applicable to all situations. Other approaches may be used. Training in the application of the decision tree is recommended. If a hazard has been identified at a step where control is necessary for safety, and no control measure exists at that step, or any other, then the product or process should be modified at that step, or at any earlier or later stage, to include a control measure. 8. Establish critical limits for each CCP Critical limits must be specified and validated if possible for each Critical Control Point. In some cases more than one critical limit will be elaborated at a particular step. Criteria often used include measurements of temperature, time, moisture level, pH, Aw, available chlorine, and sensory parameters such as visual appearance and texture.

9. Establish a monitoring system for each CCP Monitoring is the scheduled measurement or observation of a CCP relative to its critical limits. The monitoring procedures must be able to detect loss of control at the CCP. Further, monitoring should ideally provide this information in time to make adjustments to ensure control of the process to prevent violating the critical limits. Where possible, process adjustments should be made when monitoring results indicate a trend towards loss of control at a CCP. The adjustments should be taken before a deviation occurs. Data derived from monitoring must be evaluated by a designated person with knowledge and authority to carry out corrective actions when indicated. If monitoring is not continuous, then the amount or frequency of monitoring must be sufficient to guarantee the CCP is in control. Most monitoring procedures for CCPs will need to be done rapidly because they relate to on-line processes and there will not be time for lengthy analytical testing. Physical and chemical measurements are often preferred to microbiological testing because they may be done rapidly and can often indicate the microbiological control of the product. All records and documents associated with monitoring CCPs must be signed by the person(s) doing the monitoring and by a responsible reviewing official(s) of the company. 10. Establish corrective actions Specific corrective actions must be developed for each CCP in the HACCP system in order to deal with deviations when they occur. The actions must ensure that the CCP has been brought under control. Actions taken must also include proper disposition of the affected product. Deviation and product disposition procedures must be documented in the HACCP record keeping. 11. Establish verification procedures Establish procedures for verification. Verification and auditing methods, procedures and tests, including random sampling and analysis, can be used to determine if the HACCP system is working correctly. The frequency of verification should be sufficient to confirm that the HACCP system is working effectively. Examples of verification activities include:

Review of the HACCP system and its records; Review of deviations and product dispositions; Confirmation that CCPs are kept under control.

Where possible, validation activities should include actions to confirm the efficacy of all elements of the HACCP plan. 12. Establish Documentation and Record Keeping Efficient and accurate record keeping is essential to the application of a HACCP system. HACCP procedures should be documented. Documentation and record keeping should be appropriate to the nature and size of the operation. Documentation examples are:

Hazard analysis; CCP determination; Critical limit determination.

Record examples are:

CCP monitoring activities; Deviations and associated corrective actions; Modifications to the HACCP system.

TRAINING Training of personnel in industry, government and academia in HACCP principles and applications, and increasing awareness of consumers are essential elements for the effective implementation of HACCP. As an aid in developing specific training to support a HACCP plan, working instructions and procedures should be developed which define the tasks of the operating personnel to be stationed at each Critical Control Point. Cooperation between primary producer, industry, trade groups, consumer organizations, and responsible authorities is of vital importance. Opportunities should be provided for the joint training of industry and control authorities to encourage and maintain a continuous dialogue and create a climate of understanding in the practical application of HACCP. Accident Investigations INVESTIGATIVE PROCEDURES The actual procedures used in a particular investigation depend on the nature and results of the accident. The agency having jurisdiction over the location determines the administrative procedures. In general, responsible officials will appoint an individual to be in charge of the investigation. The investigator uses most of the following steps: 1. Define the scope of the investigation. 2. Select the investigators. Assign specific tasks to each (preferably in writing). 3. Present a preliminary briefing to the investigating team, including: Description of the accident, with damage estimates. Normal operating procedures. Maps (local and general). Location of the accident site. List of witnesses. Events that preceded the accident.

4. Visit the accident site to get updated information. 5. Inspect the accident site. Secure the area. Do not disturb the scene unless a hazard exists. Prepare the necessary sketches and photographs. Label each carefully and keep accurate records.

6. Interview each victim and witness. Also interview those who were present before the accident and those who arrived at the site shortly after the accident. Keep accurate records of each interview. Use a tape recorder if desired and if approved.

7. Determine What was not normal before the accident. Where the abnormality occurred. When it was first noted. How it occurred. 8. Analyze the data obtained in step 7. Repeat any of the prior steps, if necessary. 9. Determine Why the accident occurred. A likely sequence of events and probable causes (direct, indirect, basic). Alternative sequences. 10. Check each sequence against the data from step 7. 11. Determine the most likely sequence of events and the most probable causes. 12. Conduct a post-investigation briefing. 13. Prepare a summary report, including the recommended actions to prevent a recurrence. Distribute the report according to applicable instructions. An investigation is not complete until all data are analyzed and a final report is completed. In practice, the investigative work, data analysis, and report preparation proceed simultaneously over much of the time spent on the investigation. FACT-FINDING Gather evidence from many sources during an investigation. Get information from witnesses and reports as well as by observation. Interview witnesses as soon as possible after an accident. Inspect the accident site before any changes occur. Make photographs and sketches of the accident scene. Record all pertinent data on maps. Get copies of all reports. Documents containing normal operating procedures, flow diagrams, maintenance charts, or reports of difficulties or abnormalities are particularly useful. Keep complete and accurate notes in a bound notebook. Record pre-accident conditions, the accident sequence, and post-accident conditions. In addition, document the location of victims, witnesses, machinery, energy sources, and hazardous materials. In some investigations, a particular physical or chemical law, principle, or property may explain a sequence of events. Include laws in the notes taken during the investigation or in the later analysis of data. In addition, gather data during the investigation that may lend itself to analysis by these laws, principles, or properties. An appendix in the final report can include an extended discussion. INTERVIEWS In general, experienced personnel should conduct Interviews. If possible, the team assigned to this task should include an individual with a legal background conducting interviews, the team should: Appoint a speaker for the group. Get preliminary statements as soon as possible from all witnesses. Locate the position of each witness on a master chart (including the direction of view).

Arrange for a convenient time and place to talk to each witness. Explain the purpose of the investigation (accident prevention) and put each witness at ease. Listen, let each witness speak freely, and be courteous and considerate. Take notes without distracting the witness. Use a tape recorder only with consent of the witness. Use sketches and diagrams to help the witness. Emphasize areas of direct observation. Label hearsay accordingly. Be sincere and do not argue with the witness. Record the exact words used by the witness to describe each observation. Do not "put words into a witness' mouth." Word each question carefully and be sure the witness understands. Identify the qualifications of each witness (name, address, occupation, years of experience, etc.). Supply each witness with a copy of his or her statements. Signed statements are desirable.

After interviewing all witnesses, the team should analyze each witness' statement. They may wish to re-interview one or more witnesses to confirm or clarify key points. While there may be inconsistencies in witnesses' statements, investigators should assemble the available testimony into a logical order. Analyze this information along with data from the accident site. Not all people react in the same manner to a particular stimulus. For example, a witness within close proximity to the accident may have an entirely different story from one who saw it at a distance. Some witnesses may also change their stories after they have discussed it with others. The reason for the change may be additional clues. A witness who has had a traumatic experience may not be able to recall the details of the accident. A witness who has a vested interest in the results of the investigation may offer biased testimony. Finally, eyesight, hearing, reaction time, and the general condition of each witness may affect his or her powers of observation. A witness may omit entire sequences because of a failure to observe them or because their importance was not realized. PROBLEM SOLVING TECHNIQUES Accidents represent problems that must be solved through investigations. Several formal procedures solve problems of any degree of complexity. This section considers these problem solving procedures. The Scientific Method The scientific method forms the basis of nearly all problem solving techniques. It is used for conducting research. In its simplest form, it involves the following sequence: making observations, developing hypotheses, and testing the hypotheses. Even a simple research project may involve many observations. A researcher records all observations immediately. A good investigator must do the same thing. Where possible, the observations should involve quantitative measurements. Quantitative data are often important in later development and testing of the hypotheses. Such measurements may require the use of many instruments in the field as well as in the laboratory. When making observations, the investigator develops one or more hypotheses that explain the observations. The hypothesis may explain only a few of the observations or it may try to explain all of them. At this stage, the hypothesis is merely a preliminary idea. Even if rejected later, the investigator has a goal toward which to proceed.

Test the hypothesis against the original observations. A series of controlled experiments is often useful in performing this evaluation. If the hypothesis explains all of the observations, testing may be a simple process. If not, make additional observations, change the hypothesis, or develop additional hypotheses. As with scientific research, the most difficult part of any investigation is the formulation of worthwhile hypotheses. Use the following three principles to simplify this step: 1. The principle of agreement. An investigator uses this principle to find one factor that associates with each observation. 2. The principle of differences. This principle is based on the idea that variations in observations are due only to differences in one or more factors. 3. The principle of concomitant variation. This principle is the most important because it combines the ideas of both of the preceding principles. In using this principle, the investigator is interested in the factors that are common as well as those that are different in the observations. In using the scientific method, the investigator must be careful to eliminate personal bias. The investigator must be willing to consider a range of alternatives. Finally, he or she must recognize that accidents often result from the chance occurrence of factors that are too numerous to evaluate fully. Change Analysis As its name implies, this technique emphasizes change. To solve a problem, an investigator must look for deviations from the norm. As with the scientific method, change analysis also follows a logical sequence. It is based on the principle of differences described in the discussion of the scientific method. Consider all problems to result from some unanticipated change. Make an analysis of the change to determine its causes. Use the following steps in this method: Define the problem (What happened?). Establish the norm (What should have happened?). Identify, locate, and describe the change (What, where, when, to what extent). Specify what was and what was not affected. Identify the distinctive features of the change. List the possible causes. Select the most likely causes.

REPORT OF INVESTIGATION As noted earlier, an accident investigation is not complete until a report is prepared and submitted to proper authorities. Special report forms are available in many cases. Other instances may require a more extended report. Such reports are often very elaborate and may include a cover page, a title page, an abstract, a table of contents, a commentary or narrative portion, a discussion of probable causes, and a section on conclusions and recommendations. The following outline has been found especially useful in developing the information to be included in the formal report:

1. 2. 3. 4.

Background Information Where and when the accident occurred Who and what were involved Operating personnel and other witnesses Account of the Accident (What happened?) Sequence of events Extent of damage Accident type Agency or source (of energy or hazardous material) Discussion (Analysis of the Accident - HOW; WHY) Direct causes (energy sources; hazardous materials) Indirect causes (unsafe acts and conditions) Basic causes (management policies; personal or environmental factors) Recommendations (to prevent a recurrence) for immediate and long-range action to remedy: Basic causes Indirect causes Direct causes (such as reduced quantities or protective equipment or structures)

Emergency Preparedness Principles of Emergency Management Principles: Emergency management must be: 1. Comprehensive emergency managers consider and take into account all hazards, all phases, all stakeholders and all impacts relevant to disasters. 2. Progressive emergency managers anticipate future disasters and take preventive and preparatory measures to build disaster-resistant and disaster-resilient communities. 3. Risk-driven emergency managers use sound risk management principles (hazard identification, risk analysis, and impact analysis) in assigning priorities and resources. 4. Integrated emergency managers ensure unity of effort among all levels of government and all elements of a community. 5. Collaborative emergency managers create and sustain broad and sincere relationships among individuals and organizations to encourage trust, advocate a team atmosphere, build consensus, and facilitate communication. 6. Coordinated emergency managers synchronize the activities of all relevant stakeholders to achieve a common purpose. 7. Flexible emergency managers use creative and innovative approaches in solving disaster challenges. 8. Professional emergency managers value a science and knowledge-based approach; based on education, training, experience, ethical practice, public stewardship and continuous improvement. Professional Preparedness Preparedness is how we change behavior to limit the impact of disaster events on people. Preparedness is a continuous cycle of planning, managing, organizing, training, equipping, exercising, creating, evaluating, monitoring and improving activities to ensure effective coordination and the enhancement of capabilities of

concerned organizations to prevent, protect against, respond to, recover from, create resources and mitigate the effects of natural disasters, acts of terrorism, and other man-made disasters. In the preparedness phase, emergency managers develop plans of action carefully to manage and counter their risks and take action to build the necessary capabilities needed to implement such plans. Common preparedness measures include:

communication plans with easily understandable terminology and methods. proper maintenance and training of emergency services, including mass human resources such as community emergency response teams. development and exercise of emergency population warning methods combined with emergency shelters and evacuation plans. stockpiling, inventory, streamline foods supplies, and maintain other disaster supplies and equipment. The Federal Emergency Management Agency (FEMA), recommends the following for a disaster preparedness kit: one gallon of water per person per day for three days, non-perishable food for each person for three days, battery powered or hand crank radio and extra batteries, flashlights for each person and extra batteries, first aid kit, whistle, filter mask or a cotton t-shirt for each person, moist towlettes, garbage bags, and plastic ties, wrench or pliers, manual can opener, plastic sheeting and duct tape, important family documents, daily prescription medicine, other things include diapers/formula for babies and special need items. Typically a three day supply of food and water is the minimum recommendation, having a larger supply means longer survival (Federal Emergency Management Agency [FEMA), n.d.). Small comfort items can be added like a few toys for children, a candy bar, or a book to read. These small items that do not take up much space can come in handy to increase moods during survival time. develop organizations of trained volunteers among civilian populations. Professional emergency workers are rapidly overwhelmed in mass emergencies so trained, organized, responsible volunteers are extremely valuable. Organizations like Community Emergency Response Teams and the Red Cross are ready sources of trained volunteers. The latter's emergency management system has gotten high ratings from both California, and the Federal Emergency Management Agency (FEMA).

Another aspect of preparedness is casualty prediction, the study of how many deaths or injuries to expect for a given kind of event. This gives planners an idea of what resources need to be in place to respond to a particular kind of event. Emergency Managers in the planning phase should be flexible, and all encompassing carefully recognizing the risks and exposures of their respective regions and employing unconventional, and atypical means of support. Depending on the region municipal, or private sector emergency services can rapidly be depleted and heavily taxed. Non-governmental organizations that offer desired resources, i.e., transportation of displaced homeowners to be conducted by local school district buses, evacuation of flood victims to be performed by mutual aide agreements between fire departments and rescue squads, should be identified early in planning stages, and practiced with regularity. Personal Preparedness Personal preparedness focuses on preparing equipment and procedures for use when a disaster occurs, i.e., planning. Preparedness measures can take many forms including the construction of shelters, installation of warning devices, creation of back-up life-line services (e.g., power, water, sewage), and rehearsing evacuation plans. Two simple measures can help prepare the individual for sitting out the event or evacuating, as necessary. For evacuation, a disaster supplies kit may be prepared and for sheltering purposes a stockpile of supplies may be created. The preparation of a survival kit such as a "72-hour kitis often advocated by authorities. These kits may include food, medicine, flashlights, candles and money. Also, putting valuable items in safe area is also recommended.

Reference: http://en.wikipedia.org/wiki/Emergency_management#Principles_of_Emergency_Management http://www.ccohs.ca/oshanswers/hsprograms/investig.html http://www.fao.org/DOCREP/005/Y1579E/y1579e03.htm