Beruflich Dokumente
Kultur Dokumente
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UMN-UMB, Team 4 specific project: CBP21, a helper protein from the CBM33 family
Gustav Vaaje-Kolstad et al., Journal of Biological Chemistry 280: 11313 11319 & 280:28492-28497 (2005) + Patent application www.umb.no
People:
Claudia Schmidt-Dannert group with post-doc Jake Vick. Eijsink group with post-doc Gustav Vaaje-Kolstad and (since 2010) Ph.D. student Zarah Forsberg.
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GH61 proteins act synergistically with cellulose and show structural similarity with CBM33 (CBP21) CBM33 proteins are enzymes that break down chitin chains GH61 proteins are enzymes that break down cellulose chains Identification of natural CBM33 proteins that break down cellulose
CBM33
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GH61
Endo
Exo-processive
+
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Oxidohydrolase
(CBM33 or GH61), catalyzing chain cleavage in a fully crystalline context
Vaaje-Kolstad et al., 2010, Science 330:219-222
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Nb. Current potential is huge and progress is good, but very high complexity (protein production, analytical tools, theoretical biochemistry, many partners).
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