Beruflich Dokumente
Kultur Dokumente
Flavio Guzmn, MD
Pharmacology Instructor Health Sciences Faculty University of Mendoza Argentina
Psychiatry Resident Mental Health Teaching Hospital Dr. Carlos Pereyra Mendoza Argentina
Learning objective
Understand basic concepts of dopaminergic pathways and their relevance to antipsychotic effects.
symptoms) - Mesocortical pathway (negative symptoms) - Nigrostriatal pathway (EPS and TD) -Tuberoinfundibular pathway (hyperprolactinemia)
Physiology
Cognition and executive functions (DLPFC), emotions and affect (VMPFC).
Implications
Hypofunction of the mesocortical pathway might be related to cognitive and negative symptoms in schizophrenia
Summary
Hyperactivation from the VTA to limbic areas might be related to positive symptoms of schizophrenia. Hypofunction of the mesocortical pathway might in part explain cognitive and negative symptoms of schizophrenia. D2 blockade of the nigrostriatal pathway can cause EPS. D2 blockade of the tuberoinfundibular pathway increases prolactin blood levels.