Beruflich Dokumente
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Chapter 8 Part 2
Clone
A genetically identical copy of an organism
Sexual Reproduction
Chromosome Pairs
Introducing Alleles
Paired genes on homologous chromosomes often vary slightly in DNA sequence as alleles Alleles
Forms of a gene that encode slightly different versions of the genes product
Variation in Traits
Sexual reproduction mixes up alleles from two parents, resulting in new combinations of alleles (and traits) in offspring Variations in allele combinations are introduced during meiosis
Gamete
Mature, haploid reproductive cell
Haploid (n)
Having one of each type of chromosome characteristic of the species
Meiosis sorts the chromosomes into new nuclei twice (meiosis I and meiosis II) Duplicated chromosomes of a diploid nucleus (2n) are distributed into four haploid nuclei (n)
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p. 145
Gamete Formation
Zygote
Diploid (2n) cell formed by fusion of gametes First cell of a new individual, with two sets of chromosomes, one from each parent
8.7 Meiosis
In meiosis, two nuclear divisions halve the parental chromosome number
Meiosis I Meiosis II
Meiosis I
In the first nuclear division, duplicated homologous chromosomes line up and cross over, then move apart, toward opposite spindle poles Two new nuclear envelopes form around the two clusters of still-duplicated chromosomes
Crossing Over
Crossing over is recombination between nonsister chromatids of homologous chromosomes which produces new combinations of parental alleles Crossing over
Homologous chromosomes exchange corresponding segments during prophase I of meiosis
Crossing Over
crossover
A) Here, we focus on only two genes. One gene has alleles A and a; the other has alleles B and b.
B) Close contact between the homologous chromosomes promotes crossing over between nonsister chromatids, so paternal and maternal chromatids exchange segments.
crossover
Meiosis II
The second nuclear division separates sister chromatids Four haploid nuclei typically form, each with one complete set of unduplicated chromosomes
Meiosis
1 Prophase I
2 Metaphase I
3 Anaphase I
4 Telophase I
5 Prophase II
6 Metaphase II
7 Anaphase II
8 Telophase II
Anaphase II
Prophase
Anaphase Telophase
Animation: Meiosis
Meiosis and cytoplasmic division precede the development of haploid gametes in animals and spores in plants The union of two haploid gametes at fertilization results in a diploid zygote
Sporophyte
Diploid, spore-producing body of a plant
Gametophyte
A haploid, multicelled body in which gametes form during the life cycle of plants
Egg
Mature female gamete, or ovum
Fertilization
The fusion of two haploid gamete nuclei during fertilization restores the parental chromosome number in the zygote, the first cell of the new individual
Failure of cell cycle checkpoints results in the uncontrolled cell divisions that characterize cancer
Checkpoint Genes
BRCA genes are tumor suppressor genes whose products normally repair broken DNA
Cancer
Moles and other tumors are neoplasms; a benign neoplasm is noncancerous A malignant neoplasm (cancer) occurs when abnormally dividing cells disrupt body tissues, physically and metabolically Malignant neoplasms can break free and invade other tissues (metastasize)
Metastasis
Cancer cells may metastasize break loose and colonize distant tissues
4 3
1 benign tumor
2 malignant tumor
2. Often have an abnormal plasma membrane, cytoskeleton, or metabolism 3. Often have weakened capacity for adhesion because recognition proteins are altered or lost
The HeLa cell line was established more than 50 years ago without Henrietta Lacks knowledge or consent Today, consent forms are required to take tissue samples, and it is illegal to sell ones own organs or tissues