Healthcare Institute for Neuro-Recovery and

Innovation

Translational

“Turning knowledge into practice to transform lives.”

HINRI Labs © 2008

 Translational Labs
A patient-centered approach to:

“Turning knowledge into practice to

transform lives.”

HINRI Labs © 2008

 HINRI Translational Labs
Mission

Build a nationally recognized nexus

for academia, science, medicine,
business, philanthropy, and public
policy to advance patient-centered
research, rehabilitation,
restoration, and recovery from
neurological impairments due to
injury, disease, or congenital causes.
HINRI Labs © 2008
 HINRI Translational Labs Goals
• Turn knowledge into practice to transform lives by:
– Creating the nation's leading translational laboratories for
spinal cord injury, brain trauma, and neurological disorders
with collaboration centers in Atlanta, Palo Alto, and Boston
– Linking knowledge, ideas, and innovation from the
scientific, medical, philanthropic, public policy, investment,
and patient communities
• Create and support clinical trials to speed times
between innovation and application:
– Supporting translational and clinical research
– Promoting promising new technologies and commercial
applications

HINRI Labs © 2008

 HINRI Translational Labs Goals
(cont.)
• Develop patient-centric coordinated care models:
– Collaborate with experts on clinical, physical, emotional,
lifestyle, financial, family, friends, community, and faith
for optimum capabilities development

• Engage Venture Philanthropy, Foundations, & Payors:

– Fostering a pre-competitive environment to evaluate and

distribute critical intellectual property from research
– Establishing best practices and a model standard of care for
rehabilitation and restoration
– Creating economic support and rationalization of care for
recovery
HINRI Labs © 2008
 HINRI Translational Lab
The Problem Statement
Institute of Medicine – “it takes 18 years for accepted
research to become common practice”, because of:
• Inadequately focused research
• Delays in research to trials
• Delays in trials to specialist providers
• Delays in specialist knowledge to common practice
• Delays in treatment applications to help patients
• Lack of patient-centered treatments – traditional focus is on
incomplete SCI rather than acute (1st 30 days) or complete SCI
• Reimbursement and Treatment Limits

HINRI Labs © 2008

 HINRI Translational Lab
The Solution
Rapid Dissemination and Translation of Ideas &
Best Practices for:
• Research – coordinate and support new ideas
• Rehabilitation – Test and develop new individualized
patient-centered physical and emotional approaches to
rehabilitation
• Restoration – Promote and conduct clinical trial testing in
partnership with researchers, early stage companies and
trauma centers
• Recovery – Provide clinical, emotional, & lifestyle
education for individual, family, and friends to optimize
recovery and capabilities

HINRI Labs © 2008

Translational Research
Finding Patient Centered Solutions

Atlanta*
Rehabilitation Restoration

HINRI Palo
Boston* LABS Alto*

* Academia, Science,
Medicine, Business,
Recovery Philanthropy, and
Public Policy

HINRI Labs © 2008

 Translational Rehabilitation
Collaboration Traditional RehabNon-Traditional Rehab
Academia,
Business Medical
Monitoring Massage Trigger
Clinical Practice Assistive
Technology Manual Therapies
Patient
Centered
Clinical Trials Activity-Based Nutrition/Supplements
Best Practices

HINRI Labs HINRI Labs HINRI Labs Improved

Functionality
Patients Locomat & Hyperbaric Optimum
Armin Chamber Capabilities
Payors Electrophysiology Mental, Spiritual
Emotional Health
HINRI Labs © 2008
 Translational Restoration
“Proof of Principle” Research – Does the basic science &
new ideas hold true for human patients?
University HINRI Shepherd Trauma
Partners Labs Center Centers

Basic “P of P” Clinical Clinical

Research Research Research Practice

HINRI Translational Lab’s patient-centered clinical

trial platform will foster collaboration between
universities and clinical research centers.
HINRI Labs © 2008
 Translational Recovery
Independence Functionality
Spirituality Medication

Education Therapy

Leisure Family and

Patient Centered
Activities Friends
Goals

Readiness for Physical

Employment Health

Socialization Nutrition
Fulfillment Normality

HINRI Labs © 2008

 Hinri LABS
Areas of Focus
Permanent or irreversible
central nervous system disorders

• Phase 1 - “Complete” Spinal Cord Injury (SCI)

• Phase 2 - Traumatic Brain Injury (TBI) and Stroke
• Phase 3 - Neurological Disorders*

*Disease/Degeneration – Multiple Sclerosis, Amyotrophic

Lateral Sclerosis, Parkinson’s, and Alzheimer’s

HINRI Labs © 2008

 HINRI Labs – Action Plan
Phase Target Focus Method
1A Complete SCI Measurement – Neural Electrophysiology and
Plasticity, Functional Robotics
Recovery

1B Complete SCI Translation – Bench to Assistive Technology,

Bedside Holistic Medicine,
Stem Cell Research
2 Brain Injury Measurement and Imaging, Surgery,
Translation Pharmaceuticals, Stem
Cells, Emerging
Therapies
3 Neuro- Neural Injury and Basic Research
Degeneration - Cell
Disease death, nerve regeneration
and reconnection
HINRI Labs © 2008
 HINRI Labs – Rehabilitation Phase
1A and 1B
• Provide the scientific insights, new technologies and novel treatments to test, train and measure
functional recovery (neural activity, muscle pattern activity, spinal reflexes and plasticity)
– Activity-Based Rehabilitation
– New Drugs, Electrical Stimulation and Cell Transplantation Therapies
– Train Reaching and Grasping (to improve upper extremity function)

• Electrophysiology and Robotics (Lokomat and Armin)

– Control experimental conditions
– Generate standardized “training” of motor tasks
– Measure mechanical aspects of functional recovery

• “Proof of Principle” Studies

– Focus on underserved areas of investigation in SCI research
– Translate animal studies research to human SCI studies
– Neural mechanisms underlying functional recovery and neural connections across the level of injury
– Measure Brain Motor Control Assay (BMCA)
– Functional MRI and diffusion tensor imaging
 HINRI Labs Timeline 2009
Phase JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC

Atlanta – 1A
($3 MM)
Atlanta – 1B
($5 MM)
Palo Alto – 1A
($2.5 MM)
Boston – 1A
($2.5 MM)
Atlanta – 2
($7.5 MM)
Atlanta – 3
($5 MM)

HINRI Labs © 2008

 Business Model

US Military
Wounded Veterans
Coordinate & Support Patients
Strategic Partners
Research Collaboration

Test & Develop Venture Philanthropy

Best Practices Common Goals
Rehabilitation
Translational
Promote/Conduct
Clinical Trials Foundations & Charities
Restoration Common Mission

Collaborate
Patient on
Centered Collaborate
Government,onVA,
Best Practices
Clinical & Lifestyle Best Practices
Private Insurance
Rehabilitation
Recovery Rehabilitation
Capital
 Strategic Partners
• Location – The Shepherd Center has agreed to provide
the third floor in their main building for HINRI Labs
• University Partners - Emory, Georgia Tech and
Morehouse; Stanford and Harvard/MIT
• Media – CNN (Dr. Sanjay Gupta)
• Corporate - Google Health and Microsoft HealthVault
• SHARE Initiative – a $6MM partnership between
Humana, Major League Baseball, Bernie Marcus and
the McCormick Foundation to assist Wounded Veterans
and their Families at Shepherd (68 participants to date)
 Venture Philanthropy
Corporate Partners
• Dr. Louis Sullivan* – 3M; Bristol, Myers, Squibb; CIGNA
• Bernie Marcus – SHARE Initiative, Home Depot ($300 MM)
• Jeff Arnold – WebMD
• Bill Ide – Former ABA President, East West Institute
• Bob Bozeman – Google Health
• Ron Bachman - Microsoft HealthVault
• John Brandon – Apple
• John Moore – Morgan Stanley (Former Head of Global HC)
• Carter Burton – GE Healthcare Financial Services
• Sanjay Gupta – CNN Medical Director
• Steve Case – Former Vice-Chair CECP
• Anthony Begando – Tenon Consulting

* Have agreed to collaborate

 Foundations & Charities
Initial Prospect List

Foundation Partners: Advisory Panel:

• Woodruff •David Brailer – Health Evolution Partners

• Hewlett •Kleiner Perkins
• Healthcare Georgia •Draper Fisher Jurvetson
• Bill/Melinda Gates •James Robinson III – RRE Ventures
• Omidyar Network •Pete G. Peterson – Blackstone
• Google •Silicon Valley Bank – Carlyle Group
• Gordon Moore •Bono – Elevation Partners
• Henry Kravitz
 US Military
Initial Prospect List
Military Partners
• Armed Forces Service Organization (AFSO)
• United Service Organization (USO)
• Wounded Warrior Project
• Military Foundations (2) – Tenon Consulting Solutions
Advisory Panel
• Hon. Sam Nunn and/or Max Cleland
• Hon. John McCain (Orson Swindle)
• Gen. Norman Schwartzkopf
• Hon. Jeb Bush and/or Hon. Jay Rockefeller
• Tom Hanks – www.welcomebackveterans.org
• Congressional Service Academy Representatives
• Former Head(s) of VA or VA Hospital System
• Secretary of the Army and/or Joint Chiefs
 CHT Partnership

A CHT “Capabilities” Project

– Ross Mason, Fellow CHT

The Center for Health Transformation (CHT) will

partner with HINRI Translational Labs (Atlanta, Palo
Alto, and Boston) to advise, support, and promote the
creation of a national nexus, collaboration, and model
of a patient-centered standard of care in research,
rehabilitation, restoration, and recovery from
“permanent” central nervous system disorders.

HINRI Labs © 2008