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Seizures
A clinical event in which there is a sudden disturbance of neurological function in association with an abnormal or excessive neuronal discharge.
Febrile Seizures
Convulsions occurring in association with fever in children between 3 months to 6 years of age, in whom there is no evidence of intracranial pathology or metabolic derangement.
Epidemiology
Occurs in about 3% of children between 3 months and 3 years of age (UK) 10-20% of relatives having a seizure disorder including this febrile convulsions. Boys more than girls.
Diagnosis
Diagnosis of febrile seizures is based on history.
Also ask about possible ingestions of drug or toxins
Physical examination to rule out of meningitis or encephalitis, if still in doubt, perform a Lumbar Puncture. EEG could be performed but is rarely required
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Investigations
Needed to rule out other causes, per definition Blood Glucose and electrolytes CT Scan rarely required but it is could be useful for complex febrile convulsions EEG or LP seldom required, but could be used to rule out other pathologies.
Management
if in a convulsive state:
Loosen clothing around neck Wipe off vomitus Diazepham (0.5mg/kg)
Prognosis
Benign with excellent prognosis 3-4% of population have febrile convulsions 30% recurrence after the 1st attack 48% recurrence after the 2nd attack 2-7% develop afebrile seizure or epilepsy No evidence of permanent neurological deficit. No deaths reported
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Epilepsy
* A neurological condition characterised by recurrent unprovoked epileptic seizures. An epileptic seizure is the clinical manifestation of an abnormal and excessive discharge of a set of neurons in the brain An epileptic syndrome are complex signs and symptoms that define a unique epilepsy condition.
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Epidemiology
5 per 1000 school aged children
10% are severely affected.
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Causes
Perinatal Conditions:
Infections:
Encephalitis Meningitis Brain abscess
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Causes
Metabolic Conditions
Hypoglycemia Hypocalcaemia Hypomagnesaemia Hyponatremia Hypernatremia Storage diseases Reye syndrome Degenerative disorders Porphyria Pyridoxine dependency and deficiency
Poisoning
Lead Cocaine Drug toxicity Drug withdrawal
Neurocutaneous Syndromes
Tuberous sclerosis Neurofibromatosis Sturge-Weber syndrome Klippel-Trenaunay-Weber syndrome Linear sebaceous nevus Incontinentia pigmenti
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Causes
Systemic Disorders
Vasculitis (CNS or systemic) SLE Hypertensive encephalopathy Renal failure Hepatic encephalopathy
Other
Trauma Tumor Febrile Idiopathic Familial
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Motor cortex Simple partial seizure with clonic movements which may travel up arm. Post ictal (Todds) paresis may follow.
Distorted vision
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Classification of Seizures
Seizure Classification Partial
seizure activity starts in one area of the brain
Generalized
seizure involves whole brain & consciousness is affected
Simple
Retains awareness
Complex
Altered awareness and behavior
Secondary generalization
(spreading from one area to the whole brain) "jacksonian" seizure
Tonic Clonic
grand-mal or convulsion Loss of consciousness, stiffening of body then jerking of limbs
Absence
petit mal or starting fit or trance like state
Tonic or Atonic
drop attack Abrupt fall, either with stiffening (tonic) or with loss of muscle tone (atonic or astatic attacks)
Myoclonic
Sudden muscle jerks
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Partial Seizure Begins in a relatively small group of dysfunctional neurons in one of the cerebral hemispheres. May have an aura which reflects site of origin May/not- change in consciousness or more generalized motor jerking
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Partial Seizures
Simple Partial Seizures
The child will retain awareness with consciousness unimpaired
Generalised Epilepsies
Absence seizures
Transient loss of consciousness, with an abrupt onset and termination, unaccompanied by motor phenomena except for some flickering of the eyelids and minor alteration in muscle tone. Onset 4-12 years old. Absences may be typical (petit mal) or atypical can often be precepitated by hyperventilation. Occurs for a few seconds (< 30s) Child does not recall seizure. EEG would not a 3Hz Spike and wave activity with frontal accentuation.
A bsence Seizure.flv
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EEG
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Generalised Epilepsies
Myoclonic epilepsy (Juvenile Myoclonic Epilepsy)
Brief often repeatitive, jerking movement of the limbs, neck and trunk. 10-20years old, (Females: Males = 2:1) Myoclonic predominates but absences and tonicclonic seizures also occur
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Generalised Epilepsies
Tonic-Clonic Seizure
Rhythmical contraction of muscle groups following the tonic phase In the rigid tonic phase, children may fall to the ground, sometimes injuring themselves. Do not breath and become cyanosed. Followed by the clonic phase, with jerking of the limbs. Breathing is irregular, cyanosis persists and saliva may accumulate in the mouth May be biting of the tongue and incontinence of urine. Lasts a few seconds to minutes, followed by unconscious or deep sleep for several hours.
Tonic C lonic Seizure.flv
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Generalised Epilepsies
Atonic Seizures
Often combined with a myoclonic jerk followed by a transient loss of muscle tone causing a sudden fall to the floor or drop of the head. 1-2 years old, last 1-4seconds Most frequent during awakening of falling asleep. Often have Mental Retardation or underlying brain abnormalities
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Generalised Epilepsies
Infantile Spasms (West Syndrome)
4-6months Violent flexor spasms of head, trunk and limbs, followed by extension of the arms (Salaam Spasms) Last 1-2s, bursts of 20-30spasms, usually on waking 2/3 children are neurologically abnormal before onset of seizures- development process further arrested EEG- hypsarrthymia, a chaotic background of high voltage dysrhymic slow-wave activity with sharp components. 30-40% respond well to treatment Loss of skills and later learning disability or epilepsy.
Infantile spasms.flv
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Other epilepsies
Lennox-Gaustaut
1-3 years old Myoclonic single jerk, atonic drop attacks or atypical absences. Developmental arrest or regression & behaviour disorder. Poor prognosis
Differential Diagnosis
Neonates and infants
Jitteryness Benign myoclonus Apnoea Gastro-Oespophageal reflux Shuddering attacks Benign paroxymal torticollis Hyperekplexia
Young children
Breath holding spells Reflex anoxic seizures Parasomnia Benign peroxysmal vertigo Peroxysmal choreoathertosis Tics and ritualistic movements Rage attacks
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Differential Diagnosis
Childhood and Adolescents
Vasovagal syncope Migraine Narcolepsy Panic attacks pseudoseizures
Any Age
Drug-Induced dystonia Cardiac Dysrhythmias
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Investigations
EEG
- if normal, try barbiturate induced sleep, sleep deprivation recording or 24 hour monitoring.
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Medication
>1 episode Attempt to classify the seizure type(s), monotheraphy is recommended. Increase dose gradually until the desired effect is achieved Add 2nd drug if 1st has failed, optimize second drug and try to withdraw 1st drug. Rational combination (2/3 with different mechanisms) Monitor drug levels to check compliance Withdrawal after 2 years of being seizure free
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Surgical
Lobectomy and Cortical Resection Hemispherectomy
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KETOGENIC DIET
Primarily used in childhood epilepsy. Mechanism- unknown. The high-fat, low-protein, no-carbohydrate diet mimics some effects of starvation that seem to inhibit seizures. The diet is very rigid and carefully controlled and must be supervised by a physician -sometimes in a hospital setting.
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Status Epilepticus
Prolonged episode of seizure activity (>30 minutes) or an extended period of recurrent seizures between which the patient does not return to consciousness. Its a medical emergency !!
Can lead to hypoxia, brain damage and death
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