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Dr.K. Sailaja P.G. Dept of Anaesthesiology Moderator Dr. Ravinagaprasad Asst. prof Dept of Anaesthesiology Chair person Dr. Siddapa Gourav Prof Dept of Anaesthesiology. Speaker
Pre-operative risk factor assessment and minimizing the risk factors. Anesthetic management proper. Post operative jaundice.
Assessment of risk factors in moderate to severe liver disease CHILD-TURCOTT classification posted for major surgery
Gr-A Gr-B 2-3 Moderate Gr 1-2 Undernourished 2.8-3.5 30% Gr-C >3 Tense Gr 3-4 Poor <2.8 >40%
Factor
Sr.bilirubin(mg/dl <2 ) Ascites Encephalopathy Nutrition S. ALBUMIN(gm%) Risk(Mortality rate) NO NO Good >3.5 <10%
Pre op variables and peri op mortality rate in cirrhotic patients (Garrison etal)
Risk factor Mortality rate Emergency surgery 57% S.albumin <3gm/dl 58% S.bilirubin> 3mg/dl 62% PT >1.5 X control 63% Infection 64% Antibiotics >2 82% Cardiac failure 92% Pulmonary failure 100% WBC count > 10,000 cells/cumm
Anesthetic management of patients with moderate to severe liver disease includes Pre-op optimisation of condition Modifying and minimising the risk factors of mortality
Ascites indicates severe liver disease Elective surgery: carbohydrate and protein diet restrict sodium intake 2gm/day Not responding to salt restriction Use of potassium sparing diuretics alone/ loop diuretics
Tab. spironolactone 100mg/day max 400mg/d Tab. Amiloride 5-10 mg/d Frusemide 40-160 mg/d if hyponatremia (<125meq/l) restrict fluid intake 800-1000ml/d Goal: Pre-op sodium level >130mmol/L Large volume paracentesis: tense ascites - wt.loss <0.5kg/d if >1lt/d supplement with salt free albumin 10gm/d , dextran -70 8gm/d, gelatin 125ml/d.
SBP is a common and severe complication of ascites characterized by spontaneous infection of the ascitic fluid without an intraabdominal source. most common organisms are Escherichia coli and other gut bacteria; however, gram-positive bacteria, including Streptococcus viridans, Staphococcus aureus, and Enterococcus sp diagnosis of SBP : absolute neutrophil count >250/mm3 Treatment :second-generation cephalosporin, inj. cefotaxime 2gm tid x 5d
Alternative treatment ceftriaxone + amoxycillin - clavulanic acid inj. Ciprofloxacin 200mg i.v b.d x 2d followed by tab. Ciprofloxacin 500mg b.d x 5d response to therapy dec. in PMN by 50% in 48hrs. prophylaxis: high risk cases tab. Norflox tab. Ciprofloxacin 500mg b.d x5d tab. Septran ds b.d x 5d/wk
Pulmonary function Hypoxemia PaO2 <70mmHg Decreased HPV response Treat associated pul. disease (smokerCOPD) Chest physiotherapy Pulmonary toileting Bronchodilators Antibiotics
Renal system:
Pre renal Azotemia- correct by fluid administration Renal failure- Gram ve septicemia, Endotoxin mediated, Bilirubin mediated Diuresis by mannitol Antibiotic coverage (non toxic)
Asses for Hepatorenal syndrome (mortality 95%) type I doubled s.creatinine (2.5mg/dl) halved creatinine clearance 20ml/min in 2wks. type II progressive , chronic, resistant to treatment
Rx: i.v infusion of albumin dopamine + long acting vassopressin ( ornipressin / terlipressin) octreotide midodrine, an alpha-agonist (under trail) TIPS The best therapy for HRS is liver transplantation Goal: Urine out put 50ml/hr
Bleeding and clotting abnormalities Decrease in Vit K dependent factors Decreased intrinsic factors Decreased t1/2 of clotting factors due to consumptive coagulopathy Qualitative and quantitative platelet defects, thrombocytopenia Goal: PT < 2.5 sec of control
Obstructive jaundice Elective surgery Vit K can be given preoperatively Dose: 5-10mg/day x 7 IM 5-10mg TID x 3 IM In emergency : 5-10mg 4th hourly
Coagulopathy : PT 2-3 sec control FFP 2-6 units need to be transfused 1FFP increases clotting factors by 20% 250ml FFP increases fibrinogen by 10% Platelets<40,000/ clinicallybleeding diathesis - Platelet transfusion required
Hepatic Encephalopathy:
Increased Ammonia conc., increased GABA activity
Preventive measures: hydration and correction of electrolyte imbalance correcting precipitating factors vegetable protein better than animal protein
use lactulose, a nonabsorbable disaccharide acute cases- 30 40ml tid x 7d, 2-3 soft stools/d no response add Poorly absorbed antibiotics neomycin 0.5 -1gm tid x 7d metronidazole 250mg tid x 7d rifaximin - 1200mg od
General measures: Acceptable sr.Albumin >3gm/dl Acceptable Sr.Bilirubin (if >8mg/dl pre-op mannitol to be given) Anemia : iron deficiency anemia ferrous sulphate 300mg tid megaloblastic folic acid 1mg/d , vit. B12 packed cell transfusion if Hct< 28% Nutrition : calories 25- 30 kcal/kg/d protein 1-1.2gm/kg/d hepatic encephalopathy restrict to 60gm/d Other factors : stop alcohol, stop smoking, correct electrolyte imbalance
Type of Anesthesia
RA- If clotting profile is normal for surgeries on periphery Major intra-abdominal surgeries GA Monitoring: routine ASA monitoring spo2,ECG,NIBP,Etco2 Severe disease/major surgery Invasive: IBP, CVP Periodic ABG analysis RBS, Sr.electrolytes, Haematocrit PT,APTT, Thromboelastography
GA: Pre-med: no/minimal sedative Fentanyl (min dose) Metaclopromide (full stomach) Rapid sequence induction and intubation Induction: Propofol 2mg/kg (best agent) Thiopentone 3-5mg/kg (single dose) Intubation: Suxamethonium (duration slightly prolonged)
Maintanance : O2, N2O mixture NDMR- Atracurium/Cis-Atracurium (safe) large initial doses( inc. vd ) subsequent doses should be decreased Avoid injury/ insult to Liver Goal: maintain liver blood flow and O2 supply
Hypoxia, V/Q mismatch- increase Fio2 Prevent arterial hypotension, fall in cardiac out put Inhalational agent: Isoflurane best agent Sevoflurane Halothane better avoided in cases with liver disease. Fluid and blood products
Post-op Jaundice
1. 2. 3.
Only bilirubinemia:
Resorption of large haematoma, multiple blood transfusions Congenital: Gilberts, Rotors, Dubin-johnson (prognosis good), criggler-najjar syn. Intravascular haemolysis- haemolytic anaemia, G-6-PD deficiency, Sickle cell anaemia
post op intra hepatic cholestasis- mild fever , jaundice, upper abdominal pain <48hrs & recedes in 2-3wks Biliary tract obstruction: retained stones in biliary tract, duct injury, acute cholecystitis post op, acute pancreatitis. Circulatory failure: open heart surgery/traumatic circulatory shock, ischemic hepatic injury. Sepsis mainly obstructive type (high bilirubin levels)
Bilirubinemia with marked amino transferase increase: Shock liver- centrilobular necrosis due to hypoxia, viral hepatitis Drug induced hepatitis: alcohol AST:ALT >2:1 isoniazid,phenytoin,methyl dopa tetracycline, oc pills asprin, acetaminophin.
Halogenated inhalational agents: halothane hepatitis- type 1 type 2( severe form) Obesity: BMI >30 post op liver failure likely in 30% cases.
0-1wk : intra hepatic cholestasis resorption of hematoma hypotension- ischaemic hepatitis 1-2wks: above causes sepsis, biliary trauma, pancreatitis nonA,nonB hepatitis halothane hepatitis
Pre op proper history taking: h/o hepatitis(viral) familial disease,drug history, alcohol overuse, h/o jaundice past obesity, exposure to halothane Intra op: shock, retraction/major abdominal surgery, sepsis, biliary tract surgery.
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