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Whats new ?

NEW POSTER IN THE SERIES CONTEMPORARY ART OF VACCINATION

After the very successful posters showing variations on pictures painted by the famous Spanish cubist Pablo Picasso and the well-known German expressionist Franz Marc, Lohmann Animal Health is proud to present a new poster in the series Contemporary art of vaccination. This time the poster shows a variation on the picture Bridal couple at the Eiffel tower by the surrealist painter Marc Chagall. Copies of this poster are available through customer service at Lohmann Animal Health in Cuxhaven.

Issue three

NEWS
November 2006

DEAR AVIAN PROFESSIONALS,

We would like to take this opportunity to say Thank You to all our friends of LAH for the past 10 successful years of Lohmann Animal Health. Founded from the veterinary section of TAD and from LTE, the newly formed Lohmann Animal Health group needed some time to find the focus. Restructuring was required and unnecessary fat had to be converted to more productive uses. After ten years, LAH with its 3 prot centres (Feed Additives, Pharma and Vaccines), is beginning to run like a well oiled machine. With our new vaccine brand, AviPro and the unication of the old TAD, Vineland and MBL product ranges we will now get even stronger in the vaccine business. The capacity for all products has been doubled in the last ten years. And we are already in the planning phase for the next extension. But there is also enough room for improvement. And we have to take this time to grow. We are the Avian Professionals in vaccines and we will be the market leader. This is our target and we must jointly work to reach it. Yours sincerely, Dr Bruno Kaesler
Managing Director, Lohmann Animal Health GmbH & Co. KG

Whats new?

Whats new ?

NEW SUPPORT TOOLS FOR GLOBAL MARKETING

Lohmann Animal Health produced 3 new roll-ups (in English, Spanish and Polish) to support the presentation of the company and primarily the new brand AviPro on a booth (please also see picture in the article LAH strengthens its position in Central America). The roll-up, very light and easy to handle, is the ideal addition to a booth. Due to its nice design and shape it is a perfect tool to attract the attention of the fair visitors.

INJECTOR NOW AVAILABLE

Avian Professionals can now get AviPro Injectors for inactivated vaccines. The user-friendly single-barrel AviPro Injector has a changeable piston, with cylinder sizes for 0.1, 0.2, 0.25 and 0.5 ml per dose. For the double-barrel injector, each barrel can also be of different dose sizes, with a complete set of independent cylinders. The double injector still offers the option of either two separate needles or just one for both barrels. For your order of AviPro Injectors, please contact the customer service representative for your area.

CONTENTS
Events/visits
2 3 3 4 4 5 Ghen CorporationLAH Japan Distribution Agent LAH strengthens its position in Central America The ght of the year in Mannheim with LAH contribution Technical Information Days in South Africa Sales visit to Thailand Awards for Pakistani Sales

and Markus Wesjohann

Managing Director, Lohmann Animal Health GmbH & Co. KG

Next to the portable roll-ups, Lohmann recently released 5 new English brochures on the products:

THE LAUNCH OF THE RANGE IS APPROACHING!

In Cuxhaven, due to the variety and specicity of the labels and languages utilised on our products, the name changes from the German-made range of vaccines are being done on a country-by-country and product-by-product basis. Across the Atlantic, the USA operations (or Lohmann Animal Health International, LAHI) are bringing all the range of American-made AviPro products into the light of the market all together. The new labels are being approved and released by USDA at this second semester of 2006, and are already being utilised for the USA market. Live vaccines: the new AviPro range will bring one practical innovation for LAHI, which is the use of bilingual labels (English and Spanish). These labels are for the standard products, those

Products
5 6 6 AviPro ND C131new vaccine against Newcastle Disease AviPro SALMONELLA VAC E introduced to Venezuelan poultry professionals Protection of AviPro SALMONELLA VAC E against Salmonella Gallinarum

NEWS CREDITS
Publisher: Lohmann Animal Health GmbH & Co. KG Heinz-Lohmann-Strae 4 27472 Cuxhaven Germany www.lah.de Editor: Anna-Christina Riebau, Product Manager, MarketingPoultry Vaccines anna-christina.riebau@lah.de

Avian Professionals
7 7 7 7 7 7 Georg Wohlmuth Dr Annette Bolte Dr Dorian Winter Tim Hopson Dr Ioannis Mavromatis Suwannee Floethner

AviBlue AviPro IBD XTREME AviPro VIBURSA CE AviPro 226 BTO2-REO AviPro 442 ND-IB2-BTO2-REO The supply of the global market with instructive product information, in order to support the sales teams all over the world, is one of the prior aims of Lohmanns marketing department.

Whats new?
8 8 8 New poster in the series Contemporary art of vaccination New support tools for global marketing AviPro Injector now available

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THE LAUNCH OF THE APPROACHING!

which are to be used in the United States, all of Latin America and other countries which accept the English text. This step means not only a reduction of the variety of labels, but according to LAHIs President Dave Zacek, who calculates that the change from labelling to ship towards labelling as soon as the serials are cleared by USDA will permit immediate labelling on 60% of LAHIs output. This should allow for easier inventory logistics and a more agile supply (forecast, production planning and faster reactiondelivery!). The official launch of the USA range of AviPro vaccines is expected for the International Poultry Exposition in Atlanta, January 2007, when Lohmann will be presenting itself with the new image on our booth.

RANGE IS

Events/visits

LAH STRENGTHENS ITS POSITION IN CENTRAL AMERICA

See you at the International Poultry Exposition in Atlanta: hall B, stand 4748!!! From the 23rd to the 25th of August Lohmann Animal Health took part in the 19th Central American and Caribbean Poultry Congress in San Salvador (El Salvador). The company was Registrations Eduardo Bernardi and Product Manager Anna-Christina Riebau from Lohmann Animal Health in Germany. Lohmann seized this chance to introduce the new corporate design and the new brand name AviPro to the Central American poultry professionals as well as to emphasise the high prole of the German products in Central America and the Caribbean. Before the actual start of the congress several distributor meetings were organised, allowing for deeper discussions about the products: AviPro SALMONELLA VAC E AviPro SALMONELLA VAC T AviPro THYMOVAC Next to these star products of the German line the complete range of vaccines against Infectious Bursal Disease was presented to the distributors:

LAHs newly designed booth at the 19th Central American and Caribbean Poultry Congress in San Salvador

After a long day of discussions, a relaxing dinner on a coffee plantation with Lohmanns

Events/visits

new distributors for Central America

GHEN CORPORATIONLAH JAPAN DISTRIBUTION AGENT

Much like Japan itself, Ghen Corporation has an impressive history steeped in tradition while embracing modernisation. The word Ghen itself means origin, as in Genesis, which makes it appropriate, as Ghen has been part of the genesis of modern layer genetics and poultry management in Japan. Ghens entrance into poultry breeding began with the founding of its original Hy-Deo Company in 1963 to import layer breeding parent stock. To date, Lohmann Companies have been associated with Ghen for over 40 years and such wellestablished relationships lead to success in the Japanese market. Today, Ghen has grown into 4 divisions the Hy-Deo Group (Breeding Division), a Seed Group, an Antibody Group and the Bio Group (Biologics Division), which has a facility in Tochigi city where it produces, develops and evaluates vaccines. Pictured at Ghens Tochigi Laboratories are Team Manager Eiji Kato, LAHs Scott
From left to right: Eiji Kato, Scott Faul (LAH), Katsuo Sato, Kazuyuki Mima and Asako Komukai

Faul, R&D Manager Katsuo Sato, Chief Manager Kazuyuki Mima and R&D Assistant Manager Ms Asako Komukai. The Ghen logo implies origin and unity through the multiplying hexagons that

World Heritage Site. The Tokugawa Shogun who established his Shogunate at Edo (Tokyo) in 1603 is enshrined here. Not far from Group headquarters in Gifu city, Ghen maintains a memorial hall, Kinkeien, to enshrine the principles of the founders and commemorate the history of Ghen Corporation. LAH is honoured to work with the avian professionals of Ghen Corporation and be a part of the genesis of Japans modern poultry industry.

represented on the new designed booth by Area Sales Manager Francisco Carrillo, Head of Sales Wayne Collins and Head of Technical Support Mariano Salem from Lohmann Animal Health International (USA) as well as Head of Marketing and

AviPro VIBURSA L (mild IBD vaccine) AviPro GUMBORO VAC (intermediate IBD vaccine) AviPro IBD XTREME (intermediate plus IBD vaccine) LAH is ready to consolidate its name as a partner in poultry with the strengthened distributorship in the Central American region.

Events/visits

THE FIGHT OF THE YEAR IN MANNHEIM WITH LAH CONTRIBUTION

It is Saturday, the 22nd of April, a few minutes to ten and the crowds in Mannheim are about to see the boxing match of the year. The vibes are on fire when challenger Wladimir Klitschko enters the SAP Arena in Mannheim to face the heavyweight champion Chris Byrd and win back the title for his family. In a few minutes, the duel between the two top boxers will start and the atmosphere is fraught with tension. Amongst the audience some familiar faces are visible. Klaus Torborg and Jens Lth from Lohmanns sales department are Intensive discussions on the enlargement of the cooperation in poultry vaccine sales in the Ukraine between Lohmann Animal Health and Inter Zaporozhye should have made the group tired, but no one shows signs of exhaustion. It is quite the contrary: the group is captured by the atmosphere and cheers loudly for the Ukrainian challenger Wladimir Klitschko. As a crowning closure of this day, Wladimir Klitschko wins convincingly on points and becomes heavyweight IBF/IBO world champion.

From left to right: Ms Troyan, Mr K. Torborg, Mr V. Troyan, Mr A. Milovanov, Ms Milovanov, Ms Semenjachenko, Ms Esipova Front: Mr J. Lth

symbolise the universes expansion and the dot represents the sun, mother of all life. The Tochigi facility, in the foothills north of Tokyo, is located near to the Toshogu Shrine in Nikko, a UNESCO designated

Memorial hall, Kinkeien

tapering off the evening with LAHs Ukrainian distributor Inter Zaporozhye, after a successful meeting day in the Hilton Hotel in Frankfurt.

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Events/visits

Events/visits

TECHNICAL INFORMATION DAYS IN SOUTH AFRICA

With their eyes on the progress of Latin American neighbours and their farming progress, South African poultry producers and veterinarians received the visit of Dr Beatriz Cardoso (Poultry Veterinarian for Latin America) to be the international guest speaker from a series of technical information days organised by ImmunoVet Services cc, the sole agent for LAH in South Africa. AviPro 304 ND-IB-MG); IBD Control in high-risk farms in Brazil (emphasising when to use AviPro GUMBORO VAC, AviPro PPRECISE and AviPro VIBURSA CE); and Salmonella Enteritidis and Salmonella Gallinarum control in poultry: Europe and Latin Americas strategies through the use of live and inactivated vaccines (AviPro SALMONELLA VAC E and AviPro 109 SE4). Dr Dave Allwright (Western Cape) and Dr Roger Horner (KwaZulu Natal) addressed the delegates in their respective regions on AI and its impact on South Africa. The program kicked off in the picturesque town of Stellenbosch. Dr Cardoso addressed an audience of approximately 50 poultry producers. She then flew up to Johannesburg to attend South Africas Annual Poultry Expo held at The Emperors Palace in the Gauteng Province. Delegates came from all provinces within South Africa as well as other neighbouring African countries. Immuno-Vet Services cc was fortunate enough to secure a time for Dr Cardoso to address approximately 850 delegates The journey continued onto Pietermaritzburg, in KwaZulu-Natal, to address an audience of approximately 60 poultry producers. In between all the hard work, seeing clients and talking at Information Days, Dr Cardoso had an opportunity to experience more of South Africa the Cape wine, traditional food (boerewors and pap) and a Game Farm (Pilanesburg Game Reserve). Immuno-Vet Services cc is very grateful to Dr Cardoso for her time, effort and excellent presentations. on the opening day, as she discussed Poultry Industry Production Practices in Latin America.

AWARDS FOR PAKISTANI SALES

Golden Harvest has organised its annual sales meeting in Islamabad, where salespersons and distributors of Lohmann vaccines from all provinces of Pakistan gathered to update targets and discuss ongoing issues on poultry health. From the Cuxhaven office, Eduardo Bernardi joined to present some issues on inactivated vaccines and to bring the whole group back into the basics of immunology. Vaccination programmes were re-discussed, with a focus on AviPro 107 EDS, AviPro 303 ND-IB-EDS, AviPro 401 ND-IBIBD-REO. During the three-day meeting, Golden Harvests Sadaf Saeed refreshed the groups awareness on the importance of communiThe participants of the Golden Harvest Sales Meeting in Islamabad

cation, and Shahid Bokhari wrapped it up by awarding the salespeople and distributors for target achievement and sales increases. The deserved winner could choose between a trip to Thailand or to Saudi Arabia.

Products

ND C131NEW VACCINE AGAINST NEWCASTLE DISEASE

Newcastle Disease (ND) is one of the most devastating poultry diseases worldwide, caused by an avian paramyxovirus type 1 (APMV-1). It is of particular economic importance in chickens and turkeys of all ages. Clinical signs of the disease may vary from few or no symptoms to respiratory infections, diarrhoea, nervous symptoms and high mortality. Lohmann Animal Health now presents a new vaccine to prevent this disease. AviPro ND C131a, live vaccine for active immunisation against Newcastle Disease, containing a cloned lentogenic LaSota strain. Using the technique of cloning guarantees that all derivates are identical, meaning they have the same characteristics as the original. This can enable the production of vaccines that are more stable and predictable regarding both production process and performance. AviPro ND C131 can be applied via drinking water, spray or eye drop. The vaccine can be used from the second week of age. After one vaccination, immunity will develop within 7 days and will protect the young bird over a period of at least 6 weeks against clinical disease and mortality caused by infection with ND virus. Revaccinations of commercial layers during production are possible. The vaccine proved to be efficacious when incorporated into a schedule with live Hitchner B1 vaccines as well as a primer to subsequent booster vaccinations with inactivated ND vaccines (Fig. 1). Cloning techniques: The principle of cloning is to produce identical copies of one original organism. In the case of viruses, cloning can lead to a homogenous and consistent population of virus. This can be done by plaque picking, plaque purification or end point dilution. But not every cloned virus population is qualified for being a candidate for a vaccine. Clones may be superior, comparable or even inferior compared to the parent strain. That is why each cloned virus population needs to be carefully analysed and selected for aspects such as pathogenicity, immunogenicity and safety before it is chosen to be a vaccine virus.

From left to right: Dr Beatriz Cardoso (LAH Technical Support), Jens Lth (LAH Sales) and Dean Hewson (Immuno-Vet Services)

Her presentations were on Control of MS and MG in poultry flocks in Latin America (AviPro 104 MG-Bacterin and

Events/visits

SALES VISIT TO THAILAND

On the occasion of the recent visit of Mr Klaus Torborg (Head of Sales) to Thailand new strategies, the latest CRM (Customer Relationship Management) tools and the launching of AviPro were discussed with Dr Sutep and A. Foellmer of the Regional Head Office South Asia, ASEAN, Pacic in Bangkok. Due to the further nurturing of the cooperation with the Betagro Group and their recently founded affiliated company ATS playing an essential role for the business development in Thailand such close cooperation shall be underlined by a new distributorship contract under discussion. Having achieved far-reaching results beforehand, a cheerful evening at the German restaurant Bei OTTO came in naturally to close the day in style.

Relaxing amicably at the table after a hard day's work were (right): Dr Chayanon, Senior VP, Betagro Group, Dr Vorachai, GM ATS, Dr Nopporn PM ATS and Dr Surasak, Sr Sales Mgr as well as (left): K. Torborg, A. Foellmer, Dr Sutep

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Products

Avian Professionals

SALMONELLA VAC E INTRODUCED TO VENEZUELAN POULTRY PROFESSIONALS

Organised by Lohmanns Brazilian office together with the Venezuelan distributor Binveca, the launch of AviPro SALMONELLA VAC E in Venezuela took place on the 13th of June in Maracay city. The response to the invitation to this event was enormous, more than 100 veterinarians and integrators attended the meeting, where Dr Liliana Revolledo, a specialist on salmonella, held a lecture about intestinal immunology and Dr Beatriz Cardoso from Lohmanns Brazilian office presented the features and the use of this star product from LAH to the intrigued audience. AviPro SALMONELLA VAC E is a live attenuated vaccine for poultry against Salmonella Enteritidis and Salmonella Gallinarum* infections. The attenuated vaccine strain Sm24/Rif12/Ssq is designed to be sufficiently invasive to induce immunity in the bird but at the same time is made safe and sensitive to stress, resulting in very short duration of shedding from the birds, with no survival in the environment. By being administered orally, through drinking water, AviPro SALMONELLA VAC E imitates the natural route that a salmonella infection would take. Most important, oral vaccination induces immediate production of secretory IgA. This immunoglobulin will protect the gut lumen against infections of a field challenge of Salmonella Enteritidis or Salmonella Gallinarum*, this preventing invasion of other organs. To close the day all participants watched the football match Brazil versus Croatia and had the possibility to win an official ball from the World Cup, 3 small footballs and one jersey from the Brazilian or the Argentinian football team. * Official claim not yet valid in all countries

ENLARGEMENT OF LAHS NEW BACTERIOLOGIST IN TECHNICAL SUPPORT DEPARTMENT CUXHAVEN

Technical Support Department in Cuxhaven has recently been enlarged, with the additional help of Georg Wohlmuth. A natural of Freising in Bavaria, Mr Wohlmuth received academic instruction in agriculture at the Hauptuniversitt in Vienna, Austria, and in veterinary medicine at the Fachuniversitt in Berlin. Georg Wohlmuth From his experience in field veterinary practices, he comes to aid the department on the conduction of eld trials and supervision of internal animal trials. Mr Wohlmuth reports to Dr Michael Iburg, Director of Technical Support. Dr Annette Bolte has recently joined the Registration Department at Lohmann Animal Health in Cuxhaven. A native of Mnster in Westphalia, Dr Bolte graduated in veterinary medicine at the Justus-Liebig-Universitt in Gieen. With a doctorate in poultry diseases, she has spent her professional years at the Institute for Dr Annette Bolte Poultry Diseases in Gieen and at a private veterinary practice and diagnosis laboratory, focusing on quality control and care of poultry breeder stock. Dr Boltes experience in waterfowl, microbiology and pathology will be of great assistance to the development of new bacterins, working in conjunction with Process Development and R&D.

NEW AREA SALES MANAGER FOR THE MIDDLE EAST

Dr Ioannis Mavromatis has recently joined Lohmanns sales team to strengthen the companys presence in the Middle East. Based in Athens, Greece, and reporting to Sales Manager Klaus Torborg, he will provide support to the companys extensive range of poultry vaccines. Dr Ioannis Mavromatis Dr Mavromatis gained his veterinary degrees at the University of Messina, Italy, and the University of Thessaloniki, Greece. His previous experience includes working as a broiler breeder Production Manager, Sales and Service Manager of a hatchery for the Middle East, as well as Manager of Sales and Marketing for livestock products.

The participants had the chance to win, amongst others, the official FIFA football from the World Cup 2006 in Germany.

ENHANCEMENT FOR THE R&D DEPARTMENT

Dr Dorian Winter is joining the Research and Development department at LAH. A newcomer to Cuxhaven, Dr Winter was born and raised in Vienna, Austria, and has a degree in biology / genetics, with specialisation on molecular biology. His PhD thesis at the department of dermaDr Dorian Winter tology, Vienna Medical University, addressed the elicitation of dened cellular immune responses in an otherwise incurable skin cancer. Dr Winter will be reporting to Dr Dierk Rebeski. His wide knowledge on a vast array of molecular, cellular and immunologic techniques will put him on the leadership of many research projects for avian vaccines.

Products

PROTECTION OF SALMONELLA VAC E AGAINST SALMONELLA GALLINARUM

A recent publication of AVIAN DISEASES (50: 280283, 2006) demonstrated the cross-protection of AviPro SALMONELLA VAC E against challenges of Salmonella Gallinarum. The research note is called Protection Conferred by a Live Salmonella Enteritidis Vaccine Against Fowl Typhoid in Laying Hens by Pablo Chacana and Dr Horacio Terzolo, both from the Instituto Nacional de Tecnologa Agropecuaria, (INTA) in Balcarce, Argentina. Terzolo and Chacana vaccinated laying hens with the three-dose vaccination programme recommended by Lohmann, starting on the first day of life (the publication refers to TAD Salmonella vac E, the former name of AviPro SALMONELLA VAC E). The hens were challenged in production with a Salmonella Gallinarum strain (INTA 91, 2 x 105 CFU). Mortality, fecal shedding and organ invasion of Salmonella Gallinarum were assessed. In non-vaccinated birds, mortality after challenge at 28 weeks of age reached a level of 94 %. Diseased hens manifested anorexia, somnolence and depression, presenting enlarged and congested livers and spleens. Birds vaccinated with the three oral doses programme only presented 6% mortality. As far as organ invasion of the challenge strain is concerned, septicaemia was a constant feature in every dead hen, and a complete correspondence between mortality and organ invasion was found. Vaccinated hens presented significant reduction of organ invasion and shedding. The study concluded overall that vaccination with a three-dose programme of AviPro SALMONELLA VAC E protects chickens against mortality and organ colonisation and reduces fecal shedding excretion rate, hence diminishing the spread of Salmonella Gallinarum in the environment. Moreover, the study suggests that in countries where Fowl Typhoid has not been eradicated, control programmes should not only rely on the control of vertical transmission of salmonella in breeder flocks, but also on vaccination of laying hens using safe, attenuated salmonella strains.

NEW AREA MANAGER FOR LAHI

Tim Hopson joins LAHI in the position of Area Manager. He comes to us from Cargill Turkey Products where he recently served as Hatchery Manager. In addition to his turkey industry experience, Mr Hopson worked for more than eight years in the chicken industry. He had various responsibilities including production Tim Hopson supervisor for broiler and breeder ocks. Mr Hopson's education includes a B.S. in Poultry Science, Agriculture and Applied Economics from Virginia Tech. He has also recently completed an MBA from James Madison University in Harrisonburg, Virginia. Mr Hopson will be responsible for the mid-Atlantic region of the USA covering South Carolina to Maine.

LAH THAILAND APPOINTS NEW EXECUTIVE ASSISTANT

Ms Suwannee Floethner joins our office in Bangkok as Executive Assistant to M.D. With a BA in English literature and a diploma from the UK in secretarial knowledge, she has over 11 years` experience as Executive Secretary in conglomerate groups of companies such as Quele Thailand, Hoechst and Bayer. Ms Floethner reports to Axel Fllmer, LAH Managing Director for the ASEAN countries, with a main focus on planning and administrative issues.

Suwannee Floethner