HARVEY et al JOP 2012;83:279-286

Aggressive periodontitis is a disease with clinical onset

typically in teenagers and young adults-rapid loss of periodontal supporting tissues.

Occurs in two distinct forms Localized form- affects first molars and incisors Generalised form that affect all the teeth.

{Armitage 2000}

 Progression of periodontal disease during pregnancy ,lack

of immune reponsiveness to periodontal microorganisms

and specific bacterial colonization-associated with low

birth weight, premature birth, preeclampsia and even fatal death.

 To perform an analysis using both prospective and

retrospective birth outcome data in AgP based on information collected from mothers with this disease as well as their periodontally healthy (NP) female siblings and unrelated control NP subjects.

 Subjects were enrolled and examined from 1976-2010

at the Virginia Common Wealth University.

Data collection for determination of birth outcomes

for these subjects began in 1994.

Loalisesd aggressive periodontitis. Generalised aggressive periodontitis Periodontally healthy female silbings Non periodontitis patients -control

85

84

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 This study was initially performed during a long term

series of studies of clinical, genetic and biologic aspects of AgP-Family study of the disease.
Ethical clearance obtained from Conduct Of Human

Reseacrh Of Virginia University.

Written informed consent was taken

Completed questionnaires - socioeconomic status, birth weight and length of pregnancy.

Mothers provided comprehensive health history.

Data on smoking history and racial category obtained

Probing depth Plaque index

Attachment loss Gingival index

Bleeding On probing

 NP subjects with no evidence of AL other than facial

recession and no periodontal pocket>3mm.

GAgP subjects had a history of disease onset <35 years -8

teeth with 5mm attachment loss at interproximal sites., 3 of affected teeth were not first molars and incisors.
LAgP-history of disease onset <30years of age and

presented with 2 teeth with 4mm AL ,no > 2 additional teeth with AL that were not first molars or incisors.

 Age of onset of AL was routinely verified through

dental records and radiographs through out the study.

Patients were recalled and reexamined to verify

diagnosis of AgP and assess progressive disease.

Survey forms were given to assess birth outcomes

during follow-up examinations.

 Statistical software-PROC GEENMOD Analysis of Variance.

 The data indicate that there is no significant influence

of AgP on birth outcomes.

AgP is a relatively severe form of periodontal disease-

teenagers and young adults.

Literatures by Vergnes et al indicate that periodontal

disease is associated with, and possibly a risk factor for, pre term birth and low birth weight.

 The prevalence of low birth weight babies in in the

AgP group was 9.9% which was approx 3% lower than the NP mothers.
Offenbacher et al found a significant positive

association between periodontal disease and birth outcomes. Agp is a familial condition significant genetic etiology.

 So to substantiate this a NP group of mothers who

were first degree relatives of subjects with AgP were included in this study.
PI ,GI, BOP, Al, PD-was higher in GAgP group than

in the other clinical groups.-without an impact on pregnancy outcome.

 Aggressive periodontitis has many unique

biologic characteristics that differentiate it

from chronic forms of periodontitis, and the

possible lack of its association with birth weight may be another such characteristic.